CN103308611A - Multichannel sample injecting etiological diagnostic system for urinary calculus and application method - Google Patents
Multichannel sample injecting etiological diagnostic system for urinary calculus and application method Download PDFInfo
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- CN103308611A CN103308611A CN201310195206XA CN201310195206A CN103308611A CN 103308611 A CN103308611 A CN 103308611A CN 201310195206X A CN201310195206X A CN 201310195206XA CN 201310195206 A CN201310195206 A CN 201310195206A CN 103308611 A CN103308611 A CN 103308611A
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- 238000000034 method Methods 0.000 title claims abstract description 36
- 206010007027 Calculus urinary Diseases 0.000 title abstract 2
- 208000009911 Urinary Calculi Diseases 0.000 title abstract 2
- 238000012545 processing Methods 0.000 claims abstract description 107
- 238000003745 diagnosis Methods 0.000 claims abstract description 52
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 239000007791 liquid phase Substances 0.000 claims abstract description 16
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- 238000004458 analytical method Methods 0.000 claims description 36
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- 238000011321 prophylaxis Methods 0.000 claims description 35
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- 238000003199 nucleic acid amplification method Methods 0.000 claims description 18
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- 239000000203 mixture Substances 0.000 claims description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 9
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000003384 imaging method Methods 0.000 claims description 9
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- 238000005406 washing Methods 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 239000011574 phosphorus Substances 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 6
- 230000003760 hair shine Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 3
- 235000011613 Pinus brutia Nutrition 0.000 claims description 3
- 241000018646 Pinus brutia Species 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- MXZRMHIULZDAKC-UHFFFAOYSA-L ammonium magnesium phosphate Chemical compound [NH4+].[Mg+2].[O-]P([O-])([O-])=O MXZRMHIULZDAKC-UHFFFAOYSA-L 0.000 claims description 3
- 238000012742 biochemical analysis Methods 0.000 claims description 3
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- 238000004868 gas analysis Methods 0.000 claims description 3
- 210000000936 intestine Anatomy 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 230000006855 networking Effects 0.000 claims description 3
- 235000006408 oxalic acid Nutrition 0.000 claims description 3
- 238000002562 urinalysis Methods 0.000 claims description 3
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/345—Urinary calculi
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- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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Abstract
The invention relates to a multichannel sample injecting etiological diagnostic system for urinary calculus and an application method. The system comprises a biochemical analyzer, an electronic medical record system, a multichannel liquid chromatograph device and a digital photomicrography device, and further comprises a central processing computer. The biochemical analyzer, the electronic medical record system, the multichannel liquid chromatograph device and the digital photomicrography device are respectively connected with the central processing computer. The multichannel liquid phase chromatograph device comprises more than two liquid chromatographs and automatic samplers, wherein the automatic samplers are connected with the liquid chromatographs. The diagnostic system standardizes and simplifies the fussy work flow for etiological diagnosis for the first time at home and abroad, and settles the fussy detecting and diagnostic processes for automation.
Description
Technical field
The present invention relates to a kind of medical diagnosis system and application process thereof, is a kind of stone in urinary system etiological diagnosis system and application process of hyperchannel sample introduction specifically.
Background technology
Stone in urinary system is the disease of a complexity, multi-pathogenesis, be the coefficient result of E﹠H factor, finish Iithiasic etiological diagnosis work by detecting the multinomial blood urine biochemical indicator of patient, can find the lithogenous main reason of patient, for further specific aim prevention and treatment provide foundation.But the etiological diagnosis complex steps of stone in urinary system is difficult to grasp at present, causes this diagnostic techniques popularity in China and even world wide limited.
Summary of the invention
The objective of the invention is to diagnose existing defective in order to solve in the prior art stone in urinary system, provide a kind of stone in urinary system etiological diagnosis system and application process of hyperchannel sample introduction to solve the problems referred to above.
