CN105466984B - Prior-warning device and its application method for the non-explicit damage of kidney - Google Patents
Prior-warning device and its application method for the non-explicit damage of kidney Download PDFInfo
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- CN105466984B CN105466984B CN201610025621.4A CN201610025621A CN105466984B CN 105466984 B CN105466984 B CN 105466984B CN 201610025621 A CN201610025621 A CN 201610025621A CN 105466984 B CN105466984 B CN 105466984B
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- processing unit
- central processing
- kidney
- warning device
- damage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Abstract
This case is related to the prior-warning device for the non-explicit damage of kidney, comprising: fluid pipe；Air-foam detector is arranged at two ports of fluid pipe；Central processing unit is connected with air-foam detector；Microfluidic control drives probe, and setting is electrically connected on fluid pipe, and with central processing unit；Biological matrix single factor analysis module, and central processing unit data connection, and connect with microfluidic control driving probe by pipeline；Wherein, biological matrix single factor analysis module includes: specific gravity of urine detecting electrode, beta-2-microglobulin detecting electrode and cystatin C detecting electrode；Power supply is connected with central processing unit；Wherein, central processing unit is also integrated with wireless transmission port.The prior-warning device of this case drives probe by microfluidic control, can draw urine in urine collection bag system automatically, be detected according to preset frequency, and without interrupting metering, inspection cost is low, and the level of informatization is high, and convenient and efficient, development potentiality is huge.
Description
Technical field
It is the present invention relates to a kind of device for dynamically detecting of kidney injury, in particular to a kind of for the non-explicit damage of kidney
Prior-warning device and its application method.
Background technique
The various factors for causing kidney injury all may cause the damage of kidney, for example off-capacity leads to renal perfusion pressure
Relatively low, renal blood flow is reduced；Hemoglobin emboli is deposited on many reasons such as glomerulus, renal tubule, easily follows
Ring failure, renal insufficiency etc. treat even if giving in time after clinical detection finds dominant renal impairment, still there is part
Patient progress is chronic renal insufficiency, influences quality of life.Therefore how can be in time when non-explicit damage occurs for kidney
It was found that and diagnosis, and find possible reason, removal causes the injury of kidney factor in advance, takes intervening measure, is always Present clinical
A stubborn problem in medical treatment.
Renal function mainly currently is assessed by the detection of creatinine, urea nitrogen concentration to the detection of renal function, works as flesh
Acid anhydride, urea nitrogen occur showing kidney damage when concentration raising, but at this point, kidney has already appeared damage, no matter from diagnosis or control
Treat angle all and be delay and lag, and in fact, kidney early stage there is stealthy damage, the physicochemical property of urine and contained
Substance has already appeared variation, if the stealthy variation of discovery kidney can be conducive to early diagnosis and the place of disease in time at this moment
Reason reduces treatment difficulty and mitigates medical burden.The variation of urine physicochemical property and contained functional component is reaction renal function
When the important indicator of variation and monitoring renal function, critical patient or body occur abnormal, it is easiest to involve kidney, early stage kidney
It is mainly shown as that stealthy variation, this stealthy variation will appear small change in urine physicochemical property and contained substance when impaired
Change, and dynamic is presented and changes, therefore is analyzed by the capacity of renal secretion urine and the quality of urine, it can be to the body of patient
The carry out at-once monitor of environment in liquid, and indwelling catheter is routine operation, and hurtless measure is seen in critical patient self retaining catheter
It examines and changes with unit of analysis time urine volume, specific gravity of urine, beta-2-microglobulin, cystatin C etc., pass through change rate and several variations
Integrated analysis, judges the variation tendency of patient's renal function, finds potential kidney damage in time, to judge body volume in time
Amount, renal function variation, handles in time, avoids treatment delay, lead to irreversible damage.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to the structure by several single detection devices is whole
It closes, obtains a kind of device for being able to detect the dynamic change of several physicochemical properties in urine, and a kind of intelligentized by establishing
Mathematical model, the horizontal and vertical analysis to surveyed all data, calculates the probability that dysfunction or damage occurs in kidney,
The non-explicit damage for finding kidney in time in kidney asymptomatic damage early stage, is provided with for clinical and early treatment and imitates help.
To achieve the above object, the invention is realized by the following technical scheme:
A kind of prior-warning device for the non-explicit damage of kidney, comprising:
Fluid pipe is internally provided with the cavity for accommodating testing liquid；
Air-foam detector is arranged at two ports of the fluid pipe；
Central processing unit is connected with the air-foam detector；
Microfluidic control drives probe, and setting is electrically connected on the fluid pipe, and with the central processing unit, described
Central processing unit controls to be sampled in the testing liquid that the microfluidic control driving probe is extend into the fluid pipe；
Biological matrix single factor analysis module, and the central processing unit data connection, and driven with the microfluidic control
Dynamic probe is connected by pipeline, and the testing liquid for obtaining to microfluidic control driving probe sampling detects；Wherein,
The biological matrix single factor analysis module includes: specific gravity of urine detecting electrode, beta-2-microglobulin detecting electrode and cystatin C inspection
Survey electrode；
Power supply is connected with the central processing unit；
Wherein, the central processing unit is also integrated with wireless transmission port.
