CN107561038A - Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate - Google Patents
Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate Download PDFInfo
- Publication number
- CN107561038A CN107561038A CN201710800891.2A CN201710800891A CN107561038A CN 107561038 A CN107561038 A CN 107561038A CN 201710800891 A CN201710800891 A CN 201710800891A CN 107561038 A CN107561038 A CN 107561038A
- Authority
- CN
- China
- Prior art keywords
- dialyzate
- hemodialysis
- creatinine content
- central processing
- processing unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate, this method is included in the hemodialysis dialysate samples that different creatinine contents are prepared in specimen cup, spectra collection is carried out to the hemodialysis dialysate samples in above-mentioned using spectrometer outside the nearly feux rouges of Fourier transformation, establish creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model, discriminating model in will be above-mentioned is sent in central processing unit, near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, the near infrared spectrum of creatinine content in the dialyzer outlet dialyzate of collection is sent in central processing unit；Central processing unit quantitatively differentiates that model is compared to creatinine content in two kinds of dialyzates, if exceeding setting value with detection liquid hold-up, central processing unit sends alarm command to alarm.This method human error and systematic error effectively reduce, and model accuracy rate is high, improves operating efficiency.
Description
Technical field
The present invention relates to medical inspection determination techniques field, creatinine content is supervised online in more particularly to a kind of hemodialysis dialyzate
Survey method and system.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, and dialysis is controlled with the speed increase more than 10%, patient every year
The demand for the treatment of is very big.
Blood dialysis therapy is the principle using pellicle, and the blood of patient and dialyzate are introduced inside and outside dialyzer simultaneously
Side, by means of solute gradient, osmotic gradient and the spread of film both sides, by diffusion, convection current, toxin etc. is removed, by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaves required material, corrects electrolyte and soda acid is put down
Weighing apparatus is disorderly.
Creatinine (CR) is the product of human muscle's metabolism, mainly passes through the irreversible slow shape of non-enzymatic dehydration by creatine
Into, then be discharged into blood, with homaluria, it is not easy by food effect, can be by glomerular filtration, seldom can quilt in renal tubule
Absorb again, creatinine includes serum creatinine and urine creatinine, and serum creatinine measurement renal function is more meaningful, and serum creatinine concentration measure is to comment
The efficiency index of valency glomerular filtration rate(GFR, it can effectively reflect the substantial damage degree of renal function, clinically detection contributes to
Judge the state of an illness, it is significant.
When carrying out hemodialysis to the exceeded patient of creatinine content in blood, dialyzer need to be used.Dialyzer may go out
Now blocking or disrepair phenomenon.The reason for dialyzer blocks mainly has：A, blood is oversize from the pump time in vitro, and this is that dialyzer blocks
The main reason for；B, heparin dosage deficiency, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~0.5mg/
Kg, if test tube of hepari is insufficient first, additional heparin amount is big also without positive effect again in dialysis；C, dialysis person itself because disease,
Nephrosis latter stage at end, blood viscosity increase.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the changing rule of dialysate concentration.
Prior art using electrical conductivity detection, dialysate concentration monitoring etc. prevented, but there is also it is certain the shortcomings that, such as
Sample the promptness of detection not enough and produce pollution, concentration monitor needs high-precision sensor, sensor probe to occur
Corrosion phenomenon and generation situations such as cause measured value inaccuracy.
The content of the invention
It is an object of the invention to provide creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate, to solve
The problem of being proposed in above-mentioned background technology.