To achieve these goals, technical scheme of the present invention is as follows:
A kind of stone in urinary system etiological diagnosis system of hyperchannel auto injection, comprise Biochemical Analyzer, electronic medical record system, hyperchannel liquid phase chromatograph device and digital photomicrography device, it is characterized in that, also comprise for Intelligent Recognition, automatic typing analysis data and the central processing computer that draws the suggestion of diagnosis report and prophylactic treatment, described Biochemical Analyzer, electronic medical record system, the hyperchannel liquid phase chromatograph device is connected central processing computer respectively with the digital photomicrography device, described hyperchannel liquid phase chromatograph device comprises plural liquid chromatograph and automatic sampler, and described automatic sampler connects liquid chromatograph.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction is characterized in that described liquid chromatograph is ion chromatograph.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction is characterized in that, also comprises the printer that prints for the suggestion of the diagnosis report that central processing computer is drawn and prophylactic treatment, and described printer connects central processing computer.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction is characterized in that, also comprises for the scanning device of input patient examining report, described scanning device connecting central processing computer; Also comprise manual load module, described manual load module connects central processing computer.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction, it is characterized in that, described scanning device comprises that described scanner connects central processing computer after connecting the text identification module again for the scanner that document is scanned with for the text identification module of the document after the scanning being carried out data read.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction, it is characterized in that, described Biochemical Analyzer comprises light source, sampling device, cuvette, detector, signal amplification converter and data processing module, described sampling device connects cuvette, light source and detector are arranged at by the cuvette, the light that light source shines out can see through cuvette and reach detector, detector connects signal amplification converter and data processing module successively, data processing module connects central processing computer, described Biochemical Analyzer comprises that also for the cleaning equipment that cleans cuvette and connecting line, cleaning equipment connects cuvette.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel auto injection, it is characterized in that, described automatic sampler comprises specimen rotating holder, motor, sample suction tube and sampling valve, the center of described specimen rotating holder is arranged with rotating shaft, described motor connects specimen rotating holder, described motor connects the drive specimen rotating holder and rotates, described specimen rotating holder is provided with a plurality of sample to be tested pipes, described sample suction tube is arranged at sample to be tested pipe top, described liquid chromatograph comprises injector, separating column, suppressed column, electricity is led detector, pump and drip washing equipment, described injector connects separating column successively, suppressed column and electricity are led detector, drip washing equipment connects separating column by pump, described electricity is led detector and is connected central processing computer, and described sample suction tube connects the injector of liquid chromatograph by sampling valve.
The stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction, it is characterized in that, described digital photomicrography device comprises optics amplification imaging module, imageing sensor, A/D modular converter and dsp chip, described optics amplification imaging module is connection layout image-position sensor, A/D modular converter and dsp chip successively, and dsp chip connects central processing computer.
