CN104706363A - Composite type photoacoustic nondestructive dynamic blood sugar detector - Google Patents
Composite type photoacoustic nondestructive dynamic blood sugar detector Download PDFInfo
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- CN104706363A CN104706363A CN201510124549.6A CN201510124549A CN104706363A CN 104706363 A CN104706363 A CN 104706363A CN 201510124549 A CN201510124549 A CN 201510124549A CN 104706363 A CN104706363 A CN 104706363A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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Abstract
The invention discloses a composite type photoacoustic nondestructive dynamic blood sugar detector which comprises a laser device, a laser alignment unit, a focusing lens assembly, a cooling unit, a finger fixing cavity, a piezoelectric transducer array, a laser modulator, a micro DSP, a display module, a phase-locked amplifier and a pre-amplifier. The cooling unit is attached to the finger fixing cavity, and the laser device, the laser alignment unit and the focusing lens assembly are located in the same plane. Based on chirp modulation signals and the piezoelectric transducer array, the composite type photoacoustic nondestructive dynamic blood sugar detector has the capacity of obtaining blood sugar fingerprint features, the structure is simple, and the measurement accuracy can reach to over 96.5%. Meanwhile, temperature change of a portion to be measured can be effectively controlled, and the environmental influences can be effectively avoided.
Description
Technical field
The present invention relates to a kind of measuring instrument detecting blood sugar in diabetic patients level for medical science, be specifically related to a kind of compound optoacoustic dynamic nondestructive blood-sugar detecting instrument.
Background technology
A kind of hurtless measure, can survey continuously, portable dynamic glucose detector has become current blood glucose instrument development trend." diabetes map " display that International Diabetes Federation issues, within 2013, the whole world about has 3.82 hundred million adults to suffer from diabetes, and China has become the maximum country of global diabetics, total patient of diabetes patient number nearly 100,000,000, prediabetes number has reached about 1.5 hundred million.And diabetics is in order to control its PD, need to carry out incessantly measuring its blood sugar level, to reach the object making blood glucose value remain on normal range.
And blood glucose monitoring system conventional clinically is at present traumatic, bring certain misery to patient.Simultaneously, we notice that numerous enterprises is developing non-invasive determination method of blood sugar and detecting instrument, wherein are no lack of Zoomlion big business, such as Microsoft, Google, Samsung proposes in recent years and carries out the research and development of noninvasive glucose instrument, and noninvasive glucose instrument is once research and develop successfully, and the pattern for existing " blood glucose meter freely, by reagent paper is made money " will be revolutionary progress.
On the other hand, we notice and have disclosed the multinomial patent of invention about non-invasive blood sugar instrument at present, as " Noninvasive near-infrared electronic blood-glucose meter " (CN102198004A) utilizes infrared light supply (600 ~ 2500nm) transmission to point, according to the absorption spectrum of blood glucose, utilize the signal of the Mixture of expert algorithm of neutral net to sensor each in infrared sensing array to be weighted on average and obtain blood glucose value; " Non-invasive blood sugar monitor " (CN201295231Y) is capacitance by two electrode measurement patients with patient contact thus obtains the blood glucose value of patient; " self-service non-wound blood sugar measurer " (CN1271562A) utilizes infrared light emission pipe as infrared light supply (wavelength: 1000 ~ 2900nm), adopts transmission-type to measure blood glucose value.
Application number be 200710304706.7 Chinese patent disclose the method and apparatus that a kind of Woundless blood sugar detects fast, what it adopted is pulse laser, measurement uses optoacoustic effect and light scattering effect to carry out, adopt pulse laser cost higher, and it also cannot solve blood sugar test problem affected by environment.
The infrared spectrometry that above method adopts, is disturbed serious, high to environmental requirement.The impact being subject to ambient temperature is large.Why non-invasive blood sugar instrument does not delay to research and develop successfully, and tracing it to its cause is two aspects: (1) stability and accuracy are that bottleneck (2) the hurtless measure dynamic glucose detector of current noninvasive glucose instrument detects greatly affected by environment.
