CN201955341U - Diagnostic instrument for oral liquid - Google Patents
Diagnostic instrument for oral liquid Download PDFInfo
- Publication number
- CN201955341U CN201955341U CN2010206658182U CN201020665818U CN201955341U CN 201955341 U CN201955341 U CN 201955341U CN 2010206658182 U CN2010206658182 U CN 2010206658182U CN 201020665818 U CN201020665818 U CN 201020665818U CN 201955341 U CN201955341 U CN 201955341U
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- China
- Prior art keywords
- test paper
- nanoporous matrix
- shell
- mouth cavity
- cavity liquid
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- Expired - Lifetime
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Abstract
The utility model relates to a diagnostic instrument for oral liquid, which comprises a test paper and a nanometer porous substrate, wherein the test paper and the nanometer porous substrate are wrapped in a shell; the shell consists of an upper shell, a middle shell and a lower shell; the middle shell is provided with a through hole and an embedded groove for placing the test paper; the lower shell is provided with a spring; an ejector block is fixed on the spring; a locating pin protrudes from the ejector block; connecting strips are arranged at two ends of the test paper; the nanometer porous substrate is provided with a locating hole and is arranged on the ejector block; the connecting strips are placed on the nanometer porous substrate; blocking strips are arranged on the connecting strips; and a push handle is fixed on the side surface of the nanometer porous substrate. The diagnostic instrument has a simple structure and is convenient to operate, can detect any type of antigens and antibodies by replacing different test papers and effectively protect the sample collecting part from being polluted by outside, therefore, the diagnostic instrument is widely applied to early stage self-checking for various infectious diseases and hospitals.
Description
Technical field
The utility model relates to a kind of diagnostic instrments, relates in particular to a kind of mouth cavity liquid diagnostic instrments.
Background technology
Communicable disease is one of human main killer.Acquired immune deficiency syndrome (AIDS), various types of hepatitis, bird flu etc. are not threatening human beings'health and life all the time.For this serious infectious diseases, early stage diagnosis is particularly important.Early stage making a definite diagnosis helps patient and obtains treatment as early as possible, also helps the propagation of control disease.At present, still be the detection of " positive " to infectious disease " feminine gender ", main means by blood examination.But blood examination generally need puncture person under inspection's skin, belongs to a kind of wound type checking.It has not only brought misery to patient, and has increased the infected danger of medical worker.In contrast be that collecting mouth cavity liquid (comprising saliva and mucous membrane of mouth transudate) is that a kind of " not having wound " detected, and simple relatively, safety and fast.Scientific circles and medical circle just use mouth cavity liquid to carry out a large amount of development tests as detecting sample, and have successfully proved and can use mouth cavity liquid to detect disease effectively apace.
Detection at mouth cavity liquid (comprising saliva and mucous membrane of mouth transudate) is that a kind of " painless " detects, and it is simple to operate, quick.Scientific circles and medical circle just use mouth cavity liquid to carry out a large amount of development tests as detecting sample, and have successfully proved and can use mouth cavity liquid to detect disease effectively apace.From physiological angle, the material in the blood (comprising antiviral antibody, antigen etc.) can be diffused in the oral cavity by mucous membrane of mouth and salivary gland and go.So on the theory, any material in the blood can be detected in the oral cavity, and there is certain association in its content.Medical circle is filled with unbounded confidence to this, and how long think does not need, and the inspection of oral fluid will replace blood test fully.Patient goes to a hospital to see a doctor, and again need not to bear affliction to have drawn blood.In April, 2008, the American Studies personnel have drawn human saliva's protein picture group.In the paper of publication, they delineate out the prospect of following patient " spitting ptysis is seen a doctor ".The researchist believes that saliva detection is expected to become the blood drawing chemical examination of " modified version ", and finally replaces.With the saliva is ELISA, FDA (Food and Drug Adminstration) (FDA) approval of Western blot (WB) reagent of sample determination HIV antibody.For the clinical practice of sialoprotein matter research, the researchist is generally good.Saliva is seen a doctor not only convenient, and price is also inexpensive.Except the detection of some common transmittable diseases, in the future doctor even can pass through saliva tells whether patient suffers from heart disease or cancer.Because saliva test is very convenient, it can help the doctor in the ill early detection disease of patient.
