CN206177813U - Spectrum method detects helicobacter pylori's device - Google Patents

Abstract

The patent of the utility model relates to a medical testing equipment, saying more specifically relates to a spectrum method detects helicobacter pylori's device. Its structure includes: the computer, electric signal analysis module, photoelectric detector, gaseous pond, the module of blowing, speculum, solenoid valve, vacuum pump, semiconductor laser, laser -driven module. The utility model discloses utilize the wavelength modulation spectral technique to improve detection sensitivity to can real -timely diagnose the result through electric signal analysis module. The utility model discloses the device is simple, sensitivity is high, the rate of accuracy is high, does not have the wound to the human body, can carry out whether having infected in the real -time detection stomach deep and remote dream heliobacterium.

Description

A kind of device of spectroscopic methodology detection helicobacter pylori

Technical field

This utility model patent is related to a kind of medical testing equipment, in particular, is related to a kind of helicobacter pylori Detection means.

Background technology

Helicobacter pylori is one of modal pathogen in the world, and it is that chronic active gastritis, duodenum are burst The main pathogenic of infectionss, gastric ulcer and gastric cancer.Additionally, also result of study shows, helicobacter pylori and some cardiovascular Disease, respiratory system disease, disease of hematopoietic system etc. may be related.Helicobacter pylori is ground by World Health Organization's cancer within 1994 Study carefully mechanism and be set to I class carcinogens.Therefore for the simplicity of helicobacter pylori in stomach, quickly, accurately diagnosis is current medical science Very great problem in detection.

At present, in Diagnosis of Gastric helicobacter pylori many methods have been developed, including Mucosa Biopsy does soon under gastroscope The intrusive mood detection method such as fast urease methods, antibacterial culturing, and serology antibody, carbon breathing gas detection method detection etc. non-intruding Formula detection method.Mucosa Biopsy does rapid urease under gastroscope, and simple to operate, reagent is cheap, but testing result shows in specimen Bacterial density and " stove distribution " diagnostic result can be affected, should not be separately as the foundation for determining whether helicobacter pylori. Bacterial cultivation specificity is high, but complex operation, and culture technique condition is higher, and sensitivity is low, is unfit to do real-time monitoring.Non-intruding In formula detection method serology antibody test using whether there is in human body there is systemic antibody determine whether infect pylorus spiral Bacillus, but the method deficiency is that antibody still can be in the human body internal memory residual moon, meeting when detecting again after eliminating pylorus Cause higher misdiagnosis rate.Carbon isotope breathing gas detection method as helicobacter pylori detection method, in recent years Apply to clinical medicine detection, the method principle be because helicobacter pylori contains a large amount of ureases in stomach, can be by internal urine Plain reagent is hydrolyzed to carbon dioxide, and carbon dioxide can be excreted by respiratory system, therefore client need takes carbon carbamide Respiration detection is carried out after reagent when 30 minutes.Two kinds of carbon isotope reagents are mainly used in medical science detection at this stage, i.e.,¹⁴The same positions of C Element and¹³C isotopes.¹⁴The sensitivity of C isotope detection methods is high, and specificity is also very high, patient's no pain, existing Instrumental Analysis one Sample time is about 120 seconds, but¹⁴C isotopes have radioactivity, are unsuitable for popular detection.¹³C isotope detection method can be detected In the carbon dioxide of characteristics of contaminated respiratory droplets¹³CO₂With¹²CO₂Ratio, clothes for patients use¹³C urea reagent, if there is pylorus spiral in stomach Bacillus can then hydrolyze urea reagent to be become¹³CO₂So that¹³CO₂With¹²CO₂Ratio become big compared with initial value.¹³C isotopes are examined Survey method, without radioactivity, can be used for popular detection, and existing equipment analyzes each sample time and is about 90 seconds.Due to normal human Gassing time is about 15 seconds, but the time needed for above two carbon isotope detecting instrument analysis sample is long, so can not carry out Real-time detection.

Utility model content

In order to solve the defect that above-mentioned prior art is present, this utility model devises a kind of detection means, with operation Simply, sensitivity height, accuracy rate are high, to human body hurtless measure, can carry out the advantage of real-time detection.

The technical solution of the utility model is：Electromagnetic valve and vacuum pump are first evacuated gas cell, then open and blow Module allows patient against the continuous incoming call gas of gas cell, starts Laser Driven module drive semiconductor laser and sends specific center The laser of wavelength, laser is incided in gas cell by light inlet, is projected from light-emitting window after reflecting mirror multiple reflections, is passed Enter to photodetection detector, the optical signal for receiving is converted into the signal of telecommunication by detector, then by electric signal transmission to telecommunications Number analysis module, by the real-time analysis of the signal of telecommunication analysis module second harmonic signal of spectrum is obtained, and by calculating Machine carries out the mathematical algorithm Treatment Analysis of correlation.