Summary of the invention
The object of the invention is to provide a kind of hurtless measure measuring instrument detecting blood sugar in diabetic patients level for medical science, solves the greatly affected by environment of noninvasive glucose instrument, is especially subject to the problem of the impact of other tissue fluids.
Technical scheme of the present invention is: a kind of compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, and it comprises laser instrument, laser alignment unit, focus lens group, cooling unit, finger lock chamber, piezoelectric transducer array, laser modulator, DSP microprocessor, display module, lock-in amplifier and preamplifier; Cooling unit is attached on finger lock chamber; Laser instrument, laser alignment unit, focus lens group are in same plane;
Laser instrument is subject to the modulation of laser modulator, is loaded on laser beam by the chirp signal that DSP microprocessor produces, and chirp signal is sent to lock-in amplifier as with reference to signal simultaneously; With the laser beam of chirp signal by after laser alignment unit, incide focus lens group, laser beam focusing is made to arrive in finger lock chamber, after the light energy skin histology be placed in finger lock chamber absorbs, because optoacoustic effect forms ultrasound wave, piezoelectric transducer array detects ultrasound wave, convert acoustical signal to the signal of telecommunication, the signal of telecommunication that piezoelectric transducer array collects by preamplifier amplifies, be input to lock-in amplifier to detect, obtain the photoacoustce signal intensity of respective frequencies.
Further, laser instrument is subject to the modulation of laser modulator, is that the chirp signal of 0.3M ~ 11MHz is modulated to laser instrument, generating period light-intensity variation by frequency range.
Further, piezoelectric transducer array is made up of the Acoustic focusing transducer of at least two different center frequency, it detects frequency of sound wave covering frequence scope is 0.3M ~ 11MHz, the focal length of Acoustic focusing transducer is identical simultaneously, their focus overlaps with laser instrument incident light position, just in time drops on the focal plane of incident laser.
Further, cooling unit is made up of amber ear note cooling element and temperature sensor, carries out temperature adjustment, make its operating temperature be 15 ± 0.2 DEG C to finger lock chamber.
Further, finger lock chamber, primarily of optical lens, glass baffle plate and substrate composition, forms acoustic resonant cavity.
Further, centered by described laser instrument, wavelength is the near-infrared quasiconductor continuous-wave laser of 980nm.
What the present invention adopted is that continuous-wave laser uses chirp signal to modulate, and relative to pulse laser, continuous wave laser is except low price, and our modulation system makes frequency spectrum of laser acoustics enrich, and namely can cover the signal of 0.3M ~ 11MHz; And research find measuring point temperature often raise 0.1 DEG C of light intensity caused and concentration of glucose reduce 3.68mmol/L suitable (list of references: Liu Rong etc. University Of Tianjin journal .Vol.41No.12008), such temperature control is very important, can precision be improved, after avoiding using laser, introduce personal error.
Compare with prior art, the invention has the beneficial effects as follows:
(1) based on chirped modulation signal and piezoelectric transducer array, have the ability obtaining blood glucose fingerprint characteristic, and structure is simple, certainty of measurement reaches more than 96.5%.
(2) effectively control the change of tested spot temperature simultaneously, thus effectively avoid the impact of environment.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is finger control chamber structural representation;
Fig. 3 is the chirp signal figure that the present invention uses;
Fig. 4 is the deionized water and blood glucose solution (500mmol/L) optoacoustic spectrogram that obtain according to present system;
Fig. 5 is the present invention when adopting optical maser wavelength to be 980nm, and type Ⅰ diabetes mellitus human blood carbohydrate density and photoacoustic signal value measure graph of a relation in time.
Fig. 6 is the present invention when adopting optical maser wavelength to be 980nm, and type Ⅱdiabetes mellitus human blood carbohydrate density and photoacoustic signal value measure graph of a relation in time.
