CN102967701A - Urine analysis system and analysis method thereof - Google Patents
Urine analysis system and analysis method thereof Download PDFInfo
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- CN102967701A CN102967701A CN2012104940587A CN201210494058A CN102967701A CN 102967701 A CN102967701 A CN 102967701A CN 2012104940587 A CN2012104940587 A CN 2012104940587A CN 201210494058 A CN201210494058 A CN 201210494058A CN 102967701 A CN102967701 A CN 102967701A
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Abstract
The invention discloses a urine analysis system and an analysis method thereof. A sampling needle is used to extract a urine sample to form a fore-segment sample, a middle-segment sample and a posterior-segment sample, a liquid system pushes the fore-segment sample into a urine visible component analysis device for urine visible component analysis, the middle-segment sample flows through a urine physical property analysis device for urine physical property analysis, and the posterior-segment sample is dropped in a urine dry chemical analysis device for urine dry chemical analysis. According to the urine analysis system and the analysis method, physical property analysis, urine dry chemical analysis and urine visible component analysis are integrated onto a same analysis platform, and the function of automatically carrying out the urine dry chemical analysis, urine physical property analysis and urine visible component analysis can be fulfilled just by sucking the sample once, so that the workload of a user is reduced; three major analyses are completed by adopting the same urine sample, so that the efficiency of urine analysis is improved; and the urine is unnecessary to suck again for each analysis item, so that the misdiagnosis rate of analysis is reduced.
Description
Technical field
The present invention relates to the employed urinalysis instrument of medical science in-vitro diagnosis, relate in particular to a kind of urine analysis system and analytical approach thereof.
Background technology
The routine urine examination,urine for routine analysis has huge diagnostic value aspect clinical examination, clinical examination routine urinalysis project generally is divided into physical property analysis, urine dry analysis and the analysis of urine visible component.Correspondence also will not urinated dry analysis in the market, the analysis of urine visible component is tested and the instrument of the analysis integrated application of physical property.
Generally be that a urine sample is separately successively analyzed at several different instruments when hospital carries out urine analysis of blood, to obtain dry analysis result, physical property analysis result and visible component analysis result.The tomography of such mode of operation on life period between several different analysis projects if there is the burst thing to interrupt, is easy to produce the mistake with the urine specimen corresponding relation, and mistaken diagnosis occurs.Have in the market and will Accuracy and precision and urine visible component analyser be carried out online solution, but this solution shortcoming is: between the different instruments and the communication between instrument and the test tube conveyer, coordinate there are differences, be difficult for unified, any one link breaks down and causes easily that all whole on-line system can't work, even causes personal injury and property loss.
Therefore, prior art awaits further to improve and develop.
Summary of the invention
In view of above-mentioned the deficiencies in the prior art, the object of the present invention is to provide a kind of urine analysis system and analytical approach thereof, physical property analysis, urine dry analysis and urine visible component analytical integration to same analysis platform, are improved the efficient to urinalysis, reduced misdiagnosis rate.
Technical scheme of the present invention is as follows:
A kind of urinalysis method, it may further comprise the steps:
A, sampling needle extract urine sample and transfer to liquid-way system, described urine sample forms in the end of described liquid-way system and forms stage casing sample and the formation of the surplus urine sample in described sampling needle back segment sample in leading portion sample, the stage casing at described liquid-way system, described liquid-way system pushes urine visible component analytical equipment with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment urinate the physical property analysis, described sampling needle splashes into urine dry analysis device with described back segment sample and urinates dry analysis.
Described urinalysis method, wherein, what described steps A was concrete comprises:
A1, the analysis of urine visible component are: described leading portion sample is pushed sample by the syringe pump of described liquid-way system the micro-imaging mechanism of described urine visible component analytical equipment, make described leading portion sample continual and steady position of focal plane of flowing through optical imaging system in described micro-imaging mechanism, gathered the image information of described leading portion sample by described micro-imaging mechanism, and described image transmission to central processing unit carried out analyzing and processing, obtain urine visible component result; After it is disposed, after being about to described image transmission to central processing unit and finishing, stop described leading portion sample is pushed the action of described micro-imaging mechanism, and the sample lines of cleaning described micro-imaging mechanism and described urine visible component analytical equipment.