The invention provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, including base, fixed mobile jib and
Pole, the fixed mobile jib are vertically mounted on base, and the pole is arranged on fixed mobile jib by knob, the pole
It is parallel with base；Groove is provided with the pole, roller is installed in the groove, the roller is connected with solid by connecting rod
Fixed board, test bar is provided with the fixed plate, and the test bar passes through detection line and the Fourier transformation being arranged on base
The nearly outer spectrometer connection of feux rouges：A pair of elevating levers are additionally provided with the base, the pair of elevating lever is provided with lifter plate, the liter
Drop plate is provided with neck, is provided with specimen cup in the neck, the top of the specimen cup is provided with two through holes, the side of specimen cup
It is respectively equipped with funnel type inlet and drain pipe road；The bottom of the specimen cup is provided with a cavity, and rotating shaft is provided with the cavity,
The rotating shaft and the agitating screw being arranged in specimen cup are rotatablely connected, and the rotating shaft is by motor and is arranged on fixed mobile jib
Controller electrical connection；Dialyzer is additionally provided with the base, the blood entry port of the dialyzer passes through blood catheter and people
Body arterial blood outlet side connects；The blood outlet of the dialyzer is connected by blood catheter and human vein blood input side
Connect；The dialyzate entrance of the dialyzer is connected by dialysis catheter with clean dialyzate bucket；The dialyzate of the dialyzer goes out
For mouth by dialysis catheter and dialyzate monitoring probe connection, the other end that the dialyzate monitors probe is connected near infrared spectrum
Detector, the near-infrared spectrometer are connected with central processing unit by wire, and the central processing unit passes through wire point
The outer spectrometer of the nearly feux rouges of Fourier transformation and alarm are not connected with.
It is preferred that the drain pipe road is provided with rotary valve, the other end in drain pipe road is connected with devil liquor recovery bottle.
It is preferred that the dialyzate outlet of the dialyzer is connected by dialysis pipeline with devil liquor recovery bottle.
Creatinine content on-line monitoring method in a kind of hemodialysis dialyzate, comprises the following steps：
1) the hemodialysis dialysate samples of different creatinine contents are prepared in specimen cup；
2) spectra collection is carried out to the hemodialysis dialysate samples in step 1) using the outer spectrometer of the nearly feux rouges of Fourier transformation；
3) establish creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) the discriminating model in step 3) is sent in central processing unit；
5) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the saturating of collection
The near infrared spectrum of creatinine content is sent in central processing unit in parser outlet dialyzate；
6) central processing unit quantitatively differentiates that model is compared to creatinine content in the dialyzate in step 4) and step 5),
If exceeding setting value with the creatinine content in detection dialyzate, central processing unit sends alarm command, alarm hair to alarm
Go out alarm.
Compared to the prior art the present invention, the advantage is that：
Creatinine content on-line monitoring system in a kind of hemodialysis dialyzate provided by the invention, by the liter for controlling elevating lever
Drop, so as to the lifting of convenient control specimen cup, and then test bar is facilitated to be inserted freely into or extract out specimen cup so that measure
Efficiency improves；By opening the agitating screw in specimen cup, measure liquid can be made more to homogenize, and then effectively increase measure
Data；The system really realizes Fast nondestructive evaluation, and compared with other monitoring methods, human error and systematic error effectively drop
Low, model accuracy rate is high, improves operating efficiency；Reliable technology guarantee, warp are provided for the prevention, treatment, first aid of nephrosis
Ji, social effect are huge.
Brief description of the drawings
Fig. 1 is creatinine content on-line monitoring system structure chart in a kind of hemodialysis dialyzate provided by the invention.
Description of reference numerals：
1- bases, 2- fixation mobile jibs, 3- poles, 4- knobs, 5- rollers, 6- fixed plates, 7- test bars, 8- detection lines,
The outer spectrometer of the nearly feux rouges of 9- Fourier transformations, 10- elevating levers, 11- lifter plates, 12- necks, 13- specimen cups, 13-1- cavitys, 14-
Agitating screw, 15- rotating shafts, 16- funnel type inlets, 17- drain pipes road, 18- rotary valves, 19- devil liquor recovery bottles, 20- human bodies
Arterial blood outlet side, 21- dialyzers, 22- human vein blood input sides, the clean dialyzate buckets of 23-, the monitoring of 24- dialyzates
Probe, 25- near infrared light spectrum monitoring instruments, 26- central processing units, 27- alarms.
Embodiment
Below in conjunction with the accompanying drawings, the specific embodiment of the present invention is described in detail, it is to be understood that of the invention
Protection domain do not limited by embodiment.
