CN103462614B - Noninvasive in vivo blood alcohol concentration detecting instrument based on multi-wavelength light beam and processing method - Google Patents
Noninvasive in vivo blood alcohol concentration detecting instrument based on multi-wavelength light beam and processing method Download PDFInfo
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- CN103462614B CN103462614B CN201310410445.2A CN201310410445A CN103462614B CN 103462614 B CN103462614 B CN 103462614B CN 201310410445 A CN201310410445 A CN 201310410445A CN 103462614 B CN103462614 B CN 103462614B
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Abstract
The invention discloses a noninvasive in vivo blood alcohol concentration detecting instrument based on a multi-wavelength light beam and a processing method. The instrument comprises a processor, a light intensity receiving unit, a light intensity control unit, a key input unit, a temperature measuring unit, a liquid crystal display unit and a wireless communication unit. The processor controls light intensity of a light-emitting diode (LED) lamp group through the light intensity control unit, light emitted by the LED lamp group irradiates fingers or earlobes of a human body, the light intensity receiving unit collects intensity of a transmitted beam, the processor judges blood alcohol concentration value of each human body according to the information of the intensity of the transmitted beam and body temperature, and the blood alcohol concentration value is displayed through the liquid crystal display unit. The instrument has the advantages of being convenient to carry, conducting in vivo blood alcohol detection fast, precisely and efficiently, being capable of meeting the requirements of traffic policemen for detecting whether drivers break rules and regulations by driving after drinking fast in a quantitative mode on a roadside, and having wide application prospects.
Description
Technical field
The invention belongs to the alcohol detection technology in biomedicine, specifically, be a kind of based on multi-wavelength light beam noinvasive in body Blood alcohol concentration detecting instrument and method, belong to field of optical detection.
Background technology
At present, the detection for blood ethanol mainly contains expiration formula alcohol screen test method, Alcohol dehydrogenase method and headspace gas chromatography three kinds.Wherein expiration formula alcohol screen test method has simple to operate, cheap, noinvasive, tests the advantages such as quick, but precision is not high enough, if driver has eaten some food (as custard tart), also can detect higher alcohol concentration, therefore can not as the legal foundation of law enforcement.Alcohol dehydrogenase method certainty of measurement is high, but its processing procedure is loaded down with trivial details, and instrument and equipment is huge, measures efficiency low, cannot detect in real time at scene, and its precision is also subject to processing the impact of the quality of process simultaneously, and for there being wound to detect; It is high that headspace gas chromatography has certainty of measurement, and can assert as law enforcement, but its measuring process length consuming time, efficiency is low, and instrument and equipment is huge, cannot detect in real time equally and be also have wound to detect.Above-mentioned three kinds of methods all cut both ways, but also do not have a kind of method can accomplish to have simultaneously be easy to carry, fast, high accuracy, efficient etc. can meet traffic police in " roadside " fast, detection by quantitative driver whether after drinking demand of driving violating the regulations.
In addition, also favourable electrochemica biological sensor carries out blood ethanol and immediately detects, but it is still for there being wound, and does not also reach practical degree.Abroad, there are many companies and scholar to take to the research detected in real time at body of noinvasive blood ethanol, and achieve certain achievement.As American I nLight Solutions company, have developed a kind of new infrared in recent years at body alcohol content tester, the alcohol content in driver's blood can be known when taking a blood sample without the need to needle tubing.Its principle is, infrared beam is utilized constantly to move at skin surface, due to detecting alcohol contents in human bodies number have close contacting with the absorbing state of infra-red radiation, by observing the infrared radiation spectrum figure that is reflected back, know whether the alcohol content in detected person's blood exceeds standard.But widely apply in practice not yet at present, main cause is that equipment precision is not high and individual variation is larger.
Thus in actual mechanical process, traffic police measures driver by alcoholicity of exhaled gas detection method, if suspect that human pilot is driven when intoxicated, again human pilot is taken to the venous blood samples detection of the specialized agency such as clinical laboratory, hospital to determine, not only affect the law enforcement efficiency of traffic police, and have wound detection easily to affect the healthy of driver.