Fig. 7 is for repetitive measurement, the linear coupling relation of blood glucose density and photoacoustic signal value.
In figure, 11 is laser instrument, and 12 is laser alignment unit, 13 is focus lens group, and 14 is cooling unit, and 15 is finger lock chamber, 16 is the whole array of piezoelectric transducer, and 17 is laser modulator, and 18 is DSP microprocessor, 19 is display module, and 110 is lock-in amplifier, and 111 is preamplifier, 21 is finger chamber, and 22 is substrate, and 23 is lens fixed mount, 24 is anti-reflection mirror, and 25 is convex lens, and 26 is glass baffle plate.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described, and a kind of dual-wavelength difference near infrared no-wound hinders blood glucose meter:
Main feature of the present invention is: the first, employs chirp signal as modulation signal, forms photoacoustic spectrum to be detected; The second, utilize cooling unit to control the temperature at tested position, avoid the impact of ambient temperature or measuring point variations in temperature; 3rd, use and adopt Acoustic focusing transducer, significantly improve the detection efficiency of sound wave.
As shown in Figure 1, it comprises laser instrument 11, laser alignment unit 12, focus lens group 13, cooling unit 14, finger lock chamber 15, piezoelectric transducer array 16, laser modulator 17, DSP microprocessor 18, display module 19, lock-in amplifier 110 and preamplifier 111 to its structure; Cooling unit 14 is attached on finger lock chamber 15; Laser instrument 11, laser alignment unit 12, focus lens group 13 are in same plane.
Laser instrument 11 is subject to the modulation of laser modulator 17, is loaded on laser beam by the chirp signal that DSP microprocessor 18 produces, and chirp signal is sent to lock-in amplifier 110 as with reference to signal simultaneously, with the laser beam of chirp signal by after laser alignment unit 12, incide focus lens group 13, make laser beam focusing arrive finger lock chamber in 15, after the light energy skin histology be placed in finger lock chamber 15 absorbs, because optoacoustic effect forms ultrasound wave, piezoelectric transducer array detects ultrasound wave, convert acoustical signal to the signal of telecommunication, the signal of telecommunication that piezoelectric transducer array 16 collects by preamplifier 111 amplifies, be input to lock-in amplifier 110 to detect, obtain the photoacoustce signal intensity of respective frequencies, be input to after DSP microprocessor 18 processes and shown by display module.
Laser instrument 11 is subject to the modulation of laser modulator 17, is that the chirp signal of 0.3M ~ 11MHz is modulated to laser instrument, generating period light-intensity variation by frequency range.Piezoelectric transducer array 16 is made up of the Acoustic focusing transducer of at least two different center frequency, it detects frequency of sound wave covering frequence scope is 0.3M ~ 11MHz, the focal length of Acoustic focusing transducer is identical simultaneously, their focus overlaps with laser instrument 11 incident light position, just in time drops on the focal plane of incident laser.Cooling unit 14 is made up of amber ear note cooling element and temperature sensor, carries out temperature adjustment, make its operating temperature be 15 ± 0.2 DEG C to finger lock chamber 15.Finger lock chamber is made up of optical lens, glass baffle plate 26 and substrate 22, forms acoustic resonant cavity.Finger chamber 21 is for placing tested finger position; Anti-reflection mirror 24 effect is the effect near infrared light of 980nm being played to narrow-band-filter, avoids the impact of the infrared light of other wavelength; Convex lens 25 can adjust focus point, after making focus point just in time drop on glass baffle plate 26, distance glass baffle plate 262mm ~ 3mm, when the effect of glass baffle plate 26 is detections, finger plaster is on glass baffle plate 26, makes the focus point of laser just in time drop on finger skin inside; The effect of substrate 22 has two, and one is fixed finger cavity, and another one effect forms acoustic resonant cavity with glass baffle plate 26.Centered by described laser instrument 11, wavelength is the near-infrared quasiconductor continuous-wave laser of 980nm.
