CN203365324U - Diabetes detection device based on CRDS (cavity ring-down spectroscopy) - Google Patents

Abstract

The utility model relates to diabetes detection, in particular to a diabetes detection method and device based on the CRDS. The diabetes detection device specifically comprises a drive control module, an LED, an optical device module, an optical filter, a miniature gas diaphragm pump, an optical resonant cavity, a three-way air valve, a hose, an optical lens, a detector and an information processing module. The concentration of acetone gas in expired gas of an ordinary normal person is 5 ppm and far smaller than that of 40-500 ppm of acetone gas in expired gas of a diabetic patient. The CRDS has high detection sensitivity (the detection limit of the acetone gas can reach 0.2 ppm) and can guarantee the accuracy of the detection of a diabetes result. The diabetes detection device is simple, high in sensitivity and good in stability, has not damage to the person, and can detect whether the patient suffers from the diabetes very accurately and rapidly.

Description

A kind of diabetes detecting device based on Research on Cavity Ring Down Spectroscopy

Technical field

The utility model relates to the detection of diabetes, more particularly, relates to a kind of diabetes detection method and device based on Research on Cavity Ring Down Spectroscopy.

background technology

Along with economic fast development, the raising of living standards of the people, the glycosuria incidence of disease in countries in the world is all in rapid rising in recent years.The harm of diabetes is mainly from complication, and complication can cause the dysfunction of patient's whole body many places internal organs, also can cause that infection, heart change, cerebrovascular disease, renal function are decayed, lost the sight of both eyes, lower limb gangrene etc.Diabetes and complication thereof are not only directly threatening patient's health and life, have also caused the loss of national and individual manpower and financial resources simultaneously, become the huge obstacle of human social development.Therefore, diabetes how fast, without wound, to detect exactly be the key subjects that current medical circle faces.

At present, medical circle mainly contains following two class methods for detection of diabetes:

The one, blood sugar test, blood sugar test mainly includes wound blood sugar test method, Wicresoft's blood sugar test method, Woundless blood sugar detection method.It is to use blood glucose meter that wound blood sugar test method is arranged, patient points with pinprick is broken, then use disposable test strips to draw the micro blood that the finger tear oozes out, finally test strips inserted in blood glucose meter to reading out data and judged whether to suffer from diabetes, although it is simple and easy, convenient that the method operates, but the measurement range of blood sugar is subject to the restriction of the sensing range of test paper, can not accurately measure, and get the blood process at every turn and all to patient, bring pain, and there is the risk infected, most importantly the method can not continuous detecting, can't reach the Real-Time Monitoring blood sugar concentration.Wicresoft's blood sugar test method, Wicresoft's blood sugar concentration detection technique of main flow is all to utilize electricity thorn, galvanochemistry etc. at present, the body fluid relevant to concentration of glucose such as the tissue fluid of extraction human body, tears, then use various sensing technologies to measure the glucose content in these body fluid, the correlativity of concentration of glucose and the concentration of glucose in blood in last these body fluid verified according to medical science, and then infer the concentration of glucose in blood of human body, but because expense is high, use inconvenient, need the factors such as calibration, can't be widely used.The Woundless blood sugar detection method is mainly to utilize spectral analysis technique to carry out the blood sugar concentration detection, this method has changed tradition the drawback of creating blood sugar test, can not cause any wound of human body, avoided virus by the danger of blood-borne, and can realize the continuous detection of dynamic of blood sugar, but because the spectral signal that blood sugar concentration changes is very faint, and overlapping with the spectral signal that in the human bodies such as human body skin, other tissue, blood component, non-blood sugar forms, therefore signal is difficult to gather, because individual difference is large, be difficult to revise by unified mathematical model again.

