CN207147968U - Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood - Google Patents
Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood Download PDFInfo
- Publication number
- CN207147968U CN207147968U CN201720448731.1U CN201720448731U CN207147968U CN 207147968 U CN207147968 U CN 207147968U CN 201720448731 U CN201720448731 U CN 201720448731U CN 207147968 U CN207147968 U CN 207147968U
- Authority
- CN
- China
- Prior art keywords
- blood
- near infrared
- urea nitrogen
- hemodialysis
- creatinine content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- External Artificial Organs (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
It the utility model is related to urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, blood sample testing model is established using near infrared spectrometer and monitors the changes of contents of urea nitrogen creatinine in hemodialysis dialyzer inlet and outlet blood on-line, monitored, prevented according to the changes of contents rule of urea nitrogen creatinine in hemodialysis blood, avoiding hemodialysis accident from occurring, so as to provide scientific basis for the treatment of uremic patient, reach and improve the horizontal purpose of patient's treatment of kidney disease.
Description
Technical field
Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood is the utility model is related to, more particularly to one kind
Using urea nitrogen creatinine content on-line monitoring system in the hemodialysis blood of near infrared spectrum detection.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, and dialysis is controlled with the speed increase more than 10%, patient every year
The demand for the treatment of is very big.
Blood dialysis therapy is the principle using pellicle, and the blood of patient and dialyzate are introduced inside and outside dialyzer simultaneously
Side, by means of solute gradient, osmotic gradient and the spread of film both sides, by diffusion, convection current, toxin etc. is removed, by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaves required material, corrects electrolyte and soda acid is put down
Weighing apparatus is disorderly.
Urea is the main dead end product of human body protein metabolism, and amino acid deamination produces NH3And C02, both are in liver
Middle urea synthesis, every gram of protein metabolism produce about 0.3 gram of urea nitrogen.Usual kidney is the major organs of excretion urea, urea
Can reabsorption in each section of tubule after glomerular filtration.Normal adult's empty stomach urea nitrogen be 3.2~7.1mmol/L (9~
20mg/d1).Various parenchymal lesion of the kidney, such as glomerulonephritis, interstitial nephritis, acute or chronic renal failure can make blood
Urea nitrogen increases.If excluding kidney other factor, urea nitrogen 21.4mmol/L (60mg/d1) is one of uremia diagnosis index.
Creatinine (CR) is the product of human muscle's metabolism, mainly passes through the irreversible slow shape of non-enzymatic dehydration by creatine
Into, then be discharged into blood, with homaluria, it is not easy by food effect, can be by glomerular filtration, seldom can quilt in renal tubule
Absorb again, creatinine includes serum creatinine and urine creatinine, and serum creatinine measurement renal function is more meaningful, and serum creatinine concentration measure is to comment
The efficiency index of valency glomerular filtration rate(GFR, it can effectively reflect the substantial damage degree of renal function, clinically detection contributes to
Judge the state of an illness, it is significant.
When carrying out hemodialysis to the exceeded patient of urea nitrogen creatinine content in blood, dialyzer need to be used.Dialyzer
It is likely to occur blocking or disrepair phenomenon.The reason for dialyzer blocks mainly has：A, blood is oversize from the pump time in vitro, and this is dialysis
The main reason for device blocks；B, heparin dosage deficiency, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~
0.5mg/kg, if test tube of hepari is insufficient first, additional heparin amount is big also without positive effect again in dialysis；C, dialysis person itself because
Disease, nephrosis latter stage at end, blood viscosity increases.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the changing rule of haemoconcentration.Such as
When dialysis membrane progressively blocks, the urea nitrogen creatinine content in blood can gradually rise, and surpass when with normal urea nitrogen creatinine content
It when crossing certain limit, can in time be reminded by warning device, effectively avoid the generation of harm.
Furthermore by monitoring the change of urea nitrogen creatinine content in hemodialysis blood on-line, dialyzer breakage can be found in time
Situation.When hollow-fibre membrane such as dialyzer occurs damaged, the urea nitrogen creatinine content in blood can be reduced substantially, pass through monitoring
Dialyzer breakage, timely processing and the generation for avoiding accident can be found in time.