Summary of the invention
For the deficiencies in the prior art, the object of the invention is to realize portable, quick, high accuracy and detect at body Blood alcohol concentration efficiently, thus provide one based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, and in order to allow this portable instrumentation meet required precision, the invention allows for a kind of based on the processing method of multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, concrete technical scheme is as follows:
A kind of based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, its key is: the light intensity receiving element comprising processor and connect on a processor, intensity control unit, key-press input unit, temperature measurement unit and liquid crystal display, described intensity control unit is connected with LED group, the multiple LED lamp tube in 200nm ~ 2600nm wave-length coverage are comprised in this LED group, the light that described multiple LED lamp tube sends is radiated on human detection position, the transmitted light intensity information of each LED lamp tube is obtained by light intensity receiving element, temperature measurement unit is for obtaining body temperature information, processor judges blood in human body in alcohol concentration value according to described transmitted light intensity information and body temperature information, and shown by liquid crystal display.
The present invention utilizes the multiple light beams in 200nm ~ 2600nm wave-length coverage to irradiate human detection position, wave-length coverage covers ultraviolet light, visible ray and near infrared light, absorptivity within the scope of this can be chosen and affect larger multiple typical wavelengths as incident beam by human body Blood alcohol concentration, the transmitted intensity of different wave length is obtained by light intensity receiving element, absorbing state when number due to blood in human body in alcohol content is irradiated with different wave length light beam has close relationship, can know whether the alcohol content in detected person's blood exceeds standard by analyzing each wavelength transmission light intensity value, for whether traffic police checks driver, " drunk driving " provides reliable legal basis.
In order to improve accuracy of detection on the basis reducing processor cost, described processor is STM32F103RD microcontroller chip, is also connected with reference voltage unit on a processor, and this reference voltage unit adopts reference voltage to produce chip ADR363B.
Because the value with A/D conversion in STM32F103RD is all be converted to reference voltage with the supply voltage A/D of analog input, consider the power supply Possible waves of analog input, therefore high accuracy 3V reference voltage chip ADR363B unit is as the reference voltage selected, its voltage noise peak-to-peak value exported is only 3.6uV, voltage accuracy ± 3mV, temperature coefficient is only 9ppm/ DEG C.
For some special requirement, described processor is connected with radio communication unit, the data making this instrument detect gained realize wireless transmission.
Constant in order to ensure the light intensity of incident beam, described intensity control unit comprises the first integrated transporting discharging, 3rd integrated transporting discharging and the first analog switch chip and the second analog switch chip, the LED control signal that processor exports is sent in described first analog switch chip after the first integrated transporting discharging amplifies, this first analog switch chip is provided with 8 road signal output pins, every road signal output pin can connect a paths of LEDs control circuit, described second analog switch chip is provided with 8 road signal input tube feet, every road signal input tube foot can obtain the feedback signal of a paths of LEDs control circuit, the feedback signal that second analog switch chip obtains is sent in described processor through described 3rd integrated transporting discharging,
Every paths of LEDs control circuit comprises an integrated transporting discharging and an audion Q1, the signal that first analog switch chip exports sends into the normal phase input end of integrated transporting discharging, the outfan of integrated transporting discharging is connected to audion Q1 base stage through current-limiting resistance R6, the colelctor electrode of audion Q1 is connected on power supply VCC through resistance R5, the emitter stage of audion is connected with the positive pole of LED lamp tube, the negative pole of LED lamp tube connects the inverting input of integrated transporting discharging, the negative pole of LED lamp tube is also through resistance R8 ground connection, the negative pole of LED lamp tube is also connected on an input of the second analog switch chip as feedback signal sampled point.
During practical application, consider accuracy requirement and actual techniques situation, in described LED control circuit, the wavelength of LED lamp tube is 420 ± 50nm, 620 ± 50nm, 940 ± 50nm, 1300 ± 50nm, 1450 ± 50nm, 1720 ± 50nm, 1950 ± 50nm or 2300 ± 50nm.
