TWI678214B - Blood analysis module and blood collection device - Google Patents

Abstract

A blood analysis module includes a blood collection device and an optical detection device. The blood collection device is used with a needle and includes a dialysis device connection tube, a retrieval tube, and a blood carrier. The dialysis device connection tube is for a blood to be dialyzed, and a part of the extraction tube flows to the dialysis device. The blood to be dialyzed is connected to the tube and flows to the blood carrier, and the optical detection device can analyze the blood to be dialyzed on the blood carrier. The invention uses the blood collection device to enable patients to synchronously collect blood during hemodialysis and hemodialysis, so that patients can test blood and perform blood tests during hemodialysis, and solve the problem that medical practitioners in the hemodialysis process can only Problems arising from monitoring patient status using vital values.

Description

Blood analysis module and blood collection device

The invention relates to a blood analysis module and a blood collection device thereof, in particular to a blood collection device including a blood collection device capable of collecting blood during a hemodialysis process and a blood analysis module applied to the blood collection device.

According to the content of various cells and molecules in the blood is an important health indicator in the human body, blood analysis is generally performed by drawing blood. That is to say, we use a skin that is applied to a vein to puncture the skin. Blood is drawn. In addition, many patients need to undergo hemodialysis to maintain their functions due to damage to their internal organs. Hemodialysis is also commonly known as "dialysis". During the process of hemodialysis, patients may develop muscle twitching, nausea or vomiting In general, the patient can only monitor the patient's life value during the dialysis process and cannot further monitor the patient's physical condition, so that the patient may develop physical discomfort during the hemodialysis process and fail to be timely Treatment may even cause death, so it is necessary to monitor the patient's blood during the hemodialysis process. If the patient has a physical discomfort during the blood analysis, the medical staff will perform a blood test on the patient. The patient will be in a discomfort state for a long period of time until the analysis results are released. The medical staff will then The patient will be treated, and these waiting times will be extremely difficult for the patient. In addition, these patients who need to undergo kidney dialysis are all critically ill patients. Each additional second of waiting may make the patient up and down. Therefore, use blood analysis to further monitor the patient's physical condition and shorten the time for patients to wait for analysis results. Often, the goal is to provide necessary and urgent treatment to the patient more immediately.

The main purpose of the present invention is to synchronously collect blood to be dialyzed to monitor the patient's physical condition at the time of using the patient's hemodialysis, and to provide medical staff to know the patient's status reliably.

To achieve the above object, the present invention provides a blood collection device capable of collecting blood during a hemodialysis process. The blood collection device is used in conjunction with a needle formed with a blood transfusion channel. The blood collection device is characterized by including a dialysis device. A connection tube, a retrieval tube, and a blood carrier. The needle is formed with a blood transfusion channel, the dialysis device connecting tube communicates with the blood transfusion channel and can receive a blood to be dialyzed, the extraction tube communicates with the blood transfusion channel and diverges from the dialysis device connection tube, and the extraction tube is in the blood transfusion channel A portion of the blood to be dialyzed is taken when the blood to be dialyzed is flowing, and the blood carrier is connected to the collection tube and receives the blood to be dialyzed. The blood carrier includes a first blood chamber, a second blood chamber, and a first blood chamber. A liquid passage and a first one-way filter, the first blood reservoir is connected to the retrieval tube, the second blood reservoir is spaced from the first blood reservoir, and the first liquid reservoir is connected to the first A blood-receiving chamber and the second blood-receiving chamber, the first one-way filter is disposed in the first liquid passage, and the returned blood flowing from the first blood-receiving chamber to the second blood-receiving chamber is to be dialyzed Blood is filtered.

In one embodiment, the blood carrier includes a third blood storage chamber spaced from the second blood storage chamber, a second liquid passage connecting the second blood storage chamber and the third blood storage chamber, and a set A second unidirectional filter membrane in the second liquid passage for filtering the blood to be dialyzed flowing from the second blood chamber to the third blood chamber, and the filtration pore diameter of the second unidirectional filter membrane is different The pore diameter of the first unidirectional filter.

In one embodiment, the filter diameter of the second unidirectional filter is smaller than that of the first unidirectional filter. Filtration pore size.

In one embodiment, the blood carrier is made of a light-absorbing material.

In one embodiment, the first blood reservoir has a first inlet connected to the retrieval tube and a first outlet connected to the first fluid passage, and the second blood reservoir has a first fluid passage The second entrance to the road.