Prior art using electrical conductivity detection, haemoconcentration monitoring etc. prevented, but there is also it is certain the shortcomings that, such as take
The promptness of sample detection is not enough and generation pollution, concentration monitor need high-precision sensor, sensor probe that corruption may occur
The generation for situations such as losing phenomenon and causing measured value inaccuracy.
Near-infrared spectrum technique is the new technique just to grow up in recent years, is quickly to scan thing near infrared spectrometer
A kind of Instrumental Analysis means of the matter in the reflection of 670~2526nm SPECTRAL REGIONs, diffusing reflection or transmitted spectrum.Due near infrared light
Spectral analysis technology have analyze speed is fast, efficiency high, sample without chemical contamination, without sample pretreatment, online Non-Destructive Testing etc.
Advantage, it is widely applied at present in fields such as food and agricultural products detections.But literature search does not find that it is applied to blood
Dialysis on-line monitoring field.
Therefore the advantages of how combining Near Infrared Spectroscopy Detection Technology, urea nitrogen creatinine content in hemodialysis blood is monitored on-line
Change, find hemodialysis when blood in urea nitrogen creatinine content changing rule, find hemodialysis when blood in urea nitrogen creatinine contain
Amount changes and the correlation between Heart Rate, blood pressure, dialysate flow, and urea nitrogen creatinine content is in special feelings in searching blood
The condition such as changing rule under blocking or being damaged, turns into one of problem of the area research.
The content of the invention
The utility model is to solve the problems, such as that prior art is present, there is provided urea nitrogen creatinine content in a kind of hemodialysis blood
On-line monitoring system, blood sample testing model is established using near infrared spectrometer and monitors urea nitrogen flesh in hemodialysis blood on-line
The changes of contents of acid anhydride, reach prevention hemodialysis accident and occur, improve the horizontal purpose for the treatment of of kidney disease.
The utility model provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, including：Blood side is followed
Ring, dialysis fluid side circulation and dialyzer 4；The circulation of blood side includes, human body artery blood outlet side 1, blood pump 2, the first blood prison
Probing is first 14, arterial circulation conduit 3, venous blood circulation conduit 6, human vein blood input side 8, the first near infrared light
Spectrum detection data circuit 16 and near infrared light spectrum monitoring instrument 17；Arterial circulation conduit 3 connects human body artery blood outlet side 1
With the blood entry port of dialyzer 4；Venous blood circulation conduit 6 connects the blood outlet and the input of human vein blood of dialyzer 4
Side 8；First blood monitoring probe 14 is arranged on arterial circulation conduit 3 or venous blood circulation conduit 6；First near-infrared
Spectral detection data circuit 16 connects the first blood monitoring probe 14 and near infrared light spectrum monitoring instrument 17；Dialysis fluid side circulation bag
Include, dialyzate bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line 13 and dialyzate recycling bin 15；Thoroughly
Analyse the dialyzate entrance that liquid inlet line 11 connects dialyzate bucket 9 and dialyzer 4；Dialyzate outlet line 13 connects dialyzer 4
Dialyzate outlet and dialyzate recycling bin 15；Dialysis liquid pump 10 is arranged in dialyzate inlet line 11；First blood monitors
Urea nitrogen content, the near infrared spectrum of creatinine content in the blood of the collection import or export of dialyzer 4 of probe 14.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：The circulation of blood side also includes, the second blood monitoring probe 18 and the second near infrared spectrum detection data circuit 19；
First blood monitoring probe 14 is arranged on arterial circulation conduit 3；Second blood monitoring probe 18 is arranged on venous blood
On circulation conduit 6；Second near infrared spectrum detection data circuit 19 connects the second blood monitoring probe 18 and near infrared spectrum prison
Survey instrument 17.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Urea nitrogen creatinine content is near red in the collection import or export blood of dialyzer 4 of first blood monitoring probe 14
External spectrum, enter near infrared light spectrum monitoring instrument 17 through the first near infrared spectrum detection data circuit 16, with based near infrared spectrum
Hemodialysis blood in urea nitrogen creatinine content quantitatively differentiate that model compares to obtain urea nitrogen creatinine in hemodialysis blood inlet and outlet blood
