CN104706363B - Composite type photoacoustic nondestructive dynamic blood sugar detector - Google Patents
Composite type photoacoustic nondestructive dynamic blood sugar detector Download PDFInfo
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- CN104706363B CN104706363B CN201510124549.6A CN201510124549A CN104706363B CN 104706363 B CN104706363 B CN 104706363B CN 201510124549 A CN201510124549 A CN 201510124549A CN 104706363 B CN104706363 B CN 104706363B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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Abstract
The invention discloses a composite type photoacoustic nondestructive dynamic blood sugar detector which comprises a laser device, a laser alignment unit, a focusing lens assembly, a cooling unit, a finger fixing cavity, a piezoelectric transducer array, a laser modulator, a micro DSP, a display module, a phase-locked amplifier and a pre-amplifier. The cooling unit is attached to the finger fixing cavity, and the laser device, the laser alignment unit and the focusing lens assembly are located in the same plane. Based on chirp modulation signals and the piezoelectric transducer array, the composite type photoacoustic nondestructive dynamic blood sugar detector has the capacity of obtaining blood sugar fingerprint features, the structure is simple, and the measurement accuracy can reach to over 96.5%. Meanwhile, temperature change of a portion to be measured can be effectively controlled, and the environmental influences can be effectively avoided.
Description
Technical field
The present invention relates to a kind of detect the measuring instrument of blood sugar in diabetic patients level and in particular to a kind of be combined for medical science
Type optoacoustic dynamic nondestructive blood-sugar detecting instrument.
Background technology
A kind of hurtless measure, continuously can survey, and portable dynamic glucose detector has become as current blood glucose instrument development trend.
International Diabetes Federation issues《Diabetes map》Display, the whole world in 2013 there are about 3.82 hundred million adults and suffers from diabetes,
And China has become the most country of global diabetic, total patient of diabetes patient's number nearly 100,000,000, prediabetes number
Reach 1.5 hundred million about.And diabetic, in order to control its PD, needs to measure its blood sugar level incessantly, with
Reach so that blood glucose value is maintained at the purpose of normal range (NR).
And the blood glucose monitoring system clinically commonly used at present is traumatic, bring certain misery to patient.Meanwhile, I
Notice that numerous enterprises are developing non-invasive determination method of blood sugar and detecting instrument, be wherein no lack of the big enterprise of Zoomlion
Industry, such as Microsoft, Google, Samsung propose in recent years and carry out the research and development of noninvasive glucose instrument, hurtless measure
Blood glucose meter is once researched and developed successfully, and the pattern for existing " blood glucose meter is free, lean on test paper to make money " will be revolutionary progress.
On the other hand, we note that and have been disclosed for the multinomial patent of invention with regard to non-invasive blood sugar instrument up till now, such as《Noninvasive
Formula near-infrared electronic blood-glucose meter》(CN102198004A) utilize infrared light supply (600～2500nm) transmission finger, according to blood sugar
Absorption spectrum, the Mixture of expert algorithm using neutral net is weighted averagely to the signal of sensor each in infrared sensing array
After obtain blood glucose value；《Non-invasive blood sugar monitor》(CN201295231Y) it is by two electrodes with patient contact
The capacitance of measurement patient is thus obtain the blood glucose value of patient；《Self-service non-wound blood sugar measurer》(CN1271562A) it is using infrared
Light-emitting tube is as infrared light supply (wavelength：1000～2900nm), blood glucose value is measured using transmission-type.
The Chinese patent of Application No. 200710304706.7 discloses a kind of method of Woundless blood sugar quick detection and dress
Put, it uses pulse laser, measurement is to be carried out using optoacoustic effect and light scattering effect, using pulse laser cost relatively
Height, and it also cannot solve the problems, such as that blood sugar test is affected by environment.
The infra-red sepectrometry that above method adopts, is disturbed serious, high to environmental requirement.Affected by the ambient temperature
Greatly.Why non-invasive blood sugar instrument does not delay is researched and developed successfully, and tracing it to its cause is two aspects：(1) stability and accuracy are mesh
Bottleneck (2) the hurtless measure dynamic glucose detector detection of front noninvasive glucose instrument is affected by environment big.
Content of the invention
It is an object of the present invention to provide a kind of hurtless measure measuring instrument detecting blood sugar in diabetic patients level for medical science, solve
Affected by environment big, the problem especially being affected by other tissue fluid of noninvasive glucose instrument.