Described urinalysis method, wherein, described steps A 1 concrete comprising: make described leading portion sample continual and steady position of focal plane of flowing through optical system in described micro-imaging mechanism, comprise the mode of using outer layer fluid that described leading portion sample liquid is guided.
Described urinalysis method, wherein, what described steps A was concrete comprises:
A2, the analysis of urine physical property are: make described stage casing sample flow cross the sensor passage of described urine physical property analytical equipment, the physical property information of described sensor passage collecting sample after being disposed, is cleaned described urine physical property analytical equipment.
Described urinalysis method, wherein, described steps A 2 concrete comprising: described physical property information comprises proportion, color and the turbidity of described mid-stream sample.
Described urinalysis method, wherein, what described steps A was concrete comprises:
The bar mechanism that selects of A3, described urine dry analysis device selects a test strips, and by the arc manipulation mechanism of described urine dry analysis device described test strips is sent to the corresponding sample position of dripping, described sampling needle moves to the corresponding sample position of dripping, splash into described back segment sample to described test strips, then read bar mechanism by what described arc manipulation mechanism will be sent to the described test strips of described back segment sample described urine dry analysis device, read urine dry chemical information on the described test strips by the described bar mechanism of reading; After being disposed, be about to described back segment sample to described test strips drip sample complete after, clean described sampling needle.
Described urinalysis method, wherein, what described steps A was concrete comprises: described urine dry analysis device is selected first test strips, then described liquid-way system pushes urine visible component analytical equipment with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment urinate the physical property analysis, described sampling needle splashes into urine dry analysis device with described back segment sample and urinates dry analysis.
A kind of urine analysis system, it comprises the central processing unit for the operation of control urine analysis system, wherein, described urine analysis system also comprises a urinalysis workstation, described urinalysis workstation and the communication connection of described central processing unit, described urinalysis workstation comprises described urine visible component analytical equipment, described urine physical property analytical equipment, described urine dry analysis device be used for that urine sample is divided into the leading portion sample, the liquid-way system of stage casing sample and back segment sample, described urine visible component analytical equipment, described urine physical property analytical equipment, described urine dry analysis device all is connected with described liquid-way system.
Described urine analysis system, wherein, described urinalysis workstation also comprises sampling needle, is used for the sampling needle motion and the analytic liquid storing mechanism that is used for providing analytic liquid of control sampling needle movement locus; Described urine dry analysis device comprises that test strips selects bar mechanism, test strips arc manipulation mechanism, test strips to read bar mechanism; Described urine physical property analytical equipment comprises that be used to the sensor passage that carries out the urine physical analysis described urine visible component analytical equipment comprises micro-imaging mechanism;
Described sampling needle, described analytic liquid storing mechanism all are connected with described liquid-way system, described liquid-way system transfers to the correspondence analysis device with the analytic liquid in the described analytic liquid storing mechanism, described sampling needle is arranged on the described sampling needle motion, described liquid-way system is connected with described micro-imaging mechanism, is used for described leading portion sample is pushed described micro-imaging mechanism;
Described test strips selects bar mechanism to be connected with described test strips arc manipulation mechanism, and described test strips arc manipulation mechanism reads bar mechanism with described test strips and is connected.
A kind of urine analysis system provided by the invention and analytical approach thereof, with physical property analysis, urine dry analysis and urine visible component analytical integration to same analysis platform, having realized only drawing a sample can automatically urinate dry analysis, the analysis of urine physical property, urinate the function that visible component is analyzed, reduced user's workload, adopting same urine specimen just to finish three analyzes greatly, improved the efficient of urinalysis, do not need each analysis project again to draw urine, reduced the misdiagnosis rate of analyzing.
Description of drawings
Fig. 1 is the schematic flow sheet of analytical approach among the present invention;
Fig. 2 is the structural representation of analytic system among the present invention
Fig. 3 is the structural representation at urinalysis station among the present invention;
Fig. 4 is a kind of example structure synoptic diagram of urinalysis workstation among the present invention.