As shown in figure 1, the embodiments of the invention provide creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, including
Base 1, fixed mobile jib 2 and pole 3, fixed mobile jib 2 are vertically mounted on base 1, and pole 3 is arranged on by knob 4 and fixed
On mobile jib 2, pole 3 is parallel with base 1；Groove is provided with pole 3, roller 5 is installed, roller 5 is connected by connecting rod in groove
Fixed plate 6 is connected to, test bar 7 is installed in fixed plate 6, test bar 7 passes through detection line 8 and the Fourier being arranged on base 1
The outer spectrometer 9 of nearly feux rouges is converted to connect：A pair of elevating levers 10 are additionally provided with base 1, a pair of elevating levers 10 are provided with lifter plate 11, rise
Drop plate 11 is provided with neck 12, is provided with specimen cup 13 in neck 12, the top of specimen cup 13 is provided with two through holes, specimen cup 13
Side is respectively equipped with funnel type inlet 16 and drain pipe road 17；The bottom of specimen cup 13 is provided with a cavity 13-1, cavity 13-1
Interior to be provided with rotating shaft 15, rotating shaft 15 is rotatablely connected with the agitating screw 14 being arranged in 13 glasss of sample, and rotating shaft 15 is by motor with setting
Put the controller electrical connection on fixed mobile jib 2；Dialyzer 21 is additionally provided with base 1, the blood entry port of dialyzer 21 passes through
Blood catheter is connected with human body artery blood outlet side 20；The blood outlet of dialyzer 21 passes through blood catheter and human vein blood
Liquid input side 22 connects；The dialyzate entrance of dialyzer 21 is connected by dialysis catheter with clean dialyzate bucket 23；Dialyzer 21
Dialyzate outlet be connected by dialysis catheter and dialyzate monitoring probe 24, dialyzate monitors 24 other end of popping one's head in and is connected with
Near-infrared spectrometer 25, near-infrared spectrometer 25 are connected with central processing unit 26, central processing unit 26 by wire
Spectrometer 9 and alarm 27 outside the nearly feux rouges of Fourier transformation are connected to by wire.
In the present invention, drain pipe road 17 is provided with rotary valve 18, and the other end in drain pipe road 17 is connected with devil liquor recovery
Bottle 19.The dialyzate outlet of dialyzer 21 is connected by dialysis pipeline with devil liquor recovery bottle 19.
Creatinine content on-line monitoring method in a kind of hemodialysis dialyzate, comprises the following steps：
1) the hemodialysis dialysate samples of different creatinine contents are prepared in specimen cup；
2) spectra collection is carried out to the hemodialysis dialysate samples in step 1) using the outer spectrometer of the nearly feux rouges of Fourier transformation；
3) establish creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) the discriminating model in step 3) is sent in central processing unit；
5) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the saturating of collection
The near infrared spectrum of creatinine content is sent in central processing unit in parser outlet dialyzate；
6) central processing unit quantitatively differentiates that model is compared to creatinine content in the dialyzate in step 4) and step 5),
If exceeding setting value with the creatinine content in detection dialyzate, central processing unit sends alarm command, alarm hair to alarm
Go out alarm.
In summary, creatinine content on-line monitoring system in a kind of hemodialysis dialyzate provided in an embodiment of the present invention, passes through
The lifting of elevating lever is controlled, so as to the lifting of convenient control specimen cup, and then facilitates test bar to be inserted freely into or extract out
Specimen cup so that determination efficiency improves；By opening the agitating screw in specimen cup, measure liquid can be made more to homogenize, entered
And effectively increase determination data；The system really realizes Fast nondestructive evaluation, compared with other monitoring methods, human error and
Systematic error effectively reduces, and model accuracy rate is high, improves operating efficiency；Provided reliably for the prevention, treatment, first aid of nephrosis
Technology ensure, economy, social effect are huge.
Disclosed above is only several specific embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, is appointed
What what those skilled in the art can think change should all fall into protection scope of the present invention.