The application process of the stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction is characterized in that, comprises following steps:
(1) central processing computer reads the ion concentration of a plurality of patients' urine by hyperchannel liquid phase chromatograph device auto injection, calculates 24 hours total amounts of each ion according to ion concentration and twenty-four-hour urine amount;
Central computer calls calculus constituent analysis result by one of them of following four kinds of modes, the calculus composition of measuring by manual load module input chemical method or physics method; The calculus composition of measuring by scanning device input chemical method or physics method; By the case history situation input chemical method that calls patient in the electronic medical record system or the calculus composition that the physics method is measured; Obtain calculus constituent analysis result with the computer networking of calculus constituent analysis equipment;
(2) central processing computer checks 24 hours total amounts of urine oxalic acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check patient's calculi in vivo whether printing opacity, whether the intestines problem medical history is arranged, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(3) central processing computer checks the 24 hours total amounts of acid of urinating in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(4) central processing computer checks 24 hours total amounts of urine citric acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(5) central processing computer checks 24 hours total amounts of urine calcium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, check the content of blood PTH, blood calcium and serium inorganic phosphorus in the patient blood again by Biochemical Analyzer, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(6) central processing computer checks 24 hours total amounts of urine magnesium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, transfer calculus constituent analysis data, by the crystal habit in the digital photomicrography device inspection urine, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(7) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and featheriness or the crystallization of pine needle shape whether occur, transfer calculus constituent analysis data, the clear and definite ammonium magnesium phosphate composition that whether includes, transfer the case history situation of patient in the electronic medical record system, obtain data such as patient's routine urinalysis, urine cultivation, central processing computer provides above-mentioned data then, and assistance is further comprehensively judged, assigned a cause for an illness and provides the prophylactic treatment suggestion;
(8) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and the regular hexagon crystallization whether occurs, and then the result of the case history situation by transferring patient in the electronic medical record system and the calculus constituent analysis transferred, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(9) by manual load module input patient for three days on end, every day the pH value more than 3 times, if each pH value detects the constituent structure of patient's urine all greater than 5.8 by liquid chromatograph; Transfer the case history situation of patient in the electronic medical record system, check whether printing opacity of patient's calculi in vivo; And by the crystal habit in the digital photomicrography device inspection urine; When providing above-mentioned data, result in conjunction with the calculus constituent analysis of transferring, central processing computer provides next step etiological diagnosis flow process, diagnosis basis, cause of disease somatotype and corresponding prevention scheme, and the assistance clinician comprehensively judges, assigns a cause for an illness and provides the prophylactic treatment suggestion;
(10) by printer patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
The application process of the stone in urinary system etiological diagnosis system of above-mentioned a kind of hyperchannel sample introduction, it is characterized in that, describedly check that by Biochemical Analyzer the patient blood index also can identify through scanning device automatically by good after testing sanguification verification certificate, be sent to central processing computer; The described case history situation of transferring patient in the electronic medical record system, check patient's calculi in vivo whether printing opacity also can be reported through scanning device by good after testing X-ray sheet result and identify automatically, be sent to central processing computer, described content by blood PTH, blood calcium and serium inorganic phosphorus in the Biochemical Analyzer inspection patient blood also can be identified through scanning device automatically by good after testing blood biochemical analysis result information, is sent to central processing computer; The blood gas analysis result who detects patient by Biochemical Analyzer also can identify through scanning device automatically by good after testing vim and vigour biochemical studies report, is sent to central processing computer.
Beneficial effect of the present invention is: this diagnostic system workflow that etiological diagnosis is loaded down with trivial details standardization first at home and abroad and oversimplifying, the arrangement of the process of loaded down with trivial details detection and diagnosis is formed robotization, etiological diagnosis and the applying of specific aim control of stone in urinary system had great significance.
Description of drawings
Fig. 1 is one-piece construction block diagram of the present invention;
Fig. 2 is the structured flowchart of Biochemical Analyzer;
Fig. 3 is the structured flowchart of hyperchannel liquid phase chromatograph device;
Fig. 4 is the structured flowchart of automatic sampler;
Fig. 5 is the structured flowchart of digital photomicrography device;
Fig. 6 is the structured flowchart of scanning device.
Embodiment
Further understand and understanding for making architectural feature of the present invention and the effect reached had, cooperate detailed explanation in order to preferred embodiment and accompanying drawing, be described as follows:
Referring to Fig. 1, a kind of stone in urinary system etiological diagnosis system of hyperchannel sample introduction, comprise Biochemical Analyzer 100, electronic medical record system 200, hyperchannel liquid phase chromatograph device 300 and digital photomicrography device 400, comprise that also Biochemical Analyzer 100, electronic medical record system 200, hyperchannel liquid phase chromatograph device 300 and digital photomicrography device 400 are connected central processing computer 500 respectively for Intelligent Recognition, automatic typing analysis data and draw diagnosis report and the central processing computer 500 of prophylactic treatment suggestion.Biochemical Analyzer 100 is for detection of the patient blood sample; Comprise patient's medical history in the past and the examining report data of other detections of doing in the electronic medical record system 200; Hyperchannel liquid phase chromatograph device 300 auto injections read the ion concentration of a plurality of patients' urine; Digital photomicrography device 400 is for detection of patient's urine crystal form.In the time of work, control by central processing computer 500, Biochemical Analyzer 100, electronic medical record system 200, hyperchannel liquid phase chromatograph device 300 and digital photomicrography device 400 input to detected patient's data in the central processing computer 500 automatically, abandoned that diagnosis algorithm was loaded down with trivial details in the past, the defective that is difficult to grasp, having reached only needs the doctor to diagnose the cause of disease under the situation of comprehensive every detection data, perhaps directly provides diagnosis report and prophylactic treatment suggestion by central processing computer 500 comparison related diseases after because of database.
