CN103308611B - Multichannel sample injecting etiological diagnostic system for urinary calculus and application method - Google Patents

Multichannel sample injecting etiological diagnostic system for urinary calculus and application method Download PDF

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CN103308611B
CN103308611B CN201310195206.XA CN201310195206A CN103308611B CN 103308611 B CN103308611 B CN 103308611B CN 201310195206 A CN201310195206 A CN 201310195206A CN 103308611 B CN103308611 B CN 103308611B
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processing computer
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detector
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CN103308611A (en
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刘冠琳
阎亮
程跃
傅豪刚
杨文森
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Five channel medical technology (Wuhan) Co., Ltd.
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00871Communications between instruments or with remote terminals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/34Genitourinary disorders
    • G01N2800/345Urinary calculi
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/24Automatic injection systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange

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Abstract

The invention relates to a multichannel sample injecting etiological diagnostic system for urinary calculus and an application method. The system comprises a biochemical analyzer, an electronic medical record system, a multichannel liquid chromatograph device and a digital photomicrography device, and further comprises a central processing computer. The biochemical analyzer, the electronic medical record system, the multichannel liquid chromatograph device and the digital photomicrography device are respectively connected with the central processing computer. The multichannel liquid phase chromatograph device comprises more than two liquid chromatographs and automatic samplers, wherein the automatic samplers are connected with the liquid chromatographs. The diagnostic system standardizes and simplifies the fussy work flow for etiological diagnosis for the first time at home and abroad, and settles the fussy detecting and diagnostic processes for automation.

Description

A kind of urinary calculus pathogen diagnosis system of multichannel sample introduction and application process
Technical field
The present invention relates to a kind of medical diagnosis system and its application process, a kind of specifically uropoiesis of multichannel sample introduction Tying stone etiological diagnosis system and application process.
Background technology
Stone in urinary system is complicated, multi-pathogenesis a disease, is the coefficient result of E&H factor, leads to Cross the multinomial blood and urine biochemical indexes of detection patient and complete Iithiasic etiological diagnosis work, patient can be found lithogenous main The origin cause of formation, preventing and treating for further specific aim provides foundation.But the etiological diagnosis complex steps of current stone in urinary system are difficult To grasp, lead to this diagnostic techniques popularity in China or even world wide limited.
Content of the invention
The invention aims to the existing defect of stone in urinary system diagnosis in solution prior art, provide one kind many The urinary calculus pathogen diagnosis system of passage sample introduction and application process are solving the above problems.
To achieve these goals, technical scheme is as follows:
A kind of urinary calculus pathogen diagnosis system of multichannel auto injection, including Biochemical Analyzer, electronic health record system System, multichannel liquid phase chromatograph device and digital photomicrographic device are it is characterised in that also include for Intelligent Recognition, automatically Typing analysis data and the central processing computer drawing diagnosis report and prophylactic treatment suggestion, described Biochemical Analyzer, electronics Medical records system, multichannel liquid phase chromatograph device and digital photomicrographic device connect central processing computer respectively, described many Passage liquid phase chromatograph device includes plural liquid chromatograph and automatic sampler, and described automatic sampler connects liquid phase Chromatograph.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that described liquid chromatogram Instrument is ion chromatograph.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that also include for inciting somebody to action Diagnosis report that central processing computer draws and the printer that prophylactic treatment suggestion is printed, described printer connects central authorities Process computer.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that also including using Connect central processing computer in the scanning device of input patient's examining report, described scanning device;Also include being manually entered mould Block, described manual input module connects central processing computer.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that described scanning device Including the scanner for being scanned document be used for carrying out the text identification mould of digital independent to the document after scanning Block, described scanner reconnects central processing computer after connecting text identification module.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that described biochemical analysis Instrument includes light source, sampling device, cuvette, detector, signal amplification converter data processing module, and described sampling device is even Connect cuvette, light source and detector and be arranged at by cuvette, the light that light source irradiates out can reach detector by tranmittance color ware, Detector is sequentially connected signal amplification converter data processing module, and data processing module connects central processing computer, institute State the cleaning equipment that Biochemical Analyzer also includes for cleaning cuvette and connecting line, cleaning equipment connects cuvette.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel auto injection it is characterised in that described automatically Injector includes specimen rotating holder, motor, sample suction tube and sampling valve, and the center of described specimen rotating holder is arranged with Rotating shaft, described motor connection specimen rotating holder, described motor connection is rotated sample stage and rotates, and described specimen rotating holder sets Be equipped with a plurality of sample to be tested pipes, described sample suction tube is arranged above sample to be tested pipe, described liquid chromatograph include into Sample device, splitter, suppressed column, conductometric detector, pump and drip washing equipment, described injector be sequentially connected splitter, suppressed column and Conductometric detector, drip washing equipment connects splitter by pump, and described conductometric detector connects central processing computer, described sample Suction tube connects the injector of liquid chromatograph by sampling valve.
