CN109330598A - It is a kind of based on the positron radionuclide real-time counting detector for meeting detection principle - Google Patents
It is a kind of based on the positron radionuclide real-time counting detector for meeting detection principle Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/4222—Evaluating particular parts, e.g. particular organs
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/4222—Evaluating particular parts, e.g. particular organs
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
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Abstract
The present invention relates to a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, comprising: mask, it is interior to be equipped with multiple LYSO crystal probes, and for capturing γ photon；Conditioning circuit is connect with all LYSO crystal probes, the pulse signal amplification and filtering generated when for LYSO crystal probe to be captured γ photon；Pulse signal recording device, connect with conditioning circuit, sends the pulse signal obtained based on each LYSO crystal probe for recording the counting pulse of γ photon by way of timestamp, and by different counting channels；Meet detection circuit, is connect with pulse signal recording device, for being coupled by multiple counting channel return pulse signals, and by the time to each counting channel, the γ photon that recognition detection arrives.Compared with prior art, the present invention by setting conditioning circuit, pulse signal recording device and meets detection circuit, effective detection for γ photon may be implemented, to realize the detection for positron radionuclide.
Description
Technical field
The present invention relates to a kind of medical instruments, more particularly, to a kind of real-time based on the positron radionuclide for meeting detection principle
Count detection instrument.
Background technique
Positive electricity subclass radionuclide is (such as11C、13N、18F etc.) after label bioactive substance, hardly change body
Physiology, biochemical process.Therefore, clinically, in order to detect the metabolic condition of tissue, it will usually in being metabolized biological life
Necessary substance, such as: glucose, protein, nucleic acid, short-life radionuclide on label, after injecting human body, by right
In aggregation of the substance in metabolism, to reflect the situation of vital metabolic activity, so as in the life for not influencing homeostasis
Achieve the purpose that diagnosis under manage bar part.Positron radionuclide for label is after Physical Attenuation and biological metabolism, in subject
Internal retention time is very short, is discharged mostly with metabolite.In metabolite, CO2It is primary product with water.Wherein, it only exhales
Gas be in real time, therefore, can be exhaled by dynamic monitoring in positron radionuclide situation of change, indirectly understand in vivo metabolism
Situation.
Currently, clinically commonly the device of detection positron radionuclide situation is positron emission tomography (abbreviation
PET).The device is by generating when the positron annihilation that generates in highly sensitive captured by camera launching material decay process
Photon.It handles by analysis, the 3-D image that can reflect metabolism status is obtained, to achieve the purpose that diagnosis.The device can be anti-
Reflect gene, molecule, metabolism and the functional status of lesion.But the equipment, by Image detection metabolic condition, structure is complicated, volume compared with
Greatly, expensive, it is chiefly used in large hospital, is not easy to popular popularization.
Therefore, based on above-mentioned, the application provides a kind of to be detected based on the positron radionuclide real-time counting for meeting detection principle
Instrument is exhaled by the overal system design of the detector by the LYSO crystal probe Real-time and Dynamic Detection for being placed in pairs of in mask
CO in gas out2γ photon, to solve the shortcomings of the prior art and defect.
Summary of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide one kind to be based on meeting detection
The positron radionuclide real-time counting detector of principle.
The purpose of the present invention can be achieved through the following technical solutions:
It is a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, comprising:
Mask, it is interior to be equipped with multiple LYSO crystal probes, for capturing γ photon；
Conditioning circuit is connect, generation when for LYSO crystal probe to be captured γ photon with all LYSO crystal probes
Pulse signal amplification and filtering；
Pulse signal recording device, connect with conditioning circuit, for recording the counting of γ photon by way of timestamp
Pulse, and the pulse signal obtained based on each LYSO crystal probe is sent by different counting channels；
Meet detection circuit, connect with pulse signal recording device, is used for through multiple counting channel return pulse signals,
And it is coupled by the time to each counting channel, the γ photon that recognition detection arrives.
All LYSO crystal probes are distributed by circular arrangement.
The number of the LYSO crystal probe is even number.
The detector further includes counting addition device, is connect with detection circuit is met, for the γ photon detected into
Row statistics.
The detector further includes display screen, which connect with counting addition device.
The output channel number for meeting detection circuit are as follows:
Wherein: N is the port number of counting channel.