Embodiment
The invention provides a kind of urine analysis system and analytical approach thereof, clearer, clear and definite for making purpose of the present invention, technical scheme and effect, below the present invention is described in more detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
The invention provides a kind of urinalysis method, as shown in Figure 1, it may further comprise the steps:
Step 201: sampling needle 106 extracts urine sample and transfers to liquid-way system 112, described urine sample forms the leading portion sample in the end of described liquid-way system 112, in the stage casing of described liquid-way system 112, form stage casing sample and the formation of the surplus urine sample in described sampling needle back segment sample, described liquid-way system 112 pushes urine visible component analytical equipment 103 with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment 104 urinate the physical property analysis, described sampling needle 106 splashes into urine dry analysis device 105 with described back segment sample and urinates dry analysis.
In another preferred embodiment of the present invention, described urine visible component analytical procedure is: described leading portion sample is pushed sample by the syringe pump of described liquid-way system 112 the micro-imaging mechanism of described urine visible component analytical equipment 103, make described leading portion sample continual and steady position of focal plane of flowing through optical imaging system in described micro-imaging mechanism, gathered the image information of described leading portion sample by described micro-imaging mechanism, and described image transmission to central processing unit carried out analyzing and processing, obtain urine visible component result; Until its obtain image information complete after, stop described leading portion sample is pushed the action of described micro-imaging mechanism, and the sample lines of cleaning described micro-imaging mechanism and described urine visible component analytical equipment.
Further, concrete also the comprising of described urine visible component analytical procedure: make described leading portion sample continual and steady position of focal plane of flowing through optical system in described micro-imaging mechanism, comprise the mode of using outer layer fluid that described leading portion sample liquid is guided.
In another preferred embodiment of the present invention, described urine physical property analytical procedure is: make described stage casing sample flow cross the sensor passage of described urine physical property analytical equipment 104, the physical property information of described sensor passage collecting sample, after being disposed, clean described urine physical property analytical equipment 104.And described physical property information comprises proportion, color and the turbidity of described stage casing sample.
In another preferred embodiment of the present invention, concrete also the comprising of described urine dry analysis step: the bar mechanism that selects of described urine dry analysis device 105 selects a test strips, and by the arc manipulation mechanism of described urine dry analysis device 105 described test strips is sent to the corresponding sample position of dripping, described sampling needle 106 moves to the corresponding sample position of dripping, splash into described back segment sample to described test strips, then read bar mechanism by what described arc manipulation mechanism will be sent to the described test strips of described back segment sample described urine dry analysis device, read urine dry chemical information on the described test strips by the described bar mechanism of reading; After being disposed, be about to described back segment sample to described test strips drip sample complete after, clean described sampling needle.
In another preferred embodiment of the present invention, what described step 201 was concrete also comprises: described urine dry analysis device 105 is selected first test strips, then described liquid-way system 112 pushes urine visible component analytical equipment with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment urinate the physical property analysis, described sampling needle 106 splashes into urine dry analysis device with described back segment sample and urinates dry analysis.Having realized only drawing a sample can automatically urinate dry analysis, the analysis of urine physical property, urinate the function that visible component is analyzed, reduced user's workload, improve the efficient to urinalysis, guaranteed same urine sample is analyzed, reduced the misdiagnosis rate of analyzing.
Can also carry out simple deformation to above-mentioned urinalysis method, urinate the physical property analysis such as using described leading portion sample, use described stage casing sample to urinate the visible component analysis, and still use described back segment sample to urinate dry analysis, can certainly be as required the sample of corresponding section be transferred to the correspondence analysis device.When only urine specimen being urinated dry analysis with the analysis of urine visible component, then described liquid-way system 112 can only provide the sample of corresponding section to described urine dry analysis device 105 and described urine visible component analytical equipment 103 for another example; Certainly also also have other conversion, give unnecessary details no longer one by one at this.
