CN109259738A - A kind of mask for positron radionuclide count detection instrument - Google Patents
A kind of mask for positron radionuclide count detection instrument Download PDFInfo
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- CN109259738A CN109259738A CN201811288317.4A CN201811288317A CN109259738A CN 109259738 A CN109259738 A CN 109259738A CN 201811288317 A CN201811288317 A CN 201811288317A CN 109259738 A CN109259738 A CN 109259738A
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- 238000001514 detection method Methods 0.000 title claims abstract description 38
- 239000013078 crystal Substances 0.000 claims abstract description 26
- 239000000523 sample Substances 0.000 claims abstract description 12
- 229920000742 Cotton Polymers 0.000 claims description 17
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 240000006413 Prunus persica var. persica Species 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- 229910002092 carbon dioxide Inorganic materials 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 239000004202 carbamide Substances 0.000 description 6
- 239000001569 carbon dioxide Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 244000144730 Amygdalus persica Species 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- 241000590002 Helicobacter pylori Species 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 229940037467 helicobacter pylori Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010019375 Helicobacter infections Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000003075 superhydrophobic effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229910003978 SiClx Inorganic materials 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037086 body physiology Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002558 medical inspection Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Nuclear Medicine (AREA)
Abstract
The present invention relates to a kind of masks for positron radionuclide count detection instrument, comprising: mask body which is provided with air funnel;Further include: LYSO crystal probe, altogether be equipped with it is multiple, each LYSO crystal probe is made of pairs of LYSO crystal block, and each LYSO crystal block passes through signal wire and connect with detector;First catch net and the second catch net are located at two openings of air funnel, for protecting LYSO crystal probe.Compared with prior art, the present invention is easy to use, has preferable practicability and promotional value.
Description
Technical field
The present invention relates to a kind of masks, more particularly, to a kind of mask for positron radionuclide count detection instrument.
Background technique
Positive electricity subclass radionuclide is (such as11C、13N、18F etc.) after label bioactive substance, hardly change body
Physiology, biochemical process.Therefore, clinically, in order to detect the metabolic condition of tissue, it will usually in being metabolized biological life
Necessary substance, such as: glucose, protein, nucleic acid, short-life radionuclide on label, after injecting human body, by right
In aggregation of the substance in metabolism, to reflect the situation of vital metabolic activity, so as in the life for not influencing homeostasis
Achieve the purpose that diagnosis under manage bar part.Positron radionuclide for label is after Physical Attenuation and biological metabolism, in subject
Internal retention time is very short, is discharged mostly with metabolite.In metabolite, CO2It is primary product with water.Wherein, it only exhales
Gas be in real time, therefore, can be exhaled by dynamic monitoring in positron radionuclide situation of change, indirectly understand in vivo metabolism
Situation.
However, at present for positron radionuclide detection mask it is relatively fewer, there is currently many masks be mainly used for
The purposes such as antifog, dust protection and gas defence, current traditional function relatively then fewer for the mask of medical inspection device detection
Energy mask is difficult to meet detection oxygen.
Therefore, based on above-mentioned, the application provides a kind of mask for positron radionuclide count detection instrument, passes through mask knot
The design of structure connects external detection structure with it, by the CO of characteristics of contaminated respiratory droplets2γ photon detected, so facilitate medical care people
Member detects human health status, it is determined whether by helicobacter pylori infections, and then solve presently, there are deficiency and
Defect.
Summary of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide one kind to be used for positive electricity daughter nucleus
The mask of plain count detection instrument.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of mask for positron radionuclide count detection instrument, comprising:
Mask body which is provided with air funnel;
Further include:
LYSO crystal block, altogether be equipped with it is multiple, each LYSO crystal block passes through signal wire and connect with detector;
First catch net and the second catch net are located at two openings of air funnel, for protecting LYSO crystal to visit
Head.
The air funnel side wall is equipped with the string holes passed through for signal wire, and all signal wires pass through line after being pierced by air funnel
Set concentrates suit.
The mask further includes end cap, and the end cap is rotatably connected on air funnel by screw thread, and is opened up on the side wall of end cap
There is venthole.
The air funnel inner wall is equipped with the hydrophobic coating for preventing ponding.
The hydrophobic coating is nano silica figure layer, with a thickness of 20~30 microns.
The mask body is the peach core structure to match with human body face shape, and inside is equipped with what human body face matched
Groove, and the edge of mask body is fixedly installed the cotton item for preventing plowing from human body face.
The mask body is equipped with the bridge of the nose slot to match with human body bridge of the nose position, and the bridge of the nose slot is equipped with for protecting
The protection cotton of skin at nosepiece beam.
The two sides of the mask body set flexible fixing belt, and are set in fixing belt corresponding with human body ear location
Ear band.
The outside of the fixing belt is coated with the elastic rubber band of one layer of cloth, and the ear band is the cotton of circle linear structure
Band.
The mesh diameter of first catch net and the second catch net is 1mm-2mm.
Compared with prior art, the invention has the following advantages:
1) pass through the setting of the first catch net and the second catch net, it is on the one hand convenient ventilative, on the other hand then facilitate protection
LYSO crystal probe.
2) LYSO crystal probe is formed by LYSO crystal block in pairs, can by the γ photon of the CO2 in exhaled gas into
Row detection.
3) one layer of super-hydrophobic coat is arranged by air funnel inner wall, conducive to moist ponding inside air funnel is avoided, facilitates people
The water droplet discharge that body exhaled gas moisture accumulates.
4) connection structure is threadedly engaged by end cap and air funnel, facilitates user periodically to open end cap and carries out detection LYSO
Crystal probe, it is easy to repair.
5) mask body is worn over by human body face by fixing belt, it can be to avoid mask body by the setting of cotton item
Edge protrudes fillet and scratches human body face, meanwhile, it, can be to avoid exhaled gas from human body face position by the setting of cotton item
Discharge is conducive to for exhaled gas being discharged to air funnel direction.
6) setting of protection cotton can contact firmly to avoid mask with the generation of the human body bridge of the nose.
7) the peach core structure design of mask, facilitates user that mask body is directly covered on human body eye position below.
8) by the setting of elastic reducing-fixing band, facilitate detection patient that mask is fixed on human body face, and the setting of ear band,
Ear band can then be hung on human body ear to avoid mask when wearing shakiness, it, can be to avoid mask so by the support of ear
It falls, Convenient mask is worn more steady.
Detailed description of the invention
Fig. 1 is three-dimensional structure diagram of the invention;
Fig. 2 is cutting structural schematic diagram in inside of the invention;
Fig. 3 is front portion structure figure of the invention;
Fig. 4 is overall work attachment structure schematic diagram of the invention;
Fig. 5 is that pulse signal of the invention records system structure diagram;
Fig. 6 meets detection circuit structural schematic diagram for of the invention.
In figure: 1, mask body;2, cotton item;3, end cap;4, the first catch net;5, the second catch net;6, LYSO crystal
Block;7, protection cotton;8, fixing belt;9, ear band;10, signal wire;11, line set;12, air funnel;13, venthole.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.The present embodiment is with technical solution of the present invention
Premised on implemented, the detailed implementation method and specific operation process are given, but protection scope of the present invention is not limited to
Following embodiments.
A kind of mask for positron radionuclide count detection instrument, as shown in FIG. 1 to 3, comprising:
Mask body 1, which is provided with air funnel 12, and the inner end of air funnel 12 is connected to the sealing fixation of mask body 1;
Further include:
LYSO crystal block 6, is equipped with multiple altogether, and each LYSO crystal block 6 is connect with detector by signal wire 10, specifically
, the inner wall array of air funnel 12 is provided with multiple square grooves, and the fixedly embedded shape that is equipped with is length inside each square groove
The LYSO crystal block 6 of cube structure;
First catch net 4 and the second catch net 5 are located at two openings of air funnel 12, for protecting LYSO brilliant
Body probe, it is preferred that the mesh diameter of the first catch net 4 and the second catch net 5 is 1mm-2mm.
12 side wall of air funnel is equipped with the string holes passed through for signal wire 10, and all signal wires 10 lead to after being pierced by air funnel 12
It crosses line set 11 and concentrates suit.
Mask further includes end cap 3, and end cap 3 is rotatably connected on air funnel 12 by screw thread, and is offered on the side wall of end cap 3 logical
Stomata 13.
12 inner wall of air funnel is equipped with the hydrophobic coating for preventing ponding, it is preferred that hydrophobic coating is nano-silica
SiClx figure layer, with a thickness of 20~30 microns.
The frontal appearance of mask body 1 is the peach core structure to match with human body face shape, and the inside of mask body 1 is set
It is equipped with the groove to match with human body face, and the recess edge surrounding inside mask body 1 is fixedly installed for avoiding drawing
Hurt the cotton item 2 of human body face.
Mask body 1 is equipped with the bridge of the nose slot to match with human body bridge of the nose position, and the bridge of the nose slot is equipped with for protecting
The protection cotton 8 of skin at the bridge of the nose.
The two sides of mask body 1 set flexible fixing belt 8, and are set in fixing belt 8 corresponding with human body ear location
Ear band 9, it is preferred that the outside of fixing belt 8 is coated with the elastic rubber band of one layer of cloth, and ear band is the cotton strip of circle linear structure.
Mask body 1 is worn over human body face by fixing belt 8 by the application, can be to avoid face by the setting of cotton item 2
The edge protrusion fillet of cover body 1 scratches human body face;Meanwhile by the setting of the cotton item 2, can to avoid exhaled gas from
The discharge of human body face position is conducive to for exhaled gas being discharged to 12 direction of air funnel;The setting of the protection cotton 7, then for protecting
The human body bridge of the nose is protected, avoids mask from generating with the human body bridge of the nose and contacts firmly;The peach core structure of mask designs, and facilitates user directly by mask
Ontology 1 covers on human body eye position below.And pass through the setting of elastic reducing-fixing band 8, facilitate detection patient to be fixed on mask
Human body face, and the setting of ear band 9, then can hang over ear band 9 on human body ear to avoid mask when wearing shakiness, so borrow
The support of ear is helped, can be fallen to avoid mask, Convenient mask is worn more steady.
LYSO crystal probe is formed in pairs by LYSO crystal 6, it can be by the γ photon of the carbon dioxide in exhaled gas
It is detected.The gas of characteristics of contaminated respiratory droplets enters the space inside air funnel 12 through the second catch net 5, and gas and LYSO crystal are visited
Head is contacted, and the γ photon of detection carbon dioxide is facilitated;And exhaled gas is passed through after detection, with the increasing of exhaled gas
It is more, finally enter 3 inside groove of end cap through the second catch net 5 and is discharged to outside mask body 1 from venthole 13.So by the
The setting of one catch net 4 and the second catch net 5, it is on the one hand convenient ventilative, on the other hand then facilitate protection LYSO crystal probe.And
One layer of super-hydrophobic coat is set by 12 inner wall of air funnel, conducive to the moist ponding in 12 inside of air funnel is avoided, facilitates characteristics of contaminated respiratory droplets
The water droplet discharge that gas moisture accumulates;It is threadedly engaged connection structure by end cap 3 and air funnel 12, then facilitates user periodically to beat
Beginning lid 3 carries out detection LYSO crystal probe, is conducive to easy to maintenance.
As Figure 4-Figure 6, in specific work process, mask is connected into electronic system, pulse signal by signal wire
Record system meets detection circuit, counting addition device and display module.Wherein:
Detector is fallen into oblivion in pairs by positron radionuclide in equally distributed even number (can be) LYSO crystal detection gas
Go out the γ photon pulse of generation;
Electronic system amplifies filtering to γ photonic pulsed signals;
Pulse signal records system, is further processed, is obtained more accurately to the pulse signal of electronic system output
γ photonic pulsed signals;
Meet detection circuit, by channel selecting, completes the time coupling of step-by-step counting interchannel two-by-two, obtain occurring
The pulse signal for characterizing γ number of photons between paired probe;
All output umber of pulses for meeting detection circuit are overlapped by counting addition device and display module, and by result
It is shown as measured value.
It includes input channel, comparator array and output channel that pulse signal, which records system,.Wherein:
Input channel is electronic system treated output signal channel;
Comparator array is further filtered input pulse signal through comparator, and converted by setting fiducial value
For two kinds of signals of low and high level;
Output channel is the output signal channel of comparator;
Logic-based and gate array meet detection circuit, mainly include channel selection circuit and logical AND array.Wherein:
Channel selection circuit carries out selection two-by-two to all channels of pulse signal record system output and matches;
Logical AND array realizes time coupling to the pulse passage matched two-by-two, obtains that the matching in the same time occurs
Pulse signal, i.e., the positive electricity subnumber buried in oblivion on meeting line of response.
As shown in figure 4, firstly, detecting positron radionuclide due to burying in oblivion phenomenon in LSYO crystal by the N in detector
The γ number of photons of generation.Then, the pretreatment such as filtering is amplified to the output pulse of 2N detector by electronic system 2.
Further, by comparator array, pretreated signal is further filtered, and is translated into two kinds of level of height.So
Afterwards, meet detection circuit, successively matched 2N pulse output signals two-by-two by channel selecting, and pass through logical AND battle array
Column carry out time coupling, the γ photon pulse number matched to the pulse signal matched two-by-two.Finally, to output is respectively met
Umber of pulse is overlapped, and obtains total pulse output, and then is obtained all generations and met the positron annihilation thing in line of response
Number of packages, to achieve the purpose that positron radionuclide quantity in Real-time and Dynamic Detection body metabolism product.
There is urease in helicobacter pylori, carbon dioxide can be broken down urea into.Pylorus is checked in urea breath test
When the infection of pylori, it will be introduced in vivo by stablizing the substrate of positron radionuclide label first, when HP is encountered and swallowed in stomach
With positron radionuclide label urea when, it will be resolved into positron radionuclide label carbon dioxide.It has
The carbon dioxide of positron radionuclide label is absorbed through gastrointestinal tract to be discharged after blood cycles to reach lung with exhaling.And normal person does not have
Helicobacter pylori, the urea with positron radionuclide label are not decomposed, are discharged with markd urea through urinary system, breathes out
Gas in do not have with positron radionuclide label carbon dioxide.As long as therefore collecting and detecting the gas of exhalation, Ji Kezhun
Really determine whether Helicobacter pylori infection.Positron radionuclide count detection instrument detects nucleic generation without complicated PET system
Thank to distribution situation, and only need the positron radionuclide number in real-time detection characteristics of contaminated respiratory droplets gas, can dynamic knowledge urea conversion
Situation, and then the changing condition of internal helicobacter pylori is understood in real time.
Claims (10)
1. a kind of mask for positron radionuclide count detection instrument, comprising:
Mask body (1) which is provided with air funnel (12);
It is characterized by further comprising:
LYSO crystal block (6), is equipped with multiple altogether, and each LYSO crystal block (6) is connect with detector by signal wire (10);
First catch net (4) and the second catch net (5) are located at two openings of air funnel (12), for protecting LYSO
Crystal probe.
2. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that described logical
Inflator (12) side wall is equipped with the string holes passed through for signal wire (10), and all signal wires (10) pass through after being pierced by air funnel (12)
Line set (11) concentrates suit.
3. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that the face
Cover further includes end cap (3), and the end cap (3) is rotatably connected on air funnel (12) by screw thread, and is offered on the side wall of end cap (3)
Venthole (13).
4. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that described logical
Inflator (12) inner wall is equipped with the hydrophobic coating for preventing ponding.
5. a kind of mask for positron radionuclide count detection instrument according to claim 4, which is characterized in that described to dredge
Water coating is nano silica figure layer, with a thickness of 20~30 microns.
6. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that the face
Cover body (1) is the peach core structure to match with human body face shape, and inside is equipped with the groove that human body face matches, and mask
The edge of ontology (1) is fixedly installed the cotton item (2) for preventing plowing from human body face.
7. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that the face
Cover body (1) is equipped with the bridge of the nose slot to match with human body bridge of the nose position, and the bridge of the nose slot is equipped with for protecting skin at the bridge of the nose
The protection cotton (8) of skin.
8. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that the face
The two sides of cover body (1) are set flexible fixing belt (8), and ear band corresponding with human body ear location is set in fixing belt (8)
(9)。
9. a kind of mask for positron radionuclide count detection instrument according to claim 8, which is characterized in that described solid
The outside of fixed band (8) is coated with the elastic rubber band of one layer of cloth, and the ear band is the cotton strip of circle linear structure.
10. a kind of mask for positron radionuclide count detection instrument according to claim 1, which is characterized in that described
The mesh diameter of first catch net (4) and the second catch net (5) is 1mm-2mm.
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