In the present invention, liquid chromatograph 300 is ion chromatograph, because in the process of stone in urinary system etiological diagnosis, most important test mode is to detect the concentration of relevant zwitterion in patient's urine, so ion chromatograph occupies vital position in the present invention.
Also comprise the printer 600 that prints for the suggestion of the diagnosis report that central processing computer 500 is drawn and prophylactic treatment in the present invention, printer 600 connects central processing computers 500.After central process computer 500 draws last result, can patient's personal information, the diagnosis report that draws and prophylactic treatment suggestion be printed by printer 600, form last diagnosis report.
The present invention also comprises for the scanning device 700 of input patient examining report, scanning device 700 connection central processing computers 500, the effect of scanning device 700 is can be directly by scanning device 700 data scanning of any result of laboratory test list to be sent to central processing computer 500, particularly when needs were used some patient's detection data, scanning device 700 can directly be changed data and be sent to central processing computer 500; Also comprise manual load module 800 in the system, manually load module 800 connects central processing computer 500, manually effect and the scanning device 700 of load module 800 are similar, also be a kind of mode of data input, can input in the central processing computer 500 by manual load module 800 detecting data arbitrarily.
Referring to Fig. 2, Biochemical Analyzer 100 comprises light source 110, sampling device 120, cuvette 130, detector 140, signal amplification converter 150 and data processing module 160, sampling device 120 connects cuvette 130, light source 110 and detector 140 are arranged at by the cuvette, the light that light source shines out can see through cuvette 130 and reach detector 140, detector 140 connects signal amplification converter 150 and data processing module 160 successively, data processing module 160 connects central processing computer 500, in the time of work, detect sample and from sampling device 120, enter into cuvette 130, light source 110 shines cuvettes 130 and light transmission cuvette 130 is shone detector 140, after detector 140 detects light through cuvette 130, transmit signals to signal amplification converter 150, signal amplification converter 150 sends to data processing module 160 with the signal amplification and after changing, and data processing module 160 sends in the central processing computer 500 after data preparation is become the detection data well.Biochemical Analyzer 100 comprises also that for the cleaning equipment 170 that cleans cuvette and connecting line cleaning equipment 170 connects cuvette 130, and after one-time detection was finished, cleaning equipment 170 can clean pipeline and cuvette 130.
Referring to Fig. 3 and Fig. 4, hyperchannel liquid phase chromatograph device 300 comprises plural liquid chromatograph 310 and automatic sampler 320, and automatic sampler 310 connects liquid chromatograph 320, and liquid chromatograph 320 connects central processing computer 500.By the automatic absorption sample of automatic sampler 310, and then be transported to successively in each liquid chromatograph 320, reach the effect of ion concentration that auto injection reads a plurality of patients' urine.
Referring to Fig. 5, digital photomicrography device 400 comprises optics amplification imaging module 410, imageing sensor 420, A/D modular converter 430 and dsp chip 440, optics amplification imaging module 410 is connection layout image-position sensor 420, A/D modular converter 430 and dsp chip 440 successively, and dsp chip 440 connects central processing computer 500.Observation sample 401 carries out the optics amplification imaging by optics amplification imaging module 410, optics amplification imaging module 410 transmits signals to imageing sensor 420 then, imageing sensor 420 is digital signal by A/D modular converter 430 with analog signal conversion, by dsp chip net result is sent in the central processing computer 500 at last.