Preferably, the prior-warning device for the non-explicit damage of kidney, wherein the biological matrix single factor test point
Analysing module further includes that urine volume detection module and day urine/enuresis nocturna compare detection module.
Preferably, the prior-warning device for the non-explicit damage of kidney, wherein the microfluidic control drives probe
Whether enter the pinch off of pipeline including sampling syringe needle, the peristaltic pump that testing liquid can be pumped into pipeline and control testing liquid
Valve.
Preferably, the prior-warning device for the non-explicit damage of kidney, wherein the biological matrix single factor test point
Preamplifier is additionally provided between analysis module and the central processing unit.
A kind of application method of the prior-warning device for the non-explicit damage of kidney as described in any one of above scheme, packet
It includes:
Power supply is opened, air-foam detector is opened；
Microfluidic control drives probe sampling；
Biological matrix single factor analysis module analysis obtains parameter: specific gravity of urine Ug；Beta-2-microglobulin Bmg；Cystatin C
Cys；
Association probability pUg, pBmg, pCys of Ug, Bmg, Cys and kidney actual damage are counted respectively；
The non-explicit damage valuation functions of kidney are established in central processing unit:
Wherein,
A threshold value is set, the result obtained according to valuation functions is compared with the threshold value, to judge kidney by non-
The probability of explicit damage.
The beneficial effects of the present invention are:
1, the prior-warning device of this case drives probe by microfluidic control, can draw urine in urine collection bag system automatically, press
It is detected according to preset frequency, without interrupting metering, inspection cost is low, and the level of informatization is high, and convenient and efficient, development potentiality is huge
Greatly.
2, the prior-warning device and its application method of this case can find the variation of renal function early stage in time, pass through model meter
Calculate the probability damaged and possible reason, it is ensured that early intervention is provided in time, avoids occurring seriously to damage that kidney is caused to decline
The irreversibility exhausted.
3, can be achieved wireless transmission function, the portable remotes monitoring function such as mobile phone, operating performance is good, convenient in time with
Real time monitoring.
4, to traditional equipment miniaturized, specific detection pattern is not changed, multi-group electrode detection, accuracy is high, accurately
Degree is more preferable.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the prior-warning device for the non-explicit damage of kidney.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text
Word can be implemented accordingly.
As shown in Figure 1, the prior-warning device for the non-explicit damage of kidney of an embodiment is listed in this case, comprising:
Fluid pipe is internally provided with the cavity for accommodating testing liquid；
Air-foam detector is arranged at two ports of fluid pipe；
Central processing unit is connected with air-foam detector；In the presence of air-foam detector has detected bubble or bubble is deposited
When amount is greater than the set value, this collected data is counted as being dirty data by central processing unit, is not considered, and adopt again
Sample.
Microfluidic control drives probe, and setting is electrically connected on fluid pipe, and with central processing unit, central processing unit control
Microfluidic control driving probe processed, which is extend into the testing liquid in fluid pipe, to be sampled；
Biological matrix single factor analysis module, and central processing unit data connection, and it is logical with microfluidic control driving probe
Piping connection, the testing liquid for obtaining to microfluidic control driving probe sampling detect；Wherein, biological matrix Dan Yin
Plain analysis module includes: specific gravity of urine detecting electrode, beta-2-microglobulin detecting electrode and cystatin C detecting electrode；
Power supply is connected with central processing unit；It is powered for whole device；
Wherein, central processing unit is also integrated with wireless transmission port.Wireless transmission can be existing by bluetooth or WiFi etc.
Transmission technology is realized.
As another embodiment of this case, wherein biological matrix single factor analysis module further includes urine volume detection module and day
Urine/enuresis nocturna compares detection module.Here detection module is preferably that detecting electrode or any one are able to carry out urine volume measurement
Or day urine/enuresis nocturna is than the detection device of the kit form of detection.
In the above-described embodiments, microfluidic control driving probe includes sampling syringe needle, testing liquid can be pumped into pipeline
Whether peristaltic pump and control testing liquid enter the pinch off valve of pipeline.
In the above-described embodiments, preceding storing is additionally provided between biological matrix single factor analysis module and the central processing unit
Big device is used to improve the signal-to-noise ratio of system, reduces the influence of external interference.
A kind of application method of the prior-warning device for the non-explicit damage of kidney as described in any one of above scheme, packet
It includes:
Power supply is opened, air-foam detector is opened；
Microfluidic control drives probe sampling；
Biological matrix single factor analysis module analysis obtains parameter: specific gravity of urine Ug；Beta-2-microglobulin Bmg；Cystatin C
Cys；
Association probability pUg, pBmg, pCys of Ug, Bmg, Cys and kidney actual damage are counted respectively；These associations are general
The statistics needs of rate are counted in clinic.