The present invention also provides a kind of urine analysis system, and as shown in Figure 2, it comprises that described central processing unit 101 can adopt high-performance computer of the prior art, such as the high-performance computer for the central processing unit 101 of control urine analysis system operation.Described urine analysis system also comprises a urinalysis workstation 102, described urinalysis workstation 102 and described central processing unit 101 communication connections, described urinalysis workstation 102 comprises described urine visible component analytical equipment 103, described urine physical property analytical equipment 104, described urine dry analysis device 105 be used for that urine sample is divided into the leading portion sample, the liquid-way system 112 of stage casing sample and back segment sample, and described liquid-way system 112 is sent to described urine visible component analytical equipment 103 with described leading portion sample, described stage casing sample flow is crossed described urine physical property analytical equipment 104, described back segment sample is splashed on the test strips of described urine dry analysis device 105 described urine visible component analytical equipment 103, described urine physical property analytical equipment 104, described urine dry analysis device 105 all is connected with described liquid-way system 112.
101 pairs of described urinalysis workstations 102 of described central processing unit send instruction, described urinalysis workstation 102 is carried out this instruction, then send data to described central processing unit 101, processed by the data that 101 pairs of described urinalysis workstations 102 of described central processing unit send.The instruction that the described urinalysis workstations 102 of 101 pairs of described central processing units send comprises that urinalysis, instrument reset, instrument self checking, separately urinate dry analysis, separately urinate the visible component analysis, separately urinate physical property analysis, blank testing value, calibration, Quality Control, focusing, pipeline-cleaning, pipeline filling, pipeline evacuation, preparation sample, select a test strips, transmit test strips, adjust the instructions such as light source intensity.The execution instruction of described urinalysis workstation 102, comprise carry out that urinalysis, instrument reset, instrument self checking, separately urinate dry analysis, separately urinate the visible component analysis, separately urinate physical property analysis, blank testing value, calibration, Quality Control, focusing, pipeline-cleaning, pipeline filling, pipeline evacuation, preparation sample, select a test strips, transmit test strips, adjust the instructions such as light source intensity.The data that described urine workstation 102 sends for described central processing unit 101 can be the current status data of the result data of the urine visible component image data of analyzing gained, urine dry analysis gained, result data, instrument that the urine physical property is analyzed gained, the calibration data of instrument, the Quality Control data of instrument, focal position data, the instrument abnormality data that run in service that instrument focuses on etc.101 pairs of described urinalysis workstations 102 of described central processing unit send the processing that data are carried out, comprise that the image data that the urine visible component is analyzed gained is cut apart, cell recognition, cell classification, image information strengthen and process, the result that urine dry chemical, physical property, visible component are analyzed shows, the demonstration of the printing of the editing and processing of urine sample numbering, analysis result and preservation, abnormality etc.
In another preferred embodiment of the present invention, as shown in Figure 3, described urinalysis workstation 102 also comprises sampling needle 106, is used for the sampling needle motion 108 and the analytic liquid storing mechanism 100 that is used for providing analytic liquid of control sampling needle movement locus; Described urine dry analysis device 105 comprises that test strips selects bar mechanism, test strips arc manipulation mechanism, test strips to read bar mechanism; Described urine physical property analytical equipment 104 comprises that be used to the sensor passage that carries out the urine physical analysis described urine visible component analytical equipment 103 comprises micro-imaging mechanism;
Described sampling needle 106, described analytic liquid storing mechanism 100 all are connected with described liquid-way system 112, described liquid-way system 112 transfers to the correspondence analysis device with the analytic liquid in the described analytic liquid storing mechanism 100, be that described analytic liquid storing mechanism 100 is squeezed into analytic liquid in the described liquid-way system 112, described liquid-way system 112 is transferred to analytic liquid in described urine visible component analytical equipment 103, described urine physical property analytical equipment 104 and the described urine dry analysis device 105 again.Described sampling needle 106 is arranged on the described sampling needle motion 108, and described liquid-way system 112 is connected with described micro-imaging mechanism, is used for described leading portion sample is pushed described micro-imaging mechanism; Described analytic liquid storing mechanism 100 is connected with described urine visible component analytical equipment 103, described urine physical property analytical equipment 104, described urine dry analysis device 105 respectively; Described analytic liquid storing mechanism 100 also can be used as the part of described liquid-way system 112, makes the structure of described urinalysis workstation 102 compacter, has reduced the volume of described urinalysis workstation 102.