In order to ensure effective collection of transmitted light intensity signal, described light intensity receiving element comprises the first light sensitive diode D1, second light sensitive diode D2, 5th operational amplifier, 6th operational amplifier and programmable operational amplifier, the intensity signal that described first light sensitive diode D1 detects sends into No. zero input channel of programmable operational amplifier after the 5th operational amplifier amplifies, the intensity signal that second light sensitive diode D2 detects sends into an input channel of programmable operational amplifier after the 6th operational amplifier amplifies, control described programmable operational amplifier by processor and receive this programmable operational amplifier export intensity signal.
As a kind of embodiment, described first light sensitive diode D1 is silicon light sensitive diode, and measurement wave-length coverage is 200nm ~ 1100nm, and described second light sensitive diode D2 is antimony InGaAsP light sensitive diode, and measurement wave-length coverage is 1000nm ~ 2600nm.By the cooperation of light sensitive diode D1 and D2 thus the transmitted light intensity test realized within the scope of 200nm-2600nm.
Based on the description of foregoing circuit structure, the present invention also proposes a kind of based on the processing method of multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, specifically carries out according to the following steps:
Step 1: processor controls each LED lamp tube work in LED group by intensity control unit according to constant intensity of illumination;
Step 2: processor obtains intensity signal and the body temperature information of each LED lamp tube transillumination in described LED group successively by light intensity receiving element and temperature measurement unit;
Step 3: processor according to
Calculate Blood alcohol concentration value y
*, wherein:
C
0, c
2i-1, c
2i, c
tand c
t' be default coefficient, M is the number of LED lamp tube in LED group, R
ibe the transmitted intensity of i-th LED lamp tube and the common logarithm of the meansigma methods of incident intensity ratio more than 3 in pulse cycle, T is body temperature.
As a kind of embodiment, be provided with 3 LED lamp tube, i.e. M=3, i=1:M in described LED group, its wavelength is followed successively by 620 ± 50nm, 1300 ± 50nm, 2300 ± 50nm, coefficient c
0, c
2i-1, c
2i, c
tand c
t' be respectively:
c
0=7.8093,c
1=-8.7772,c
2=-80.9564,
c
3=7.8045,c
4=21.6076,c
5=-2.1435,
c
6=21.6076,c
T=-0.4240,c
T′=0.0058。
The method has taken into full account the impact of Blood alcohol concentration on incident beam Absorption and body temperature, the empirical value of existing precision instrument is utilized to carry out the design factor of each Testing index of matching, by these coefficients by program Solidification in microprocessor, directly can calculate the Blood alcohol concentration value of each Testing index, reduce the amount of calculation of processor, the cost required when selecting processor is cheaper, and accuracy of detection also can meet the standard of precision instrument.
Remarkable result of the present invention is: circuit structure is simple, with low cost, by the cooperation of light intensity sensor and temperature detecting unit, microprocessor just can utilize these coefficient calculations to go out accurate Testing index, and equipment precision is high, Applicable temperature scope is wide, portable type can be realized, fast, high accuracy, efficiently to detect at body Blood alcohol concentration, the demand that traffic police is quick in " roadside ", whether detection by quantitative driver breaks rules and regulations after drinking is driven can be met well, and have boundless application prospect.
Accompanying drawing explanation
Fig. 1 is schematic block circuit diagram of the present invention;
Fig. 2 is the front end output control circuit figure of intensity control unit in Fig. 1;
Fig. 3 is each paths of LEDs control circuit of intensity control unit figure in Fig. 1;
Fig. 4 is the rear end feedback circuit figure of intensity control unit in Fig. 1;
Fig. 5 is the control circuit schematic diagram of light intensity receiving element in Fig. 1.
Detailed description of the invention
Below in conjunction with accompanying drawing, the specific embodiment of the present invention and operation principle are described in further detail.
See accompanying drawing 1, a kind of based on multi-wavelength noinvasive at body Blood alcohol concentration detecting instrument, comprise processor 1 and be connected to the light intensity receiving element 2 on processor 1, intensity control unit 3, key-press input unit 4, temperature measurement unit 5 and liquid crystal display 6, described intensity control unit 3 is connected with LED group 9, the multiple LED lamp tube in 200nm ~ 2600nm wave-length coverage are comprised in this LED group 9, the light that described multiple LED lamp tube sends is radiated on human detection position, the transmitted light intensity information of each LED lamp tube is obtained by light intensity receiving element 2, temperature measurement unit 5 is for obtaining body temperature information, processor 1 judges blood in human body in alcohol concentration value according to described transmitted light intensity information and body temperature information, and shown by liquid crystal display 6, processor 1 is also connected with radio communication unit 7.