Content simultaneously records in real time.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Urea nitrogen creatinine content quantitatively differentiates that model refers to prepare different urine in hemodialysis blood based near infrared spectrum
The hemodialysis blood sample of plain nitrogen content, creatinine content, spectra collection is carried out to the blood sample using near infrared spectrometer, so as to
Set up urea nitrogen content, creatinine content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Urea nitrogen creatinine content on-line monitoring system is provided with bubble capture monitor 7 in hemodialysis blood, is arranged on vein
On blood circulation conduit 6.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：First blood monitoring probe 14 or the second blood monitoring probe 18 include probing shell 21, blood channel 24, near
Infrared receiver room 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at probing shell 21
Probing shell 21 is run through in both sides, centre by blood channel 24, and near-infrared receiving chamber 29 and near infrared emission room 32 are respectively by near
Infrared receiver hole 25 connects blood channel 24 near infrared emission hole 30, and near-infrared receiving batter 25 and near infrared emission hole 30 are same
Axle；Near infrared emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber 29 is near
The position in infrared receiver hole 25 is provided with near-infrared receiving closed tube 27；Near-infrared receiving chamber 29 is provided with circuit board 28 and near-infrared receiving closed tube
27 connections；The outside of probing shell 21 is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29, closely red by wire guide 22
Outer bay 32 and outside；Blood channel 24 is provided with quartz glass 33 and covers near-infrared receiving batter 25 and near infrared emission hole 30；
First blood monitoring probe 14 or the second blood monitoring probe 18 also connect probing shell 21 including two closures 26 and distinguish shape
Into near-infrared receiving chamber 29 and near infrared emission room 32；Blood near infrared light monitoring blood channel 24, the spectrum of collection
Signal monitors probe the 14, second blood monitoring 18 inner leads of probe through the first blood and drawn by connector 23 from conduit,
Data circuit 16 is detected through the first near infrared spectrum, the second near infrared spectrum detection data circuit 19 enters near infrared spectrum respectively
Monitor 17, obtain urea nitrogen creatinine content in hemodialysis blood and record in real time.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Closure 26 is threadedly coupled with probing shell 21 by sealing.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Connector 23, probing shell 21 and closure 26 use stainless steel.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Blood near infrared light normal transmission blood channel 24.
Further, the utility model also provides urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, also has
There are following characteristics：Urea nitrogen creatinine content on-line monitoring system is provided with heparin pump 20 in hemodialysis blood, is arranged on arterial blood and follows
On ring conduit 3；The parenteral solution of preparation injects blood through heparin pump 20.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the utility model.
The beneficial effect of invention
1st, by the content of urea nitrogen creatinine in on-line real time monitoring blood, it can quickly judge whether dialyzer blocks up
Plug or disrepair phenomenon, so as to timely processing, prevent the generation of malpractice；
2nd, the detection time of on-line monitoring is short, and urea nitrogen creatinine content data are more in the blood of acquisition, help to find out blood
Thoroughly when blood in urea nitrogen creatinine content changing rule, when helping to search out hemodialysis in blood urea nitrogen creatinine content change
With the correlation between Heart Rate, blood pressure, dialysate flow, so as to for the treatment of uremic patient provide scientific basis；
3rd, Fast nondestructive evaluation is really realized, compared with other monitoring methods, human error and systematic error effectively reduce,
Model accuracy rate is high, improves operating efficiency；
4th, the prevention, treatment, first aid for nephrosis provide reliable technology guarantee, and economy, social effect are huge.
Brief description of the drawings
Fig. 1 is urea nitrogen creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the present utility model.
Fig. 2 is the structural representation of the blood monitoring probe in the utility model.