The 2nd, breathing gas detects, and breathing gas detects and mainly comprises gas chromatography, selection ion flow pipe Mass Spectrometer Method method, Electronic Nose Technology detection method.Being applied to of success of gas chromatography detects content of acetone in the gas of breathing out, but because its qualitative ability of gas chromatography is poor, therefore it need to can be analyzed more accurately in conjunction with other detecting device on-line couplings, and expensive.Although select ion flow pipe Mass Spectrometer Method method can the acetone of characteristics of contaminated respiratory droplets be detected online, but because the characteristics of contaminated respiratory droplets minimum gas is of a great variety, cause it inevitably to form many ionic bunch of compounds, made the gained collection of illustrative plates too complicated, increased the difficulty of resolving.Electronic Nose Technology detection method device is portable, simple to operate, practical, but the sensor array of Electronic Nose is normally usingd electric signal and is analyzed as the signal detected, so often be subject to the very large and sensor of such environmental effects easily and other gases in breath react, affect testing result.

The utility model content

For the defect existed in above-mentioned prior art, the utility model device is simple, to the people without wound, highly sensitive, good stability, can detect very quickly and accurately patient and whether suffer from diabetes.

Principle of work of the present utility model is as follows:

In general normal person's breath, acetone gas concentration is 5ppm, but for the diabetic along with significant quantities of fat consumption, in blood, ketoboidies is also constantly gathering, thereby cause people's ketoacidosis, simultaneously because the ketoboidies concentration in blood is excessive, further cause ketoboidies menses tube wall to be seen through in alveolar, through respiratory system, excrete, in breath, acetone gas concentration (40-500ppm) is high a lot, the high detection sensitivity that utilizes the chamber dying oscillation absorption spectrum to have (detect the acetone gas limit and can reach 0.2ppm), guaranteed to detect the accuracy of diabetes result.

Suppose the long L of being in chamber, in chamber, the absorption coefficient of medium is α, and incident intensity is I ₀, cavity mirrors reflectivity is R, can calculate thus transmitted light intensity I (t) to be:

$I\left(t\right)=I_0\exp (-\frac{t}{\mathrm{\τ}})---\left(1\right)$

Wherein, Decay

$\mathrm{\τ}=\frac{2L/c}{\mathrm{Ln}(1/R^2)+2\mathrm{\αL}}---\left(2\right)$

C is the light velocity in vacuum.Be generally used for the cavity mirrors reflectivity R that swings experiment>0.999 of declining, chamber, formula (2) can be approximated to be:

$\mathrm{\τ}=\frac{L/c}{(1-R)+\mathrm{\αL}}---\left(3\right)$

Make the life-span of cavity be:

${\mathrm{\τ}}_0=\frac{L/c}{1-R}---\left(4\right)$

Be filled with the life-span of front and back by measuring sample gas, can realize the absolute measurement to the sample gas absorption coefficient, that is:

$\mathrm{\α}=\frac{1}{c}(\frac{1}{\mathrm{\τ}}-\frac{1}{{\mathrm{\τ}}_0})---\left(5\right)$

Utilize α=n σ and p=nkT, wherein, n is gas concentration, and σ is the absorption of sample cross section, and k is Boltzmann constant, the p gas pressure intensity, and T is temperature, can calculate sample gas concentration thus.

The utility model is a kind of diabetes detecting device based on Research on Cavity Ring Down Spectroscopy, specifically comprises drive control module, LED, optical device module, optical filter, minitype gas membrane pump, optical resonator, three-way air valve, flexible pipe, lens, detector, message processing module.At first open minitype gas membrane pump and three-way air valve, three-way air valve is controlled and is opened N through drive control module ₂blow vent, pass into N ₂clean other residual gas in optical resonator.Then LED modulates through drive control module, launch the detection light of specific centre wavelength, acetone gas with this understanding, absorb strong, no interference, after detection light is stable, successively by optical device module and optical filter, incide in optical resonator, the light transmitted through optical resonator again through lens focus to detector, the light signal that detector receives is converted into electric signal, the electric signal transmission after conversion is to message processing module and show cavity Decay data.Three-way air valve is controlled and is opened the sample gas blow vent through drive control module, patient blows continuously by flexible pipe in chamber, surveying light incides in the optical resonator of sample gas, the optical resonator transmitted light again through lens focus to detector, the light signal that detector receives is converted into electric signal transmission to message processing module and shows chamber Decay data.The last concentration that demonstrates acetone in patient's breath in message processing module, and determine according to this value whether patient suffers from diabetes.

