CN219391938U - Full-automatic binary channels glycosylated hemoglobin analyzer - Google Patents
Full-automatic binary channels glycosylated hemoglobin analyzer Download PDFInfo
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- CN219391938U CN219391938U CN202320591610.8U CN202320591610U CN219391938U CN 219391938 U CN219391938 U CN 219391938U CN 202320591610 U CN202320591610 U CN 202320591610U CN 219391938 U CN219391938 U CN 219391938U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The utility model discloses a full-automatic double-channel glycosylated hemoglobin analyzer, which comprises an analyzer body, wherein a sample injection disc assembly for loading a sample tube to be measured is arranged outside the analyzer body; a sample injection needle assembly is arranged in the analyzer body, a sample to be detected is sucked through a sample injection needle of the sample injection needle assembly for detection, and the sample injection needle is also connected with a hemolytic agent reagent bottle for sucking a hemolytic agent and cleaning the sample injection needle; one end of the glycosylated hemoglobin analysis assembly is connected with a hemolysis tank so that the hemolysis agent sucked by the sample injection needle and the sample to be tested are uniformly mixed in the hemolysis tank; the other end of the glycosylated hemoglobin analysis assembly is connected with a plurality of eluent reagent bottles, the sample to be tested is eluted through the eluent, single-wavelength visible light emitted by the optical system passes through the colorimetric pool and then passes through the photocell, and the photocell converts an optical signal into a detection result of an electric signal and transmits the detection result to the processing unit of the analyzer.
Description
Technical Field
The utility model relates to the technical field of glycosylated hemoglobin analyzers, in particular to a full-automatic dual-channel glycosylated hemoglobin analyzer.
Background
Glycosylated hemoglobin analyzer is to measure HbA 1c The instrument which can most respond the combination degree of the hemoglobin and the glucose, and the glycosylated hemoglobin is a good index of the disease control degree of diabetics and can reflect the staged blood sugar level. Glycosylated hemoglobin HbA 1c The method is widely used in clinic as an effective detection index for screening, diagnosing, controlling blood sugar and checking curative effect of diabetes.
But measuring HbA 1c The horizontal large-scale instrument is usually single-channel, and the steps of one detection comprise sample suction, sample analysis and pipeline flushing, and each detection needs to wait for the completion of all the steps to carry out the next detection, so that the detection analysis efficiency of the glycosylated hemoglobin analyzer is low, and the increasingly-large sample detection requirements are difficult to meet.
Disclosure of Invention
The utility model aims to provide a full-automatic double-channel glycosylated hemoglobin analyzer, which is characterized in that two sets of glycosylated hemoglobin analysis assemblies are arranged left and right, analysis and cleaning processes are overlapped, and a set of sample injection needle, a hemolysis pool, an eluent reagent bottle and a waste liquid bottle for collecting waste liquid are shared; the analysis efficiency of the analyzer is improved by nearly one time compared with that of the original single assembly component instrument.
In order to solve the technical problems, the utility model provides a full-automatic double-channel glycosylated hemoglobin analyzer, which comprises an analyzer body, wherein a sample feeding disc assembly for loading a sample tube to be measured is arranged on the outer side of the analyzer body;
a sample injection needle assembly is arranged in the analyzer body, a sample to be detected is sucked through a sample injection needle of the sample injection needle assembly for detection, and the sample injection needle is also connected with a hemolytic agent reagent bottle for sucking a hemolytic agent and cleaning the sample injection needle;
one end of the glycosylated hemoglobin analysis assembly is connected with a hemolysis tank so that the hemolysis agent sucked by the sample injection needle and the sample to be tested are uniformly mixed in the hemolysis tank;
the other end of the glycosylated hemoglobin analysis assembly is connected with a plurality of eluent reagent bottles, the sample to be tested is eluted through the eluent, single-wavelength visible light emitted by the optical system passes through the colorimetric pool and then passes through the photocell, and the photocell converts an optical signal into a detection result of an electric signal and transmits the detection result to the processing unit of the analyzer.
Preferably, the two sets of glycosylated hemoglobin analysis assemblies are symmetrically arranged at the left side and the right side in the analyzer body, and the two sets of glycosylated hemoglobin analysis assemblies share the sample injection needle, the hemolysis tank, the eluent reagent bottle and the waste liquid bottle for collecting waste liquid.