The non-explicit damage valuation functions of kidney are established in central processing unit:
Wherein,
(pUg pBmg pCysc) is row vector；
It is one-column matrix；
A threshold value is set, the result obtained according to valuation functions is compared with the threshold value, to judge kidney by non-
The probability of explicit damage.
As a result output can realize the transmission of network remote by wireless transmission, by the network platform, it can be achieved that data
It is long-range reading and remote alarms.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (4)
1. a kind of prior-warning device for the non-explicit damage of kidney characterized by comprising
Fluid pipe is internally provided with the cavity for accommodating testing liquid；
Air-foam detector is arranged at two ports of the fluid pipe；
Central processing unit is connected with the air-foam detector；
Microfluidic control drives probe, and setting is electrically connected on the fluid pipe, and with the central processing unit, the center
Processor controls to be sampled in the testing liquid that the microfluidic control driving probe is extend into the fluid pipe；
Biological matrix single factor analysis module, and the central processing unit data connection, and drive and visit with the microfluidic control
Needle is connected by pipeline, and the testing liquid for obtaining to microfluidic control driving probe sampling detects；Wherein, described
Biological matrix single factor analysis module includes: specific gravity of urine detecting electrode, beta-2-microglobulin detecting electrode and cystatin C detection electricity
Pole；
Power supply is connected with the central processing unit；
Wherein, the central processing unit is also integrated with wireless transmission port；
The application method of the prior-warning device includes:
Power supply is opened, air-foam detector is opened；
Microfluidic control drives probe sampling；
Biological matrix single factor analysis module analysis obtains parameter: specific gravity of urine Ug；Beta-2-microglobulin Bmg；Cystatin C Cys；
Association probability pUg, pBmg, pCys of Ug, Bmg, Cys and kidney actual damage are counted respectively；
The non-explicit damage valuation functions of kidney are established in central processing unit:
Wherein,
A threshold value is set, the result obtained according to valuation functions is compared with the threshold value, to judge kidney by non-dominant
The probability of damage.
2. being used for the prior-warning device of the non-explicit damage of kidney as described in claim 1, which is characterized in that the biological matrix list
Factor analysis module further includes that urine volume detection module and day urine/enuresis nocturna compare detection module.
3. being used for the prior-warning device of the non-explicit damage of kidney as described in claim 1, which is characterized in that the microfluidic control is driven
Dynamic probe includes sampling whether syringe needle, the peristaltic pump that testing liquid can be pumped into pipeline and control testing liquid enter pipeline
Pinch off valve.
4. being used for the prior-warning device of the non-explicit damage of kidney as described in claim 1, which is characterized in that the biological matrix list
Preamplifier is additionally provided between factor analysis module and the central processing unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610025621.4A CN105466984B (en) | 2016-01-14 | 2016-01-14 | Prior-warning device and its application method for the non-explicit damage of kidney |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610025621.4A CN105466984B (en) | 2016-01-14 | 2016-01-14 | Prior-warning device and its application method for the non-explicit damage of kidney |
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| CN105466984A CN105466984A (en) | 2016-04-06 |
| CN105466984B true CN105466984B (en) | 2018-12-28 |
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| CN106361289A (en) * | 2016-09-30 | 2017-02-01 | 重庆工商大学 | Early warning system for chronic renal failure |
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| WO2010091231A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102967701A (en) * | 2012-11-28 | 2013-03-13 | 长春迪瑞医疗科技股份有限公司 | Urine analysis system and analysis method thereof |
| CN103874923A (en) * | 2011-08-26 | 2014-06-18 | 阿斯图特医药公司 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20140262777A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| CN204379865U (en) * | 2014-12-03 | 2015-06-10 | 郑以山 | The networking on-line measuring device of a kind of miniature human body environment checkout gear and blood purification environment |
| CN205317718U (en) * | 2016-01-14 | 2016-06-15 | 郑以山 | A early warning device that is used for non - dominance of kidney to harm |
-
2016
- 2016-01-14 CN CN201610025621.4A patent/CN105466984B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091231A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN103874923A (en) * | 2011-08-26 | 2014-06-18 | 阿斯图特医药公司 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102967701A (en) * | 2012-11-28 | 2013-03-13 | 长春迪瑞医疗科技股份有限公司 | Urine analysis system and analysis method thereof |
| US20140262777A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| CN204379865U (en) * | 2014-12-03 | 2015-06-10 | 郑以山 | The networking on-line measuring device of a kind of miniature human body environment checkout gear and blood purification environment |
| CN205317718U (en) * | 2016-01-14 | 2016-06-15 | 郑以山 | A early warning device that is used for non - dominance of kidney to harm |
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