Claims (4)
1. creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, including base (1), fixed mobile jib (2) and pole (3),
Characterized in that, the fixed mobile jib (2) is vertically mounted on base (1), the pole (3) is arranged on by knob (4)
On fixed mobile jib (2), the pole (3) is parallel with base (1)；
Groove is provided with the pole (3), roller (5) is installed, the roller (5) is connected with by connecting rod in the groove
Fixed plate (6), test bar (7) is installed, the test bar (7) is by detection line (8) and is arranged on bottom on the fixed plate (6)
Outer spectrometer (9) connection of the nearly feux rouges of Fourier transformation on seat (1)；
A pair of elevating levers (10) are additionally provided with the base (1), the pair of elevating lever (10) is provided with lifter plate (11), described
Lifter plate (11) is provided with neck (12), is provided with specimen cup (13) in the neck (12), is set above the specimen cup (13)
There are two through holes, the side of specimen cup (13) is respectively equipped with funnel type inlet (16) and drain pipe road (17)；
The bottom of the specimen cup (13) is provided with a cavity (13-1), is provided with rotating shaft (15) in the cavity (13-1), described turn
Axle (15) and the agitating screw (14) being arranged in sample (13) cup are rotatablely connected, and the rotating shaft (15) is by motor with being arranged on
Controller electrical connection on fixed mobile jib (2)；
Dialyzer (21) is additionally provided with the base (1), the blood entry port of the dialyzer (21) passes through blood catheter and people
Body arterial blood outlet side (20) connects；The blood outlet of the dialyzer (21) is defeated by blood catheter and human vein blood
Enter side (22) connection；
The dialyzate entrance of the dialyzer (21) is connected by dialysis catheter with clean dialyzate bucket (23)；The dialyzer
(21) dialyzate outlet monitors probe (24) with dialyzate by dialysis catheter and is connected, the dialyzate monitoring probe (24)
The other end is connected with near-infrared spectrometer (25), and the near-infrared spectrometer (25) is connected with centre by wire
Device (26) is managed, the central processing unit (26) is connected to spectrometer (9) and alarm outside the nearly feux rouges of Fourier transformation by wire
Device (27).
2. creatinine content on-line monitoring system in a kind of hemodialysis dialyzate as claimed in claim 1, it is characterised in that it is described go out
Liquid pipe road (17) is provided with rotary valve (18), and the other end of drain pipe road (17) is connected with devil liquor recovery bottle (19).
3. creatinine content on-line monitoring system in a kind of hemodialysis dialyzate as claimed in claim 2, it is characterised in that described
The dialyzate outlet of parser (21) is connected by dialysis pipeline with devil liquor recovery bottle (19).
4. creatinine content on-line monitoring method in a kind of hemodialysis dialyzate, it is characterised in that comprise the following steps：
1) the hemodialysis dialysate samples of different creatinine contents are prepared in specimen cup；
2) spectra collection is carried out to the hemodialysis dialysate samples in step 1) using the outer spectrometer of the nearly feux rouges of Fourier transformation；
3) establish creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) the discriminating model in step 3) is sent in central processing unit；
5) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the dialyzer of collection
The near infrared spectrum of creatinine content is sent in central processing unit in outlet dialyzate；
6) central processing unit quantitatively differentiates that model is compared to creatinine content in the dialyzate in step 4) and step 5), if band
Creatinine content in detection dialyzate exceedes setting value, and central processing unit sends alarm command to alarm, and alarm sends report
Alert sound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710800891.2A CN107561038A (en) | 2017-09-07 | 2017-09-07 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710800891.2A CN107561038A (en) | 2017-09-07 | 2017-09-07 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107561038A true CN107561038A (en) | 2018-01-09 |
Family
ID=60979582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710800891.2A Pending CN107561038A (en) | 2017-09-07 | 2017-09-07 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107561038A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109709066A (en) * | 2019-03-04 | 2019-05-03 | 永仁牧云生物科技有限公司 | Quality determining method is used in a kind of processing of olive oil |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102901707A (en) * | 2012-07-26 | 2013-01-30 | 苏州天和自动化系统有限公司 | Spectrum detection rod capable of continuously measuring |