Referring to Fig. 6, scanning device 700 comprises for the scanner 710 that document is scanned with for the text identification module 720 of the document after the scanning being carried out data read, connects central processing computer 500 again after scanner 710 connects text identification modules 720.When using, 710 pairs of laboratory test reports 701 of scanner scan, and will detect data after scanner 710 is identified the laboratory test report of scanning by text identification module 720 then again and be sent in the central processing computer 500.
A kind of application process of stone in urinary system etiological diagnosis system of hyperchannel sample introduction comprises following steps:
(1) central processing computer reads the ion concentration of a plurality of patients' urine by hyperchannel liquid phase chromatograph device auto injection, calculates 24 hours total amounts of each ion according to ion concentration and twenty-four-hour urine amount;
Central computer calls calculus constituent analysis result by one of them of following four kinds of modes, the calculus composition of measuring by manual load module input chemical method or physics method; The calculus composition of measuring by scanning device input chemical method or physics method; By the case history situation input chemical method that calls patient in the electronic medical record system or the calculus composition that the physics method is measured; Obtain calculus constituent analysis result with the computer networking of calculus constituent analysis equipment;
(2) central processing computer checks 24 hours total amounts of urine oxalic acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check patient's calculi in vivo whether printing opacity, whether the intestines problem medical history is arranged, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(3) central processing computer checks the 24 hours total amounts of acid of urinating in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(4) central processing computer checks 24 hours total amounts of urine citric acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(5) central processing computer checks 24 hours total amounts of urine calcium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, check the content of blood PTH, blood calcium and serium inorganic phosphorus in the patient blood again by Biochemical Analyzer, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(6) central processing computer checks 24 hours total amounts of urine magnesium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, transfer calculus constituent analysis data, by the crystal habit in the digital photomicrography device inspection urine, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(7) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and featheriness or the crystallization of pine needle shape whether occur, transfer calculus constituent analysis data, the clear and definite ammonium magnesium phosphate composition that whether includes, transfer the case history situation of patient in the electronic medical record system, obtain data such as patient's routine urinalysis, urine cultivation, central processing computer provides above-mentioned data then, and assistance is further comprehensively judged, assigned a cause for an illness and provides the prophylactic treatment suggestion;
(8) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and the regular hexagon crystallization whether occurs, and then the result of the case history situation by transferring patient in the electronic medical record system and the calculus constituent analysis transferred, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(9) by manual load module input patient for three days on end, every day the pH value more than 3 times, if each pH value detects the constituent structure of patient's urine all greater than 5.8 by liquid chromatograph; Transfer the case history situation of patient in the electronic medical record system, check whether printing opacity of patient's calculi in vivo; And by the crystal habit in the digital photomicrography device inspection urine; When providing above-mentioned data, result in conjunction with the calculus constituent analysis of transferring, central processing computer provides next step etiological diagnosis flow process, diagnosis basis, cause of disease somatotype and corresponding prevention scheme, and the assistance clinician comprehensively judges, assigns a cause for an illness and provides the prophylactic treatment suggestion;
(10) by printer patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
In the present invention, also can identify automatically through scanning device by good after testing sanguification verification certificate by Biochemical Analyzer inspection patient blood index, be sent to central processing computer; The described case history situation of transferring patient in the electronic medical record system, check patient's calculi in vivo whether printing opacity also can be reported through scanning device by good after testing X-ray sheet result and identify automatically, be sent to central processing computer, described content by blood PTH, blood calcium and serium inorganic phosphorus in the Biochemical Analyzer inspection patient blood also can be identified through scanning device automatically by good after testing blood biochemical analysis result information, is sent to central processing computer; The blood gas analysis result who detects patient by Biochemical Analyzer also can identify through scanning device automatically by good after testing vim and vigour biochemical studies report, is sent to central processing computer.