A kind of urinary calculus pathogen diagnosis system of above-mentioned multichannel sample introduction is it is characterised in that described digital micrograph Camera includes optical amplifier image-forming module, imageing sensor, A/D modular converter and dsp chip, described optical amplifier imaging Module is sequentially connected imageing sensor, A/D modular converter and dsp chip, and dsp chip connects central processing computer.
A kind of application process of the above-mentioned urinary calculus pathogen diagnosis system of multichannel sample introduction is it is characterised in that wrap Containing following steps:
(1) central processing computer reads the urine of multiple patients by multichannel liquid phase chromatograph device auto injection Ion concentration, calculates each ion 24 hourly amount according to ion concentration and twenty-four-hour urine amount;
Central computer calls stone composition analysis result by one of them of following four mode, manually inputs Module inputs the stone composition that chemical method or Physical are measured;Chemical method is inputted by scanning device or Physical is surveyed Fixed stone composition;Measured by the case history situation input chemical method or Physical calling patient in electronic medical record system Stone composition;Computer networking with stone composition analytical equipment obtains stone composition analysis result;
(2) central processing computer is checked in urine by liquid chromatograph and urinates oxalic acid 24 hourly amount, then transfers electricity The case history situation of patient in sub- medical records system, check in patient body calculus whether printing opacity, whether have intestines problem medical history, by number Code photomicrographic device checks the crystal habit in urine, the result of the stone composition analysis transferred, and then central authorities process and calculate Machine provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(3) central processing computer is checked in urine by liquid chromatograph and urinates uric acid 24 hourly amount, then transfers electricity The case history situation of patient in sub- medical records system, is checked in patient body calculus whether printing opacity, is checked by digital photomicrography device Crystal habit in urine, transfer stone composition analysis result, then central processing computer provide above-mentioned data, assist Further comprehensive descision, assign a cause for an illness and provide prophylactic treatment suggestion;
(4) central processing computer is checked in urine by liquid chromatograph and urinates citric acid 24 hourly amount, then transfers The case history situation of patient in electronic medical record system, is checked in patient body calculus whether printing opacity, is examined by digital photomicrography device The crystal habit having urine examined in liquid, transfer stone composition analysis result, then central processing computer provide above-mentioned data, association Help further comprehensive descision, assign a cause for an illness and provide prophylactic treatment suggestion;
(5) central processing computer checks urinary calcium 24 hourly amount in urine by liquid chromatograph, then transfers electronics The case history situation of patient in medical records system, checks in patient body calculus whether printing opacity, then by Biochemical Analyzer inspection patient's blood The content of blood PTH, blood calcium and serium inorganic phosphorus in liquid, checks the crystal habit in urine, the knot transferred by digital photomicrography device The result of stone constituent analysis, then central processing computer provide above-mentioned data, assist further comprehensive descision, assign a cause for an illness And provide prophylactic treatment suggestion;
(6) central processing computer is checked in urine by liquid chromatograph and urinates magnesium 24 hourly amount, then transfers electronics The case history situation of patient in medical records system, checks in patient body calculus whether printing opacity, transfers stone composition analyze data, by number Code photomicrographic device checks the crystal habit in urine, and then central processing computer provides above-mentioned data, assists further Comprehensive descision, assign a cause for an illness and be given prophylactic treatment suggestion;
