CN107345899A - A kind of total internal reflection micro-fluidic chip detects all-in-one - Google Patents
A kind of total internal reflection micro-fluidic chip detects all-in-one Download PDFInfo
- Publication number
- CN107345899A CN107345899A CN201610290001.3A CN201610290001A CN107345899A CN 107345899 A CN107345899 A CN 107345899A CN 201610290001 A CN201610290001 A CN 201610290001A CN 107345899 A CN107345899 A CN 107345899A
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- China
- Prior art keywords
- main frame
- light source
- chamber
- sales kit
- internal reflection
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention has driven a kind of total internal reflection micro-fluidic chip detection all-in-one, is made up of main frame casing, sales kit (SK) and display, it is characterised in that：Rectangular main frame casing is divided into above and below lower chamber and upper chamber two layers by chamber dividing plate, and has independent transparent doors；Lower chamber is provided with total reflection light source and receiver, upper chamber are provided with sample stage, regulation light source etc..The present invention have relative to prior art it is very easy to use, can micro, quick, the accurate simultaneous determination difference factor, the advantages of greatly improving the diagnosis detection efficiency of all-in-one.
Description
Technical field
The present invention relates to a kind of in-vitro diagnosis all-in-one, is more specifically a kind of total internal reflection micro-fluidic chip detection all-in-one for belonging to the external diagnostic field of Medical Devices.
Background technology
In-vitro diagnosis（In Vitro Diagnosis, IVD）Refer to the diagnosis for being detected and being carried out after taking out blood, body fluid, tissue samples from human body, clinically more than 80% medical diagnosis on disease depends on IVD at present, is described as " eyes " of doctor.Care diagnostic plays extremely important effect in the overall process of prevention from suffering from the diseases, diagnosis, monitoring and guiding treatment before IVD plays more and more important role, particularly bed in modern society, is modern diseases and the indispensable instrument of health control.Because micro-fluidic chip is developed rapidly, and the bottleneck that today hinders microflow control technique to develop is still the problem of limiting manufacture processing and the application aspect of its development early stage.Total internal reflection optical detection technique is exactly one and meets the optical detective technology integrated with micro-fluidic chip.It is but at present that both are integrated also more rare.
For the polyfactorial disposable checkout and diagnosis to cancer and cardiovascular and cerebrovascular disease, it is necessary to a kind of total reflection micro-fluidic chip detection all-in-one.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of total internal reflection micro-fluidic chip to detect all-in-one.The object of the present invention is achieved like this：
A kind of total internal reflection micro-fluidic chip detects all-in-one, is made up of main frame casing, sales kit (SK) and display three parts.It is characterized in that：Rectangular main frame casing is divided into above and below lower chamber and upper chamber two layers by chamber dividing plate, and has independent transparent doors.So two operation interval non-interference are easy in design, avoid pollution effect.Lower chamber is provided with total reflection light source and receiver.It is totally reflected the transmitting of light source and receiver and against observation window, above the chamber dividing plate above observation window, i.e., chamber dividing plate side is provided with sample stage in top box room above receiving terminal.Sample stage is capable of the micro-fluidic chip of fixed placement detection.There is regulation light source directly over sample stage, for adjusting total reflection lens and light path.Regulation light source is fixed on the inboard box body wall of upper chamber by slide rail；Sales kit (SK) connects on the right side of main frame casing and with mainframe box body phase；Sales kit (SK) is highly less than main frame casing, and display is placed on the table top of sales kit (SK).The sales kit (SK) height of optimization is the 1/3-1/2 of main frame box height.
It so can both ensure in use, equipment volume is integrally intensive seldom takes up space, can take apart again and be divided into two parts, it is easy to remove.Sampling pump and receiving flask are installed inside sales kit (SK), analysis detection function is become one.
In above-mentioned technical proposal, the preferable sampling pump and receiving flask are by sample introduction conduit and go out sample conduit and connected with detection chip, and the sense channel of all-in-one perfects complete.Also, detection chip is special and 7 passages of Aided design of the present invention total reflection micro-fluidic chip, has ensured the polyfactorial disposable checkout and diagnosis that can realize cancer and cardiovascular and cerebrovascular disease.
The present invention has the following advantages that relative to prior art：
1. as the application method of other in-vitro diagnosis all-in-ones, use is very convenient；
2. being combined by two kinds of total internal reflection detection technique, microfluidic chip technology technologies, micro, quick, the accurate simultaneous determination difference factor of energy, the diagnosis detection efficiency of all-in-one is greatly improved.
Brief description of the drawings
Fig. 1 is the overall schematic of the present invention.
Wherein：1. main frame casing；2. total internal reflection light source and receiver；3. observation window；4. lower chamber；5. chamber dividing plate；6. go out sample conduit；7. detection chip；8. regulation light source；9. slide rail；Chamber on 10.；11. transparent doors；12. sample introduction conduit；13. sample stage；14. display；15. sales kit (SK)；16. sampling pump；17. receiving flask.