The technical scheme is that：A kind of compound optoacoustic dynamic nondestructive blood-sugar detecting instrument, it includes laser instrument, laser
Collimation unit, focus lens group, cooling unit, finger lock chamber, piezoelectric transducer array, laser modulator, DSP microprocessor
Device, display module, lock-in amplifier and preamplifier；Cooling unit is attached on finger lock chamber；Laser instrument, laser alignment
Unit, focus lens group are in approximately the same plane；
Laser instrument is modulated by laser modulator, and the chirp signal that DSP microprocessor is produced is loaded into laser beam
On, chirp signal is sent to lock-in amplifier as reference signal simultaneously；Laser beam with chirp signal passes through laser
After collimation unit, incide focus lens group so that laser beam focusing is in finger lock chamber, light energy is placed on finger
After skin histology in lock chamber absorbs, because optoacoustic effect forms ultrasonic wave, piezoelectric transducer array detects ultrasonic wave, will
Acoustical signal is converted into electric signal, and the electric signal that piezoelectric transducer array collects is amplified by preamplifier, is input to lock and mutually puts
Big device is detected, obtains the photoacoustce signal intensity of respective frequencies.
Further, laser instrument is modulated by laser modulator, by the chirp signal for 0.3M～11MHz for the frequency range
Modulate laser instrument, generate periodic intensity fluctuation.
Further, piezoelectric transducer array is made up of the Acoustic focusing transducer of at least two different center frequency, its
Detection frequency of sound wave covering frequence scope is 0.3M～11MHz, and the focal length of Acoustic focusing transducer is identical simultaneously, their focus
Overlap with laser instrument incident light position, just fall on the focal plane of incident laser.
Further, cooling unit is made up of peltier cooling element and temperature sensor, carries out temperature to finger lock chamber
Degree is adjusted so that its operating temperature is 15 ± 0.2 DEG C.
Further, finger lock chamber is mainly made up of optical lens, glass baffle plate and substrate, forms acoustic resonant cavity.
Further, centered on described laser instrument, wavelength is the near-infrared semiconductor continuous-wave laser of 980nm.
The present invention is used continuous-wave laser and is modulated using chirp signal, with respect to pulse laser, continuously
Except low price, our modulation system makes frequency spectrum of laser acoustics enrich to laser instrument, you can to cover 0.3M～11MHz's
Signal；And study discovery measuring point temperature and often raise 0.1 DEG C of light intensity causing and concentration of glucose reduction 3.68mmol/L
Quite (bibliography：Liu Rong etc. University Of Tianjin journal .Vol.41No.12008), such temperature control is very important, can improve
Precision, it is to avoid using introducing human error after laser.
Compared with prior art, the invention has the beneficial effects as follows：
(1) it is based on chirped modulation signal and piezoelectric transducer array, there is the ability obtaining blood sugar fingerprint characteristic, Er Qiejie
Structure is simple, and certainty of measurement reaches more than 96.5%.
(2) effective control tested spot temperature change simultaneously, thus be prevented effectively from the impact of environment.
Brief description
Fig. 1 is the structural representation of the present invention；
Fig. 2 is finger control chamber structural representation；
The chirp signal figure that Fig. 3 uses for the present invention；
Fig. 4 is the deionized water and blood sugar solution (500mmol/L) optoacoustic spectrogram obtaining according to present system；
When Fig. 5 adopts optical maser wavelength for 980nm for the present invention, IDDM human blood carbohydrate density is measured with photoacoustic signal value
Graph of a relation in time.
When Fig. 6 adopts optical maser wavelength for 980nm for the present invention, type II diabetes human blood carbohydrate density is measured with photoacoustic signal value
Graph of a relation in time.
Fig. 7 is to measure for multiple, the linear coupling relation of blood sugar density and photoacoustic signal value.
In figure, 11 is laser instrument, and 12 is laser alignment unit, and 13 is focus lens group, and 14 is cooling unit, and 15 is finger
Lock chamber, 16 is the whole array of PZT (piezoelectric transducer), and 17 is laser modulator, and 18 is DSP microprocessor, and 19 is display module, and 110 are
Lock-in amplifier, 111 is preamplifier, and 21 is finger chamber, and 22 is substrate, and 23 is lens fixed mount, and 24 is anti-reflection mirror, and 25 are
Convex lens, 26 is glass baffle plate.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings, and a kind of dual-wavelength difference near infrared no-wound hinders blood glucose meter：
The present invention is mainly characterized by：First, employ chirp signal as modulated signal, form photoacoustic spectrum to be detected；
Second, control the temperature at tested position using cooling unit, it is to avoid the impact of environment temperature or measuring point temperature change；The
Three, using using Acoustic focusing transducer hence it is evident that improve sound wave detection efficiency.
