CN203216844U - Spectroscopic stomach helicobacter pylori infection diagnosis device - Google Patents

Abstract

The utility model relates to detection of helicobacter pylori, and particularly relates to spectroscopic stomach helicobacter pylori infection diagnosis method and device. The spectroscopic stomach helicobacter pylori infection diagnosis device concretely comprises a drive control module, a tunable semiconductor laser device, an optical fiber, an optical fiber isolator, an optical fiber collimator, an optical resonant cavity, a vacuum pump, a three-way air valve, a hose, a lens, a probe and an information processing module. The cavity is utilized to enhance high detection sensitivity of an absorption spectrum; the accuracy of a diagnosis result is ensured. The device disclosed by the utility model is simple, convenient to operate, high in sensitivity, good in stability, and free of wound to a human body; whether the helicobacter pylori is infected in the stomach can be accurately and rapidly diagnosed.

Description

Helicobacter pylori infections diagnostic device in a kind of spectrum formula stomach

Technical field

The utility model relates to the detection of helicobacter pylori, more particularly, relates to helicobacter pylori infections diagnostic method and device in a kind of spectrum formula stomach.

Background technology

Helicobacter pylori has been confirmed as the main paathogenic factor of chronic gastritis, peptic ulcer.Helicobacter pylori infections can cause gastric mucosa congestion, oedema, even forms rotten to the corn, ulcer, and closely related with cancer of the stomach.1996, WHO classified helicobacter pylori as " one-level carcinogen ".The existing population infection more than 41% in the whole world helicobacter pylori, developing country even can reach 60%.Therefore, how fast helicobacter pylori infections, accurately diagnosis is the key subjects that current medical circle faces.

At present, medical circle is used for diagnosis stomach helicobacter pylori infections will following several method: fast urease test method, serology E1SA method, stomach lining pathological biopsy method, bacterial cultivation, ¹⁴C breath test method.The urease test method is inexpensive, easy, quick fast, the better method of the clinical diagnosis helicobacter pylori infections of can yet be regarded as, but easily be affected because sneaking into factors such as blood in personal experience's difference, reagent quality, the biopsy specimen, make accuracy not high.Serology E1SA method, namely detect the antibody horizontal of helicobacter pylori in the serum by blood drawing, behind helicobacter pylori infections, it can produce corresponding helicobacter pylori antibody in human body, make to detect and present positive findings, but need just be positive semi-load several months behind the nonspecific infection, at helicobacter pylori infections during the initial stage, do this detection and false negative result can occur, even helicobacter pylori is uprooted, this antibody descends slowly, and the patient often needs 1-2 just can turn out cloudy, and makes healing person carry the black-cooking pot of " positive " for a long time.Stomach lining pathological biopsy method, needs of patients stand to insert the hardship of mirror, if helicobacter pylori is the kitchen range distribution and easily causes failing to pinpoint a disease in diagnosis (rate of missed diagnosis 10%), but the operating experience and the correct sampling that rely on the doctor to enrich can reduce its rate of missed diagnosis.Bacterial cultivation is a species specificity height, and susceptibility is strong, and technical equipment is less demanding, and inexpensive good method, but condition harshness are operated more loaded down with trivial details, complicated. ¹⁴C breath test method, this inspection is highly sensitive, specificity is also very high, patient's no pain, be a kind of method that detects helicobacter pylori the most popular to people in recent years, but because there is radiation hazard in this inspection, children, pregnant woman, nursing women and old and weak person Ying Shenyong, and apparatus expensive detects the cost height.

The utility model content

At the defective that exists in the above-mentioned prior art, the utility model device is simple, and is easy to operate, highly sensitive, and good stability does not have wound to human body, can diagnose out quickly and accurately very much whether infect helicobacter pylori in the stomach.