Further, described drive control module, comprise energy supply control module, signal generator, three-way air valve control circuit.

Further, described optical device module, comprise coupled lens, optical fiber, two catoptrons, achromat.

Further, described LED, launch specific centre wavelength, and wavelength coverage is [260-300nm], and acetone gas with this understanding, absorbs strong.

Further, described optical resonator, be comprised of two concave mirrors that are coated with highly reflecting films, cavity mirrors reflectivity R>0.999, and the detection light wavelength that LED sends is in mirror Gao Fan district, chamber.

Above-mentioned a kind of diabetes detecting device based on Research on Cavity Ring Down Spectroscopy, device is simple, to the people without wound, highly sensitive, good stability, can diagnose out quickly and accurately very much patient whether to suffer from diabetes.

The accompanying drawing explanation

Accompanying drawing is structural representation of the present utility model.

Wherein: comprise drive control module 1, LED2, optical device module 3, optical filter 4, minitype gas membrane pump 5, optical resonator 6, three-way air valve 7, flexible pipe 8, lens 9, detector 10, message processing module 11.

Embodiment

Consult accompanying drawing, while using the diabetes detecting device of Research on Cavity Ring Down Spectroscopy, at first open minitype gas membrane pump 5 and three-way air valve 7, three-way air valve 7 is controlled and is opened N through drive control module 1 ₂blow vent, pass into N ₂clean interior other the residual gas of optical resonator 6.Then LED2 is through drive control module 1 modulation, launch the detection light of specific centre wavelength, acetone gas with this understanding, absorb strong, no interference, after detection light is stable, successively by optical device module 3 and optical filter 4, incide in optical resonator 6, the light transmitted through optical resonator 6 focuses to detector 10 through lens 9 again, and the light signal that detector 10 receives is converted into electric signal, and the electric signal transmission after conversion is to message processing module 11 and show cavity Decay data.Three-way air valve 7 is controlled and is opened the sample gas blow vent through drive control module 1, patient blows continuously by flexible pipe 8 in chamber, surveying light incides in the optical resonator 6 of sample gas, optical resonator 6 transmitted lights focus to detector 10 through lens 9 again, and the light signal that detector 10 receives is converted into electric signal transmission to message processing module 11 and shows chamber Decay data.Last two groups of data that obtain above Treatment Analysis in message processing module the concentration that demonstrates acetone in patient's breath, and determine according to this value whether patient suffers from diabetes.

The foregoing is only specific embodiment of the utility model, but technical characterictic of the present utility model is not limited to this, any those skilled in the art is in field of the present utility model, and the variation of doing or modification all are encompassed among the scope of the claims of the present utility model.

Claims (3)

1. the diabetes detecting device based on Research on Cavity Ring Down Spectroscopy, it is characterized in that: after detection light is stable, successively by optical device module (3) and optical filter (4), incide in optical resonator (6), the light transmitted through optical resonator (6) focuses to detector (10) through lens (9) again, the light signal that detector (10) receives is converted into electric signal, and the electric signal transmission after conversion is to message processing module (11) and show cavity Decay data.

2. a kind of diabetes detecting device based on Research on Cavity Ring Down Spectroscopy as claimed in claim 1 is characterized in that: described LED (2), launch specific centre wavelength, and wavelength coverage is [260-300nm], acetone gas with this understanding, absorbs strong.

3. a kind of diabetes detecting device based on Research on Cavity Ring Down Spectroscopy as claimed in claim 1, it is characterized in that: described optical resonator (6), by two concave mirrors that are coated with highly reflecting films, formed, cavity mirrors reflectivity R>0.999, the detection light wavelength that LED (2) sends is in mirror Gao Fan district, chamber.

Images