(7) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization whether plumage occurs Hairy or loose acicular crystal, transfer stone composition analyze data, clear and definite whether include ammonium magnesium phosphate composition, transfer electronics disease Go through the case history situation of patient in system, obtain the data such as patient's routine urinalysis, urine culture, then central processing computer be given above-mentioned Data, assists further comprehensive descision, assigns a cause for an illness and provide prophylactic treatment suggestion;
(8) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization whether just occur Hexagonal crystal, then again by the case history situation transferring patient in electronic medical record system and transfer stone composition analysis As a result, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provide prevention Treatment recommendations;
(9) manually input module inputs patient's pH value for three days on end, above three times a day, if each pH value is all higher than 5.8, the constituent structure of patient urine is detected by liquid chromatograph;Transfer the case history situation of patient in electronic medical record system, inspection Look in patient body calculus whether printing opacity;And the crystal habit in urine is checked by digital photomicrography device;Above-mentioned being given While data, in conjunction with the result of the stone composition analysis transferred, central processing computer provides the etiological diagnosis stream of next step Journey, diagnosis basis, Pathogeny types and corresponding prevention scheme, assist clinician's comprehensive descision, assign a cause for an illness and provide prevention Treatment recommendations;
(10) by printer, patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
A kind of application process of the above-mentioned urinary calculus pathogen diagnosis system of multichannel sample introduction is it is characterised in that institute State and check that patient blood index can also be scanned through equipment by good after testing sanguification verification certificate by Biochemical Analyzer Automatic identification, is sent to central processing computer;The described case history situation transferring patient in electronic medical record system, checks patient body Whether printing opacity can also be scanned through equipment automatic identification by good after testing X-ray result report to interior calculus, is sent to Central processing computer, in the described inspection patient blood by Biochemical Analyzer, the content of blood PTH, blood calcium and serium inorganic phosphorus can also be led to Cross good after testing blood biochemical analysis result information and be scanned through equipment automatic identification, be sent to central processing computer; Detect that by Biochemical Analyzer the Results of Blood-gas of patient can also be by good after testing vim and vigour biochemical studies report Announcement is scanned through equipment automatic identification, is sent to central processing computer.
Beneficial effects of the present invention are:This diagnostic system is at home and abroad first by workflow specification loaded down with trivial details for etiological diagnosis Change and simplify, the process of loaded down with trivial details detection and diagnosis is arranged and forms automation, the etiological diagnosis to stone in urinary system and pin Popularization and application to property preventing and treating have great significance.
Brief description
Fig. 1 is the overall structure block diagram of the present invention;
Fig. 2 is the structured flowchart of Biochemical Analyzer;
Fig. 3 is the structured flowchart of multichannel liquid phase chromatograph device;
Fig. 4 is the structured flowchart of automatic sampler;
Fig. 5 is the structured flowchart of digital photomicrography device;
Fig. 6 is the structured flowchart of scanning device.