Preferably, the glycosylated hemoglobin analysis assembly comprises a sample pump installed below the hemolysis tank, and the sample to be tested is pumped into the optical system for detection by the sample pump.
Preferably, a reagent pump is installed on a pipeline between the eluent reagent bottle and the optical system, and the eluent is pumped by the reagent pump to elute the sample to be detected.
Preferably, a first bubble detector is installed on a pipeline in front of the reagent pump, and the first bubble detector detects whether the reagent entering the reagent pump contains bubbles or not.
Preferably, a pre-temperature tube, a pre-treatment column and a chromatographic column are sequentially arranged in a sample injection pipeline of the optical system along the flowing direction of the sample to be detected, and are used for separating the sample to be detected before the sample enters the optical system.
Preferably, a back flushing flow channel is also connected between the reagent pump and the chromatographic column, a positive and negative electromagnetic valve is arranged on the back flushing flow channel, and the eluent is pumped by the reagent pump to reversely flush the pre-warming pipe, the pretreatment column and the chromatographic column.
Preferably, a filter and a pipeline pressurizer are sequentially arranged on a sample outlet pipeline of the optical system along the flowing direction of the sample to be detected, and the sample is discharged into a waste liquid bottle through the filter and the pipeline pressurizer.
Preferably, a second sample pump is installed on a pipeline between the sample injection needle and the hemolytic agent reagent bottle, and the sample to be detected or the hemolytic agent in the hemolytic agent reagent bottle is sucked by the second sample pump.
Preferably, a second bubble detector is installed on the pipeline in front of the second sample pump, and the second bubble detector detects whether the hemolytic agent entering the second sample pump contains bubbles or not.
Compared with the prior art, the utility model has the beneficial effects that:
1. the utility model utilizes the principle of cation exchange chromatography, adopts the method of ion exchange chromatography column chromatography, and separates each sub-component of glycosylated hemoglobin through elution. Then measuring the eluted sub-component (HbA) of the glycosylated hemoglobin by a single wavelength visible light colorimetric method 1ab 、HbA 1c ) Thereby obtaining the percentage of each sub-component of glycosylated hemoglobin in the hemoglobin;
2. in addition, the full-automatic double-channel glycosylated hemoglobin analyzer is provided with two sets of glycosylated hemoglobin analysis assemblies at left and right, the analysis and cleaning processes are overlapped, and a set of sample injection needle, a hemolysis pool, an eluent reagent bottle and a waste liquid bottle for collecting waste liquid are shared; after the assembly component on one side completes the suction of one sample under the control of a program, the assembly component on the other side sucks the next sample, so that the analysis efficiency of the analyzer is improved by nearly one time compared with that of the original single assembly component instrument.
Drawings
FIG. 1 is a side view of a fully automatic dual channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 2 is a schematic diagram showing the internal structure of a fully automatic dual-channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 3 is a front view of a fully automatic dual channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 4 is a schematic diagram of a fully automatic dual-channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 5 is a schematic diagram of a glycosylated hemoglobin analysis assembly of the left side of a full-automatic dual-channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 6 is a schematic diagram of a glycosylated hemoglobin analysis assembly on the right side of a full-automatic dual-channel glycosylated hemoglobin analyzer according to the present utility model;
FIG. 7 is a schematic diagram of a glycosylated hemoglobin analysis assembly according to the present utility model.
In the figure: 1. an analyzer body; 2. a sample introduction disc assembly; 3. a sample injection needle assembly; 4. a glycosylated hemoglobin analysis assembly; 5. a hemolytic agent reagent bottle; 6. a hemolysis pool; 7. an eluent reagent bottle; 8. a waste liquid bottle; 31. a sample injection needle; 41. a first sample pump; 42. an optical system; 43. a reagent pump; 44. a pre-warming pipe; 45. a pretreatment column; 46. a chromatographic column; 47. back flushing the runner; 48. a filter; 49. a filter; 410. a first bubble detector; 411. a second sample pump; 412. and a second bubble detector.
Detailed Description
The utility model is described in further detail below with reference to the attached drawings and specific examples. Advantages and features of the utility model will become more apparent from the following description and from the claims. It should be noted that the drawings are in a very simplified form and are all to a non-precise scale, merely for convenience and clarity in aiding in the description of embodiments of the utility model.
In the description of the present utility model, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the present utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art in a specific case.