Principle of work of the present utility model is as follows:

Suppose the long L of being in chamber, the absorption coefficient of medium is α in the chamber, and the refractive index of medium is n, and incident intensity is I _i, wavelength is λ, and cavity mirrors reflectivity is R, and transmissivity is T, can calculate transmitted light intensity I thus _tFor:

In the formula Be the phase shift of light round trip in the chamber, can be expressed as:

The transmission coefficient in chamber can be expressed as:

Transmission coefficient ratio when so, not absorbing gas in the chamber contains absorption gas and chamber is:

$T_n=\frac{T\left(\mathrm{\α}\right)}{T\left(0\right)}=\frac{{(1-R)}^2\exp (-\mathrm{\αL})}{{(1-\mathrm{Rexp}(-\mathrm{\αL}))}^2}---\left(4\right)$

The one way absorption loss of medium is much smaller than the loss of cavity in the chamber, namely α (v)＜＜1-R, formula (4) right-hand member is carried out Taylor expansion, that is:

$T_n\≈1-\frac{(1+R)\mathrm{aL}}{1-R}\≈1-\frac{2\mathrm{aL}}{1-R}\≈1-\frac{2\mathrm{FaL}}{\mathrm{\π}}---\left(5\right)$

F is the fineness in chamber in the formula.Following formula is compared with the Lambert Beer law in the traditional one way absorption spectrum, and it effectively absorbs the path and has been enhanced

Doubly, the fineness of resonator cavity generally all is a very big value in the cavity reinforced absorption spectrum technology, makes effective extinction path of cavity reinforced absorption spectrum become very long, thereby makes cavity reinforced absorption spectrum have very high detection sensitivity.

In the gas that the people breathes out, ¹³CO2 with ¹²The ratio of CO2 is very little, has infected helicobacter pylori in the stomach when patient infects, and patient obeys down ¹³Behind the C isotope labeling urea capsule, owing in the helicobacter pylori urine enzyme is arranged, ¹³The hydrolysis under the urease effect of C isotope labeling urea capsule produces ¹³CO ₂, ¹³CO ₂Through blood be recycled to reach lung after with exhale discharging, therefore make in the gas of breathing out ¹³CO ₂With ¹²CO ₂Ratio become big.The high detection sensitivity that utilizes the cavity reinforced absorption spectrum technology to have can obtain in the breath exactly ¹³CO ₂With ¹²CO ₂Ratio, can determine whether infected helicobacter pylori in patient's stomach according to the size of this ratio.

The utility model is helicobacter pylori infections diagnostic device in a kind of spectrum formula stomach, specifically comprises drive control module, semiconductor laser with tunable, optical fiber, fibre optic isolater, optical fiber collimator, optical resonator, vacuum pump, three-way air valve, flexible pipe, lens, detector, message processing module.At first open vacuum pump and three-way air valve N ₂Blow vent feeds N ₂Clean other residual gas in the optical resonator.Semiconductor laser with tunable is modulated through drive control module then, launches the laser of specific centre wavelength, and laser successively passes through fibre optic isolater and optical fiber collimator by Optical Fiber Transmission, incides in the optical resonator.Again the three-way air valve blow vent is switched to the sample blow vent, allow patient face toward flexible pipe breath in the optical resonator continuously, the optical resonator transmitted light focuses to detector through lens again, and the light signal that detector receives is converted into electric signal and transfers to message processing module and carry out data and handle.In message processing module, demonstrate in the patient expired gas at last ¹³CO ₂With ¹²CO ₂Ratio, and determine whether infected helicobacter pylori in patient's stomach according to this ratio.

Further, described drive control module comprises Laser Power Devices control module, signal generator, the three-way air valve control circuit.

Further, described three-way air valve, wherein a blow vent is connected with cavity, and two blow vents are N respectively in addition ₂Blow vent and sample blow vent, sample blow vent external hose, the Kai Heguan of each blow vent all are to control through circuit.

Further, described semiconductor laser with tunable is launched the laser of specific centre wavelength, ¹³CO ₂With ¹²CO ₂Gas absorbs strong, no interference with this understanding.

Further, described optical resonator, formed by two blocks of concave mirror and piezoelectric ceramics that are coated with highly reflecting films, laser enters in the described optical resonator, effective absorption path that intracavity gas can obtain to grow very much, thereby make cavity reinforced absorption spectrum have very high high detection sensitivity, guaranteed the accuracy of diagnostic result.

Further, described piezoelectric ceramics makes its vibration through the drive control module driving, changes the length of optical resonator, makes detection light enter optical resonator.

Further, described patient expired gas is for patient obeys down ¹³Behind the C isotope labeling urea capsule, in half an hour, the gas of exhalation.

Helicobacter pylori infections diagnostic device in above-mentioned a kind of spectrum formula stomach, device is simple, and easy to operate, highly sensitive, good stability can diagnose out quickly and accurately whether infect helicobacter pylori in the stomach very much.

Description of drawings

Accompanying drawing is structural representation of the present utility model.

Wherein: comprise semiconductor laser with tunable 1, optical fiber 2, fibre optic isolater 3, optical fiber collimator 4, optical resonator 5, vacuum pump 6, three-way air valve 7, flexible pipe 8, lens 9, detector 10, message processing module 11, drive control module 12.

Embodiment

Consult accompanying drawing, when using in the spectrum formula stomach helicobacter pylori infections diagnostic device, at first open vacuum pump 6 and three-way air valve 7, three-way air valve 7 is opened N through drive control module 12 controls ₂Blow vent feeds N ₂Clean other residual gas in the optical resonator 5.Semiconductor laser with tunable 1 is launched the laser of specific centre wavelength through drive control module 12 modulation then, ¹³CO ₂With ¹²CO ₂Gas with this understanding, absorb strong, no interference, laser is by optical fiber 2 transmission process fibre optic isolaters 3, enter optical fiber collimator 4, piezoelectric ceramics drives through drive control module 12 and makes its vibration in the optical resonator 5, change the length of optical resonator 5, the detection light through optical fiber collimator 4 is entered in the optical resonator 5.Again three-way air valve 7 blow vents are switched to the sample blow vent, allow clothes down ¹³The patient of C isotope labeling urea capsule faces toward flexible pipe 8 continuously to optical resonator 5 interior breaths, the light that transmits through optical resonator 5 focuses to detector 10 through lens 9 again, the light signal that detector 10 receives is converted into electric signal, and the electric signal after the conversion transfers to message processing module 11 and carries out the data processing.Demonstrate in the breath at message processing module 12 at last ¹³CO ₂With ¹²CO ₂Ratio, and determine whether infected helicobacter pylori in patient's stomach according to this ratio.

The above only is specific embodiment of the utility model, but technical characterictic of the present utility model is not limited thereto, any those skilled in the art is in field of the present utility model, and the variation of doing or modification all are encompassed among the claim of the present utility model.

Claims (2)

1. helicobacter pylori infections diagnostic device in the spectrum formula stomach, it is characterized in that: laser successively passes through fibre optic isolater and optical fiber collimator by Optical Fiber Transmission, incide in the optical resonator, again the three-way air valve blow vent is switched to the sample blow vent, allow patient face toward flexible pipe breath in the optical resonator continuously, the optical resonator transmitted light focuses to detector through lens again, and the light signal that detector receives is converted into electric signal and transfers to message processing module and carry out data and handle.

2. helicobacter pylori infections diagnostic device in a kind of spectrum formula stomach as claimed in claim 1, it is characterized in that: described optical resonator, formed by two blocks of concave mirror and piezoelectric ceramics that are coated with highly reflecting films, laser enters in the described optical resonator, effective absorption path that intracavity gas can obtain to grow very much, thereby make cavity reinforced absorption spectrum have very high high detection sensitivity, guaranteed the accuracy of diagnostic result.

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