Further, described Blow off module and electromagnetic valve connect respectively gas cell upper end air inlet and lower end bleeding point, And QI KOU periphery carries out strict seal.

Further, described semiconductor laser sends the laser of specific wavelength, in this wave-length coverage¹³CO₂With¹²CO₂Absorption signal is strong, does not interfere with, and has suitable ratio relation between two absworption peaks.

Further, it is made up of with aluminium sheet sealing acrylic cylinder outside described gas cell, there is two panels reflectance inside Very high concave mirror, gas can obtain very long effective absorption path in this gas cell, so as to enhance detectivity, Ensure that the accuracy of diagnosis.

Further, described signal of telecommunication analysis module can be real-time collection analysises data, it is ensured that device Real-time.

Further, the gas that described patient breathes out when blowing to take urea reagent 30 minutes.

A kind of device of above-mentioned spectroscopic methodology detection helicobacter pylori, simple to operate, sensitivity, accuracy rate is high, can be fast It is fast effective, and it is diagnosed to be in stomach whether there is infection helicobacter pylori in real time.

Description of the drawings

Accompanying drawing is a kind of structural representation of embodiment of the present utility model.

Specific embodiment

The device that this utility model is used includes：Computer (1), signal of telecommunication analysis module (2), photodetector (3), Gas cell (4), Blow off module (5), reflecting mirror (6), electromagnetic valve (7), vacuum pump (8), semiconductor laser (9), Laser Driven Module (10).

Refering to accompanying drawing：Opens solenoid valve (7) and vacuum pump (8) are evacuated gas cell (4), then open Blow off module (5), allow and take¹³The patient of C isotope urea reagent after the tablet has been ingested 30 minutes when continuously to gas cell incoming call gas, expiration terminates After be again turned on electromagnetic valve (7) and vacuum pump (8), gas cell (4) is evacuated, start Laser Driven module (10), drive Semiconductor laser (9) sends the laser of specific centre wavelength, in this wavelength band,¹³CO₂With¹²CO₂Absorb strong, without dry Disturb, and have suitable ratio relation between two absworption peaks.Laser incides gas cell (4) by light inlet, through reflection Effective absorption path of laser is increased after mirror multiple reflections, sensitivity is improve, then is projected from light-emitting window, into photodetection Device (3), photodetector (3) converts optical signals into the signal of telecommunication, and the electric signal transmission after conversion to the signal of telecommunication is analyzed into mould Block (2), by signal of telecommunication analysis module (2), in real time analysis is incoming to computer (1) by the second harmonic signal for obtaining, final logical Crossing computer (1) carries out the mathematical algorithm Treatment Analysis of correlation, so that it is determined that¹³CO₂With¹²CO₂Mathematical quotient relation, and according to Whether helicobacter pylori is infected in this ratio in judgement patient's stomach.

The foregoing is only concrete real-time detection example of the present utility model, but technical characteristic of the present utility model not office Be limited to this, for this utility model those skilled in the art, without departing from design of the present utility model under, can also do Go out several real-time detection apparatus, should all belong to protection domain of the present utility model.

Claims (2)

1. a kind of device of spectroscopic methodology detection helicobacter pylori, the device includes：Computer (1), signal of telecommunication analysis module (2), photodetector (3), gas cell (4), Blow off module (5), reflecting mirror (6), electromagnetic valve (7), vacuum pump (8), quasiconductor Laser instrument (9), Laser Driven module (10), it is characterised in that：Electromagnetic valve (7) and vacuum pump (8) are first pumped into gas cell (4) very Sky, then opens Blow off module (5) and allows patient against the continuous incoming call gas of gas cell (4), starts Laser Driven module (10) and drives Dynamic semiconductor laser (9) sends the laser of specific centre wavelength, and laser incides gas cell (4) by light inlet, through anti- Penetrate after mirror (6) multiple reflections and projected from light-emitting window, incoming to photodetection detector (3), photodetector (3) is by what is received Optical signal is converted into the signal of telecommunication, then by electric signal transmission to signal of telecommunication analysis module (2), by signal of telecommunication analysis module (2) Real-time analysis obtains the second harmonic signal of spectrum, and the mathematical algorithm for carrying out correlation by computer (1) is processed and divided Analysis.

2. the device of a kind of spectroscopic methodology detection helicobacter pylori according to claim 1, it is characterised in that：Described gas Body pond (4) is outside to be made up of acrylic cylinder with aluminium sheet sealing, and gas can obtain very long effective suction in this gas cell (4) Path is received, so as to enhance detectivity, it is ensured that the accuracy of diagnosis.