Its structure is as shown in figure 1, it includes laser instrument 11, laser alignment unit 12, focus lens group 13, cooling unit
14th, finger lock chamber 15, piezoelectric transducer array 16, laser modulator 17, DSP microprocessor 18, display module 19, lock are mutually put
Big device 110 and preamplifier 111；Cooling unit 14 is attached on finger lock chamber 15；Laser instrument 11, laser alignment unit
12nd, focus lens group 13 is in approximately the same plane.
Laser instrument 11 is subject to modulating of laser modulator 17, and the chirp signal that DSP microprocessor 18 is produced is loaded into sharp
On light light beam, chirp signal is sent to lock-in amplifier 110 as reference signal simultaneously；Laser beam with chirp signal
After laser alignment unit 12, incide focus lens group 13 so that laser beam focusing is in finger lock chamber 15, luminous energy
After the skin histology that amount is placed in finger lock chamber 15 absorbs, because optoacoustic effect forms ultrasonic wave, PZT (piezoelectric transducer) battle array
Row detect ultrasonic wave, convert acoustic signals into electric signal, the electricity that piezoelectric transducer array 16 is collected by preamplifier 111
Signal amplifies, and is input to lock-in amplifier 110 and is detected, obtain the photoacoustce signal intensity of respective frequencies, is input to the micro- place of DSP
Reason device 18 is shown by display module after processing.
Laser instrument 11 is subject to modulating of laser modulator 17, by the chirp signal modulation for 0.3M～11MHz for the frequency range
To laser instrument, generate periodic intensity fluctuation.Piezoelectric transducer array 16 is by the Acoustic focusing of at least two different center frequency
Transducer forms, and its detection frequency of sound wave covering frequence scope is 0.3M～11MHz, the focal length phase of Acoustic focusing transducer simultaneously
With their focus is overlapped with laser instrument 11 incident light position, just falls on the focal plane of incident laser.Cooling unit 14 by
Peltier cooling element and temperature sensor composition, carry out temperature adjustment to finger lock chamber 15 so that its operating temperature is 15
±0.2℃.Finger lock chamber is made up of optical lens, glass baffle plate 26 and substrate 22, forms acoustic resonant cavity.Finger chamber 21 is
For placing tested finger position；Anti-reflection mirror 24 effect is the effect that the near infrared light to 980nm plays narrow-band-filter, it is to avoid its
The impact of the infrared light of his wavelength；Convex lens 25 can adjust focus point so that focus point just falls after glass baffle plate 26, away from
From glass baffle plate 262mm～3mm, the effect of glass baffle plate 26 be during detection finger plaster on glass baffle plate 26 so that laser
Focus point just falls inside finger skin；The effect of substrate 22 has two, and one is fixed finger cavity, and another one acts on
It is to form acoustic resonant cavity with glass baffle plate 26.Centered on described laser instrument 11, the near-infrared semiconductor for 980nm for the wavelength connects
Continuous wave laser.
Setting up detection algorithm Mathematical Modeling is the theoretical foundation selecting optoacoustic spectral technology.The acoustical signal producing is in cell tissue
In propagation equation can be described with following formula：
Here I represents laser intensity, and v is sound wave spread speed in cell tissue, and α is the absorption coefficient of light, and β is thermal expansion
Coefficient, CpIt is specific heat capacity, p is sound pressure.
The histiocytic situation for weak absorbing, sound pressure p can be written as：
Here k is system weighting constant, E0For incident intensity energy, n is experiment experience constant (between 1 and 2).
So using chirp signal as shown in Fig. 2 it includes the signal of frequency 0.01MHz～10MHz, time delay is
0.1s, in 10 minutes sampling times, can calculate a blood glucose value every 30s, form kinetic measurement.
Give deionized water and blood sugar solution (500mmol/L) optoacoustic spectrogram in Fig. 4, from absorption spectrum it can be seen that
There is the peak value of optoacoustic absorption spectra near 980nm, select the near-infrared laser of 980nm can realize accurately measuring the mesh of blood glucose value
's.
When Fig. 5 and Fig. 6 represents using optical maser wavelength for 980nm respectively, IDDM human blood carbohydrate density and photoacoustic signal value
Measurement graph of a relation and type II diabetes human blood carbohydrate density and the measurement of photoacoustic signal value in time graph of a relation in time, from relation
In figure can be clearly seen for I type and type II diabetes people, and photoacoustic signal value and blood sugar density have extraordinary linear relationship.