U.S.'s Kerry Pood's biomedicine (Calypte Biomecical Co.) is the company that a family is engaged in the oral fluid disease detection.The said firm releases a kind of saliva of buccal cavity acquired immune deficiency syndrome (AIDS) fast detecting equipment in China.This method and equipment have obtained the registration and the selling license of state food and drug administration.The above-mentioned saliva of buccal cavity detection method of Kerry Pood company can detect HIV-1 or HIV-2 virus in 30 minutes, levels of precision is suitable with accredited laboratory of FDA (Food and Drug Adminstration) standard blood testing standard.According to the data of introducing of Kerry Pood company, above-mentioned fast detecting product can be used by medical testing agency, as the get the Green Light part of the HIV antibody test integrated application used of multiple fast detecting and other.But the contained parts of this kit are more, the running program complexity.
Acquired immune deficiency syndrome (AIDS) that U.S. Ao Luoxiuer (Orasure) company produces and hepatitis B oral fluid fast detecting product have obtained using widely at U.S.'s various big hospital and Center for Disease Control (CDC).The saliva acquired immune deficiency syndrome (AIDS) checkout equipment that he provided is an incorporate disposable use instrument.Testing result was read in 20 minutes.Rate of accuracy reached to 99.8%.Be different from kit, this instrument is a kind of collection that collects the mouth cavity liquid sample, analyzes and the results are shown in a brand-new instrument all over the body.
The patent of Ao Luoxiuer (Orasure) company and domestic similarly patent, application number is respectively 200710169737,200720086186,200710169735 disclosed technology paths and has following problem: (1) sample collection part all adopts micron order capillary matrix, and that micron order capillary matrix gets voidage is general bigger.Therefore, can be detained more mouth cavity liquid, reduce the efficient of sample collection in the sample collection part.In addition, micron-sized aperture is still bigger, makes that some minute impurities in the sample can be passed through, and the detection test paper after flowing to gets on, and advances the Children's Film Studio of China and rings testing result; (2) sample collection partly is directly exposed to outside the plastic casing, so both has been unfavorable for clean operation, and has increased the size of whole detecting device again.
Practical content
In order to overcome above defective, the technical matters that this practicality will solve is: a kind of mouth cavity liquid diagnostic instrments quick, easy and simple to handle is provided.
In order to overcome the defective that exists in the background technology, this practicality solves the technical scheme that its technical matters adopted: a kind of mouth cavity liquid diagnostic instrments, comprise the detection test paper, also be provided with nanoporous matrix, described detection test paper, nanoporous matrix is wrapped in the shell, described shell is by upper casing, mesochite, lower casing is formed, have through hole on the described mesochite, place the embedded groove that detects test paper, described lower casing is provided with spring, be fixed with angled slide block on the described spring, be extruded with register pin on the described angled slide block, the two ends of described detection test paper are provided with connection strap, have pilot hole on the described nanoporous matrix, described nanoporous matrix is placed on the angled slide block, be placed with connection strap on the described nanoporous matrix, described connection strap is provided with the blocking-up bar, and the side of described nanoporous matrix is fixed with pushing hands.
According to this practical another one embodiment, the mouth cavity liquid diagnostic instrments comprises that further described upper casing is provided with venthole and inspections and examinations result's display window.
According to this practical another one embodiment, the mouth cavity liquid diagnostic instrments comprises that further described connection strap away from nanoporous matrix is provided with the absorption piece, and an end of another connection strap passes the through hole on the mesochite and is attached on the bottom surface of mesochite.