Set up the theoretical foundation that detection algorithm mathematical model is selective light sound spectrum technology.The propagation equation of acoustical signal in cell tissue produced can describe in order to lower formula:
Here I represents laser intensity, and v is sound wave spread speed in cell tissue, and α is the absorption coefficient of light, and β is thermal coefficient of expansion, C
pbe specific heat capacity, p is sound pressure.
For the histiocytic situation of weak absorbing, sound pressure p can be written as:
Here k is system weighting constant, E
0for incident intensity energy, n is experiment experience constant (between 1 and 2).
As shown in Figure 2, it comprises the signal of frequency 0.01MHz ~ 10MHz to such employing chirp signal, and time delay is 0.1s, in 10 minutes sampling times, can calculate a blood glucose value every 30s, and formative dynamics is measured.
Give deionized water and blood glucose solution (500mmol/L) optoacoustic spectrogram in Fig. 4, the peak value that there is optoacoustic absorption spectra near 980nm can be found out from absorption spectrum, select the near-infrared laser of 980nm can realize the object of Measurement accuracy blood glucose value.
When Fig. 5 and Fig. 6 represents that employing optical maser wavelength is 980nm respectively, type Ⅰ diabetes mellitus human blood carbohydrate density and photoacoustic signal value are measured graph of a relation in time and type Ⅱdiabetes mellitus human blood carbohydrate density and photoacoustic signal value and are measured graph of a relation in time, can clearly find out from graph of a relation for I type and type Ⅱdiabetes mellitus people, photoacoustic signal value and blood glucose density have extraordinary linear relationship.
Fig. 7 is for repetitive measurement, provides the blood glucose value V that PA detects
pAwith medical measured value V
clinicalbetween linear coupling close be
V
PA＝0.965V
Clinical+12.65 (3)
Both dependencys reach 96.5%, and can measure blood glucose value exactly, certainty of measurement reaches more than 96.5%.
The above embodiment only have expressed the detailed description of the invention of the application, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the application's protection domain.It should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from technical scheme design, can also make some distortion and improvement, these all belong to the protection domain of the application.
Claims (6)
1. a compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, is characterized in that: it comprises laser instrument, laser alignment unit, focus lens group, cooling unit, finger lock chamber, piezoelectric transducer array, laser modulator, DSP microprocessor, display module, lock-in amplifier and preamplifier; Cooling unit is attached on finger lock chamber; Laser instrument, laser alignment unit, focus lens group are in same plane;
Laser instrument is subject to the modulation of laser modulator, is loaded on laser beam by the chirp signal that DSP microprocessor produces, and chirp signal is sent to lock-in amplifier as with reference to signal simultaneously; With the laser beam of chirp signal by after laser alignment unit, incide focus lens group, laser beam focusing is made to arrive in finger lock chamber, after the light energy skin histology be placed in finger lock chamber absorbs, because optoacoustic effect forms ultrasound wave, piezoelectric transducer array detects ultrasound wave, convert acoustical signal to the signal of telecommunication, the signal of telecommunication that piezoelectric transducer array collects by preamplifier amplifies, be input to lock-in amplifier to detect, obtain the photoacoustce signal intensity of respective frequencies.
2. one according to claim 1 compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, is characterized in that: laser instrument is subject to the modulation of laser modulator, is that the chirp signal of 0.3M ~ 11MHz is modulated to laser instrument, generating period light-intensity variation by frequency range.
3. one according to claim 1 compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, it is characterized in that: piezoelectric transducer array is made up of the Acoustic focusing transducer of at least two different center frequency, it detects frequency of sound wave covering frequence scope is 0.3M ~ 11MHz, the focal length of Acoustic focusing transducer is identical simultaneously, their focus overlaps with laser instrument incident light position, just in time drops on the focal plane of incident laser.