Specific embodiment
Effect for making the architectural feature to the present invention and reached has a better understanding and awareness, in order to preferably Embodiment and accompanying drawing cooperation detailed description, are described as follows:
Referring to Fig. 1, a kind of urinary calculus pathogen diagnosis system of multichannel sample introduction, including Biochemical Analyzer 100, electronics Medical records system 200, multichannel liquid phase chromatograph device 300 and digital photomicrographic device 400, also include for Intelligent Recognition, Automatic input analysis data and the central processing computer 500 drawing diagnosis report and prophylactic treatment suggestion, Biochemical Analyzer 100th, electronic medical record system 200, multichannel liquid phase chromatograph device 300 and digital photomicrographic device 400 connect central authorities respectively Process computer 500.Biochemical Analyzer 100 is used for detecting patient blood sample;Patient is comprised conventional in electronic medical record system 200 Medical history and did other detection examining report data;Multichannel liquid phase chromatograph device 300 auto injection reads many The ion concentration of the urine of individual patient;Digital photomicrography device 400 is used for detecting patient urine crystal form.Work when Wait, by the control of central processing computer 500, Biochemical Analyzer 100, electronic medical record system 200, multichannel liquid chromatograph Device 300 and digital photomicrographic device 400 automatically by the data input of the patient detecting to central processing computer 500 In, abandoned conventional diagnosis algorithm loaded down with trivial details it is difficult to the defect grasped, reached and only needed to doctor in comprehensive items detection data In the case of diagnose the cause of disease, or directly compared by central processing computer 500 be given after related diseases factor data bank diagnosis report and Prophylactic treatment is advised.
In the present invention, liquid chromatograph 300 is ion chromatograph, because the process in stone in urinary system etiological diagnosis In, most important test mode is the concentration of related zwitterion in detection patient urine, so ion chromatograph is in the present invention In occupy vital position.
Also include the diagnosis report for drawing central processing computer 500 in the present invention and prophylactic treatment suggestion is beaten Print off the printer 600 coming, printer 600 connects central processing computer 500.When central processing computer 500 draws finally Result after, the diagnosis report that, can be drawn the personal information of patient by printer 600 and prophylactic treatment suggestion print Come, form last diagnosis report.
Present invention additionally comprises including for inputting the scanning device 700 of patient's examining report, scanning device 700 connects central authorities Process computer 500, the effect of scanning device 700 is directly to pass through scanning device 700 by any result of laboratory test list Data scanning is sent to central processing computer 500, particularly in the detection data needing to use some patients, scanning device Direct for data conversion can be sent to central processing computer 500 by 700;Manual input module 800 is also included, manually in system Input module 800 connects central processing computer 500, and the effect of manual input module 800 is similar with scanning device 700, is also A kind of mode of data input, can by arbitrary detection data manually input module 800 input to central authorities process calculate In machine 500.
Referring to Fig. 2, Biochemical Analyzer 100 includes light source 110, sampling device 120, cuvette 130, detector 140, signal Amplification converter 150 data processing module 160, sampling device 120 connects cuvette 130, light source 110 and detector 140 and sets It is placed in by cuvette, the light that light source irradiates out can reach detector 140 by tranmittance color ware 130, and detector 140 is sequentially connected Signal amplification converter 150 data processing module 160, data processing module 160 connects central processing computer 500, work When, detection sample enters in cuvette 130 from sampling device 120, and light source 110 irradiates cuvette 130 and by light It is irradiated to detector 140 through cuvette 130, after detector 140 detects the light through cuvette 130, signal is transmitted To signal amplification converter 150, signal is amplified and is sent to data processing module after changing by signal amplification converter 150 160, data processing module 160 is sent in central processing computer 500 after well data preparation is changed into detection data.Biochemical Analyzer 100 also includes the cleaning equipment 170 for cleaning cuvette and connecting line, and cleaning equipment 170 connects cuvette 130, after one-time detection completes, cleaning equipment 170 can be carried out to pipeline and cuvette 130.
Referring to Fig. 3 and Fig. 4, multichannel liquid phase chromatograph device 300 includes plural liquid chromatograph 310 and automatically Injector 320, automatic sampler 310 connects liquid chromatograph 320, and liquid chromatograph 320 connects central processing computer 500. By the automatic sucking sample of automatic sampler 310, then it is fed sequentially in each liquid chromatograph 320, reach automatically again Sample introduction reads the effect of the ion concentration of urine of multiple patients.
Automatic sampler 310 includes specimen rotating holder 311, motor 312, sample suction tube 313 and sampling valve 314, rotation The center of sample stage 311 is arranged with rotating shaft 315, and motor 312 connects specimen rotating holder 311, and motor 312 connects drive rotation Turn sample stage 311 to rotate, specimen rotating holder 311 is provided with a plurality of sample to be tested pipes 316, sample suction tube 313 is arranged at Above sample to be tested pipe 316, when work, motor 312 is rotated sample stage 311 315 rotations around the shaft thus driving rotation The sample to be tested pipe 316 turning on sample stage 311 rotates, and sample suction tube 313 is to the sample in the sample to be tested pipe 316 of lower section Carry out automatic ration extraction, be fed sequentially in each liquid chromatograph 320 finally by sampling valve 314.
Liquid chromatograph 320 includes injector 321, splitter 322, suppressed column 323, conductometric detector 324, pump 325 and Drip washing equipment 326, injector 321 is sequentially connected splitter 322, suppressed column 323 and conductometric detector 324, and drip washing equipment 326 leads to Cross pump 325 and connect splitter 322, conductometric detector 324 connects central processing computer 500.Sample suction tube 313 passes through sample introduction Valve 314 connects the injector 321 of liquid chromatograph 320.Institute's test sample product all by automatic sampler 310 enter be then delivered to into In sample device 321, then enter back into splitter 322, enter during splitter 322 because various ion pair splitter 322 intermediate ions are handed over The relative affinity changing resin is of different sizes, and sample is separated into discontinuous bands of a spectrum on splitter 322, and is leached successively and sets Leacheate wash-out in standby 326, eventually enters into conductometric detector 324;Conductometric detector 324 can detect the electrical conductivity of solution, Thus calculating in solution by the concentration of measured ion.It is introduced into the background that suppressed column 323 can reduce leacheate in drip washing equipment 326 Conductance, strengthens the conductance of tested component, thus lifting measurement accuracy.
Referring to Fig. 5, digital photomicrography device 400 includes optical amplifier image-forming module 410, imageing sensor 420, A/D Modular converter 430 and dsp chip 440, optical amplifier image-forming module 410 is sequentially connected imageing sensor 420, A/D modular converter 430 and dsp chip 440, dsp chip 440 connects central processing computer 500.Observation sample 401 is imaged mould by optical amplifier Block 410 carries out optical amplifier imaging, and then optical amplifier image-forming module 410 transmits signals to imageing sensor 420, and image passes Sensor 420 converts analog signals into data signal by A/D modular converter 430, sends out final result finally by dsp chip Deliver in central processing computer 500.
Referring to Fig. 6, after scanning device 700 includes the scanner 710 for being scanned document and is used for scanning Document carry out the text identification module 720 of digital independent, during scanner 710 reconnects after connecting text identification module 720 Centre processes computer 500.When use, scanner 710 is scanned to laboratory test report 701, and then scanner 710 will again The laboratory test report of scanning after text identification module 720 identification, detection data is sent in central processing computer 500.
A kind of application process of the urinary calculus pathogen diagnosis system of multichannel sample introduction comprises the steps of:
(1) central processing computer reads the urine of multiple patients by multichannel liquid phase chromatograph device auto injection Ion concentration, calculates each ion 24 hourly amount according to ion concentration and twenty-four-hour urine amount;
Central computer calls stone composition analysis result by one of them of following four mode, manually inputs Module inputs the stone composition that chemical method or Physical are measured;Chemical method is inputted by scanning device or Physical is surveyed Fixed stone composition;Measured by the case history situation input chemical method or Physical calling patient in electronic medical record system Stone composition;Computer networking with stone composition analytical equipment obtains stone composition analysis result;
(2) central processing computer is checked in urine by liquid chromatograph and urinates oxalic acid 24 hourly amount, then transfers electricity The case history situation of patient in sub- medical records system, check in patient body calculus whether printing opacity, whether have intestines problem medical history, by number Code photomicrographic device checks the crystal habit in urine, the result of the stone composition analysis transferred, and then central authorities process and calculate Machine provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(3) central processing computer is checked in urine by liquid chromatograph and urinates uric acid 24 hourly amount, then transfers electricity The case history situation of patient in sub- medical records system, is checked in patient body calculus whether printing opacity, is checked by digital photomicrography device Crystal habit in urine, transfer stone composition analysis result, then central processing computer provide above-mentioned data, assist Further comprehensive descision, assign a cause for an illness and provide prophylactic treatment suggestion;
(4) central processing computer is checked in urine by liquid chromatograph and urinates citric acid 24 hourly amount, then transfers The case history situation of patient in electronic medical record system, is checked in patient body calculus whether printing opacity, is examined by digital photomicrography device The crystal habit having urine examined in liquid, transfer stone composition analysis result, then central processing computer provide above-mentioned data, association Help further comprehensive descision, assign a cause for an illness and provide prophylactic treatment suggestion;
(5) central processing computer checks urinary calcium 24 hourly amount in urine by liquid chromatograph, then transfers electronics The case history situation of patient in medical records system, checks in patient body calculus whether printing opacity, then by Biochemical Analyzer inspection patient's blood The content of blood PTH, blood calcium and serium inorganic phosphorus in liquid, checks the crystal habit in urine, the knot transferred by digital photomicrography device The result of stone constituent analysis, then central processing computer provide above-mentioned data, assist further comprehensive descision, assign a cause for an illness And provide prophylactic treatment suggestion;
(6) central processing computer is checked in urine by liquid chromatograph and urinates magnesium 24 hourly amount, then transfers electronics The case history situation of patient in medical records system, checks in patient body calculus whether printing opacity, transfers stone composition analyze data, by number Code photomicrographic device checks the crystal habit in urine, and then central processing computer provides above-mentioned data, assists further Comprehensive descision, assign a cause for an illness and be given prophylactic treatment suggestion;
(7) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization whether plumage occurs Hairy or loose acicular crystal, transfer stone composition analyze data, clear and definite whether include ammonium magnesium phosphate composition, transfer electronics disease Go through the case history situation of patient in system, obtain the data such as patient's routine urinalysis, urine culture, then central processing computer be given above-mentioned Data, assists further comprehensive descision, assigns a cause for an illness and provide prophylactic treatment suggestion;
(8) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization whether just occur Hexagonal crystal, then again by the case history situation transferring patient in electronic medical record system and transfer stone composition analysis As a result, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provide prevention Treatment recommendations;
(9) manually input module inputs patient's pH value for three days on end, above three times a day, if each pH value is all higher than 5.8, the constituent structure of patient urine is detected by liquid chromatograph;Transfer the case history situation of patient in electronic medical record system, inspection Look in patient body calculus whether printing opacity;And the crystal habit in urine is checked by digital photomicrography device;Above-mentioned being given While data, in conjunction with the result of the stone composition analysis transferred, central processing computer provides the etiological diagnosis stream of next step Journey, diagnosis basis, Pathogeny types and corresponding prevention scheme, assist clinician's comprehensive descision, assign a cause for an illness and provide prevention Treatment recommendations;
(10) by printer, patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
In the present invention, check that patient blood index can also be by good after testing sanguification by Biochemical Analyzer Verification certificate is scanned through equipment automatic identification, is sent to central processing computer;The described disease transferring patient in electronic medical record system Go through situation, check whether printing opacity can also be scanned through setting by good after testing X-ray result report in patient body calculus Standby automatic identification, is sent to central processing computer, described by Biochemical Analyzer check blood PTH in patient blood, blood calcium and The content of serium inorganic phosphorus can also be scanned through equipment automatic identification by good after testing blood biochemical analysis result information, transmission To central processing computer;Detect that by Biochemical Analyzer the Results of Blood-gas of patient can also be by good after testing blood The report of gas biochemical studies is scanned through equipment automatic identification, is sent to central processing computer.