In implementation process, high performance-price ratio 32-bit microprocessor selected by processor 1, and model is STM32F103RD, and the A/D converter of 12, band, 1 μ s conversion speed, the flash memorizer having 384K to can be used for program and data to store, highest frequency can reach 72MHz in it.Liquid crystal display 6 is made up of FM12864 image lattice LCDs, and temperature measurement unit 5 utilizes 18B20 to realize the measurement of temperature, and radio communication unit 7 utilizes NRF2401+ wireless communication module to form, and LED group 9 is made up of multi-wavelength's LED.On the one hand, processor 1 controls the luminous intensity of LED group 9 by intensity control unit 3, ensures the stable of incident intensity; On the other hand, processor 1 is converted to corresponding digital value for analog voltage light intensity receiving element 2 and temperature measurement unit 5 exported, realize the collection of light intensity and temperature, pass through internal algorithm, calculate the Blood alcohol concentration value of each index, utilize wireless communication unit 7 to realize and external communication simultaneously.
Consider the power supply Possible waves of analog input, in order to meet the concordance between disparate modules, processor 1 is also connected with reference voltage unit 8, this reference voltage unit 8 selects a high accuracy 3V reference voltage chip ADR363B, output voltage noise peak peak value is only 6.8 μ V, voltage accuracy ± 3mV, temperature coefficient is only 9ppm/ DEG C.
As shown in Fig. 2 Fig. 4, in order to ensure the intensity of illumination of incident beam, described intensity control unit 3 comprises the first integrated transporting discharging U1, 3rd integrated transporting discharging U3 and the first analog switch chip CD4051-1 and the second analog switch chip CD4051-2, the LED control signal DA1 that processor 1 exports sends in described first analog switch chip CD4051-1 after the first integrated transporting discharging U1 amplifies, this first analog switch chip CD4051-1 is provided with 8 road signal output pins, every road signal output pin can connect a paths of LEDs control circuit, described second analog switch chip CD4051-2 is provided with 8 road signal input tube feet, every road signal input tube foot can obtain the feedback signal of a paths of LEDs control circuit, the feedback signal that second analog switch chip CD4051-2 obtains is sent in described processor 1 through described 3rd integrated transporting discharging U3,
In implementation process, resistance R3, R4 is provided with between processor 1 and the first integrated transporting discharging U1, electric capacity C3, C4, resistance R2 is provided with between the first integrated transporting discharging U1 outfan and inverting input, the two ends of resistance R2 are parallel with electric capacity C1, and the inverting input of the first integrated transporting discharging U1 is also through resistance R1 ground connection.Resistance R9 and electric capacity C5 is provided with between processor 1 and the 3rd integrated transporting discharging U3.
See Fig. 3, every paths of LEDs control circuit comprises an an integrated transporting discharging U2 and audion Q1, the signal that first analog switch chip CD4051-1 exports sends into the normal phase input end of integrated transporting discharging U2, the outfan of integrated transporting discharging U2 is connected to audion Q1 base stage through current-limiting resistance R6, the colelctor electrode of audion Q1 is connected on power supply VCC through resistance R5, the emitter stage of audion is connected with the positive pole of LED lamp tube, the negative pole of LED lamp tube connects the inverting input of integrated transporting discharging U2, the negative pole of LED lamp tube is also through resistance R8 ground connection, the negative pole of LED lamp tube is also connected on an input of the second analog switch chip CD4051-2 as feedback signal sampled point.
In implementation process, can select 2-8 paths of LEDs control circuit, the wavelength of LED lamp tube can select at least two kinds of combinations in 420 ± 50nm, 620 ± 50nm, 940 ± 50nm, 1300 ± 50nm, 1450 ± 50nm, 1720 ± 50nm, 1950 ± 50nm or 2300 ± 50nm.