4. one according to claim 1 compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, it is characterized in that: cooling unit is made up of amber ear note cooling element and temperature sensor, temperature adjustment is carried out to finger lock chamber, makes its operating temperature be 15 ± 0.2 DEG C.
5. one according to claim 1 compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, is characterized in that: finger lock chamber, primarily of optical lens, glass baffle plate and substrate composition, forms acoustic resonant cavity.
6. one according to claim 1 compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, is characterized in that: centered by described laser instrument, wavelength is the near-infrared quasiconductor continuous-wave laser of 980nm.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105559794A (en) * | 2016-02-23 | 2016-05-11 | 杨立峰 | Wearable noninvasive dynamic blood glucose monitor based on photo-acoustic spectrometry features |
| CN106889993A (en) * | 2017-04-11 | 2017-06-27 | 郜键 | FM/cw laser imaging non-blood sampling type blood sugar detection method based on light intensity modulation |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| JP2018171178A (en) * | 2017-03-31 | 2018-11-08 | 日本電信電話株式会社 | Constituent concentration measuring device and method |
| CN109540802A (en) * | 2018-12-13 | 2019-03-29 | 东北大学 | The photoacoustic detection device and method of concentration of glucose in a kind of biological fluid |
| CN109662720A (en) * | 2018-11-27 | 2019-04-23 | 中国科学院深圳先进技术研究院 | Multiband optoacoustic Woundless blood sugar concentration prediction system based on deep learning |
| CN110638466A (en) * | 2019-09-17 | 2020-01-03 | 广东普洛宇飞生物科技有限公司 | Positioning device and method |
| CN113108696A (en) * | 2021-04-06 | 2021-07-13 | 合肥埃科光电科技有限公司 | Light source wavelength scanning spectrum confocal sensor |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105559794A (en) * | 2016-02-23 | 2016-05-11 | 杨立峰 | Wearable noninvasive dynamic blood glucose monitor based on photo-acoustic spectrometry features |
| CN105559794B (en) * | 2016-02-23 | 2018-03-23 | 杨立峰 | A kind of Wearable hurtless measure Dynamic Blood Glucose Monitoring instrument based on optoacoustic spectrum signature |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| JP2018171178A (en) * | 2017-03-31 | 2018-11-08 | 日本電信電話株式会社 | Constituent concentration measuring device and method |
| CN106889993A (en) * | 2017-04-11 | 2017-06-27 | 郜键 | FM/cw laser imaging non-blood sampling type blood sugar detection method based on light intensity modulation |
| CN106889993B (en) * | 2017-04-11 | 2020-05-15 | 郜键 | FM/cw laser imaging non-blood sampling type blood sugar detection method based on light intensity modulation |
| CN109662720A (en) * | 2018-11-27 | 2019-04-23 | 中国科学院深圳先进技术研究院 | Multiband optoacoustic Woundless blood sugar concentration prediction system based on deep learning |
| CN109662720B (en) * | 2018-11-27 | 2022-04-15 | 中国科学院深圳先进技术研究院 | Multi-band photoacoustic noninvasive blood glucose concentration prediction system based on deep learning |
| CN109540802A (en) * | 2018-12-13 | 2019-03-29 | 东北大学 | The photoacoustic detection device and method of concentration of glucose in a kind of biological fluid |
| CN109540802B (en) * | 2018-12-13 | 2021-06-04 | 东北大学 | Photoacoustic detection device and method for glucose concentration in biological fluid |
| CN110638466A (en) * | 2019-09-17 | 2020-01-03 | 广东普洛宇飞生物科技有限公司 | Positioning device and method |
| CN110638466B (en) * | 2019-09-17 | 2022-06-03 | 广东普洛宇飞生物科技有限公司 | Positioning device and method |
| CN113108696A (en) * | 2021-04-06 | 2021-07-13 | 合肥埃科光电科技有限公司 | Light source wavelength scanning spectrum confocal sensor |
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