| CN202757880U (en) * | 2012-07-26 | 2013-02-27 | 苏州天和自动化系统有限公司 | Spectrum detecting rod capable of continuously detecting |
| CN104535631A (en) * | 2015-01-20 | 2015-04-22 | 三诺生物传感股份有限公司 | Electrochemical measurement method |
| CN104949978A (en) * | 2015-07-01 | 2015-09-30 | 南京普朗医疗设备有限公司 | Two-channel intelligent handheld detector |
| CN105628640A (en) * | 2015-09-24 | 2016-06-01 | 首都师范大学 | Terahertz spectrum technology based urine detection method |
| WO2016141451A1 (en) * | 2015-03-11 | 2016-09-15 | Hormoz Azizian | Method and technique for verification of olive oil composition |
| CN206248604U (en) * | 2016-09-29 | 2017-06-13 | 吉林工程技术师范学院 | A kind of use electrochemica biological sensor determines the device of Lactose in Milk content |
| CN106918573A (en) * | 2017-04-26 | 2017-07-04 | 上海健康医学院 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
-
2017
- 2017-09-07 CN CN201710800891.2A patent/CN107561038A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102901707A (en) * | 2012-07-26 | 2013-01-30 | 苏州天和自动化系统有限公司 | Spectrum detection rod capable of continuously measuring |
| CN202757880U (en) * | 2012-07-26 | 2013-02-27 | 苏州天和自动化系统有限公司 | Spectrum detecting rod capable of continuously detecting |
| CN104535631A (en) * | 2015-01-20 | 2015-04-22 | 三诺生物传感股份有限公司 | Electrochemical measurement method |
| WO2016141451A1 (en) * | 2015-03-11 | 2016-09-15 | Hormoz Azizian | Method and technique for verification of olive oil composition |
| CN104949978A (en) * | 2015-07-01 | 2015-09-30 | 南京普朗医疗设备有限公司 | Two-channel intelligent handheld detector |
| CN105628640A (en) * | 2015-09-24 | 2016-06-01 | 首都师范大学 | Terahertz spectrum technology based urine detection method |
| CN206248604U (en) * | 2016-09-29 | 2017-06-13 | 吉林工程技术师范学院 | A kind of use electrochemica biological sensor determines the device of Lactose in Milk content |
| CN106918573A (en) * | 2017-04-26 | 2017-07-04 | 上海健康医学院 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109709066A (en) * | 2019-03-04 | 2019-05-03 | 永仁牧云生物科技有限公司 | Quality determining method is used in a kind of processing of olive oil |
| CN109709066B (en) * | 2019-03-04 | 2023-07-25 | 永仁太谷农业发展有限公司 | Quality detection method for olive oil processing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6666840B1 (en) | Method for determining waste products in the dialysis liquid in dialysis treatment | |
| CN1083576C (en) | Fluid sampling module | |
| CN104062260B (en) | A kind of containing the near infrared online detection method in naringin Chinese Traditional Medicine | |
| CN102621092B (en) | Method for detecting Danhong injection ethanol precipitation process on line | |
| JPS62270136A (en) | Method and apparatus for measuring gas partial pressure in blood | |
| CN102253230A (en) | Automatic analyzer and analysis method of blood platelets | |
| CN104390926A (en) | Online rapid detection method of herba andrographis concentrated decolorization process | |
| CN107561038A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN105517490B (en) | Full-automatic citric acid partially anti-freezing function machine | |
| CN109300543A (en) | A kind of data monitoring method for haemodialysis | |
| CN206804517U (en) | Creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN103308611B (en) | Multichannel sample injecting etiological diagnostic system for urinary calculus and application method | |
| CN206710304U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis dialyzate | |
| CN110346323B (en) | Method for detecting Huagaisan concentrated solution on line based on near infrared spectrum technology | |
| CN207147968U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN202126438U (en) | Automatic analyzer for platelets | |
| CN104297441B (en) | The application of the online quality monitoring hierarchy of control of a kind of infrared spectrum in Mongolian medicinal preparation | |
| CN106918573B (en) | Online monitoring method and system for creatinine content in hemodialysis dialysate | |
| Lin et al. | Optoelectronic online monitoring system for hemodialysis and its data analysis | |
| CN110152087A (en) | A kind of monitoring method of blood dialysis | |
| CN106983923B (en) | Online monitoring method and system for urea nitrogen content in hemodialysis blood | |
| CN106908410A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN109444367B (en) | Flow path system for fully automatically measuring oil content, animal and vegetable oil content in water | |
| Livshits et al. | Back to the “Gold Standard”: How Precise is Hematocrit Detection Today? | |
| CN106896082A (en) | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis blood |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180109 |
|
| RJ01 | Rejection of invention patent application after publication |