Described test strips selects bar mechanism to be connected with described test strips arc manipulation mechanism, and described test strips arc manipulation mechanism reads bar mechanism with described test strips and is connected, so that the test strips operation is errorless.
Obvious, also can carry out accommodation to described urine visible component analytical equipment 103, described urine physical property analytical equipment 104 with described urine dry analysis device 105 as required, such as on the basis of above-mentioned urine analysis system, delete described urine physical property analytical equipment 104, keep described urine visible component analytical equipment 103 and described urine dry analysis device 105, only urine specimen is urinated visible component analysis and urine dry analysis; Obvious also can delete described urine dry analysis device 105, and keep described urine visible component analytical equipment 103 and described urine physical property analytical equipment 104, only urine specimen be urinated visible component analysis and the analysis of urine physical property; Suchlike conversion is not being given unnecessary details one by one at this.
In order further to describe urinalysis workstation of the present invention, below enumerate a specific embodiment and carry out further description, as shown in Figure 4.Described central processing unit 101 communicates to connect by cable with described urinalysis workstation 102, described sampling needle 106 connects described urine physical property analytical equipment 104, and described urine physical property analytical equipment 104 can be the sensor passage of a sensor or a plurality of sensor composition.Described urine physical property analytical equipment 104 is connected electromagnetic valve 5 again, and solenoid valve 5 connects the binary channels sample lines.Described binary channels sample lines comprises: solenoid valve 6, solenoid valve 7 and solenoid valve 9, solenoid valve 8 and solenoid valve 10, solenoid valve 11 and solenoid valve 12, solenoid valve 13.The binary channels sample lines connects syringe pump 15 and imaging chamber 32.Described syringe pump 15 is walked around the binary channels sample lines by solenoid valve 14 and solenoid valve 5 and is connected with described sampling needle 106.Syringe 17 connects solenoid valve 7 and the solenoid valve 9 of binary channels sample lines, and syringe 19 connects imaging chamber 32.Syringe 15, syringe 17, syringe 19 are connected to sheath fluid bottle 26 by solenoid valve 13, solenoid valve 16, solenoid valve 18 respectively.Sheath fluid 24 is connected to sheath fluid bottle 26 by liquid pump 25, sheath fluid bottle 26 is connected with waste liquid pool 28 by connection liquid pump 27, solenoid valve 23, solenoid valve 23 connected electromagnetic valves 22, solenoid valve 22 is connected to imaging chamber 32 jointly with solenoid valve 18, there are two outlets in imaging chamber 32, difference connected electromagnetic valve 20 and solenoid valve 21, solenoid valve 20 and solenoid valve 21 all are connected to waste liquid pool 28, and waste liquid pool 28 is connected to waste liquid 30 by liquid pump 29.Solenoid valve 21 is connected with solenoid valve 22.Optical lighting system 31 and optical imaging system 33 are placed in the both sides of imaging chamber 32, be used for gathering the image information of imaging chamber's 32 interior samples, select bar mechanism 34, arc manipulation mechanism 36, read the 37 order installations of bar mechanism, test strips 35 also can be placed on and select in the bar mechanism 34.Sample transfer device 38 is placed on the outside of described urinalysis workstation 102, for delivery of urine specimen.
Should be understood that application of the present invention is not limited to above-mentioned giving an example, for those of ordinary skills, can be improved according to the above description or conversion that all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (9)
1. urinalysis method, it may further comprise the steps:
A, sampling needle extract urine sample and transfer to liquid-way system, described urine sample forms in the end of described liquid-way system and forms stage casing sample and the formation of the surplus urine sample in described sampling needle back segment sample in leading portion sample, the stage casing at described liquid-way system, described liquid-way system pushes urine visible component analytical equipment with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment urinate the physical property analysis, described sampling needle splashes into urine dry analysis device with described back segment sample and urinates dry analysis.