See Fig. 5, in order to ensure the reliable reception of transmitted light intensity information, described light intensity receiving element 2 comprises the first light sensitive diode D1, second light sensitive diode D2, 5th operational amplifier U5, 6th operational amplifier U6 and programmable operational amplifier U7, the intensity signal that described first light sensitive diode D1 detects sends into No. zero input channel CH0 of programmable operational amplifier U7 after the 5th operational amplifier U5 amplifies, the intensity signal that second light sensitive diode D2 detects sends into an input channel CH1 of programmable operational amplifier U7 after the 6th operational amplifier U6 amplifies, control described programmable operational amplifier U7 by processor 1 and receive this programmable operational amplifier U7 export intensity signal.
In implementation process, described first light sensitive diode D1 is silicon light sensitive diode, and measurement wave-length coverage is 200nm ~ 1100nm, and described second light sensitive diode D2 is antimony InGaAsP light sensitive diode, and measurement wave-length coverage is 1000nm ~ 2600nm.By the cooperation of light sensitive diode D1 and D2 thus the transmitted light intensity infomation detection realized in 200nm ~ 2600nm wave-length coverage.
State in realization on the basis of circuit structure, below emphasis set forth based on the processing method of multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument described, be specially:
First be wavelength and the design factor of determining each LED lamp tube in instrument, be specially:
1) ultraviolet-visible-near infrared spectrometer is utilized to scan human whole blood within the scope of 200nm-2600nm, the absworption peak of the whole blood analyzed and the more smooth wavelength of absorptance.
2) by the wavelength location of each absworption peak of whole blood, in relative analysis chemistry, the absworption peak of each group, functional group or molecule etc. is analyzed, and therefrom analyzes the reason of each absworption peak appearance.
3) ultraviolet-visible-near infrared spectrometer is utilized to scan the blood ethanol of the known variable concentrations of human body within the scope of 200nm-2600nm, the situation of change of each absworption peak wavelength light intensity during contrast whole blood, analyzes wavelength that light intensity alcohol concentration changes greatly, light intensity not with absworption peak wavelength and the wavelength band of alcohol concentration change.
4) according to the data obtained, 2-4 kind wavelength is selected from the wavelength that light intensity alcohol concentration changes greatly, from light intensity not with alcohol concentration change absworption peak wavelength select 1-3 kind wavelength, from light intensity not with alcohol concentration change wave band select 1-3 kind wavelength, finally determine 4-10 kind measure wavelength.
Then obtain above-mentioned 4-10 kind and measure the common logarithm relation of wavelength in body Blood alcohol concentration and transmitted intensity and the meansigma methods of incident intensity ratio more than 3 in pulse cycle, be specially:
1) utilizing the 4-10 kind determined to measure wavelength, measuring different human body when not drinking simultaneously, finger and ear-lobe place different wave length transmitted intensity and body temperature.
2) utilize the 4-10 kind determined to measure wavelength, measure simultaneously different human body after drinking time, finger and ear-lobe place different wave length transmitted intensity and body temperature, and draw blood simultaneously and utilize headspace gas chromatography to measure its true Blood alcohol concentration.
3) collect the 4-10 kind determined and measure wavelength transmission light intensity and the common logarithm of the meansigma methods of incident intensity ratio more than 3 in pulse cycle, the relation data of body temperature, and analyze the position of reality in the larger wavelength 3-8 kind wavelength of the common logarithm relation of body Blood alcohol concentration and transmitted intensity and the meansigma methods of incident intensity ratio more than 3 in pulse cycle and measurement.
In this example, wavelength 3 kinds of wavelength that the common logarithm relation of Blood alcohol concentration and transmitted intensity and the meansigma methods of incident intensity ratio more than 3 in pulse cycle is larger are analyzed, be followed successively by 620 ± 50nm, 1300 ± 50nm, 2300 ± 50nm, it detects position is ear-lobe place, and the data recorded are as shown in table 1:
Table 1 three wavelength light beam measurement data
Then analyze 3 kinds and measure the physical relationship formula of wavelength at the common logarithm, body temperature etc. of body Blood alcohol concentration and transmitted intensity and the meansigma methods of incident intensity ratio more than 3 in pulse cycle, be specially: utilize the data of above-mentioned acquisition and partial least square method to carry out data analysis.