Embodiment
Referring to Fig. 1, a kind of total internal reflection micro-fluidic chip detects all-in-one, and a kind of total internal reflection micro-fluidic chip detects all-in-one, is made up of main frame casing 1, sales kit (SK) 15 and the three parts of display 14, it is characterised in that：Rectangular main frame casing 1 is divided into lower chamber 4 and upper chamber two layers about 10 by chamber dividing plate 5, and has independent transparent doors 11；Lower chamber 4 is provided with total reflection light source and receiver 2, is totally reflected the transmitting of light source and receiver 2 and opposite observation window 3 above receiving terminal；Above the chamber dividing plate 5 of the top of observation window 3, i.e., sample stage 13 is installed in the upper side of 10 inner cabinet's dividing plate of chamber 5；The fixed placement detection chip 7 of sample stage 13；There is regulation light source 8 directly over sample stage 13, regulation light source 8 is fixed on by slide rail 9 on the inboard box body wall of upper chamber 10；Sales kit (SK) 15 is connected on the right side of main frame casing 1 and with main frame casing 1；The height of sales kit (SK) 15 is less than main frame casing 1, and display 14 is placed on the table top of sales kit (SK) 15.Sampling pump 16 and receiving flask 17 are installed inside sales kit (SK) 15.The sampling pump 16 and receiving flask 17 of scheme optimization are by sample introduction conduit 12 and go out sample conduit 6 and connected with detection chip 7, and detection chip 7 is to be totally reflected micro-fluidic chip with 7 passages of equipment detection Aided design.
In use, first by sampling pump 16 and receiving flask 17 and sample introduction conduit 12 and going out sample conduit 6, it is connected and connects, by sample introduction conduit 12 and goes out sample conduit 6 and connected with detection chip 7, inspection No leakage, open power supply；Open display 14；Open the luminous incidence angle of the calibration of regulation light source 8 total reflection light source and receiver 2.Fix and survey chip 7, open the sample introduction of sampling pump 16 and start to detect, pass through the testing result of display 14.
Claims (2)
1. a kind of total internal reflection micro-fluidic chip detects all-in-one, it is made up of main frame casing, sales kit (SK) and display, it is characterised in that：Rectangular main frame casing is divided into above and below lower chamber and upper chamber two layers by chamber dividing plate, and has independent transparent doors；Lower chamber is provided with total reflection light source and receiver, is totally reflected the transmitting of light source and receiver and opposite observation window above receiving terminal；Above chamber dividing plate above observation window, i.e., chamber dividing plate side is provided with sample stage in top box room；Sample stage fixed placement detection chip；There is regulation light source directly over sample stage, regulation light source is fixed on the inboard box body wall of upper chamber by slide rail；Sales kit (SK) connects on the right side of main frame casing and with mainframe box body phase；Sales kit (SK) is highly less than main frame casing, and display is placed on the table top of sales kit (SK)；Sampling pump and receiving flask are installed inside sales kit (SK).
A kind of 2. total internal reflection micro-fluidic chip detection all-in-one according to claim 1, it is characterised in that：The sampling pump and receiving flask, by sample introduction conduit and go out sample conduit and connected with detection chip, detection chip is the 7 passage total internal reflection micro-fluidic chips with equipment detection Aided design；Sales kit (SK) height is the 1/3-1/2 of main frame box height.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610290001.3A CN107345899A (en) | 2016-05-05 | 2016-05-05 | A kind of total internal reflection micro-fluidic chip detects all-in-one |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610290001.3A CN107345899A (en) | 2016-05-05 | 2016-05-05 | A kind of total internal reflection micro-fluidic chip detects all-in-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107345899A true CN107345899A (en) | 2017-11-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610290001.3A Pending CN107345899A (en) | 2016-05-05 | 2016-05-05 | A kind of total internal reflection micro-fluidic chip detects all-in-one |
Country Status (1)
| Country | Link |
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| CN (1) | CN107345899A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109682586A (en) * | 2019-01-14 | 2019-04-26 | 重庆大学 | A kind of methods and applications carrying out the evaluation and test experiment of extracorporeal blood vessel bracket based on micro-fluidic chip |
| CN110242791A (en) * | 2019-06-17 | 2019-09-17 | 章伟 | Sample feeding system applied to microfluidic system |
-
2016
- 2016-05-05 CN CN201610290001.3A patent/CN107345899A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109682586A (en) * | 2019-01-14 | 2019-04-26 | 重庆大学 | A kind of methods and applications carrying out the evaluation and test experiment of extracorporeal blood vessel bracket based on micro-fluidic chip |
| CN110242791A (en) * | 2019-06-17 | 2019-09-17 | 章伟 | Sample feeding system applied to microfluidic system |
| CN110242791B (en) * | 2019-06-17 | 2021-01-01 | 营口世纪电子仪器有限公司 | Sample introduction system applied to microfluidic system |
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Application publication date: 20171114 |