Reference：
1- human body artery blood outlet sides；2- blood pumps；3- arterial circulation conduits；4- dialyzers；5- hollow-fibre membranes；
6- venous blood circulation conduits；7- bubble capture monitors；8- human vein blood input sides；The clean dialyzate buckets of 9-；10- is saturating
Analyse liquid pump；11- dialyzate inlet lines；12- dialyzer dialysis fluid sides；13- dialyzate outlet lines；The blood of 14- first monitors
Probe；The used dialyzate recycling bins of 15-；The near infrared spectrums of 16- first detect data circuit；17- near infrared light spectrum monitoring instruments；
The blood of 18- second monitoring probe；The near infrared spectrums of 19- second detect data circuit；20- heparin pumps；21- probing shells；22- is led
String holes；23- connectors；24- blood channels；25- near-infrared receiving batters；26- closures；27- near-infrared receiving closed tubes；28- circuits
Plate；29- near-infrared receiving chambers；30- near infrared emissions hole；31- near infrared emission pipes；32- near infrared emissions room；33- quartz glass
Glass.
Embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
Fig. 1 is urea nitrogen creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the present utility model.
As shown in figure 1, urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood, including：Circulate, thoroughly blood side
Analyse the circulation of liquid side and dialyzer 4.Dialyzer 4 has hollow-fibre membrane 5 and dialysis fluid side 12.
The circulation of blood side includes：Human body artery blood outlet side 1, blood pump 2, the first blood monitoring probe 14, arterial blood
Circulation conduit 3, the second blood monitoring probe 18, venous blood circulation conduit 6, human vein blood input side 8, the first near-infrared
Spectral detection data circuit 16, the second near infrared spectrum detection data circuit 19 and near infrared light spectrum monitoring instrument 17.
Arterial circulation conduit 3 connects the blood entry port of human body artery blood outlet side 1 and dialyzer 4.Venous blood
Circulation conduit 6 connects blood outlet and the human vein blood input side 8 of dialyzer 4.First blood monitoring probe 14 is arranged on
On arterial circulation conduit 3.First near infrared spectrum detection data circuit 16 connects the first blood monitoring probe 14 and near red
External spectrum monitor 17.Second blood monitoring probe 18 is arranged on venous blood circulation conduit 6.Second near infrared spectrum detects
Data circuit 19 connects the second blood monitoring probe 18 and near infrared light spectrum monitoring instrument 17.
Dialysis fluid side circulation includes：Dialyzate bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line
13 and dialyzate recycling bin 15.Dialyzate inlet line 11 connects the dialyzate entrance of dialyzate bucket 9 and dialyzer 4.Dialyzate
Outlet line 13 connects dialyzate outlet and the dialyzate recycling bin 15 of dialyzer 4.Dialysis liquid pump 10 is arranged on dialyzate import
On pipeline 11.
The near infrared spectrum of urea nitrogen creatinine content, warp in the collection import blood of dialyzer 4 of first blood monitoring probe 14
First near infrared spectrum detection data circuit 16 enters near infrared light spectrum monitoring instrument 17, with the hemodialysis blood based near infrared spectrum
Middle urea nitrogen creatinine content quantitatively differentiates that model compares to obtain urea nitrogen creatinine content in hemodialysis blood inlet blood and remembered in real time
Record.The near infrared spectrum of urea nitrogen creatinine content, near through second in the collection exit blood of dialyzer 4 of second blood monitoring probe 18
Infrared spectrum detection data circuit 19 enters near infrared light spectrum monitoring instrument 17, with urea in the hemodialysis blood based near infrared spectrum
Nitrogen creatinine content quantitatively differentiates that model compares to obtain urea nitrogen creatinine content in hemodialysis blood exit blood and recorded in real time.