In one embodiment, the blood carrier includes a third blood storage chamber spaced from the second blood storage chamber, a second liquid passage connecting the second blood storage chamber and the third blood storage chamber, and a set A second unidirectional filtering membrane in the second liquid passage for filtering the blood to be dialyzed flowing from the second blood compartment to the third blood compartment, the second chamber having a second connection The third outlet of the liquid passage has a third inlet connected to the second liquid passage, and the filter diameter of the second unidirectional filter membrane is different from that of the first unidirectional filter membrane.

In one embodiment, the blood carrier is disposable.

In addition, the present invention also provides a blood analysis module. The blood analysis module includes a blood collection device and an optical detection device. The blood collection device is used with a needle, and the needle is formed with a blood transfusion tract, the blood The collection device includes a blood carrier connected to the blood transfusion tract and being different from the connection tube of the dialysis device, and a blood carrier connected to the extraction tube and receiving the blood to be dialyzed. A portion of the blood to be dialyzed is taken, and the blood carrier includes a first blood compartment connected to the retrieval tube, a second blood compartment disposed at a distance from the first blood compartment, and a first blood compartment connected to the first blood compartment. A first fluid passage with the second blood reservoir, and a first fluid passage disposed in the first fluid passage and filtering the blood to be dialyzed flowing from the first blood reservoir to the second blood reservoir. A unidirectional filter. The optical detection device is provided corresponding to the blood carrier, and the optical detection device includes a plurality of surfaces facing the first blood compartment and the second blood compartment, respectively. The detection light source generating parts, a plurality of corresponding optical sensing parts respectively provided with one of the detection light source generating parts, and a processor connected to the optical sensing parts, each of the detecting light source generating parts generates a detecting light source, and each of the detecting Different light source wavelengths

In one embodiment, the optical detection device includes a casing provided with the detection light source generating members, the optical sensing members, and the processor. The casing has a detection space for receiving the blood carrier. The detection light source generating elements and the optical sensing elements are disposed facing the detection space.

In one embodiment, the optical detection device has a power supply module connected to the detection light source generating components, the optical sensing components, and the processor.

According to the foregoing summary of the invention, compared with conventional technology, the present invention has the following features: The present invention allows the patient who needs hemodialysis to take part of the blood to be dialyzed directly during the dialysis process through the blood collection device. After the blood to be dialyzed is collected to the blood carrier, the blood carrier containing the blood to be dialyzed is directly analyzed by the optical detection device, so that the patient can be controlled immediately during the hemodialysis process, so that The patient's physical condition is monitored at any time, so that medical personnel do not need to rely on the life value displayed on the machine to judge the patient's physical condition, and can also treat the patient immediately to prevent the disease from being delayed.

10‧‧‧ Blood Analysis Module

20‧‧‧ blood collection device

21‧‧‧ needle

211‧‧‧ blood transfusion

22‧‧‧ Dialysis device connection tube

23‧‧‧Capture tube

24‧‧‧ Blood Carrier

241‧‧‧First Blood Chamber

242‧‧‧Second Blood Chamber

243‧‧‧The first passage

244‧‧‧The first one-way filter

245‧‧‧First Entrance

246‧‧‧Exit 1

247‧‧‧Second Entrance

248‧‧‧Third Blood Chamber

249‧‧‧Second Passage

250‧‧‧Second one-way filter

251‧‧‧Second exit

252‧‧‧third entrance

30‧‧‧Optical detection device

31‧‧‧Detect light source generator

32‧‧‧optical sensor

33‧‧‧Processor

34‧‧‧shell

341‧‧‧ Detection space

35‧‧‧Power Supply Module

50‧‧‧ hemodialysis device

FIG. 1 is a schematic diagram of a blood collection device according to an embodiment of the present invention.

FIG. 2 is a schematic diagram of a blood carrier according to an embodiment of the present invention.

FIG. 3 is a top view of a blood carrier according to an embodiment of the present invention.

FIG. 4 is a schematic diagram of an optical detection device according to an embodiment of the present invention.

FIG. 5 is a schematic cross-sectional view of an optical detection device according to an embodiment of the present invention.

FIG. 6 is a schematic diagram of a blood carrier according to another embodiment of the present invention.