The detection circuit that meets includes multiple and door, and respectively the counting channel different with two connects respectively from the input terminal of door
It connects；
The pulse signal recording device includes processor, memory, and is stored in memory and by the processing
The program that device executes, the processor perform the steps of when executing described program
Receive the pulse signal with timestamp that each counting channel is sent；
The timestamp matching with the presence or absence of two pulse signals is compared, if it has, then judgement detects a γ photon, and
It externally sends once for characterizing the step-by-step counting for detecting γ photon, in turn, by accumulative step-by-step counting, one can be obtained
It fixes time the interior positive electricity subnumber buried in oblivion, realizes the purpose of count detection.
Compared with prior art, the invention has the following advantages:
1) by the way that conditioning circuit, pulse signal recording device is arranged and meets detection circuit, is stamped to pulse signal the time
Effective detection for γ photon may be implemented in the mode of stamp, to realize the detection for positron radionuclide, effect is good.
2) the application is recorded the gas of exhalation by detector, electronic system, pulse signal by the design of mask
Device meets detection circuit and counting addition device, display module progress γ photonic pulsed signals detection and counting, by just
The detection of electron species situation facilitates detection data of the doctor by annihilation photon, analyzes patient's state of an illness, obtains meeting patient's feelings
The concrete condition of condition, and make corresponding therapeutic scheme rescues people and provides good convenience to attend.
2) the application use and it is easy to operate.
As long as 3) collect and detect the gas of exhalation, Helicobacter pylori infection can be relatively accurately determined whether.
Detailed description of the invention
Fig. 1 is overall structure figure of the invention；
Fig. 2 is γ photonic pulsed signals recording device structure figure of the invention；
Fig. 3 meets detection circuit structure chart for of the invention；
Fig. 4 is the schematic illustration for meeting detection；
In figure: 1, mask；2, conditioning circuit；3, pulse signal recording device；4, meet detection circuit；5, counting addition
Device；6, display screen.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.The present embodiment is with technical solution of the present invention
Premised on implemented, the detailed implementation method and specific operation process are given, but protection scope of the present invention is not limited to
Following embodiments.
It is a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, as shown in FIG. 1 to 3, comprising:
Mask 1, it is interior to be equipped with pairs of multiple LYSO crystal probes, for capturing γ photon；
Conditioning circuit 2 is connect, generation when for LYSO crystal probe to be captured γ photon with all LYSO crystal probes
Pulse signal amplification and filtering；
Pulse signal recording device 3 is connect with conditioning circuit 2, by being recorded based on γ photon by way of timestamp
Rapid pulse punching, and the pulse signal obtained based on each LYSO crystal probe is sent by different counting channels；
Meet detection circuit 4, connect with pulse signal recording device 3, for receiving pulse letter by multiple counting channels
Number, and coupled by the time to each counting channel, the γ photon that recognition detection arrives；
Counting addition device 5 is connect with detection circuit 4 is met, for counting to the γ photon detected.
Display screen 6, the display screen are connect with counting addition device 5.
Multiple probes being made of pairs of LYSO crystal are provided in mask 5, probe connects electronics system as detector
System 2, all LYSO crystal probes are distributed by circular arrangement, and the number of LYSO crystal probe is even number, and LYSO crystal can be two-by-two
Matching detects γ photon in pairs, for high-efficiency omnibearing, and is converted to electric signal.Conditioning circuit 2 can use electronic system.
Positron radionuclide of the detector in real-time detection characteristics of contaminated respiratory droplets gas buries in oblivion generation on meeting line of response
γ photon, and convert optical signals to electronic signal transmission electron system 2；Electronic system 2 is connected by multiple channels
Pulse signal recording device 3；Electronic system 2 detects detector and the electric signal transmitted is amplified and filtered, and should
Signal is transferred to pulse signal recording device 3；Pulse signal recording device 3 records the counting of γ photon by way of timestamp
Pulse, and pulse signal is transferred to by multiple counting channels and meets detection circuit 4；Meet detection circuit 4 then by each
The time of counting channel couples, and screens out pairs of γ number of photons, effectively obtains that the positron emission between paired probe occurs
Event；Meet detection circuit 4 positron emission event signal is output to counting addition device 5 and count, counting addition device 5 connects
It connects display module 6 and is shown count information by display module 6.
Pulse signal recording device 3 records each γ number of photons measured of popping one's head in the form of pulse train；When two
Meeting in line of response between a detector, when having positive electron to bury in oblivion, corresponding two detectors can measure pulsatile once；
But due to the presence of Compton scattering, the pulse that detector measures both had included the γ photon for meeting response and generating, and was also included scattered
The γ photon penetrated.
Meet detection circuit 4 for the counting pulse between any two probe, time coupling is realized by logical AND array, is obtained
Pairs of matched pulse signal；Pulse recording port number determines the output umber of pulse of coincident circuit；Assuming that counting channel is N,
Then the port number of coincident circuit final output pulse is.
Generation is calculated between two probes according to the umber of pulse of each output channel of coincident circuit in counting addition device 5
Positive electricity subevent accumulative total；Assuming that meet output pulse sum be M, can acquire bury in oblivion phenomenon positive electron sum be M.
Pulse signal recording device 3 includes input channel, comparator array and output channel；It uses in the left side of comparator array
In receiving the 1st grade of output pulse, the 1st grade of output pulse is emitted by electronic system；The right side of comparator array exports the 2nd grade
Output pulse is to meeting detection circuit.
Meet the output channel number of detection circuit 4 are as follows:
Wherein: N is the port number of counting channel.
It for meeting detection circuit 4, can be realized by way of pure hardware circuit, for example, meeting the packet of detection circuit 4
Multiple and door is included, respectively the counting channel different with two is connect respectively from the input terminal of door；
Certainly, meeting detection circuit 4 can also be realized by way of software and hardware combining, such as pulse signal recording device
3 include processor, memory, and the program for being stored in memory and being executed by processor, and processor executes real when program
Existing following steps:
Receive the pulse signal with timestamp that each counting channel is sent；
The timestamp matching with the presence or absence of two pulse signals is compared, if it has, then judgement detects a γ photon, and
It externally sends once for characterizing the step-by-step counting for detecting γ photon.
As shown in figure 4, theoretically, for the position where photon, the line with the center of circle is OK, and the position for crossing photon is made
Vertical line and circle intersect at A and B respectively, and pulse signal caused by two at A and B probe is exactly that timestamp is consistent.
Firstly, design of the application by mask, the gas of exhalation is believed by detector 1, electronic system 2, pulse
Number recording device 3 meets detection circuit 4 and counting addition device 5, display module 6 carry out the detection of γ photonic pulsed signals and meter
Number facilitates detection data of the doctor by annihilation photon by the detection to positron radionuclide situation, analyzes patient's state of an illness, obtains
To meeting the concrete condition of patient's condition, and corresponding therapeutic scheme is made, rescues people to attend good convenience is provided.
Secondly, the technical solution of the application use and it is easy to operate, the design principle of the application is: positive electron label object
Matter is most of to be discharged in the form of carbon dioxide and water after by body metabolism.By being placed in LYSO crystal pairs of in mask
Probe can in Real-time and Dynamic Detection exhaled gas carbon dioxide γ photon.So realize the Real-time and Dynamic Detection of γ photon, such as
This can cause detection error to avoid due to interval detection data fluctuation, and the detection time of the equipment is slightly extended, is obtained
Detection data changes with the dynamic fluctuation of time, can obtain more accurate and actual detection data.
Again, the technical solution of the application can accurately determine whether pylorus as long as collecting and detecting the gas of exhalation
Helicobacter infection.Positron radionuclide count detection instrument is metabolized distribution situation without complicated PET system detection nucleic, and only needs
Positron radionuclide number in real-time detection characteristics of contaminated respiratory droplets gas, can dynamic knowledge urea conversion situation, and then understand in real time
The changing condition of internal helicobacter pylori.Real-time detection positron radionuclide provides new technical solution and think of in terms of for medical treatment
Road has preferable practical value and promotional value.
It mainly include channel selecting as shown in figure 3, meeting detection circuit structural schematic diagram for logic-based and gate array
Circuit and logical AND array.Wherein:
Channel selection circuit carries out selection two-by-two to all channels of pulse signal recording device output and matches；
Logical AND array realizes time coupling to the pulse passage matched two-by-two, obtains that the matching in the same time occurs
Pulse signal, i.e., the positive electricity subnumber buried in oblivion on meeting line of response.
As shown in figures 1 and 3, firstly, detecting positron radionuclide due to burying in oblivion in LSYO crystal by the N in detector
The γ number of photons that phenomenon generates.Then, by electronic system 2 to the output pulse of 2N detector amplify filtering etc. it is pre-
Reason.Further, by comparator array, pretreated signal is further filtered, and is translated into two kinds of level of height.
Then, meet detection circuit 4, successively matched 2N pulse output signals two-by-two by channel selecting, and pass through logic
With array, time coupling, the γ photon pulse number matched are carried out to the pulse signal matched two-by-two.Finally, to respectively meeting
Output umber of pulse is overlapped, and obtains total pulse output, and then is obtained all generations and fallen into oblivion in the positive electron met in line of response
Go out event number, to achieve the purpose that positron radionuclide quantity in Real-time and Dynamic Detection body metabolism product.
There is urease in helicobacter pylori, carbon dioxide can be broken down urea into.Pylorus is checked in urea breath test
When the infection of pylori, it will be introduced in vivo by stablizing the substrate of positron radionuclide label first, when HP is encountered and swallowed in stomach
With positron radionuclide label urea when, it will be resolved into positron radionuclide label carbon dioxide.It has
The carbon dioxide of positron radionuclide label is absorbed through gastrointestinal tract to be discharged after blood cycles to reach lung with exhaling.And normal person does not have
Helicobacter pylori, the urea with positron radionuclide label are not decomposed, are discharged with markd urea through urinary system, breathes out
Gas in do not have with positron radionuclide label carbon dioxide.As long as therefore collecting and detecting the gas of exhalation, Ji Kezhun
Really determine whether Helicobacter pylori infection.Positron radionuclide count detection instrument detects nucleic generation without complicated PET system
Thank to distribution situation, and only need the positron radionuclide number in real-time detection characteristics of contaminated respiratory droplets gas, can dynamic knowledge urea conversion
Situation, and then the changing condition of internal helicobacter pylori is understood in real time.
Claims (8)
1. a kind of based on the positron radionuclide real-time counting detector for meeting detection principle characterized by comprising
Mask (1), it is interior to be equipped with multiple LYSO crystal probes, for capturing γ photon；
Conditioning circuit (2) connect with all LYSO crystal probes, generates when for LYSO crystal probe to be captured γ photon
Pulse signal amplification and filtering；
Pulse signal recording device (3) is connect with conditioning circuit (2), by being recorded based on γ photon by way of timestamp
Rapid pulse punching, and the pulse signal obtained based on each LYSO crystal probe is sent by different counting channels；
Meet detection circuit (4), connect with pulse signal recording device (3), for receiving pulse letter by multiple counting channels
Number, and coupled by the time to each counting channel, the γ photon that recognition detection arrives.
2. it is according to claim 1 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is that all LYSO crystal probes are distributed by circular arrangement.
3. it is according to claim 2 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is that the number of the LYSO crystal probe is even number.
4. it is according to claim 1 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is that the detector further includes counting addition device (5), connect with detection circuit (4) is met, for the γ light detected
Son is counted.
5. it is according to claim 4 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is that the detector further includes display screen (6), which connect with counting addition device (5).
6. it is according to claim 4 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is, the output channel number for meeting detection circuit (4) are as follows:
Wherein: N is the port number of counting channel.
7. it is according to claim 1 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is that the detection circuit (4) that meets includes multiple and door, respectively from the input terminal of the door counting channel different with two respectively
Connection.
8. it is according to claim 1 a kind of based on the positron radionuclide real-time counting detector for meeting detection principle, it is special
Sign is, the pulse signal recording device (3) includes processor, memory, and is stored in memory and by described
The program that device executes is managed, the processor performs the steps of when executing described program
Receive the pulse signal with timestamp that each counting channel is sent；
The timestamp matching with the presence or absence of two pulse signals is compared, if it has, then judgement detects a γ photon, and externally
It sends once for characterizing the step-by-step counting for detecting γ photon, in turn, by accumulative step-by-step counting, a timing can be obtained
The interior positive electricity subnumber buried in oblivion, realizes the purpose of count detection.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN118033713A (en) * | 2024-02-29 | 2024-05-14 | 安徽省辐射环境监督站 | Method for calculating activity of positron radioactive drug and coincidence measuring device |
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