Beneficial effect of the present invention is: this diagnostic system workflow that etiological diagnosis is loaded down with trivial details standardization first at home and abroad and oversimplifying, the arrangement of the process of loaded down with trivial details detection and diagnosis is formed robotization, etiological diagnosis and the applying of specific aim control of stone in urinary system had great significance.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and the instructions is principle of the present invention; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the present invention.The protection domain that the present invention requires is defined by appending claims and equivalent thereof.
Claims (10)
1. the stone in urinary system etiological diagnosis system of a hyperchannel auto injection, comprise Biochemical Analyzer, electronic medical record system, hyperchannel liquid phase chromatograph device and digital photomicrography device, it is characterized in that, also comprise for Intelligent Recognition, automatic typing analysis data and the central processing computer that draws the suggestion of diagnosis report and prophylactic treatment, described Biochemical Analyzer, electronic medical record system, the hyperchannel liquid phase chromatograph device is connected central processing computer respectively with the digital photomicrography device, described hyperchannel liquid phase chromatograph device comprises plural liquid chromatograph and automatic sampler, and described automatic sampler connects liquid chromatograph.
2. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 1 is characterized in that, described liquid chromatograph is ion chromatograph.
3. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 1 and 2, it is characterized in that, also comprise the printer that prints for the suggestion of the diagnosis report that central processing computer is drawn and prophylactic treatment, described printer connects central processing computer.
4. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 3 is characterized in that, also comprises for the scanning device of input patient examining report, described scanning device connecting central processing computer; Also comprise manual load module, described manual load module connects central processing computer.
5. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 4, it is characterized in that, described scanning device comprises that described scanner connects central processing computer after connecting the text identification module again for the scanner that document is scanned with for the text identification module of the document after the scanning being carried out data read.
6. according to the stone in urinary system etiological diagnosis system of claim 4 or 5 described a kind of hyperchannel auto injections, it is characterized in that, described Biochemical Analyzer comprises light source, sampling device, cuvette, detector, signal amplification converter and data processing module, described sampling device connects cuvette, light source and detector are arranged at by the cuvette, the light that light source shines out can see through cuvette and reach detector, detector connects signal amplification converter and data processing module successively, data processing module connects central processing computer, described Biochemical Analyzer comprises that also for the cleaning equipment that cleans cuvette and connecting line, cleaning equipment connects cuvette.
7. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 6, it is characterized in that, described automatic sampler comprises specimen rotating holder, motor, sample suction tube and sampling valve, the center of described specimen rotating holder is arranged with rotating shaft, described motor connects specimen rotating holder, described motor connects the drive specimen rotating holder and rotates, described specimen rotating holder is provided with a plurality of sample to be tested pipes, described sample suction tube is arranged at sample to be tested pipe top, described liquid chromatograph comprises injector, separating column, suppressed column, electricity is led detector, pump and drip washing equipment, described injector connects separating column successively, suppressed column and electricity are led detector, drip washing equipment connects separating column by pump, described electricity is led detector and is connected central processing computer, and described sample suction tube connects the injector of liquid chromatograph by sampling valve.
8. the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 7, it is characterized in that, described digital photomicrography device comprises optics amplification imaging module, imageing sensor, A/D modular converter and dsp chip, described optics amplification imaging module is connection layout image-position sensor, A/D modular converter and dsp chip successively, and dsp chip connects central processing computer.