According to this practical another one embodiment, the mouth cavity liquid diagnostic instrments comprises that further described blocking-up bar includes one or more detersives and buffering agent.
According to this practical another one embodiment, the mouth cavity liquid diagnostic instrments comprises that further the aperture of described nanoporous matrix is the 50-900 nanometer.
According to this practical another one embodiment, the mouth cavity liquid diagnostic instrments comprises that further described nanoporous matrix made by one or more plastic materials.
This practical beneficial effect is: simple in structure; easy to operate; can collect and detect mouth cavity liquid fast; can detect various biomolecule contained in antigen, antibody and the human body of any kind; and protected the sample collection part not to be subjected to the damage and the distortion that might produce in external contamination and the transportation effectively; be fit to large-scale production, can be widely used in the early stage self check and the hospital of various infectious diseases.
Description of drawings
Below in conjunction with drawings and Examples the utility model is further specified.
Fig. 1 is the structural representation of the preferred embodiments of the present invention;
Fig. 2 is the plan structure synoptic diagram that nanoporous matrix of the present invention is not stretched out shell;
Fig. 3 is the plan structure synoptic diagram that nanoporous matrix of the present invention is stretched out shell;
Fig. 4 is the plan structure synoptic diagram of upper casing;
Fig. 5 is the plan structure synoptic diagram of mesochite;
Fig. 6 is the plan structure synoptic diagram of lower casing;
Among the figure: 1, detect test paper, 2, nanoporous matrix, 3, shell, 3a, upper casing, the 3b mesochite, 3c, lower casing, 4, the blocking-up bar, 5, absorb piece, 6, display window, 8, pushing hands, 9, spring, 10, angled slide block, 11, embedded groove, 12, register pin, 13, connection strap, 14, through hole, 15, pilot hole, 16, connection strap, 17, venthole.
Embodiment
With preferred embodiment the utility model is described in further detail in conjunction with the accompanying drawings now.These accompanying drawings are the synoptic diagram of simplification, basic structure of the present utility model only is described in a schematic way, so it only show the formation relevant with the utility model.
As Fig. 1; Fig. 2; Fig. 3; Fig. 4; Fig. 5; shown in Figure 6; a kind of mouth cavity liquid diagnostic instrments; comprise and detect test paper 1; also be provided with nanoporous matrix 2; the sampling end of nanoporous matrix 2 can be designed to circle; oval; the shape of any suitable collection mouth cavity liquid such as rectangle; described detection test paper 1; nanoporous matrix 2 is wrapped in the shell 3; shell 3 can be any shape and color; protected nanoporous matrix 2 not to be subjected to issuable distortion or damage in external contamination and the transportation effectively; 3 whiles of shell are as the handle of whole instrument; the person under inspection can hold shell 3 the nanoporous matrix 2 of instrument is stretched in the face; described shell 3 is by upper casing 3a; mesochite 3b; lower casing 3c forms; have through hole 14 on the described mesochite 3b; place the embedded groove 11 that detects test paper 1; described lower casing 3c is provided with spring 9; be fixed with angled slide block 10 on the described spring 9; be extruded with register pin 12 on the described angled slide block 10; have pilot hole 15 on the described nanoporous matrix 2; described nanoporous matrix 2 is placed on the angled slide block 10; be placed with connection strap 16 on the described nanoporous matrix 2; described connection strap 16 is provided with blocking-up bar 4, thereby the blocking-up reagent on the blocking-up bar 4 can reduce the incidence that the generation of non-specific adsorption reduces " false positive ".The composition material of blocking-up bar 4 is including, but not limited to paper, cellulose, glass fibre or polyester.Blocking-up bar 4 can be designed to the form of semi-permeable diaphragm, thereby liquid that can not gets on from detecting the test paper 1 nanoporous matrix 2 that flows backwards back, and the side of described nanoporous matrix 2 is fixed with pushing hands 8.
As shown in Figure 4, set out pore 17 and inspections and examinations result's display window 6 on the described upper casing 3a.