The detailed description and technical contents of the present invention are described below with reference to the drawings: Please refer to FIGS. 1 to 3. The present invention provides a blood analysis module 10. The blood analysis module 10 is mainly composed of a blood collection device 20 and an optical device. The detection device 30 is composed. Here, the blood collection device 20 will be described first. The blood collection device 20 has the feature that a blood to be dialyzed can be collected during hemodialysis. The blood collection device 20 is used with a hemodialysis device 50, and the blood collection device 20 Need to be used with a needle 21, which is formed with a blood transfusion channel 211. The blood collection device 20 includes a dialysis device connection tube 22, a retrieval tube 23, and a blood carrier 27. Specifically, one end of the dialysis device connection tube 22 is connected to the blood transfusion channel 211 to receive a blood to be dialyzed, and the other end is connected to the hemodialysis device 50 to enable the blood to be dialyzed for hemodialysis, and the extraction tube 23 is connected. The blood transfusion channel 211 is different from the dialysis device connecting tube 22. Moreover, during the hemodialysis process, the blood to be dialyzed does not only flow to the retrieval tube 23, but flows to the retrieval tube 23 and the infusion tube dialysis device connection tube 22 at the same time. During the dialysis process, a portion of the blood to be dialyzed is taken when the blood to be dialyzed flows from the blood transfusion tract.

The blood carrier 24 is connected to the extraction tube 23, and the blood carrier 24 includes a first blood storage chamber 241, a second blood storage chamber 242 spaced from the first blood storage chamber 241, and a connection to the blood storage chamber 24. The first blood receiving chamber 241 and the second blood receiving chamber 242 have a first liquid passage 243 and a first unidirectional filter membrane 244 disposed in the first liquid passage 243. In addition, the blood carrier 24 is a single-use consumable, so as to prevent the blood carrier 24 from being contaminated after the second use, which will cause subsequent analysis data to be inaccurate. In addition, the material of the blood carrier 24 is a light-absorbing material. Analysis causes interference. The structure to which the blood carrier 24 belongs is further described, wherein the first blood storage chamber 241 has a first inlet 245 connected to the retrieval tube 23 and a first outlet 246 connected to the first liquid passage 243, and the first The second blood storage chamber 242 has a second inlet 247 connected to the first liquid passage 243, that is, two ends of the first liquid passage 243 are connected to the first outlet 246 and the second outlet 247, respectively. Furthermore, the first unidirectional filter membrane 244 is placed in the first liquid passage 243, and the size of the first unidirectional filter membrane 244 is set to be the same as the longitudinal cross-sectional area of the first liquid passage 243. , So that the first one-way filter membrane 244 can completely filter the blood to be dialyzed. After the blood to be dialyzed is filtered by the first one-way filter membrane 244, the filtered blood to be dialyzed will meet the detection requirements, so that the blood to be dialyzed can be easily separated without going through complicated centrifugal procedures. To meet different blood test items.

On the other hand, the optical detection device 30 is provided corresponding to the blood carrier 24. The optical detection device 30 includes a plurality of detection light source generating members 31 facing the first blood chamber 241 and the second blood chamber 242, respectively. The plural numbers respectively correspond to one of the optical sensing elements 32 provided on the detection light source generating element 31 and a processor 33 connected to the optical sensing elements 32. Specifically, each of the detection light source generating members 31 generates a detection light source, and the wavelength of each of the detection light sources is different. In order for the optical sensing members 32 to receive each of the detection light sources separately, they are not affected by other detection light sources. For the interference, the optical sensing member 32 and the detection light source generating member 31 can be set one-to-one during the assembly process. On the other hand, each of the detection light source generating members 31 is also set corresponding to each of the blood storage chambers 241 and 242, so that each of the detection light sources can completely project light to the corresponding blood storage chamber. 241 and the second blood-containing chamber 242 perform blood tests for different items, and the wavelengths of the detection light sources corresponding to the first and second blood-containing chambers 241 and 242 are different to obtain different detection parameters. Furthermore, in order that the light source generating member 31 can be more reliably irradiated on On the blood source carrier 22, the light source generating member 31 may be disposed in the optical detection device 30 and may directly face the blood carrier 22. In addition, the optical sensing elements 32 can fully receive the light reflected from the blood to be dialyzed, and the optical sensing elements 32 are also directly disposed facing the blood carrier 22. In addition, the processor 33 is disposed in the optical detection device 30 and can accept an electrical signal transmitted by the optical sensing elements 32 and analyze the electrical signal at the same time.

From now on, the implementation status of the blood analysis module 10 will be described. When the patient is undergoing hemodialysis, the needle 21 will be inserted into the blood vessel. At this time, the blood to be dialyzed is subjected to the hemodialysis device 50. The action will cause the blood to be dialyzed to flow from the blood vessel to the blood transfusion channel 211. When the blood to be dialyzed flows out of the blood transfusion channel 211 and flows to the extraction tube 23, part of the blood to be dialyzed flows into the blood carrier 24 through the extraction tube 23, and further enters the first blood compartment 241 And flows toward the second blood storage chamber 242, and when the blood to be dialyzed passes through the first liquid passage 243, the first one-way filter 244 will flow from the first blood storage chamber 241 to the second blood tank The blood to be dialyzed in the blood chamber 242 is filtered, so that the blood to be dialyzed meets the testing requirements. On the other hand, the detection light source generating member 31 projects the detection light source to the first blood-containing chamber 241 and the second blood-containing chamber 242 respectively, and then uses the light-source sensing member 32 to receive the reflection of the blood to be dialyzed, respectively. Light, and transmits a telecommunication signal to the processor 33. The processor 33 receives the telecommunication signal and analyzes the telecommunication signal to obtain complex analysis parameters. The analysis parameters may be respectively one of the sodium ion concentration and potassium ion concentration in the blood to be dialyzed. When one of the parameters such as the sodium ion concentration and potassium ion concentration in the patient's blood is abnormal, the medical staff can make the patient perform further medical diagnosis and treatment.

In the present invention, through the blood analysis module 10, the patient can simultaneously obtain the blood to be dialyzed for analysis during dialysis. Compared with the old habits, the patient can only Monitoring the patient's life value and unable to further monitor the patient's physical condition, so that the patient may have physical discomfort during the hemodialysis process and fail to be treated in a timely manner, and may even cause death. Therefore, during the hemodialysis process At the same time, regular blood monitoring of patients is necessary. The present invention further allows the blood carrier 22 to perform blood analysis directly after receiving the blood to be dialyzed through the optical detection device 30, which will shorten the waiting time for the analysis result, and can immediately detect the discomfort of the patient, The patient is provided with the necessary treatment. During the hemodialysis process, the blood analysis module 10 of the present invention can not only monitor the patient's physical condition at any time, but also enable medical personnel to detect the patient's discomfort more immediately and provide more immediate treatment.

Please refer to FIG. 6 again. In an embodiment, the blood carrier 24 may further include two or more blood containing chambers. For example, the blood carrier 24 may further include a first blood vessel 24 spaced from the second blood vessel 242. Three blood-receiving chambers 248, a second fluid passage 249 connecting the second blood-reception chamber 242 and the third blood-reception chamber 248, and a second one-way filter membrane 250 disposed in the second fluid-passage 249 . Among them, the first blood-containing chamber 241, the second blood-containing chamber 242, and the third blood-containing chamber 248 have the same appearance. In addition, two ends of the second fluid passage 249 communicate with the second blood compartment 242 and the third blood compartment 248, respectively. In more detail, the second blood compartment 242 is in addition to the second inlet 247. There is a second outlet 251, and the third blood storage chamber 248 has a pair of third inlets 252 corresponding to the second outlet 251, that is, two ends of the second liquid passage 249 are respectively connected to the second blood storage The second outlet 251 of the chamber 242 and the third inlet 252 of the third blood storage chamber 248. The second one-way filter membrane 250 is disposed on the second liquid passage 249. The size of the second one-way filter membrane 250 can be consistent with the diameter of the second liquid passage 249, so that the second one-way filter The membrane 250 can completely filter the blood to be dialyzed flowing from the second blood chamber 242 to the third blood chamber 248. Further, the filtering pore diameter of the second one-way filter membrane 250 is different from the filtering pore size of the first one-way filter membrane 244. More specifically, in order to filter the blood to be dialyzed, the first blood volume is allowed to The blood to be dialyzed in the chamber 241, the second blood-receiving chamber 242, and the third blood-receiving chamber 248 meet the detection requirements, and the pore diameter of the second unidirectional filter membrane 250 needs to be smaller than that of the first unidirectional filter membrane 244. That is to say, the pore diameters of the one-way filter membranes 244 and 250 must be arranged from large to small, so as to effectively filter the blood to be dialyzed and obtain more accurate analysis results.

Continuing, in an embodiment, the optical detection device 30 further includes a casing 34 provided with the detection light source generating members 31, the optical sensing members 32, and the processor 33, and the casing 34 is more shaped. There is a detection space 341. The detection space 341 is used to receive the blood carrier 22, so that the optical detection device 30 can be closer to the blood carrier 22 and perform more accurate analysis. In detail, the detection light source generating members 31 and the optical sensing members 32 are disposed facing the detection space 341, that is, when the blood carrier 22 is placed in the detection space 341, the blood carrier 22 is Facing the detection light source generating members 31 and the optical sensing members 32 directly. On the other hand, the optical detection device 30 has a power supply module 35 connected to the detection light source generating elements 31, the optical sensing elements 32 and the processor 33. The power supply module 35 may further include a voltage converter and a power transmission line. The power supply module 35 may supply power to the detection light source generating members 31, the optical sensing members 32, and the processor 33.

Claims (10)

A blood collection device capable of collecting blood during a hemodialysis process. The blood collection device is used with a needle, the needle is formed with a blood transfusion channel, and the blood collection device includes a dialysis device connection tube, which communicates with the blood transfusion channel and can Receiving a blood to be dialyzed; a retrieval tube communicating with the blood transfusion tract and diverging from the connection tube of the dialysis device, the retrieval tube taking a portion of the blood to be dialyzed when the blood is flowing from the blood transfusion tract; and A blood carrier is connected to the retrieval tube and receives the blood to be dialyzed when a hemodialysis device acts. The blood carrier includes a first blood compartment connected to the retrieval tube, and a blood compartment disposed at a distance from the first blood compartment. A second blood storage chamber, a first liquid passage connecting the first blood storage chamber and the second blood storage chamber, and a second blood storage chamber disposed in the first liquid passage and flowing to the first blood storage chamber A first unidirectional filtering membrane for filtering the blood to be dialyzed in the second blood chamber, and the first blood chamber and the second blood chamber can receive projections from a detection light source, respectively. The blood collection device according to claim 1, wherein the blood carrier includes a third blood storage chamber spaced apart from the second blood storage chamber, and a connection between the second blood storage chamber and the third blood storage chamber A second liquid passage and a second one-way filter membrane disposed in the second liquid passage and filtering the blood to be dialyzed flowing from the second blood compartment to the third blood compartment, the The filtering pore diameter of the second unidirectional filter membrane is different from the filtering pore diameter of the first unidirectional filter membrane, and the third blood chamber can receive the projection of the detection light source. The blood collection device according to claim 2, wherein a filtering pore diameter of the second unidirectional filtering membrane is smaller than a filtering pore diameter of the first unidirectional filtering membrane. The blood collection device according to claim 1 or 2 or 3, wherein the blood carrier is made of a light-absorbing material. The blood collection device according to claim 1 or 3, wherein the first blood reservoir has a first inlet connected to the extraction tube and a first outlet connected to the first liquid passage, and the second The blood reservoir has a second inlet connected to the first liquid passage. The blood collection device according to claim 5, wherein the blood carrier comprises a third blood storage chamber spaced from the second blood storage chamber, and a connection between the second blood storage chamber and the third blood storage chamber A second one-way filter disposed in the second one and filtering the blood to be dialyzed flowing from the second blood compartment to the third blood compartment, the first The two chambers have a second outlet connected to the second liquid passage, the third blood storage chamber has a third inlet connected to the second liquid passage, and the filtering aperture of the second one-way filter membrane is different from that of the first The pore diameter of a unidirectional filter. The blood collection device according to claim 1 or 2 or 3, wherein the blood carrier is disposable. A blood analysis module is characterized by comprising: a blood collection device used with a needle, the needle is formed with a blood transfusion tract, the blood collection device includes a blood transfusion tract connected to the blood transfusion tract and receives a to-be-dialyzed when a hemodialysis device acts A dialysis device connection tube for blood, an extraction tube that communicates with the blood transfusion channel and is different from the connection tube of the dialysis device, and a blood carrier connected to the extraction tube and receiving the blood to be dialyzed, the extraction tube is at the blood transfusion A portion of the blood to be dialyzed is taken when the blood to be dialyzed is collected, and the blood carrier includes a first blood chamber connected to the extraction tube, and a second blood chamber separated from the first blood chamber. A first liquid passage connecting the first blood chamber and the second blood chamber, and a first liquid passage arranged in the first liquid chamber and flowing from the first blood chamber to the second blood chamber The first unidirectional filter membrane for filtering the blood to be dialyzed, the first blood receiving chamber and the second blood receiving chamber can respectively receive the projection of a detection light source; and an optical detection device is provided corresponding to the blood carrier, and the optical Detection device package A plurality of detection light source generating elements facing the first and second blood containing chambers respectively, a plurality of optical sensing elements corresponding to one of the detection light source generating elements and a processor connected to the optical sensing elements respectively Each detection light source generating element generates a detection light source, and each detection light source has a different wavelength. The blood analysis device according to claim 8, wherein the optical detection device includes a housing provided with the detection light source generating members, the optical sensing members, and the processor, and the housing has a housing for containing The detection space of the blood carrier is disposed, and the detection light source generating elements and the optical sensing elements are disposed facing the detection space. The blood analysis device according to claim 8 or 9, wherein the optical detection device has a power supply module connected to the detection light source generating components, the optical sensing components, and the processor.