Fig. 7 is for the multiple blood glucose value V measuring, providing PA detectionPAWith medical measured value VClinicalBetween linear coupling
Conjunction relation is
VPA=0.965VClinical+12.65 (3)
Both correlations reach 96.5%, you can accurately measure blood glucose value, and certainty of measurement reaches more than 96.5%.
Embodiment described above only have expressed the specific embodiment of the application, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the application protection domain can not be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, on the premise of conceiving without departing from technical scheme, some deformation can also be made and improve, these broadly fall into this
The protection domain of application.
Claims (1)
1. a kind of compound optoacoustic dynamic nondestructive blood-sugar detecting instrument it is characterised in that：It include laser instrument, laser alignment unit,
Focus lens group, cooling unit, finger lock chamber, piezoelectric transducer array, laser modulator, DSP microprocessor, display mould
Block, lock-in amplifier and preamplifier；Cooling unit is attached on finger lock chamber；Laser instrument, laser alignment unit, focusing
Lens group is in approximately the same plane；
Laser instrument is modulated by laser modulator, and the chirp signal that DSP microprocessor is produced is loaded on laser beam, with
When chirp signal is sent to lock-in amplifier as reference signal；Laser beam with chirp signal passes through laser alignment list
After unit, incide focus lens group so that laser beam focusing is in finger lock chamber, light energy is placed on finger lock chamber
After interior skin histology absorbs, because optoacoustic effect forms ultrasonic wave, piezoelectric transducer array detects ultrasonic wave, by acoustical signal
It is converted into electric signal, the electric signal that piezoelectric transducer array collects is amplified by preamplifier, is input to lock-in amplifier and enters
Row detection, obtains the photoacoustce signal intensity of respective frequencies；
Laser instrument is modulated by laser modulator, and the chirp signal for 0.3M ~ 11MHz for the frequency range is modulated laser instrument,
Generate periodic intensity fluctuation；
Piezoelectric transducer array is made up of the Acoustic focusing transducer of at least two different center frequency, and its detection frequency of sound wave covers
Lid frequency range is 0.3M ~ 11MHz, and the focal length of Acoustic focusing transducer is identical simultaneously, their focus and laser instrument incident light
Position overlaps, and just falls on the focal plane of incident laser；
Cooling unit is made up of peltier cooling element and temperature sensor, temperature adjustment is carried out to finger lock chamber so that its
Operating temperature is 15 ± 0.2 DEG C；
Finger lock chamber is mainly made up of optical lens, glass baffle plate and substrate, forms acoustic resonant cavity；
Centered on described laser instrument, wavelength is the near-infrared semiconductor continuous-wave laser of 980nm.
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| CN105559794B (en) * | 2016-02-23 | 2018-03-23 | 杨立峰 | A kind of Wearable hurtless measure Dynamic Blood Glucose Monitoring instrument based on optoacoustic spectrum signature |
| CN108013866A (en) * | 2016-11-02 | 2018-05-11 | 北京大学 | A kind of new sign data detection method and wearable sign detection device |
| JP6619379B2 (en) * | 2017-03-31 | 2019-12-11 | 日本電信電話株式会社 | Component concentration measuring apparatus and method |
| CN106889993B (en) * | 2017-04-11 | 2020-05-15 | 郜键 | FM/cw laser imaging non-blood sampling type blood sugar detection method based on light intensity modulation |
| CN109662720B (en) * | 2018-11-27 | 2022-04-15 | 中国科学院深圳先进技术研究院 | Multi-band photoacoustic noninvasive blood glucose concentration prediction system based on deep learning |
| CN109540802B (en) * | 2018-12-13 | 2021-06-04 | 东北大学 | Photoacoustic detection device and method for glucose concentration in biological fluid |
| CN110638466B (en) * | 2019-09-17 | 2022-06-03 | 广东普洛宇飞生物科技有限公司 | Positioning device and method |
| CN113108696A (en) * | 2021-04-06 | 2021-07-13 | 合肥埃科光电科技有限公司 | Light source wavelength scanning spectrum confocal sensor |
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| DE4445683A1 (en) * | 1994-12-21 | 1996-06-27 | Boehringer Mannheim Gmbh | Method for examining a scattering medium with intensity-modulated light |
| JP4234393B2 (en) * | 2002-10-31 | 2009-03-04 | 株式会社東芝 | Biological information measuring device |
| US8332006B2 (en) * | 2004-05-06 | 2012-12-11 | Nippon Telegraph And Telephone Corporation | Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method |
| US8930145B2 (en) * | 2010-07-28 | 2015-01-06 | Covidien Lp | Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring |
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