9. the application process of the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 1 is characterized in that, comprises following steps:
(1) central processing computer reads the ion concentration of a plurality of patients' urine by hyperchannel liquid phase chromatograph device auto injection, calculates 24 hours total amounts of each ion according to ion concentration and twenty-four-hour urine amount;
Central computer calls calculus constituent analysis result by one of them of following four kinds of modes, the calculus composition of measuring by manual load module input chemical method or physics method; The calculus composition of measuring by scanning device input chemical method or physics method; By the case history situation input chemical method that calls patient in the electronic medical record system or the calculus composition that the physics method is measured; Obtain calculus constituent analysis result with the computer networking of calculus constituent analysis equipment;
(2) central processing computer checks 24 hours total amounts of urine oxalic acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check patient's calculi in vivo whether printing opacity, whether the intestines problem medical history is arranged, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(3) central processing computer checks the 24 hours total amounts of acid of urinating in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(4) central processing computer checks 24 hours total amounts of urine citric acid in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(5) central processing computer checks 24 hours total amounts of urine calcium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, check the content of blood PTH, blood calcium and serium inorganic phosphorus in the patient blood again by Biochemical Analyzer, by the crystal habit in the digital photomicrography device inspection urine, the result of the calculus constituent analysis of transferring, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(6) central processing computer checks 24 hours total amounts of urine magnesium in the urine by liquid chromatograph, transfer the case history situation of patient in the electronic medical record system then, check whether printing opacity of patient's calculi in vivo, transfer calculus constituent analysis data, by the crystal habit in the digital photomicrography device inspection urine, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(7) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and featheriness or the crystallization of pine needle shape whether occur, transfer calculus constituent analysis data, the clear and definite ammonium magnesium phosphate composition that whether includes, transfer the case history situation of patient in the electronic medical record system, obtain data such as patient's routine urinalysis, urine cultivation, central processing computer provides above-mentioned data then, and assistance is further comprehensively judged, assigned a cause for an illness and provides the prophylactic treatment suggestion;
(8) by the crystal habit in the digital photomicrography device inspection urine, check in the urine crystallization and the regular hexagon crystallization whether occurs, and then the result of the case history situation by transferring patient in the electronic medical record system and the calculus constituent analysis transferred, central processing computer provides above-mentioned data then, assists further comprehensively to judge, assign a cause for an illness and provide prophylactic treatment suggestion;
(9) by manual load module input patient for three days on end, every day the pH value more than 3 times, if each pH value detects the constituent structure of patient's urine all greater than 5.8 by liquid chromatograph; Transfer the case history situation of patient in the electronic medical record system, check whether printing opacity of patient's calculi in vivo; And by the crystal habit in the digital photomicrography device inspection urine; When providing above-mentioned data, result in conjunction with the calculus constituent analysis of transferring, central processing computer provides next step etiological diagnosis flow process, diagnosis basis, cause of disease somatotype and corresponding prevention scheme, and the assistance clinician comprehensively judges, assigns a cause for an illness and provides the prophylactic treatment suggestion;
(10) by printer patient information, diagnostic result and corresponding prophylactic treatment scheme are printed.
10. the application process of the stone in urinary system etiological diagnosis system of a kind of hyperchannel auto injection according to claim 9, it is characterized in that, describedly check that by Biochemical Analyzer the patient blood index also can identify through scanning device automatically by good after testing sanguification verification certificate, be sent to central processing computer; The described case history situation of transferring patient in the electronic medical record system, check patient's calculi in vivo whether printing opacity also can be reported through scanning device by good after testing X-ray sheet result and identify automatically, be sent to central processing computer, described content by blood PTH, blood calcium and serium inorganic phosphorus in the Biochemical Analyzer inspection patient blood also can be identified through scanning device automatically by good after testing blood biochemical analysis result information, is sent to central processing computer; The blood gas analysis result who detects patient by Biochemical Analyzer also can identify through scanning device automatically by good after testing vim and vigour biochemical studies report, is sent to central processing computer.
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| CN201310195206.XA CN103308611B (en) | 2012-09-07 | 2013-05-22 | Multichannel sample injecting etiological diagnostic system for urinary calculus and application method |
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| CN103308611B (en) | 2017-02-22 |
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