CN108634964A - A kind of non-invasive blood sugar instrument based on spectrum - Google Patents
A kind of non-invasive blood sugar instrument based on spectrum Download PDFInfo
- Publication number
- CN108634964A CN108634964A CN201810417235.9A CN201810417235A CN108634964A CN 108634964 A CN108634964 A CN 108634964A CN 201810417235 A CN201810417235 A CN 201810417235A CN 108634964 A CN108634964 A CN 108634964A
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- China
- Prior art keywords
- blood sugar
- circuit
- spectrum
- invasive blood
- sugar instrument
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
Abstract
The invention discloses a kind of Woundless blood sugar measuring apparatus combined with measurement of bldy temperature based on infrared spectrometry, including fixing device, infrared light supply transmitter, body temperature transducer, spectrum receiving device, filtering and amplifying circuit and Λ/D conversion circuits, photoelectric switching circuit, microprocessor and display unit etc..The fixing device is configured as the blood glucose meter integrating device；The infrared light supply transmitter is configured as sending out infrared light；The body temperature transducer is configured for measurement of bldy temperature；The spectrum receiving device is configured as receiving the spectrum that Infrared irradiation crosses dermal tissue；The filtering and amplifying circuit and Λ/D conversion circuits, which are used for being collected thermistor signal, to be handled and is input to the microprocessor；The photoelectric switching circuit is configured as to the body temperature transducer and the collected signal circuit conversion of the spectrum acquisition device；The microprocessor is configured for algorithm calculation processing；The display unit is configured as display blood glucose concentration value.
Description
Technical field
The present invention relates to blood sugar test fields, are related to a kind of non-invasive blood-sugar detecting instrument
Background technology
Diabetes are a kind of common non-infectious chronic diseases for but seriously endangering human health, delay diabetes and its
The important means of complication is frequently measured the blood sugar concentration of patient, and the injection of insulin is determined with this result
Amount helps patient to reduce blood sugar concentration.There are one prominent features for traditional blood sugar detecting method, it is necessary to blood samples of patients is obtained,
However for diabetic, the wound conjunction more refractory than the wound of non-diabetic people of needle thorn easily causes bacterium sense
Dye, causes complication.The present invention relies on Beer law based on the diffusing reflection principle of near-infrared, in addition the influence of body temperature index
Effect, establishes blood sugar test model.The fitting prediction that blood sugar concentration is carried out by the spectroscopic data and temperature data that measure, is realized
The noninvasive measurement for carrying out blood sugar concentration of patient is learned, reduces the assay method that conventional method frequently carries out minimally invasive acquisition blood, subtracts
The pain of light patient.
Invention content
1. in view of the defect of existing traditional technology, how rope technical problems to be solved of the present invention are by noninvasive side
Formula accurately obtains the blood glucose value of patient.
2. to achieve the above object, the present invention provides a kind of non-invasive blood sugar instruments based on spectral measurement, as shown in Figure 1.
Electricity is converted including fixing device, infrared light supply transmitter, body temperature transducer, spectrum acquisition device, filtering and amplifying circuit and A/D
Road, photoelectric switching circuit, microprocessor and display unit.The fixing device is configured as the blood glucose meter integrating device, right
Each section measuring instrument and receive the integrated of process instrumentation；The infrared light supply transmitter is configured as sending out infrared light；Institute
State the measurement that temperature sensor is configured for body temperature；The spectrum receiving device, which is configured as receiving, passes through Infrared irradiation
Cross the diffusing reflection spectrum after dermal tissue；The filtering and amplifying circuit and Λ/D conversion circuits are used for the temperature-sensitive to temperature sensor
After resistance signal is collected processing, it is input in the microprocessor, the photoelectric switching circuit is configured as to described
Temperature sensor and the collected signal of the spectrum acquisition device carry out circuit conversion；The microprocessor is configured as receiving
The temperature and spectral signal of the conversion circuit carry out algorithm calculation processing；The display unit is configured as display and passes through blood glucose
The blood glucose concentration value that computational algorithm obtains.
3. further, the human body is ear-lobe.
4. the optical wavelength that further, the light emitting source is sent out be 1300nm and 1550nm, by verify 1300nm and
The statistical difference of two wavelength transmission light intensity of 1550nm and blank group is anisotropic, it was demonstrated that Beer-Lambert law lower ear-lobe tissue is to difference
The absorbing state of near infrared light, while illustrating that the transmitted light of two wavelength of 1300nm and 1550nm carries respective blood glucose
Information.These light intensity signals are analyzed by processing, utilize effective blood glucose information therein so that the noninvasive dynamics monitoring of near-infrared
It is possibly realized.
5. further, the sensor includes photoelectric converter and measurement light probe, the center for measuring light probe
Fiber optic bundle is used as emitting incident light, is used as reception light at the another way fiber optic bundle of concentric circular pattern with the central bundle
The measurement light is transmitted to the photoelectric converter by fibre.
6. further, the temp sensor device is thermistor, tentatively counted using Monte Carlo simulations method
It has calculated and has not had reflective light intensity caused by blood sugar concentration and human body temperature variation, and simulation is calculated by glucose solution experiment
Validity is verified, and finally according to the oral glucose tolerance test of diabetic, has estimated the temperature in experiment made on the living
Influence of the degree variation to blood sugar concentration model error.Show near 37 DEG C, 0.1 DEG C of hypothermia, caused diffusing reflection light intensity with
Blood sugar concentration raising 2.7mmol/L is suitable, and the Woundless blood sugar based near infrared spectrum is predicted, body temperature is one very heavy
The error source wanted, so the adjusting that the measurement and body temperature to body temperature predict blood sugar concentration is to reduce the important step of error source
Suddenly.
7. further, the photoelectric converter is the InGaAs detectors with semiconductor cooler.
8. further, the central bundle outer diameter is 0.5mm~2mm, wherein a diameter of 5 μm of every thin optic fibre
~20 μm.
9. further, the detection circuit includes signal conditioning circuit, analogue filter circuit, signal amplification circuit and string
Mouth circuit.
10. further, the temperature sensor is thermistor, proximal end thermistor and distal end thermistor are surveyed
The resistance signal obtained is input to after temperature sensing circuit, filtering and amplifying circuit and Λ/D conversion circuits in microprocessor.
11. the near infrared spectroscopy that further, non-invasive blood sugar instrument of the present invention uses carries out concentration of glucose survey
The theoretical foundation of examination is lambert-beer law：
In formula：Λ (δ) is absorbance of the sample to special wavelength light, and Ι 0 and Ι is respectively incident intensity and transmission
Luminous intensity, ε i (δ) are absorptivity of i-th kind of absorbent in respective wavelength light, and l i are light path of the light in respective absorption object
Long, Ci is respective absorption object concentration.By law it is found that having between the absorbance of sample and constituent concentration to be measured many related
Property, the concentration variation of sample composition can cause the variation that spectral signature absorbs.First by the dense of spectroscopic data Λ and sample
It spends C and establishes correction mathematical model, can specifically be divided into two processes of calibration and prediction.Calibration process is using known to certain amount
The sample sets application of component content returns line method and finds out the relationship between spectrum parameter and sample composition concentration, and prediction process is just
It is that the spectrum parameter of unknown sample constituent concentration is substituted into the formula that calibration process acquires, obtains the component content of unknown sample.
12. further, the temperature sensor of the invention is a kind of electronic temperature sensor, this temperature
Sensor can predict current body temperature according to the trend that prediction algorithm rises according to body temperature, can most stay alone within the 4s times soon
Body temperature.
13. further, the microprocessor can be collected into the reflectance spectrum of temperature sensor and ear-lobe tissue, pass through
Fitting algorithm predicts the blood sugar concentration of current measured.
14. further, the display unit receives the prediction blood sugar concentration calculated from microprocessor, carry out
Display.
15. the preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is not necessarily to
Creative work, which according to the present invention can be conceived, makes many modifications and variations.Therefore, all technology people in the art
Member
16. under this invention's idea on the basis of existing technology can by logical analysis, reasoning, or a limited experiment
It, all should be in the protection domain being defined in the patent claims with obtained technical solution.
Description of the drawings
Fig. 1 is non-invasive blood sugar instrument institutional framework schematic diagram；
Fig. 2 is non-invasive glucose monitor schematic drawing.
Claims (11)
1. a kind of non-invasive blood sugar instrument based on spectrum, including fixing device, infrared light supply transmitter, body temperature transducer, spectrum connect
Receiving apparatus, filtering and amplifying circuit and A/D conversion circuits, photoelectric switching circuit, microprocessor and display unit.The fixing device
It is configured as the blood glucose meter integrating device, to each section measuring instrument and receives process instrumentation and integrates；The infrared light supply
Transmitter is configured as sending out infrared light；The temperature sensor is configured for the measurement of body temperature；The spectrum receives
Device is configured as receiving the diffusing reflection spectrum after Infrared irradiation crosses dermal tissue；The filtering and amplifying circuit and A/D
After conversion circuit is used for being collected processing to the thermistor signal of temperature sensor, it is input in the microprocessor,
The photoelectric switching circuit is configured as carrying out electricity to the temperature sensor and the collected signal of the spectrum acquisition device
It converts on road；The microprocessor is configured as receiving the temperature of the conversion circuit and spectral signal carries out algorithm calculation processing；
The display unit is configured as the blood glucose concentration value that display is obtained by blood glucose computational algorithm.
2. non-invasive blood sugar instrument as described in claim 1, which is characterized in that the human body is ear-lobe.
3. non-invasive blood sugar instrument as described in claim 1, which is characterized in that the optical wavelength that the infrared light supply is sent out is
1300nm and 1550nm.
4. non-invasive blood sugar instrument as described in claim 1, which is characterized in that the sensor includes AOTF light splitting original papers.
5. non-invasive blood sugar instrument as described in claim 1, which is characterized in that the sensor carries out spectrum survey using double light path
Amount, wherein being 1300nm all the way, another is 1550nm.It receives and is scattered back the measurement come from the human body
Light.
6. non-invasive blood sugar instrument as claimed in claim 5, which is characterized in that the sensor includes photoelectric converter and measurement light
Probe, the central bundle for measuring light probe is used as emitting incident light, with the central bundle at concentric circular pattern
Another way fiber optic bundle be used as reception optical fiber, the measurement light is transmitted to the photoelectric converter.
7. non-invasive blood sugar instrument as claimed in claim 6, which is characterized in that the photoelectric converter is with semiconductor cooler
InGaAs detectors.
8. non-invasive blood sugar instrument as claimed in claim 6, which is characterized in that the central bundle outer diameter is 0.5mm~2mm,
A diameter of 5 μm~20 μm of wherein every thin optic fibre.
9. non-invasive blood sugar instrument as claimed in claim 6, which is characterized in that the detection circuit includes signal conditioning circuit, mould
Quasi- filter circuit, signal amplification circuit and serial port circuit.
10. non-invasive blood sugar instrument as described in claim 1, which is characterized in that earphone jack of the power supply from smart mobile phone.
11. temperature sensor as described in claim 1 is thermistor, measured by proximal end thermistor and distal end thermistor
Resistance signal be input in microprocessor after temperature sensing circuit, filtering and amplifying circuit and A/D conversion circuits.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810417235.9A CN108634964A (en) | 2018-05-04 | 2018-05-04 | A kind of non-invasive blood sugar instrument based on spectrum |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810417235.9A CN108634964A (en) | 2018-05-04 | 2018-05-04 | A kind of non-invasive blood sugar instrument based on spectrum |
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| CN108634964A true CN108634964A (en) | 2018-10-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110391012A (en) * | 2019-07-29 | 2019-10-29 | 广东美的白色家电技术创新中心有限公司 | A kind of grade of the glycemic index of food materials determines method and device |
| CN111295132A (en) * | 2017-11-09 | 2020-06-16 | 国际商业机器公司 | Cognitive optogenetics probes and assays |
-
2018
- 2018-05-04 CN CN201810417235.9A patent/CN108634964A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111295132A (en) * | 2017-11-09 | 2020-06-16 | 国际商业机器公司 | Cognitive optogenetics probes and assays |
| CN111295132B (en) * | 2017-11-09 | 2021-12-14 | 国际商业机器公司 | Cognitive optogenetics probes and assays |
| US11484731B2 (en) | 2017-11-09 | 2022-11-01 | International Business Machines Corporation | Cognitive optogenetics probe and analysis |
| CN110391012A (en) * | 2019-07-29 | 2019-10-29 | 广东美的白色家电技术创新中心有限公司 | A kind of grade of the glycemic index of food materials determines method and device |
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Application publication date: 20181012 |