In addition, described connection strap 13 away from nanoporous matrix 2 is provided with and absorbs piece 5, and an end of another connection strap 13 passes the through hole 14 on the mesochite 3b and is attached on the bottom surface of mesochite 3b.
Further, blocking-up bar 4 includes one or more detersives and buffering agent, and wherein detersive contains but is not limited to bovine serum albumin(BSA), dissociative type deoxycholic acid and N-sodium lauroyl sarcosine, and buffering agent is used to regulate the pH value of mouth cavity liquid sample.
In the present embodiment, the aperture of nanoporous matrix 2 is the 50-900 nanometer, and therefore the voidage of whole sample significantly reduces, and has reduced the loss of mouth cavity liquid sample, and nano aperture helps to filter out the minute impurities in the mouth cavity liquid sample, plays and purifies sample, reduces the effect that detects error.This nanoporous matrix 2 is made by one or more plastic materials, and plastic material is including, but not limited to high density polyethylene, polypropylene, teflon, nylon, polyester or polyethersulfone resin.
Because some person under inspection's mouth cavity liquid viscosity is too big, the mouth cavity liquid that causes collecting can't be sent to the surveyed area that detects test paper 1 by capillarity, perhaps transfer rate causes whole diagnostic procedure consuming time long too slowly, and can be used this moment with dilution, accelerates the time of diagnosis.
When using this instrument, the person under inspection moves pushing hands 8, nanoporous matrix 2 and then moves, after moving a certain distance, spring 9 on the lower casing 3c makes the register pin 12 on the angled slide block 10 snap in pilot hole 15 on the nanoporous matrix 2, simultaneously the connection strap 16 of nanoporous matrix 2 one ends is connected with connection strap 13 on being attached to mesochite 3b bottom surface, nanoporous matrix 2 is inserted in the mouth, being contained in regular hour in the mouth or person under inspection by the two rows tooth then contacts the sampling end of nanoporous matrix 2 with mucous membrane of mouth, and scraping back and forth, collect the mucous membrane transudate.When person under inspection's mouth cavity liquid viscosity is too big, this moment, the person under inspection can insert a period of time in the dilution with nanoporous matrix 2, the sampling end of nanoporous matrix 2 has absorbed mouth cavity liquid or behind the mixing material after the diluted, liquid flows towards the other end by capillarity, the impurity particle that exists in the sample etc. is filtered out by nano-porous structure, follow through connection strap 16, blocking-up bar 4, thereby the blocking-up reagent on the blocking-up bar 4 can reduce the incidence that the generation of non-specific adsorption reduces " false positive ".Behind blocking-up bar 4, liquid sample begins to flow to connection strap 13 and flows to detecting test paper 1 then then, crosses when detecting test paper 1 when flow of liquid and has an effect with being fixed on the reagent that detects on the test paper 1, and produce a signal that can be detected.In general, this signal can be coloured lines.Whether person under inspection and medical worker can observe lines by display window 6 and exist, thereby determine " feminine gender " or " positive ".Final liquid flows to the end of connection strap 13, is absorbed piece 5 and absorbs and locking.Because register pin 12 snaps in the pilot hole 15 on the nanoporous matrix 2, makes nanoporous matrix 2 can not return in the shell 3, expression was used, and gave the person under inspection with prompting, prevented cross-infection.
This instrument can the multiple material of disposable detection, and this material is including, but not limited to the antigen and the antibody of various diseases such as aids antibody, various types of hepatitis virus antibody, various types of hepatitis antigen, smallpox antibody, syphilis antibody.This material also can be variously to exist molecule in the human body including, but not limited to glucose, transaminase, and cholesterol, lecithin, cocaine, nicotine, various hormone can plant growth factor or the like.The precision of this instrument diagnoses is greater than 99.7%, and detecting test paper according to used difference can be slightly different.As complete commodity, this instrument can be sold as a diagnosis box with its aid.These aids are placed the shelf of buffering medicine bottle including, but not limited to damping fluid, instructions, teaching audio and video files or the like.
With above-mentioned foundation desirable embodiment of the present utility model is enlightenment, and by above-mentioned description, the related work personnel can carry out various change and modification fully in the scope that does not depart from this utility model technological thought.The technical scope of this utility model is not limited to the content on the instructions, must determine its technical scope according to the claim scope.
Claims (6)
1. mouth cavity liquid diagnostic instrments, comprise the detection test paper, it is characterized in that: also be provided with nanoporous matrix, described detection test paper, nanoporous matrix is wrapped in the shell, described shell is by upper casing, mesochite, lower casing is formed, have through hole on the described mesochite, place the embedded groove that detects test paper, described lower casing is provided with spring, be fixed with angled slide block on the described spring, be extruded with register pin on the described angled slide block, the two ends of described detection test paper are provided with connection strap, have pilot hole on the described nanoporous matrix, described nanoporous matrix is placed on the angled slide block, is placed with connection strap on the described nanoporous matrix, described connection strap is provided with the blocking-up bar, and the side of described nanoporous matrix is fixed with pushing hands.
2. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: described upper casing is provided with venthole and inspections and examinations result's display window.
3. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: described connection strap away from nanoporous matrix is provided with the absorption piece, and an end of another connection strap passes the through hole on the mesochite and is attached on the bottom surface of mesochite.
4. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: described blocking-up bar includes one or more detersives and buffering agent.
5. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: the aperture of described nanoporous matrix is the 50-900 nanometer.
6. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: described nanoporous matrix is made by one or more plastic materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010206658182U CN201955341U (en) | 2010-12-17 | 2010-12-17 | Diagnostic instrument for oral liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010206658182U CN201955341U (en) | 2010-12-17 | 2010-12-17 | Diagnostic instrument for oral liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201955341U true CN201955341U (en) | 2011-08-31 |
Family
ID=44499449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010206658182U Expired - Lifetime CN201955341U (en) | 2010-12-17 | 2010-12-17 | Diagnostic instrument for oral liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201955341U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525570A (en) * | 2011-12-27 | 2012-07-04 | 深圳市爱速尔生物技术有限公司 | Sample collector |
| CN102539752A (en) * | 2010-12-17 | 2012-07-04 | 苏州万木春生物技术有限公司 | Oral fluid diagnosing instrument |
| CN102565385A (en) * | 2011-12-27 | 2012-07-11 | 深圳市爱速尔生物技术有限公司 | Rapid detection instrument for epidemic antigen and antibody of living animal |
| CN102854310A (en) * | 2011-12-27 | 2013-01-02 | 深圳市爱速尔生物技术有限公司 | Living-animal food safety rapid detector |
| CN103185789A (en) * | 2011-12-27 | 2013-07-03 | 深圳市爱速尔生物技术有限公司 | RV-ADV antigen feces rapid detector |
-
2010
- 2010-12-17 CN CN2010206658182U patent/CN201955341U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102539752A (en) * | 2010-12-17 | 2012-07-04 | 苏州万木春生物技术有限公司 | Oral fluid diagnosing instrument |
| CN102525570A (en) * | 2011-12-27 | 2012-07-04 | 深圳市爱速尔生物技术有限公司 | Sample collector |
| CN102565385A (en) * | 2011-12-27 | 2012-07-11 | 深圳市爱速尔生物技术有限公司 | Rapid detection instrument for epidemic antigen and antibody of living animal |
| CN102854310A (en) * | 2011-12-27 | 2013-01-02 | 深圳市爱速尔生物技术有限公司 | Living-animal food safety rapid detector |
| CN103185789A (en) * | 2011-12-27 | 2013-07-03 | 深圳市爱速尔生物技术有限公司 | RV-ADV antigen feces rapid detector |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20110831 Effective date of abandoning: 20140924 |
|
| RGAV | Abandon patent right to avoid regrant |