If the Blood alcohol concentration of matching is y
*, its expression formula is expressed as:
In formula, M value is 3, c
0represent the Fitting Calculation coefficient; c
2i-1represent the design factor of the first power of i-th kind of wavelength; R
irepresent the common logarithm of i-th kind of wavelength transmission light intensity and the meansigma methods of incident intensity ratio more than 3 in pulse cycle; c
2irepresent the design factor of the quadratic power of i-th kind of wavelength; T represents body temperature during measurement; c
trepresent the design factor to the first power of body temperature T, c
t' represent the design factor of the quadratic power to body temperature T.
Coefficient c is obtained by the matching of partial least square method
0, c
2i-1, c
2i, c
tand c
t' be respectively:
c
0=7.8093,c
1=-8.7772,c
2=-80.9564,
c
3=7.8045,c
4=21.6076,c
5=-2.1435,
c
6=21.6076,c
T=-0.4240,c
T′=0.0058。
After analyzing this coefficient, be cured in processor 1 by program by formula (a) and corresponding coefficient thereof, processor 1 can realize date processing according to following steps:
Step 1: processor 1 controls each LED lamp tube work in LED group 9 by intensity control unit 3 according to constant intensity of illumination;
Step 2: processor 1 obtains intensity signal and the body temperature information of each LED lamp tube transillumination in described LED group 9 successively by light intensity receiving element 2 and temperature measurement unit 5;
Step 3: processor 1 according to
Calculate Blood alcohol concentration value y
*.
The present invention adopts in ultraviolet-visible-near infrared band and more can reflect that several wavelength of Blood alcohol concentration are as detection light beam wavelength, introduce the body temperature relevant with metabolism as compensation simultaneously, higher in body Blood alcohol concentration accuracy of detection than existing method for reflection etc., Applicable temperature is wider, has good application prospect.
Claims (8)
1. one kind based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: comprise processor (1) and be connected to the light intensity receiving element (2) on processor (1), intensity control unit (3), key-press input unit (4), temperature measurement unit (5) and liquid crystal display (6), described intensity control unit (3) is connected with LED group (9), the multiple LED lamp tube in 200nm ~ 2600nm wave-length coverage are comprised in this LED group (9), the light that described multiple LED lamp tube sends is radiated on human detection position, the transmitted light intensity information of each LED lamp tube is obtained by light intensity receiving element (2), temperature measurement unit (5) is for obtaining body temperature information, processor (1) judges blood in human body in alcohol concentration value according to described transmitted light intensity information and body temperature information, and by liquid crystal display (6) display,
Described intensity control unit (3) comprises the first integrated transporting discharging (U1), 3rd integrated transporting discharging (U3) and the first analog switch chip and the second analog switch chip, the LED control signal (DA1) that processor (1) exports is sent in described first analog switch chip after the first integrated transporting discharging (U1) amplifies, this first analog switch chip is provided with 8 road signal output pins, every road signal output pin can connect a paths of LEDs control circuit, described second analog switch chip is provided with 8 road signal input tube feet, every road signal input tube foot can obtain the feedback signal of a paths of LEDs control circuit, the feedback signal that second analog switch chip obtains is sent in described processor (1) through described 3rd integrated transporting discharging (U3),
Every paths of LEDs control circuit comprises an integrated transporting discharging (U2) and an audion Q1, the signal that first analog switch chip exports sends into the normal phase input end of integrated transporting discharging (U2), the outfan of integrated transporting discharging (U2) is connected to audion Q1 base stage through current-limiting resistance R6, the colelctor electrode of audion Q1 is connected on power supply VCC through resistance R5, the emitter stage of audion is connected with the positive pole of LED lamp tube, the negative pole of LED lamp tube connects the inverting input of integrated transporting discharging (U2), the negative pole of LED lamp tube is also through resistance R8 ground connection, the negative pole of LED lamp tube is also connected on an input of the second analog switch chip as feedback signal sampled point.
2. according to claim 1 based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: described processor (1) is STM32F103RD microcontroller chip, processor (1) is also connected with reference voltage unit (8), and this reference voltage unit (8) adopts reference voltage to produce chip ADR363B.
3. according to claim 1 based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: described processor (1) is connected with radio communication unit (7).
4. according to claim 1 based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: in described LED control circuit, the wavelength of LED lamp tube is 420 ± 50nm, 620 ± 50nm, 940 ± 50nm, 1300 ± 50nm, 1450 ± 50nm, 1720 ± 50nm, 1950 ± 50nm or 2300 ± 50nm.
5. according to claim 1 based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: described light intensity receiving element (2) comprises the first light sensitive diode D1, second light sensitive diode D2, 5th operational amplifier (U5), 6th operational amplifier (U6) and programmable operational amplifier (U7), the intensity signal that described first light sensitive diode D1 detects sends into No. zero input channel (CH0) of programmable operational amplifier (U7) after the 5th operational amplifier (U5) amplifies, the intensity signal that second light sensitive diode D2 detects sends into an input channel (CH1) of programmable operational amplifier (U7) after the 6th operational amplifier (U6) amplifies, control described programmable operational amplifier (U7) by processor (1) and receive the intensity signal that this programmable operational amplifier (U7) exports.
6. according to claim 5 based on multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: described first light sensitive diode D1 is silicon light sensitive diode, measurement wave-length coverage is 200nm ~ 1100nm, described second light sensitive diode D2 is antimony InGaAsP light sensitive diode, and measurement wave-length coverage is 1000nm ~ 2600nm.
7. as claimed in claim 1 based on the processing method of multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that carrying out according to the following steps:
Step 1: processor (1) controls each LED lamp tube work in LED group (9) by intensity control unit (3) according to constant intensity of illumination;
Step 2: processor (1) obtains intensity signal and the body temperature information of each LED lamp tube transillumination in described LED group (9) successively by light intensity receiving element (2) and temperature measurement unit (5);
Step 3: processor (1) according to
Calculate Blood alcohol concentration value y
*, wherein:
C
0, c
2i-1, c
2i, c
tand c
t' be default coefficient, M is the number of LED lamp tube in LED group (9), R
irepresent the transmitted intensity of i-th LED lamp tube and the common logarithm of the meansigma methods of incident intensity ratio more than 3 in pulse cycle, T is body temperature.
8. according to claim 7 based on the processing method of multi-wavelength light beam noinvasive at body Blood alcohol concentration detecting instrument, it is characterized in that: in described LED group (9), be provided with 3 LED lamp tube, i.e. M=3, i=1 ~ M, its wavelength is followed successively by 620 ± 50nm, 1300 ± 50nm, 2300 ± 50nm, coefficient c
0, c
2i-1, c
2i, c
tand c
t' be respectively:
c
0＝7.8093,c
1＝-8.7772,c
2＝-80.9564,
c
3＝7.8045,c
4＝21.6076,c
5＝-2.1435,
c
6＝21.6076,c
T＝-0.4240,c
T'＝0.0058。
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| US5615672A (en) * | 1993-01-28 | 1997-04-01 | Optiscan, Inc. | Self-emission noninvasive infrared spectrophotometer with body temperature compensation |
| US7734321B2 (en) * | 2007-07-13 | 2010-06-08 | All Protect, Llc | Apparatus for non-invasive spectroscopic measurement of analytes, and method of using the same |
| JP2010004933A (en) * | 2008-06-24 | 2010-01-14 | Toyota Industries Corp | Non-invasive alcohol sensor |
| US8256286B2 (en) * | 2009-04-24 | 2012-09-04 | Sober Steering Sensors, Llc | System and method for detecting and measuring ethyl alcohol in the blood of a motorized vehicle driver transdermally and non-invasively in the presence of interferents |
| CN102163362B (en) * | 2010-02-22 | 2013-03-20 | 谢国华 | An anti-drunk driving and safe-health driving method |
| CN102525481B (en) * | 2011-12-14 | 2014-03-19 | 山东大学 | Detection method and system for alcohol content in human body on the basis of near infrared spectrum |
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| CN103462614A (en) | 2013-12-25 |
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