Beneficial effects of the present invention are:This diagnostic system is at home and abroad first by workflow specification loaded down with trivial details for etiological diagnosis Change and simplify, the process of loaded down with trivial details detection and diagnosis is arranged and forms automation, the etiological diagnosis to stone in urinary system and pin Popularization and application to property preventing and treating have great significance.
General principle, principal character and the advantages of the present invention of the present invention have been shown and described above.The technology of the industry The simply present invention it should be appreciated that the present invention is not restricted to the described embodiments, described in above-described embodiment and specification for the personnel Principle, without departing from the spirit and scope of the present invention the present invention also have various changes and modifications, these change and Improvement both falls within the range of claimed invention.The protection domain of application claims by appending claims and its Equivalent defines.

Claims (6)

1. a kind of urinary calculus pathogen diagnosis system of multichannel auto injection, including Biochemical Analyzer, electronic medical record system, Multichannel liquid phase chromatograph device and digital photomicrographic device are it is characterised in that also include for Intelligent Recognition, automatic input Analysis data and the central processing computer drawing diagnosis report and prophylactic treatment suggestion, described Biochemical Analyzer, electronic health record System, multichannel liquid phase chromatograph device and digital photomicrographic device connect central processing computer respectively, described multichannel Liquid phase chromatograph device includes plural liquid chromatograph and automatic sampler, and described automatic sampler connects liquid chromatogram Instrument;
Also include the printer that the diagnosis report for drawing central processing computer and prophylactic treatment suggestion are printed, institute State printer and connect central processing computer;
Also include connecting central processing computer for the scanning device inputting patient's examining report, described scanning device;Also wrap Include manual input module, described manual input module connects central processing computer.
2. the urinary calculus pathogen diagnosis system of a kind of multichannel auto injection according to claim 1, its feature exists In described liquid chromatograph is ion chromatograph.
3. the urinary calculus pathogen diagnosis system of a kind of multichannel auto injection according to claim 1, its feature exists In described scanning device includes the scanner for being scanned document and is used for carrying out data reading to the document after scanning The text identification module taking, described scanner reconnects central processing computer after connecting text identification module.
4. the urinary calculus pathogen diagnosis system of a kind of multichannel auto injection according to claim 1, its feature exists In described Biochemical Analyzer includes light source, sampling device, cuvette, detector, signal amplification converter data process mould Block, described sampling device connects cuvette, light source and detector and is arranged at by cuvette, and the light that light source irradiates out can pass through Cuvette reaches detector, and detector is sequentially connected signal amplification converter data processing module, and data processing module connects Central processing computer, described Biochemical Analyzer also includes the cleaning equipment for cleaning cuvette and connecting line, and cleaning sets Standby connection cuvette.
5. the urinary calculus pathogen diagnosis system of a kind of multichannel auto injection according to claim 1, its feature exists In described automatic sampler includes specimen rotating holder, motor, sample suction tube and sampling valve, the center of described specimen rotating holder Position is arranged with rotating shaft, described motor connection specimen rotating holder, and described motor connection is rotated sample stage and rotates, described rotation Turn and a plurality of sample to be tested pipes are provided with sample stage, described sample suction tube is arranged above sample to be tested pipe, described liquid phase Chromatograph includes injector, splitter, suppressed column, conductometric detector, pump and drip washing equipment, and described injector is sequentially connected and separates Post, suppressed column and conductometric detector, drip washing equipment connects splitter by pump, and described conductometric detector connects central authorities and processes calculating Machine, described sample suction tube connects the injector of liquid chromatograph by sampling valve.
6. the urinary calculus pathogen diagnosis system of a kind of multichannel auto injection according to claim 5, its feature exists In, described digital photomicrography device includes optical amplifier image-forming module, imageing sensor, A/D modular converter and dsp chip, Described optical amplifier image-forming module is sequentially connected imageing sensor, A/D modular converter and dsp chip, and dsp chip connects centre Reason computer.
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