2. urinalysis method according to claim 1 is characterized in that, what described steps A was concrete comprises:
A1, the analysis of urine visible component are: described leading portion sample is pushed sample by the syringe pump of described liquid-way system the micro-imaging mechanism of described urine visible component analytical equipment, make described leading portion sample continual and steady position of focal plane of flowing through optical imaging system in described micro-imaging mechanism, gathered the image information of described leading portion sample by described micro-imaging mechanism, and described image transmission to central processing unit carried out analyzing and processing, obtain urine visible component result; After it is disposed, stop described leading portion sample is pushed the action of described micro-imaging mechanism, and the sample lines of cleaning described micro-imaging mechanism and described urine visible component analytical equipment.
3. urinalysis method according to claim 2, it is characterized in that, described steps A 1 concrete comprising: make described leading portion sample continual and steady position of focal plane of flowing through optical system in described micro-imaging mechanism, comprise the mode of using outer layer fluid that described leading portion sample liquid is guided.
4. urinalysis method according to claim 1 is characterized in that, what described steps A was concrete comprises:
A2, the analysis of urine physical property are: make described stage casing sample flow cross the sensor passage of described urine physical property analytical equipment, the physical property information of described sensor passage collecting sample after being disposed, is cleaned described urine physical property analytical equipment.
5. urinalysis method according to claim 4 is characterized in that, described steps A 2 concrete comprising: described physical property information comprises proportion, color and the turbidity of described mid-stream sample.
6. urinalysis method according to claim 1 is characterized in that, what described steps A was concrete comprises:
The bar mechanism that selects of A3, described urine dry analysis device selects a test strips, and by the arc manipulation mechanism of described urine dry analysis device described test strips is sent to the corresponding sample position of dripping, described sampling needle moves to the corresponding sample position of dripping, splash into described back segment sample to described test strips, then read bar mechanism by what described arc manipulation mechanism will be sent to fast with the described test strips of described back segment sample described urine dry analysis device, read urine dry chemical information on the described test strips by the described bar mechanism of reading; After being disposed, clean described sampling needle.
7. urinalysis method according to claim 1, it is characterized in that, what described steps A was concrete comprises: described urine dry analysis device is selected first test strips, then described liquid-way system pushes urine visible component analytical equipment with described leading portion sample and urinates the visible component analysis, described stage casing sample flow is crossed urine physical property analytical equipment urinate the physical property analysis, described sampling needle splashes into urine dry analysis device with described back segment sample and urinates dry analysis.
8. urine analysis system, it comprises the central processing unit for the operation of control urine analysis system, it is characterized in that, described urine analysis system also comprises a urinalysis workstation, described urinalysis workstation and the communication connection of described central processing unit, described urinalysis workstation comprises described urine visible component analytical equipment, described urine physical property analytical equipment, described urine dry analysis device be used for that urine sample is divided into the leading portion sample, the liquid-way system of stage casing sample and back segment sample, described urine visible component analytical equipment, described urine physical property analytical equipment, described urine dry analysis device all is connected with described liquid-way system.
9. urine analysis system according to claim 8 is characterized in that, described urinalysis workstation also comprises sampling needle, is used for the sampling needle motion and the analytic liquid storing mechanism that is used for providing analytic liquid of control sampling needle movement locus; Described urine dry analysis device comprises that test strips selects bar mechanism, test strips arc manipulation mechanism, test strips to read bar mechanism; Described urine physical property analytical equipment comprises that be used to the sensor passage that carries out the urine physical analysis described urine visible component analytical equipment comprises micro-imaging mechanism;
Described sampling needle, described analytic liquid storing mechanism all are connected with described liquid-way system, described liquid-way system transfers to the correspondence analysis device with the analytic liquid in the described analytic liquid storing mechanism, described sampling needle is arranged on the described sampling needle motion, described liquid-way system is connected with described micro-imaging mechanism, is used for described leading portion sample is pushed described micro-imaging mechanism;
Described test strips selects bar mechanism to be connected with described test strips arc manipulation mechanism, and described test strips arc manipulation mechanism reads bar mechanism with described test strips and is connected.
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| Publication number | Publication date |
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| CN102967701B (en) | 2015-02-25 |
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