The workflow of urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood：The circulation of blood side refers to human body
The blood that arterial blood outlet side 1 exports is through the blood channel in blood pump 2, the first blood monitoring probe 14, arterial circulation
Conduit 3 enters dialyzer 4, and blood carries out solute with dialyzate through the hollow-fibre membrane 5 in dialyzer 4 and exchanged, then through venous blood
Liquid circulation conduit 6, the blood channel in the second blood monitoring probe 18, human vein blood input side 8 return to human body；Dialyzate
Side circulation refers to that the dialyzate in clean dialyzate bucket 9 enters dialyzer through liquid pump 10 of dialysing, dialyzate inlet line 11 and dialysed
Liquid side 12, carry out solute with the blood in hollow-fibre membrane 5 and exchange, then enter used dialyzate through dialyzate outlet line 13
Recycling bin 15；The near-infrared for the blood that the collection dialyzer 4 of first blood monitoring probe the 14, second blood monitoring probe 18 is imported and exported
Spectrum, enter respectively through the first near infrared spectrum detection data circuit 16, the second near infrared spectrum detection data circuit 19 near red
External spectrum monitor 17, quantitatively differentiate model ratio with urea nitrogen content, creatinine content in the hemodialysis blood based near infrared spectrum
To obtaining urea nitrogen creatinine content in hemodialysis dialyzer inlet and outlet blood and recording in real time.
Urea nitrogen creatinine content quantitatively differentiates that model refers to prepare different urea in hemodialysis blood based near infrared spectrum
The hemodialysis blood sample of nitrogen creatinine content, spectra collection is carried out to the blood sample using near infrared spectrometer, so as to set up
Urea nitrogen content, creatinine content quantitatively differentiate model in hemodialysis blood based near infrared spectrum.
Supervised from the blood that dialyzer 4 comes out through venous blood circulation conduit 6, the second blood monitoring probe 18, bubble capture
Survey device 7, human vein blood input side 8 returns to human body.
The blood that human body artery blood outlet side 1 exports is through blood pump 2, the first blood monitoring probe 14, heparin pump 20, artery
Blood circulation conduit 3 enters dialyzer 4；The parenteral solution of preparation injects blood through heparin pump 20.
Fig. 2 is the structural representation of the blood monitoring probe in the utility model.
As shown in Fig. 2 the first blood monitoring probe 14 and the second blood monitoring probe 18 lead to including probing shell 21, blood
Road 24, near-infrared receiving chamber 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at spy
Probing shell 21 is run through in the both sides of casing 21, centre by blood channel 24, and near-infrared receiving chamber 29 and near infrared emission room 32 are divided
Blood channel 24, near-infrared receiving batter 25 and near infrared emission are not connected near infrared emission hole 30 by near-infrared receiving batter 25
Hole 30 is coaxial；Near infrared emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber
29 are provided with near-infrared receiving closed tube 27 in the position of near-infrared receiving batter 25；Near-infrared receiving chamber 29 is provided with circuit board 28 and near-infrared
Reception pipe 27 connects.
The outside of probing shell 21 is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29, closely by wire guide 22
Infrared emission room 32 and outside；Blood channel 24 is provided with quartz glass 33 and covers near-infrared receiving batter 25 and near infrared emission hole
30；First blood monitoring probe 14 or the second blood monitoring probe 18 also connect probing shell 21 including two closures 26 and distinguished
Form near-infrared receiving chamber 29 and near infrared emission room 32.
Blood near infrared light monitoring blood channel 24, the spectral signal of collection through the first blood monitoring probe 14,
Second blood monitoring, 18 inner leads of probe are drawn by connector 23 from conduit, respectively through the first near infrared spectrum testing number
Enter near infrared light spectrum monitoring instrument 17 according to circuit 16, the second near infrared spectrum detection data circuit 19, obtain urinating in hemodialysis blood
Plain nitrogen creatinine content simultaneously records in real time.
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Connector 23, probing shell 21 and closure 26 use stainless steel.
Blood near infrared light normal transmission blood channel 24.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the utility model.
Although the utility model is disclosed as above with preferred embodiment, they be not for limiting the utility model,
It is any to be familiar with this area technical professional, in the spirit and scope for not departing from the utility model, the change made, change
Type, addition or replacement, still fall within the protection domain of technical solutions of the utility model.
Claims (10)
- A kind of 1. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood, it is characterised in that：Including blood side is circulated, thoroughly Analyse the circulation of liquid side and dialyzer (4)；Described blood side circulation includes, human body artery blood outlet side (1), blood pump (2), the first blood monitoring probe (14), Arterial circulation conduit (3), venous blood circulation conduit (6), human vein blood input side (8), the first near infrared spectrum Detect data circuit (16) and near infrared light spectrum monitoring instrument (17)；The arterial circulation conduit (3) connects the human body and moved The blood entry port of arteries and veins blood outlet side (1) and dialyzer (4)；The venous blood circulation conduit (6) connects the dialyzer (4) Blood outlet and the human vein blood input side (8)；The first blood monitoring probe (14) is arranged on the artery On blood circulation conduit (3) or the venous blood circulation conduit (6)；The first near infrared spectrum detection data circuit (16) Connect the first blood monitoring probe (14) and the near infrared light spectrum monitoring instrument (17)；Described dialysis fluid side circulation includes, dialyzate bucket (9), dialysis liquid pump (10), dialyzate inlet line (11), dialyzate Outlet line (13) and dialyzate recycling bin (15)；The dialyzate inlet line (11) connects the dialyzate bucket (9) and institute State the dialyzate entrance of dialyzer (4)；The dialyzate outlet line (13) connect the dialyzer (4) dialyzate outlet and The dialyzate recycling bin (15)；Dialysis liquid pump (10) is arranged on the dialyzate inlet line (11)；Urea nitrogen content, creatinine contain in described the first blood monitoring probe (14) collection dialyzer (4) import or export blood The near infrared spectrum of amount.
- 2. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 1, it is characterised in that：It is described Blood side circulation also include, the second blood monitoring probe (18) and the second near infrared spectrum detect data circuit (19)；It is described First blood monitoring probe (14) is arranged on the arterial circulation conduit (3)；The second blood monitoring probe (18) It is arranged on the venous blood circulation conduit (6)；Second near infrared spectrum detection data circuit (19) connection described the Two blood monitoring probe (18) and the near infrared light spectrum monitoring instrument (17).
- 3. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 1, it is characterised in that：It is described The first blood monitoring probe (14) collection dialyzer (4) import or export blood in urea nitrogen creatinine content near infrared light Spectrum, detect data circuit (16) through first near infrared spectrum and enter the near infrared light spectrum monitoring instrument (17), with based near Urea nitrogen creatinine quantitatively differentiates that model compares to obtain urea nitrogen in hemodialysis blood inlet and outlet blood in the hemodialysis blood of infrared spectrum Creatinine content simultaneously records in real time.
- 4. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 3, it is characterised in that：Urea nitrogen creatinine quantitatively differentiates that model refers to prepare different urea nitrogens in the described hemodialysis blood based near infrared spectrum The hemodialysis blood sample of creatinine content, spectra collection is carried out to the blood sample using near infrared spectrometer, so as to set up base Urea nitrogen content, creatinine content quantitatively differentiate model in the hemodialysis blood of near infrared spectrum.
- 5. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 1, it is characterised in that：Urea nitrogen creatinine content on-line monitoring system is provided with bubble capture monitor (7) in described hemodialysis blood, is arranged on quiet On arteries and veins blood circulation conduit (6).
- 6. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：Described the first blood monitoring probe (14) and/or the second blood monitoring probe (18) include probing shell (21), blood Passage (24), near-infrared receiving chamber (29) and near infrared emission room (32)；Described near-infrared receiving chamber (29) and near-infrared hair Penetrate room (32) and be respectively provided at probing shell (21) both sides, probing shell (21), near-infrared receiving are run through in centre by blood channel (24) Receive room (29) and blood is connected near infrared emission hole (30) by near-infrared receiving batter (25) respectively near infrared emission room (32) Passage (24), near-infrared receiving batter (25) and near infrared emission hole (30) are coaxial；Described near infrared emission room (32) is near red The position of outer launch hole (30) is provided near infrared emission pipe (31)；Described near-infrared receiving chamber (29) is in near-infrared receiving batter (25) position is provided with near-infrared receiving closed tube (27)；Described near-infrared receiving chamber (29) is provided with circuit board (28) and near-infrared receiving Closed tube (27) connects；Connector (23) is provided with outside described probing shell (21), the connector (23) connects near red by wire guide (22) Outer receiving chamber (29), near infrared emission room (32) and outside；It is near that described blood channel (24) is provided with quartz glass (33) covering Infrared receiver hole (25) and near infrared emission hole (30)；Described the first blood monitoring probe (14) or the second blood monitoring probe (18) also include two closures (26) and connect probing shell (21), form near-infrared receiving chamber (29) and near infrared emission respectively Room (32)；Blood near infrared light monitoring blood channel (24), the spectral signal of collection through the first blood monitor probe (14), Second blood monitoring probe (18) inner lead is drawn by connector (23) from conduit, is examined respectively through the first near infrared spectrum Survey data circuit (16), the second near infrared spectrum detection data circuit (19) enter near infrared light spectrum monitoring instrument (17), obtain blood Urea nitrogen creatinine content and recorded in real time in saturating blood.
- 7. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 6, it is characterised in that：Described closure (26) is threadedly coupled with probing shell (21) by sealing.
- 8. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 6, it is characterised in that：Described connector (23), probing shell (21) and closure (26) uses stainless steel.
- 9. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 6, it is characterised in that：Blood in described near infrared light normal transmission blood channel (24).
- 10. urea nitrogen creatinine content on-line monitoring system in hemodialysis blood according to claim 1, it is characterised in that：Urea nitrogen creatinine content on-line monitoring system is provided with heparin pump (20) in described hemodialysis blood, is arranged on arterial blood and follows On ring conduit (3)；The parenteral solution of preparation injects blood through heparin pump (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720448731.1U CN207147968U (en) | 2017-04-26 | 2017-04-26 | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720448731.1U CN207147968U (en) | 2017-04-26 | 2017-04-26 | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207147968U true CN207147968U (en) | 2018-03-27 |
Family
ID=61658248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720448731.1U Expired - Fee Related CN207147968U (en) | 2017-04-26 | 2017-04-26 | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207147968U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106896082A (en) * | 2017-04-26 | 2017-06-27 | 上海健康医学院 | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis blood |
-
2017
- 2017-04-26 CN CN201720448731.1U patent/CN207147968U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106896082A (en) * | 2017-04-26 | 2017-06-27 | 上海健康医学院 | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis blood |
| CN106896082B (en) * | 2017-04-26 | 2024-02-13 | 上海健康医学院 | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis blood |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4773423A (en) | Blood loss measurement | |
| CN102253230B (en) | Automatic analyzer and analysis method of blood platelets | |
| Paolini et al. | Hemoscan™: A Dialysis Machine-Integrated Blood Volume Monitor | |
| CN205656141U (en) | But conventional analytical equipment of simultaneous measurement CRP and blood | |
| CN207147968U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| Paiva et al. | Comparison between the HemoCue® and an automated counter for measuring hemoglobin | |
| CN206710304U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis dialyzate | |
| CN206804517U (en) | Creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN106983923A (en) | Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN106918573A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CA2268519A1 (en) | System and method for noninvasive hemodynamic measurements in hemodialysis shunts | |
| CN203324287U (en) | Combined microdialysis experiment system | |
| Virga et al. | Comparison of fast peritoneal equilibration tests with 1.36 and 3.86% dialysis solutions | |
| CN106896082A (en) | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN106990068A (en) | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN106970043A (en) | Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN106908410A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN109470533A (en) | A kind of preparation method of the source of people whole blood matrix quality-control product for portable glucose meter | |
| CN109234152A (en) | A kind of circulating tumor cell separator | |
| CN107561038A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN114674781A (en) | Non-invasive glucometer accuracy-based determination device and determination method | |
| CN109239374A (en) | A kind of liquid thrombin time detection reagent | |
| CN108852367A (en) | Blood extracorporeal circulation formula high-precision blood glucose continuous monitor device based on light microfluid | |
| Livshits et al. | Back to the “Gold Standard”: How Precise is Hematocrit Detection Today? | |
| Yoshida et al. | Evaluation of a new method for measuring vascular access recirculation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180327 Termination date: 20210426 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |