CN106990068B - Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate - Google Patents
Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate Download PDFInfo
- Publication number
- CN106990068B CN106990068B CN201710282694.6A CN201710282694A CN106990068B CN 106990068 B CN106990068 B CN 106990068B CN 201710282694 A CN201710282694 A CN 201710282694A CN 106990068 B CN106990068 B CN 106990068B
- Authority
- CN
- China
- Prior art keywords
- dialysate
- near infrared
- urea nitrogen
- hemodialysis
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 192
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 title claims abstract description 96
- 229940109239 creatinine Drugs 0.000 title claims abstract description 96
- 238000012544 monitoring process Methods 0.000 title claims abstract description 74
- 238000001631 haemodialysis Methods 0.000 title claims abstract description 70
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 70
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000008280 blood Substances 0.000 claims description 59
- 239000000523 sample Substances 0.000 claims description 59
- 210000004369 blood Anatomy 0.000 claims description 58
- 238000002329 infrared spectrum Methods 0.000 claims description 54
- 238000001514 detection method Methods 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 17
- 230000017531 blood circulation Effects 0.000 claims description 15
- 230000008321 arterial blood flow Effects 0.000 claims description 14
- 230000004087 circulation Effects 0.000 claims description 14
- 229960002897 heparin Drugs 0.000 claims description 12
- 229920000669 heparin Polymers 0.000 claims description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 11
- 239000000004 hemodialysis solution Substances 0.000 claims description 10
- 238000011084 recovery Methods 0.000 claims description 10
- 238000001228 spectrum Methods 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 230000008859 change Effects 0.000 abstract description 10
- 238000011282 treatment Methods 0.000 abstract description 10
- 208000017169 kidney disease Diseases 0.000 abstract description 4
- 238000007689 inspection Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 description 9
- 239000012528 membrane Substances 0.000 description 8
- 230000006378 damage Effects 0.000 description 5
- 239000012510 hollow fiber Substances 0.000 description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 239000004202 carbamide Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000022558 protein metabolic process Effects 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000009615 deamination Effects 0.000 description 1
- 238000006481 deamination reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000006334 interstitial nephritis Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000000411 transmission spectrum Methods 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
Abstract
The invention relates to a method and a system for online monitoring the content of urea nitrogen creatinine in hemodialysis dialysate, which are characterized in that a near infrared spectrometer is adopted to establish a dialysate sample inspection model and online monitor the content change of urea nitrogen creatinine in the hemodialysis dialysate, and according to the content change rule of urea nitrogen creatinine in the hemodialysis dialysate, the occurrence of hemodialysis accidents is monitored, prevented and avoided, so that scientific basis is provided for the treatment of uremic patients, and the aim of improving the renal disease treatment level of the patients is achieved.
Description
Technical Field
The invention relates to a method and a system for online monitoring of urea nitrogen creatinine content in hemodialysis dialysate, in particular to a method and a system for online monitoring of urea nitrogen creatinine content in hemodialysis dialysate by near infrared spectrum detection.
Background
Currently, blood purification is widely required in clinical treatment. Taking kidney disease dialysis treatment as an example, about 200 ten thousand end-stage renal patients in China receive 40 ten thousand hemodialysis treatments, the rate of increase of over 10% per year, and the demand of patients for dialysis treatment is great.
The hemodialysis treatment is to introduce the blood and the dialysate of the patient into the inner and outer sides of the dialyzer simultaneously by using the principle of a semipermeable membrane, and remove excessive water and metabolic waste in the body by diffusion, convection, toxin removal and the like by means of solute gradients, permeation gradients and dispersion on the two sides of the membrane, and simultaneously leave required substances to correct electrolyte and acid-base balance disorder.
Urea is the main end product of human protein metabolism and deamination of amino acids to produce NH 3 And C0 2 Both synthesize urea in the liver, producing about 0.3 gram of urea nitrogen per gram of protein metabolism. Typically the kidneys are urea-excretedThe main organ, urea, can be reabsorbed in each segment of tubule after filtration from glomeruli. The nitrogen content of the normal adult fasting urea is 3.2-7.1 mmol/L (9-20 mg/d 1). Various kidney parenchymal lesions such as glomerulonephritis, interstitial nephritis, acute and chronic renal failure can increase blood urea nitrogen. If the kidney external factor is eliminated, 21.4mmol/L (60 mg/d 1) of urea nitrogen is one of the uremia diagnosis indexes.
Creatinine (CR) is a product of human muscle metabolism, is mainly formed by creatine through irreversible non-enzymatic dehydration reaction, is released into blood, is excreted along with urine, is not easily influenced by diet, can be filtered through glomerulus, is seldom absorbed again in renal tubules, creatinine comprises blood creatinine and urine creatinine, the blood creatinine measures renal function more effectively, serum creatinine concentration measurement is an effective index for evaluating glomerular filtration rate, can effectively reflect the substantial injury degree of renal function, is beneficial to judging illness state in clinical detection, and has important significance.
When hemodialysis treatment is performed on uremic patients, a dialyzer is required. The dialyzer may be clogged or broken. The reasons for dialyzer clogging are mainly: a. the blood is too long from the pump off, which is the main cause of dialyzer clogging; b. the dosage of heparin is insufficient, the injection quantity of heparin for the first dialysis of patients is very important, generally 0.2-0.5 mg/kg, and if the first heparinization is insufficient, the additional heparin quantity in the dialysis is larger, and no obvious effect exists; c. the dialyzer itself has increased blood viscosity at the end stage of the disease or kidney disease.
The dialyzer should be replaced in time after being blocked, otherwise, the extracorporeal circulation is stopped, and the arterial blood path and the venous blood path are blocked, so that a great deal of blood of a dialyzer is lost, and the damage is great. In order to discover the blocking phenomenon of the dialyzer in time, the dialysis process needs to be monitored on line to find the change rule of the concentration of the dialyzate. If when the dialysis membrane is gradually blocked, the urea nitrogen content in the dialysis liquid becomes low gradually, and when the urea nitrogen content exceeds a certain limit with the normal urea nitrogen content, the dialysis liquid can be timely reminded by the alarm device, so that the occurrence of harm is effectively avoided.
Furthermore, the damage condition of the dialyzer can be found in time by monitoring the change of the urea nitrogen creatinine content in the hemodialysis liquid on line. If the hollow fiber membrane of the dialyzer is damaged, the urea nitrogen content in the dialyzate can be obviously improved, and the damage of the dialyzer can be timely found through monitoring, so that the accident can be timely treated and avoided.
The prior art adopts conductivity detection, dialysate concentration monitoring and the like for prevention, but has certain defects, such as insufficient timeliness of sampling detection, pollution, high-precision sensor for concentration monitoring, inaccurate measured value caused by corrosion of a sensor probe and the like.
Near infrared spectroscopy is a novel technology developed in recent years, and is an instrument analysis means for rapidly scanning reflection, diffuse reflection or transmission spectra of substances in a 670-2526 nm spectral region by using a near infrared spectrometer. The near infrared spectrum analysis technology has the advantages of high analysis speed, high efficiency, no chemical pollution of samples, no need of sample pretreatment, online nondestructive detection and the like, and is widely applied to the fields of food and agricultural product detection and the like. However, the literature search does not find its application in the field of hemodialysis on-line monitoring.
Therefore, how to combine the advantages of the near infrared spectrum detection technology, on-line monitoring of the change of the urea nitrogen creatinine content in the hemodialysis dialysate, searching for the change rule of the urea nitrogen creatinine content in the dialysate during hemodialysis, searching for the correlation between the change of the urea nitrogen creatinine content in the dialysate during hemodialysis and the heart rate, blood pressure and dialysis blood flow of a patient, and searching for the change rule of the urea nitrogen creatinine content in the dialysate under special conditions such as blockage or breakage becomes one of the subjects of the research in the field.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a method and a system for online monitoring the urea nitrogen creatinine content in hemodialysis dialysate.
The invention provides an online monitoring method for urea nitrogen creatinine content in hemodialysis liquid, which comprises the following steps:
1) Preparing hemodialysis liquid samples with different urea nitrogen contents and creatinine contents;
2) A near infrared spectrometer is adopted to carry out spectrum acquisition on a hemodialysis dialysate sample with urea nitrogen content and creatinine content;
3) Establishing a near infrared spectrum-based quantitative identification model of urea nitrogen and creatinine content in hemodialysis dialysate;
4) And 3) carrying out near infrared spectrum acquisition on the hemodialysis dialyzate by using an on-line monitoring probe, comparing the acquired near infrared spectrum of urea nitrogen content and creatinine content in the dialyzate at the outlet of the dialyzate with the quantitative identification model of urea nitrogen content and creatinine content in the dialyzate established in the step 3), and determining the urea nitrogen creatinine content in the dialyzate at the outlet of the dialyzate to be detected.
In addition, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which comprises the following steps: blood side circulation, dialysate side circulation and dialyzer 4; the blood side circulation comprises a human body arterial blood output side 1, a blood pump 2, an arterial blood circulation conduit 3, a venous blood circulation conduit 6 and a human body venous blood input side 8; the arterial blood circulation conduit 3 is connected with the arterial blood output side 1 of the human body and the blood inlet of the dialyzer 4, and the blood pump 2 is arranged on the arterial blood circulation conduit 3; the venous blood circulation conduit 6 connects the blood outlet of the dialyzer 4 with the venous blood inlet side 8 of the human body; the dialysate side circulation comprises a dialysate barrel 9, a dialysate pump 10, a dialysate inlet pipeline 11, a dialysate monitoring probe 14, a dialysate outlet pipeline 13, a dialysate recovery barrel 15, a near infrared spectrum detection data line 16 and a near infrared spectrum monitor 17; a dialysate inlet line 11 connects the dialysate barrel 9 and the dialysate inlet of the dialyzer 4, and a dialysate pump 10 is provided on the dialysate inlet line 11; the dialysate outlet line 13 connects the dialysate inlet of the dialyzer 4 and the dialysate recovery tank 15; the dialysate monitoring probe 14 is arranged on the dialysate outlet pipeline 13, and the near infrared spectrum detection data line 16 is connected with the dialysate monitoring probe 14 and the near infrared spectrum monitor 17; the dialysate monitoring probe 14 collects near infrared spectra of urea nitrogen creatinine content in the dialysate exiting the dialyzer 4.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the near infrared spectrum monitor 17 obtains a near infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe 14, and obtains and records the urea nitrogen creatinine content in the hemodialysis dialysate based on comparison of a quantitative identification model of the urea nitrogen creatinine content in the hemodialysis dialysate of the near infrared spectrum.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the quantitative identification model of urea nitrogen creatinine content in hemodialysis dialysate based on near infrared spectrum refers to preparing hemodialysis dialysate samples with different urea nitrogen content and creatinine content, and performing spectrum acquisition on the dialysate samples by adopting a near infrared spectrometer so as to establish the quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate based on near infrared spectrum.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the online monitoring system for urea nitrogen creatinine content in hemodialysis dialysate is provided with a bubble capturing monitor 7 which is arranged on a venous blood circulation catheter 6.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the dialysate monitoring probe 14 includes a probe housing 21, a dialysate channel 24, a near infrared receiving chamber 29 and a near infrared transmitting chamber 32; the near infrared receiving chamber 29 and the near infrared transmitting chamber 32 are respectively arranged at two sides of the probe shell 21, the middle part of the near infrared receiving chamber penetrates through the probe shell 21 through the dialysate channel 24, the near infrared receiving chamber 29 and the near infrared transmitting chamber 32 are respectively communicated with the dialysate channel 24 through the near infrared receiving hole 25 and the near infrared transmitting hole 30, and the near infrared receiving hole 25 and the near infrared transmitting hole 30 are coaxial; the near infrared emission chamber 32 is provided with a near infrared emission tube 31 at the position of the near infrared emission hole 30; the near infrared receiving chamber 29 is provided with a near infrared receiving pipe 27 at the position of the near infrared receiving hole 25; the near infrared receiving chamber 29 is provided with a circuit board 28 communicated with the near infrared receiving tube 27; the dialysate channel 24 is connected to the dialysate outlet or dialysate outlet line 13 of the dialyzer 4 and is fed to the spent dialysate recovery tank 15; the outside of the probe shell 21 is provided with a connector 23, and the connector 23 is communicated with the near infrared receiving chamber 29, the near infrared transmitting chamber 32 and the outside through a wire guide 22; the dialysate channel 24 is provided with quartz glass 33 covering the near infrared receiving hole 25 and the near infrared emitting hole 30; the dialysate monitoring probe 14 further comprises two sealing caps 26 connected to the probe housing 21 to form a near infrared receiving chamber 29 and a near infrared transmitting chamber 32, respectively; the dialysate in the dialysate channel 24 is monitored by near infrared light, the collected spectrum signals are led out from the conduit through the connector 23 by the wires inside the dialysate monitoring probe 14, and the urea nitrogen creatinine content in the hemodialysis dialysate is obtained by a near infrared spectrum detection data line and a near infrared spectrum monitor and recorded in real time.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the seal cap 26 is connected with the probe housing 21 by seal threads.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the connector 23, the probe housing 21 and the seal cover 26 are made of stainless steel.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: near infrared light is transmitted perpendicularly through the dialysate in the dialysate channel 24.
Further, the invention also provides an online monitoring system for urea nitrogen creatinine content in hemodialysis liquid, which is characterized by comprising the following steps: the online monitoring system for urea nitrogen creatinine content in hemodialysis dialysate is provided with a heparin pump 20 which is arranged on an arterial blood circulation catheter 3; the prepared injection is injected into blood through the heparin pump 20.
The technical characteristics, experimental steps and the like which are not described in the invention are matched by adopting the mature prior art.
Advantageous effects of the invention
1. The urea nitrogen creatinine content in the dialyzate is monitored in real time on line, so that whether the dialyzate is blocked or damaged can be rapidly judged, and medical accidents are timely treated and prevented;
2. the online monitoring has short detection time, the obtained data of the urea nitrogen creatinine content in the dialysate is more, the change rule of the urea nitrogen creatinine content in the dialysate during hemodialysis is found, and the correlation between the change of the urea nitrogen creatinine content in the dialysate during hemodialysis and the heart rate, the blood pressure and the dialyzing blood flow of a patient is found, so that a scientific basis is provided for the treatment of uremic patients;
3. the rapid nondestructive detection is truly realized, compared with other monitoring methods, the human error and the system error are effectively reduced, the model accuracy is high, and the working efficiency is improved;
4. provides reliable technical guarantee for the prevention, treatment and first aid of the kidney disease, and has great economic and social significance.
Drawings
Fig. 1 is a schematic diagram of an online monitoring system for urea nitrogen creatinine content in hemodialysis solution.
Fig. 2 is a schematic structural view of a dialysate monitoring probe according to the present invention.
Reference numerals:
1-human arterial blood output side; 2-blood pump; 3-arterial blood circulation catheter; a 4-dialyzer; 5-hollow fiber membranes; 6-venous blood circulation catheters; 7-a bubble capture monitor; 8-human venous blood input side; 9-cleaning a dialysate barrel; 10-a dialysate pump; 11-dialysate inlet line; 12-dialyzer dialysate side; 13-dialysate outlet line; 14-a dialysate monitoring probe; 15-spent dialysate recovery drum; 16-near infrared spectrum detection data line; 17-near infrared spectrum monitor; 20-heparin pump; 21-a probe housing; 22-wire guides; 23-connecting heads; 24-dialysate channel; 25-near infrared receiving holes; 26-sealing cover; 27-a near infrared receiving tube; 28-a circuit board; 29-a near infrared receiving chamber; 30-near infrared emission holes; 31-a near infrared emission tube; 32-a near infrared emission chamber; 33-quartz glass.
Detailed Description
The invention is further described below with reference to the drawings and specific embodiments.
A urea nitrogen creatinine content on-line monitoring method in hemodialysis dialysate comprises the following steps:
1) Preparing hemodialysis liquid samples with different urea nitrogen contents and creatinine contents, wherein the number of the samples meets the requirement of establishing a sample test model;
2) A near infrared spectrometer is adopted to carry out spectrum acquisition on a hemodialysis dialysate sample with urea nitrogen content and creatinine content;
3) Establishing a near infrared spectrum-based quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate;
4) And 3) carrying out near infrared spectrum acquisition on the hemodialysis dialyzate by using an on-line monitoring probe, comparing the acquired near infrared spectrum of urea nitrogen content and creatinine content in the dialyzate of the hemodialysis dialyzate with the quantitative identification model of urea nitrogen content and creatinine content in the dialyzate established in the step 3), and rapidly determining the urea nitrogen creatinine content in the dialyzate of the dialyzate to be detected.
Fig. 1 is a schematic diagram of an online monitoring system for urea nitrogen creatinine content in hemodialysis solution.
As shown in fig. 1, an online monitoring system for urea nitrogen creatinine content in hemodialysis solution includes: blood side circulation, dialysate side circulation and dialyzer 4. The dialyzer 4 has hollow fiber membranes 5 and a dialysate side 12.
The blood side circulation includes a human arterial blood output side 1, a blood pump 2, an arterial blood circulation conduit 3, a venous blood circulation conduit 6, and a human venous blood input side 8. The arterial blood circulation conduit 3 is connected with the arterial blood output side 1 of the human body and the blood inlet of the dialyzer 4, and the blood pump 2 is arranged on the arterial blood circulation conduit 3; the venous blood circulation conduit 6 connects the blood outlet of the dialyzer 4 with the venous blood inlet side 8 of the person.
The dialysate side circulation includes a dialysate tank 9, a dialysate pump 10, a dialysate inlet line 11, a dialysate monitoring probe 14, a dialysate outlet line 13, a dialysate recovery tank 15, a near infrared spectrum detection data line 16, and a near infrared spectrum monitor 17. A dialysate inlet line 11 connects the dialysate barrel 9 and the dialysate inlet of the dialyzer 4, and a dialysate pump 10 is provided on the dialysate inlet line 11; the dialysate outlet line 13 connects the dialysate outlet of the dialyzer 4 and the dialysate recovery tank 15; the dialysate monitoring probe 14 is arranged on the dialysate outlet pipeline 13, and the near infrared spectrum detection data line 16 is connected with the dialysate monitoring probe 14 and the near infrared spectrum monitor 17; the dialysate monitoring probe 14 collects the near infrared spectrum of urea nitrogen creatinine content in the dialysate exiting the dialyzer 4; the near infrared spectrum monitor 17 obtains a near infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe 14, and obtains and records the urea nitrogen creatinine content in the hemodialysis dialysate based on comparison of a quantitative identification model of the urea nitrogen creatinine content in the hemodialysis dialysate of the near infrared spectrum.
An online monitoring system for urea nitrogen creatinine content in hemodialysis solution further comprises a bubble capturing monitor 7 and a heparin pump 20. A bubble trap monitor 7 is provided on the venous blood circulation catheter 6. A heparin pump 20 is provided on the arterial blood circulation catheter 3.
The working flow of the online monitoring system for urea nitrogen creatinine content in hemodialysis liquid comprises the following steps: the blood output from the arterial blood output side 1 of the human body in the blood side circulation enters the dialyzer 4 through the blood pump 2 and the arterial blood circulation conduit 3, and the blood exchanges solute with the dialysate through the hollow fiber membrane 5 in the dialyzer 4 and returns to the human body through the venous blood circulation conduit 6 and the venous blood input side 8 of the human body. The dialysate in the clean dialysate barrel 9 circulated at the dialysate side enters the dialysate side 12 of the dialyzer through the dialysate pump 10 and the dialysate inlet pipeline 11, exchanges solute with blood in the hollow fiber membrane 5, and enters the used dialysate recycling barrel 15 through the dialysate channel and the dialysate outlet pipeline 13 in the dialysate monitoring probe 14; the dialysate monitoring probe 14 collects near infrared spectrum of the dialysate from the dialyzer 4, and obtains urea nitrogen creatinine content in the hemodialysis dialysate by comparing with a quantitative identification model of urea nitrogen content and creatinine content in the hemodialysis dialysate based on near infrared spectrum through the near infrared spectrum detection data line 16 and the near infrared spectrum monitor 17 and recording in real time.
The quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate based on near infrared spectrum refers to preparing hemodialysis dialysate samples with different urea nitrogen content and creatinine content, and performing spectrum acquisition on the dialysate samples by adopting a near infrared spectrometer, so that the quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate based on near infrared spectrum is established.
Blood from the dialyzer 4 is returned to the human body through the venous blood circulation tube 6, the bubble trap monitor 7, and the human venous blood input side 8.
The blood output from the arterial blood output side 1 of the human body enters the dialyzer 4 through the blood pump 2, the heparin pump 20 and the arterial blood circulation conduit 3; the prepared injection is injected into blood through the heparin pump 20.
Fig. 2 is a schematic structural view of a dialysate monitoring probe according to the present invention.
As shown in fig. 2, the dialysate monitoring probe 14 includes a probe housing 21, a dialysate channel 24, a near infrared receiving chamber 29, and a near infrared emitting chamber 32; the near infrared receiving chamber 29 and the near infrared transmitting chamber 32 are respectively arranged at two sides of the probe shell 21, the middle part of the near infrared receiving chamber penetrates through the probe shell 21 through the dialysate channel 24, the near infrared receiving chamber 29 and the near infrared transmitting chamber 32 are respectively communicated with the dialysate channel 24 through the near infrared receiving hole 25 and the near infrared transmitting hole 30, and the near infrared receiving hole 25 and the near infrared transmitting hole 30 are coaxial; the near infrared emission chamber 32 is provided with a near infrared emission tube 31 at the position of the near infrared emission hole 30; the near infrared receiving chamber 29 is provided with a near infrared receiving pipe 27 at the position of the near infrared receiving hole 25; the near infrared receiving chamber 29 is provided with a circuit board 28 communicated with the near infrared receiving tube 27; the dialysate channel 24 is connected to the dialysate outlet or dialysate outlet line 13 of the dialyzer 4 and is fed to the spent dialysate recovery tank 15.
The outside of the probe shell 21 is provided with a connector 23, and the connector 23 is communicated with the near infrared receiving chamber 29, the near infrared transmitting chamber 32 and the outside through a wire guide 22; the dialysate channel 24 is provided with quartz glass 33 covering the near infrared receiving hole 25 and the near infrared emitting hole 30; the dialysate monitoring probe 14 further comprises two sealing caps 26 connected to the probe housing 21 to form a near infrared receiving chamber 29 and a near infrared transmitting chamber 32, respectively.
The dialysate in the dialysate channel 24 is monitored by near infrared light, the collected spectrum signals are led out from the conduit through the connector 23 by the wires inside the dialysate monitoring probe 14, and the urea nitrogen creatinine content in the hemodialysis dialysate is obtained by a near infrared spectrum detection data line and a near infrared spectrum monitor and recorded in real time.
The seal cap 26 is connected with the probe housing 21 by seal threads.
The connector 23, the probe housing 21 and the seal cover 26 are made of stainless steel.
Near infrared light is transmitted perpendicularly through the dialysate in the dialysate channel 24.
The technical characteristics, experimental steps and the like which are not described in the invention are matched by adopting the mature prior art.
While the present invention has been described with reference to the preferred embodiments, it will be understood by those skilled in the art that the foregoing and various other changes, modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims.
Claims (8)
1. A method for on-line monitoring urea nitrogen creatinine content in hemodialysis dialysate is characterized by comprising the following steps of: the method comprises the following steps:
1) Preparing hemodialysis liquid samples with different urea nitrogen contents and creatinine contents;
2) Respectively carrying out spectrum acquisition on hemodialysis dialysate samples with urea nitrogen content and creatinine content by adopting a near infrared spectrometer;
3) Establishing a near infrared spectrum-based quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate;
4) And 3) carrying out near infrared spectrum acquisition on the hemodialysis dialyzate by using an on-line monitoring probe, comparing the acquired near infrared spectrum of urea nitrogen content and creatinine content in the dialyzate at the outlet of the dialyzate with the quantitative identification model of urea nitrogen content and creatinine content in the dialyzate established in the step 3), and determining the urea nitrogen creatinine content in the dialyzate at the outlet of the dialyzate to be detected.
2. The method for on-line monitoring of urea nitrogen creatinine content in hemodialysis solution according to claim 1, wherein the method comprises the following steps:
the quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate based on near infrared spectrum refers to preparing hemodialysis dialysate samples with different urea nitrogen content and creatinine content, and performing spectrum acquisition on the dialysate samples by adopting a near infrared spectrometer, so that the quantitative identification model of urea nitrogen content and creatinine content in hemodialysis dialysate based on near infrared spectrum is established.
3. An on-line monitoring system for urea nitrogen creatinine content in hemodialysis dialysate is characterized in that: comprising, a blood side circulation, a dialysate side circulation and a dialyzer (4);
the blood side circulation comprises a human body arterial blood output side (1), a blood pump (2), an arterial blood circulation catheter (3), a venous blood circulation catheter (6) and a human body venous blood input side; the arterial blood circulation conduit (3) is connected with the arterial blood output side (1) of the human body and the blood inlet of the dialyzer (4), and the blood pump (2) is arranged on the arterial blood circulation conduit (3); the venous blood circulation conduit (6) connects the blood outlet of the dialyzer (4) and the venous blood input side (8) of the person;
the dialysate side circulation comprises a dialysate barrel (9), a dialysate pump (10), a dialysate inlet pipeline (11), a dialysate monitoring probe (14), a dialysate outlet pipeline (13), a dialysate recovery barrel (15), a near infrared spectrum detection data line (16) and a near infrared spectrum monitor (17); the dialysate inlet pipeline (11) is connected with the dialysate barrel (9) and a dialysate inlet of the dialyzer (4), and the dialysate pump (10) is arranged on the dialysate inlet pipeline (11); the dialysate outlet line (13) connects the dialysate outlet of the dialyzer (4) and the dialysate recovery tank (15); the dialysate monitoring probe (14) is arranged on the dialysate outlet pipeline (13), and the near infrared spectrum detection data line (16) is connected with the dialysate monitoring probe (14) and the near infrared spectrum monitor (17); the dialysate monitoring probe (14) collects near infrared spectra of urea nitrogen creatinine content in the dialysate from the dialyzer (4);
the near infrared spectrum monitor (17) acquires a near infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe (14), and obtains the urea nitrogen creatinine content in the hemodialysis dialysate based on quantitative identification model comparison of the urea nitrogen creatinine content in the hemodialysis dialysate of the near infrared spectrum and records in real time;
the online monitoring system for urea nitrogen creatinine content in hemodialysis dialysate is provided with a bubble capturing monitor (7) which is arranged on a venous blood circulation catheter (6).
4. The on-line monitoring system for urea nitrogen creatinine content in hemodialysis solution of claim 3, wherein:
the dialysate monitoring probe (14) comprises a probe shell (21), a dialysate channel (24), a near infrared receiving chamber (29) and a near infrared transmitting chamber (32); the near infrared receiving chamber (29) and the near infrared transmitting chamber (32) are respectively arranged at two sides of the probe shell (21), the middle part of the near infrared receiving chamber penetrates through the probe shell (21) through the dialysate channel (24), the near infrared receiving chamber (29) and the near infrared transmitting chamber (32) are respectively communicated with the dialysate channel (24) through the near infrared receiving hole (25) and the near infrared transmitting hole (30), and the near infrared receiving hole (25) and the near infrared transmitting hole (30) are coaxial; the near infrared transmitting chamber (32) is provided with a near infrared transmitting tube (31) at the position of the near infrared transmitting hole (30); the near infrared receiving chamber (29) is provided with a near infrared receiving pipe (27) at the position of the near infrared receiving hole (25); the near infrared receiving chamber (29) is provided with a circuit board (28) which is communicated with the near infrared receiving tube (27); the dialysate channel (24) is connected with a dialysate outlet or a dialysate outlet pipeline (13) of the dialyzer (4) and is conveyed to a used dialysate recovery barrel (15);
the probe shell (21) is externally provided with a connector (23), and the connector (23) is communicated with a near infrared receiving chamber (29), a near infrared transmitting chamber (32) and the outside through a wire guide (22); the dialysate channel (24) is provided with quartz glass (33) which covers the near infrared receiving hole (25) and the near infrared transmitting hole (30); the dialysate monitoring probe (14) further comprises two sealing covers (26) connected with the probe shell (21) to form a near infrared receiving chamber (29) and a near infrared transmitting chamber (32) respectively;
the dialysate in the dialysate channel (24) is monitored by near infrared light, the collected spectrum signal is led out from the conduit through the connector (23) by the inner wire of the dialysate monitoring probe (14), and the urea nitrogen creatinine content in the hemodialysis dialysate is obtained by the near infrared spectrum detection data line (16) and the near infrared spectrum monitor (17) and recorded in real time.
5. The on-line monitoring system for urea nitrogen creatinine content in hemodialysis solution according to claim 4, wherein:
the sealing cover (26) is connected with the probe shell (21) through sealing threads.
6. The on-line monitoring system for urea nitrogen creatinine content in hemodialysis solution according to claim 4, wherein:
the connector (23), the probe shell (21) and the sealing cover (26) are made of stainless steel.
7. The on-line monitoring system for urea nitrogen creatinine content in hemodialysis solution according to claim 4, wherein:
the near infrared light is transmitted vertically through the dialysate in the dialysate channel (24).
8. The on-line monitoring system for urea nitrogen creatinine content in hemodialysis solution of claim 3, wherein:
the online monitoring system for urea nitrogen creatinine content in hemodialysis dialysate is provided with a heparin pump (20) which is arranged on an arterial blood circulation catheter (3); the prepared injection is injected into blood by a heparin pump (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710282694.6A CN106990068B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710282694.6A CN106990068B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106990068A CN106990068A (en) | 2017-07-28 |
| CN106990068B true CN106990068B (en) | 2023-07-11 |
Family
ID=59417088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710282694.6A Active CN106990068B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106990068B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105950704A (en) * | 2016-04-26 | 2016-09-21 | 天津市宝坻区人民医院 | Method for simultaneous determination of double items of urea nitrogen and creatinine in serum |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019592A1 (en) * | 1996-11-01 | 1998-05-14 | Rio Grande Medical Technologies, Inc. | Dialysis monitoring method and apparatus |
| CN103889481B (en) * | 2011-08-02 | 2016-03-09 | 美敦力公司 | With the hemodialysis system of flow path with controlled compliance volume |
| US11674903B2 (en) * | 2014-04-23 | 2023-06-13 | Virginia Tech Intellectual Properties, Inc. | System and method for monitoring the health of dialysis patients |
| CN206710304U (en) * | 2017-04-26 | 2017-12-05 | 上海健康医学院 | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis dialyzate |
-
2017
- 2017-04-26 CN CN201710282694.6A patent/CN106990068B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105950704A (en) * | 2016-04-26 | 2016-09-21 | 天津市宝坻区人民医院 | Method for simultaneous determination of double items of urea nitrogen and creatinine in serum |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106990068A (en) | 2017-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1083576C (en) | Fluid sampling module | |
| KR100318579B1 (en) | Hemodialysis Monitor System for Hemodialysis Machine | |
| US7537688B2 (en) | Blood purification device | |
| KR19990029075A (en) | Hemodialysis monitor system for hemodialysis | |
| US4266021A (en) | Method and apparatus for the measurement of the concentration of a compound in a liquid medium | |
| JP2016517734A (en) | Biological fluid separation device and biological fluid separation and inspection system | |
| CN106918573B (en) | Online monitoring method and system for creatinine content in hemodialysis dialysate | |
| CN106983923B (en) | Online monitoring method and system for urea nitrogen content in hemodialysis blood | |
| CN106990068B (en) | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis dialysate | |
| CN106896082B (en) | Online monitoring method and system for urea nitrogen creatinine content in hemodialysis blood | |
| CN106970043B (en) | Online monitoring method and system for urea nitrogen content in hemodialysis dialysate | |
| CN106908410B (en) | Online monitoring method and system for creatinine content in hemodialysis blood | |
| CN206710304U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis dialyzate | |
| CN207147968U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN209173054U (en) | A kind of filtering device for blood dialysis with blood filtering function | |
| CN207101561U (en) | A kind of haemodialyser for the detectable liquid level being easily installed | |
| Aukland | Spectrophotometric determination of hemoglobin oxygen saturation in small blood samples | |
| JPS6323099Y2 (en) | ||
| CN219391938U (en) | Full-automatic binary channels glycosylated hemoglobin analyzer | |
| CN110779961A (en) | Bicarbonate radical detection device, use method thereof and dialysis machine | |
| CN102711607B (en) | Gravity flow mensuration system | |
| TWI678214B (en) | Blood analysis module and blood collection device | |
| CN113694280B (en) | Method for monitoring in-vitro dialyzer toxin content distribution in real time | |
| Cattini et al. | Design and performance of an Hb measuring system: Viability of its use in a haemodialysis | |
| CN111398186A (en) | Hemoglobin and derivative testing device thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |