CN102866258B - Urinary calculus pathogen diagnosis system and application method thereof - Google Patents

Urinary calculus pathogen diagnosis system and application method thereof Download PDF

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CN102866258B
CN102866258B CN201210328025.5A CN201210328025A CN102866258B CN 102866258 B CN102866258 B CN 102866258B CN 201210328025 A CN201210328025 A CN 201210328025A CN 102866258 B CN102866258 B CN 102866258B
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刘冠琳
阎亮
程跃
傅豪刚
杨文森
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Five channel medical technology (Wuhan) Co., Ltd.
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Abstract

The invention relates to a urinary calculus pathogen diagnosis system, which comprises a biochemical analyzer, an electronic medical record system, a liquid-phase chromatographic instrument and a digital microscopic photography device, and the urinary calculus pathogen diagnosis system also comprises a central processing computer, wherein the biochemical analyzer, the electronic medical record system, the liquid-phase chromatographic instrument and the digital microscopic photography device are respectively connected with the central processing computer. The invention relates to an application method of the urinary calculus pathogen diagnosis system. The application method comprises the following steps that (1) ion concentration of urine of a patient is read through the liquid-phase chromatographic instrument, and a calculus component analysis result is called; (2) to (9) different data is detected; and (10) a final result is printed. The urinary calculus pathogen diagnosis system and the application method thereof have beneficial effects that complicated working flow of the pathogen both at home and abroad is firstly standardized and simplified, the complicated detection and diagnosis process is arranged to form automation, and an important significance for popularizing the pathogen diagnosis and the purposeful prevention of urinary calculus can be realized.

Description

A kind of stone in urinary system etiological diagnosis system and application process thereof
Technical field
The present invention relates to a kind of medical diagnosis system and application process thereof, specifically a kind of stone in urinary system etiological diagnosis system and application process thereof.
Background technology
Stone in urinary system is the disease of complicated a, multi-pathogenesis, it is the coefficient result of E&H factor, Iithiasic etiological diagnosis work is completed by detecting the multinomial blood and urine biochemical indexes of patient, the lithogenous main reason of patient can be found, for further specific aim prevention and therapy provides foundation.But the etiological diagnosis complex steps of stone in urinary system at present, is difficult to grasp, causes this diagnostic techniques popularity in China and even world wide limited.
Summary of the invention
The object of the invention is, in order to the defect solved in prior art existing for stone in urinary system diagnosis, to provide a kind of stone in urinary system etiological diagnosis system and application process thereof to solve the problems referred to above.
To achieve these goals, technical scheme of the present invention is as follows:
A kind of stone in urinary system etiological diagnosis system, comprise Biochemical Analyzer, electronic medical record system, liquid chromatograph and digital photomicrography device, it is characterized in that, also comprise for Intelligent Recognition, automatic input analysis data and the central processing computer drawing diagnosis report and prophylactic treatment suggestion, described Biochemical Analyzer, electronic medical record system, liquid chromatograph are connected central processing computer respectively with digital photomicrography device.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, it is characterized in that, described liquid chromatograph is ion chromatograph.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, is characterized in that, also comprise the printer that diagnosis report for being drawn by central processing computer and prophylactic treatment suggestion are printed, described printer connects central processing computer.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, is characterized in that, also comprises the scanning device for inputting patient's examining report, described scanning device connects central processing computer; Also comprise manual input module, described manual input module connects central processing computer.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, it is characterized in that, described scanning device comprises the scanner for being carried out scanning by document and is used for the text identification module that the document after to scanning carries out digital independent, and described scanner connects central processing computer after connecting text identification module again.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, it is characterized in that, described Biochemical Analyzer comprises light source, sampling device, cuvette, detector, signal amplification converter and data processing module, described sampling device connects cuvette, light source and detector are arranged at by cuvette, light source irradiation light out can reach detector through cuvette, detector is connection signal amplification converter and data processing module successively, data processing module connects central processing computer, described Biochemical Analyzer also comprises the cleaning equipment for cleaning cuvette and connecting line, cleaning equipment connects cuvette.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, it is characterized in that, described liquid chromatograph comprises injector, separating column, suppressed column, conductometric detector, pump and drip washing equipment, described injector connects separating column, suppressed column and conductometric detector successively, drip washing equipment connects separating column by pump, and described conductometric detector connects central processing computer.
Above-mentioned a kind of stone in urinary system etiological diagnosis system, it is characterized in that, described digital photomicrography device comprises optical amplifier image-forming module, imageing sensor, A/D modular converter and dsp chip, described optical amplifier image-forming module is connection layout image-position sensor, A/D modular converter and dsp chip successively, and dsp chip connects central processing computer.
A kind of above-mentioned stone in urinary system etiological diagnosis systematic difference method, is characterized in that, comprise following steps:
(1) central processing computer reads the ion concentration of patient urine by liquid chromatograph, calculates each ion 24 hourly amount according to ion concentration and twenty-four-hour urine gauge;
Central computer calls stone composition analysis result by one of them of following four kinds of modes, manually load module input chemical method or the stone composition that measures of Physical; By the stone composition that scanning device input chemical method or Physical measure; By the stone composition that the case history situation input chemical method or Physical that call patient in electronic medical record system measure; Stone composition analysis result is obtained with the computer networking of stone composition analytical equipment;
(2) central processing computer is checked in urine by liquid chromatograph and urinates oxalic acid 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, whether have intestines problem medical history, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(3) central processing computer checks in urine by liquid chromatograph sour 24 hourly amounts of urinating, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(4) central processing computer is checked in urine by liquid chromatograph and urinates citric acid 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(5) central processing computer is checked in urine by liquid chromatograph and urinates calcium 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the content of blood PTH, blood calcium and serium inorganic phosphorus in patient blood is checked again by Biochemical Analyzer, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(6) central processing computer is checked in urine by liquid chromatograph and urinates magnesium 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, transfer stone composition and analyze data, the crystal habit in urine is checked by digital photomicrography device, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(7) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization and whether occur featheriness or loose acicular crystal, transfer stone composition and analyze data, clearly whether include ammonium magnesium phosphate composition, transfer the case history situation of patient in electronic medical record system, obtain the data such as Urinary is conventional, urine cultivation, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(8) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization and whether occur regular hexagon crystallization, and then by result that the case history situation of transferring patient in electronic medical record system and the stone composition transferred are analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(9) manually load module input patient for three days on end, every day the pH value of more than 3 times, if each pH value is all greater than 5.8, by the constituent structure of liquid chromatograph detection patient urine; Transfer the case history situation of patient in electronic medical record system, check patient calculi in vivo whether printing opacity; And check the crystal habit in urine by digital photomicrography device; While providing above-mentioned data, in conjunction with the result that the stone composition transferred is analyzed, central processing computer provides next step etiological diagnosis flow process, diagnosis basis, Pathogeny types and corresponding prevention scheme, assists clinician's comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(10) by printer, patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
A kind of above-mentioned stone in urinary system etiological diagnosis systematic difference method, it is characterized in that, describedly check that patient blood index also can be identified through scanning device by sanguification verification certificate good after testing automatically by Biochemical Analyzer, be sent to central processing computer; The described case history situation transferring patient in electronic medical record system, check whether printing opacity also can be identified through scanning device by X-ray report the test good after testing patient's calculi in vivo automatically, be sent to central processing computer, describedly check that the content of blood PTH, blood calcium and serium inorganic phosphorus in patient blood also can be identified through scanning device by blood biochemical analysis result information good after testing automatically by Biochemical Analyzer, be sent to central processing computer; The Results of Blood-gas being detected patient by Biochemical Analyzer also can be identified through scanning device by vim and vigour biochemical studies good after testing report automatically, is sent to central processing computer.
Beneficial effect of the present invention is: this diagnostic system is at home and abroad first by workflow loaded down with trivial details for etiological diagnosis standardization and simplification, the process of loaded down with trivial details diagnosis and detection is arranged and forms robotization, the etiological diagnosis of stone in urinary system and applying of specific aim control are had great significance.
Accompanying drawing explanation
Fig. 1 is one-piece construction block diagram of the present invention;
Fig. 2 is the structured flowchart of Biochemical Analyzer;
Fig. 3 is the structured flowchart of liquid chromatograph;
Fig. 4 is the structured flowchart of digital photomicrography device;
Fig. 5 is the structured flowchart of scanning device;
Embodiment
For making to have a better understanding and awareness architectural feature of the present invention and effect of reaching, coordinating detailed description in order to preferred embodiment and accompanying drawing, being described as follows:
Referring to Fig. 1, a kind of stone in urinary system etiological diagnosis system, comprise Biochemical Analyzer 100, electronic medical record system 200, liquid chromatograph 300 and digital photomicrography device 400, also comprise for Intelligent Recognition, automatic input analysis data and the central processing computer 500 drawing diagnosis report and prophylactic treatment suggestion, Biochemical Analyzer 100, electronic medical record system 200, liquid chromatograph 300 are connected central processing computer 500 respectively with digital photomicrography device 400.Biochemical Analyzer 100 is for detecting patient blood sample; Patient's medical history in the past and other the examining report data detected done are comprised in electronic medical record system 200; Liquid chromatograph 300 is for detecting the concentration of relevant zwitterion in patient urine; Digital photomicrography device 400 is for detecting patient urine crystal form.When work, by the control of central processing computer 500, the data of the patient detected input in central processing computer 500 by Biochemical Analyzer 100, electronic medical record system 200, liquid chromatograph 300 and digital photomicrography device 400 automatically, abandon that diagnosis algorithm was loaded down with trivial details in the past, be difficult to the defect grasped, reach and only need doctor to diagnose the cause of disease when comprehensive every detection data, or directly by providing diagnosis report and prophylactic treatment suggestion after central processing computer 500 comparison related diseases factor data bank.
In the present invention, liquid chromatograph 300 is ion chromatograph, because in the process of stone in urinary system etiological diagnosis, most important test mode detects the concentration of relevant zwitterion in patient urine, so ion chromatograph occupies vital position in the present invention.
Also comprise the printer 600 that diagnosis report for being drawn by central processing computer 500 and prophylactic treatment suggestion are printed in the present invention, printer 600 connects central processing computer 500.After central processing computer 500 draws last result, by printer 600, the suggestion of the personal information of patient, the diagnosis report drawn and prophylactic treatment can be printed, form last diagnosis report.
The present invention also comprises scanning device 700 for inputting patient's examining report, scanning device 700 connects central processing computer 500, the effect of scanning device 700 is directly by scanning device 700, the data scanning of any result of laboratory test list to be sent to central processing computer 500, particularly when needing the detection data using some patient, data directly can be changed and be sent to central processing computer 500 by scanning device 700; Manual input module 800 is also comprised in system, manual input module 800 connects central processing computer 500, effect and the scanning device 700 of manual input module 800 are similar, also be a kind of data input mode, can by detect arbitrarily data manually load module 800 input in central processing computer 500.
Referring to Fig. 2, Biochemical Analyzer 100 comprises light source 110, sampling device 120, cuvette 130, detector 140, signal amplification converter 150 and data processing module 160, sampling device 120 connects cuvette 130, light source 110 and detector 140 are arranged at by cuvette, light source irradiation light out can reach detector 140 through cuvette 130, detector 140 is connection signal amplification converter 150 and data processing module 160 successively, data processing module 160 connects central processing computer 500, when work, detect sample and enter into cuvette 130 from sampling device 120, light source 110 irradiates cuvette 130 and light transmission cuvette 130 is irradiated to detector 140, after detector 140 detects the light through cuvette 130, transmit signals to signal amplification converter 150, signal amplifies and is sent to data processing module 160 after conversion by signal amplification converter 150, data processing module 160 is sent in central processing computer 500 after data preparation being become well detection data.Biochemical Analyzer 100 also comprises the cleaning equipment 170 for cleaning cuvette and connecting line, and cleaning equipment 170 connects cuvette 130, and after one-time detection completes, cleaning equipment 170 can clean pipeline and cuvette 130.
Referring to Fig. 3, liquid chromatograph 300 comprises injector 310, separating column 320, suppressed column 330, conductometric detector 340, pump 350 and drip washing equipment 360, injector 310 connects separating column 320, suppressed column 330 and conductometric detector 340 successively, drip washing equipment 360 connects separating column 320 by pump 350, and conductometric detector 340 connects central processing computer 500.Institute's test sample product all inject from injector 310, and then enter separating column 320, because the relative affinity of various ion pair separating column 320 ion exchange resin varies in size when entering separating column 320, sample is separated into discontinuous bands of a spectrum on separating column, and the leacheate wash-out be leached successively in equipment 360, finally enter conductometric detector 340; Conductometric detector 340 can detect the conductivity of solution, thus calculates in solution by the concentration of measured ion.Introduce the background conductance that suppressed column 330 can reduce leacheate in drip washing equipment 360, strengthen the conductance of tested component, thus promote estimating precision.
Referring to Fig. 4, digital photomicrography device 400 comprises optical amplifier image-forming module 410, imageing sensor 420, A/D modular converter 430 and dsp chip 440, optical amplifier image-forming module 410 is connection layout image-position sensor 420, A/D modular converter 430 and dsp chip 440 successively, and dsp chip 440 connects central processing computer 500.Observation sample 401 carries out optical amplifier imaging by optical amplifier image-forming module 410, then optical amplifier image-forming module 410 transmits signals to imageing sensor 420, simulating signal is converted to digital signal by A/D modular converter 430 by imageing sensor 420, is sent in central processing computer 500 by net result finally by dsp chip.
Referring to Fig. 5, scanning device 700 comprises the scanner 710 for being carried out scanning by document and is used for the text identification module 720 that the document after to scanning carries out digital independent, and scanner 710 connects central processing computer 500 after connecting text identification module 720 again.When using, scanner 710 pairs of laboratory test reports 701 scan, and then detection data are sent in central processing computer 500 after being identified by text identification module 720 by the laboratory test report of scanning by scanner 710 again.
A kind of stone in urinary system etiological diagnosis systematic difference method comprises following steps:
(1) central processing computer reads the ion concentration of patient urine by liquid chromatograph, calculates each ion 24 hourly amount according to ion concentration and twenty-four-hour urine gauge;
Central computer calls stone composition analysis result by one of them of following four kinds of modes, manually load module input chemical method or the stone composition that measures of Physical; By the stone composition that scanning device input chemical method or Physical measure; By the stone composition that the case history situation input chemical method or Physical that call patient in electronic medical record system measure; Stone composition analysis result is obtained with the computer networking of stone composition analytical equipment;
(2) central processing computer is checked in urine by liquid chromatograph and urinates oxalic acid 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, whether have intestines problem medical history, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(3) central processing computer checks in urine by liquid chromatograph sour 24 hourly amounts of urinating, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(4) central processing computer is checked in urine by liquid chromatograph and urinates citric acid 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(5) central processing computer is checked in urine by liquid chromatograph and urinates calcium 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, the content of blood PTH, blood calcium and serium inorganic phosphorus in patient blood is checked again by Biochemical Analyzer, the crystal habit in urine is checked by digital photomicrography device, the result that the stone composition transferred is analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(6) central processing computer is checked in urine by liquid chromatograph and urinates magnesium 24 hourly amount, then the case history situation of patient in electronic medical record system is transferred, check patient calculi in vivo whether printing opacity, transfer stone composition and analyze data, the crystal habit in urine is checked by digital photomicrography device, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(7) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization and whether occur featheriness or loose acicular crystal, transfer stone composition and analyze data, clearly whether include ammonium magnesium phosphate composition, transfer the case history situation of patient in electronic medical record system, obtain the data such as Urinary is conventional, urine cultivation, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(8) crystal habit in urine is checked by digital photomicrography device, check in urine crystallization and whether occur regular hexagon crystallization, and then by result that the case history situation of transferring patient in electronic medical record system and the stone composition transferred are analyzed, then central processing computer provides above-mentioned data, assists further comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(9) manually load module input patient for three days on end, every day the pH value of more than 3 times, if each pH value is all greater than 5.8, by the constituent structure of liquid chromatograph detection patient urine; Transfer the case history situation of patient in electronic medical record system, check patient calculi in vivo whether printing opacity; And check the crystal habit in urine by digital photomicrography device; While providing above-mentioned data, in conjunction with the result that the stone composition transferred is analyzed, central processing computer provides next step etiological diagnosis flow process, diagnosis basis, Pathogeny types and corresponding prevention scheme, assists clinician's comprehensive descision, assigns a cause for an illness and provides prophylactic treatment suggestion;
(10) by printer, patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
In the present invention, check that patient blood index also can be identified through scanning device by sanguification verification certificate good after testing automatically by Biochemical Analyzer, be sent to central processing computer; The described case history situation transferring patient in electronic medical record system, check whether printing opacity also can be identified through scanning device by X-ray report the test good after testing patient's calculi in vivo automatically, be sent to central processing computer, describedly check that the content of blood PTH, blood calcium and serium inorganic phosphorus in patient blood also can be identified through scanning device by blood biochemical analysis result information good after testing automatically by Biochemical Analyzer, be sent to central processing computer; The Results of Blood-gas being detected patient by Biochemical Analyzer also can be identified through scanning device by vim and vigour biochemical studies good after testing report automatically, is sent to central processing computer.
Beneficial effect of the present invention is: this diagnostic system is at home and abroad first by workflow loaded down with trivial details for etiological diagnosis standardization and simplification, the process of loaded down with trivial details diagnosis and detection is arranged and forms robotization, the etiological diagnosis of stone in urinary system and applying of specific aim control are had great significance.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; the just principle of the present invention described in above-described embodiment and instructions; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in claimed scope of the present invention.The protection domain of application claims is defined by appending claims and equivalent thereof.

Claims (7)

1. a stone in urinary system etiological diagnosis system, comprise Biochemical Analyzer, electronic medical record system, liquid chromatograph and digital photomicrography device, it is characterized in that, also comprise for Intelligent Recognition, automatic input analysis data and the central processing computer drawing diagnosis report and prophylactic treatment suggestion, described Biochemical Analyzer, electronic medical record system, liquid chromatograph is connected central processing computer respectively with the digital photomicrography device of the crystal habit checked in urine, described liquid chromatograph is ion chromatograph, for detecting urine oxalic acid, to urinate acid, the acid of urine Chinese holly edge, urine calcium, 24 hourly amounts of urine magnesium.
2. a kind of stone in urinary system etiological diagnosis system according to claim 1, it is characterized in that, also comprise the printer that diagnosis report for being drawn by central processing computer and prophylactic treatment suggestion are printed, described printer connects central processing computer.
3. a kind of stone in urinary system etiological diagnosis system according to claim 2, is characterized in that, also comprises the scanning device for inputting patient's examining report, described scanning device connects central processing computer; Also comprise manual input module, described manual input module connects central processing computer.
4. a kind of stone in urinary system etiological diagnosis system according to claim 3, it is characterized in that, described scanning device comprises the scanner for being carried out scanning by document and is used for the text identification module that the document after to scanning carries out digital independent, and described scanner connects central processing computer after connecting text identification module again.
5. a kind of stone in urinary system etiological diagnosis system according to claim 3 or 4, it is characterized in that, described Biochemical Analyzer comprises light source, sampling device, cuvette, detector, signal amplification converter and data processing module, described sampling device connects cuvette, light source and detector are arranged at by cuvette, light source irradiation light out can reach detector through cuvette, detector is connection signal amplification converter and data processing module successively, data processing module connects central processing computer, described Biochemical Analyzer also comprises the cleaning equipment for cleaning cuvette and connecting line, cleaning equipment connects cuvette.
6. a kind of stone in urinary system etiological diagnosis system according to claim 5, it is characterized in that, described liquid chromatograph comprises injector, separating column, suppressed column, conductometric detector, pump and drip washing equipment, described injector connects separating column, suppressed column and conductometric detector successively, drip washing equipment connects separating column by pump, and described conductometric detector connects central processing computer.
7. a kind of stone in urinary system etiological diagnosis system according to claim 6, it is characterized in that, described digital photomicrography device comprises optical amplifier image-forming module, imageing sensor, A/D modular converter and dsp chip, described optical amplifier image-forming module is connection layout image-position sensor, A/D modular converter and dsp chip successively, and dsp chip connects central processing computer.
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