Examples
The utility model provides a full-automatic double-channel glycosylated hemoglobin analyzer, referring to fig. 1-4, comprising an analyzer body 1, wherein a sample feeding tray assembly 2 for loading a sample tube to be measured is arranged outside the analyzer body 1; a sample injection needle assembly 3 is arranged in the analyzer body 1, a sample to be detected is sucked through a sample injection needle 31 of the sample injection needle assembly 3 for detection, and the sample injection needle 31 is also connected with a hemolytic agent reagent bottle 5 for sucking a hemolytic agent and cleaning the sample injection needle; two sets of glycosylated hemoglobin analysis assemblies 4, wherein one end of each glycosylated hemoglobin analysis assembly 4 is connected with a hemolysis tank 6, so that the hemolysis agent sucked by the sample injection needle 31 and the sample to be tested are uniformly mixed in the hemolysis tank 6; the other end of the glycosylated hemoglobin analysis assembly 4 is connected with a plurality of eluent reagent bottles 7, the sample to be tested is eluted through the eluent, single-wavelength visible light emitted by the optical system passes through the colorimetric pool and then passes through the photocell, and the photocell converts a light signal into a detection result of an electric signal and transmits the detection result to the processing unit of the analyzer.
Wherein, the analyzer adopts classical accurate methodology principle-liquid chromatography ion exchange chromatography, and the existing test method is used for analyzing HbA 1c Can directly separate HbA from gold standard 1c And the point-by-point absorbance is continuously measured on line, and the accuracy is obtained through integrationAnalysis method of area percentage. The adoption of the real-time chromatographic display technology presents the original data according to the basic principle of an analysis instrument, reproduces the testing process and provides a credible result for clinic. And the influence of bubbles on detection results is reduced by the automatic detection and elimination technology of bubbles in the colorimetric pool.
In the utility model, the sample feeding disc assembly 2 comprises a rotating motor, an index disc, a 0-bit disc and a photoelectric sensor, wherein the rotating motor drives the circular test tube rack to rotate under the control of a program, the 0-bit disc and the photoelectric sensor cooperate to provide an initial origin for the program, and the index disc and the photoelectric sensor cooperate to accurately determine the rotating angle for the program.
Specifically, referring to fig. 5 and 6, two sets of the glycosylated hemoglobin analysis assemblies 4 are symmetrically installed at the left and right sides in the analyzer body 1, and the two sets of the glycosylated hemoglobin analysis assemblies 4 share the sample injection needle 31, the hemolysis tank 6, the eluent reagent bottle 7 and the waste liquid bottle 8 for collecting waste liquid.
In this embodiment, referring to fig. 4 and 7, the glycosylated hemoglobin analysis assembly 4 includes a first sample pump 41 installed below the hemolysis tank 6, and the sample to be tested is pumped into the optical system 42 for detection by the first sample pump 41.
The optical system 42 includes a light source, a cuvette, and a photocell; the light passes through the photocell after passing through the cuvette, and the photocell converts the light signal into an electric signal.
Further, a reagent pump 43 is installed on a pipeline between the eluent reagent bottle 7 and the optical system 42, and the eluent is pumped by the reagent pump 43 to elute the sample to be tested.
A first bubble detector 410 is installed on the pipeline in front of the reagent pump 43, and the first bubble detector 410 detects whether the reagent entering the reagent pump 43 contains bubbles, so as to avoid the influence of the bubbles on the detection result.
A pre-temperature tube 44, a pre-treatment column 45 and a chromatographic column 46 are sequentially arranged in the sample feeding pipeline of the optical system 42 along the flowing direction of the sample to be detected, and are used for separating the sample to be detected before entering the optical system 42. The pre-temperature tube 44 prevents the high performance liquid chromatography column and the reagent from being influenced by the change of the ambient temperature, and the high performance liquid chromatography column is filled with 0.5-5 g of inlet resin, so that the accuracy of the test result is improved; the provided high-sensitivity integrated photometer enables the wavelength to be accurate, the light source to be stable, an all-aluminum alloy structure is adopted, the anti-interference capability is strong, the light source passes through the micro cuvette through the focusing of a plurality of lenses, the high-sensitivity receiving element converts the optical signal into an electric signal to be output to the processing unit, and the curve is recorded and analyzed.
The pre-heating tube 44 has the function of regulating the temperature of the pre-treatment column 45, the chromatographic column 46, the eluent and the sample, so that the temperature in the column is always kept at about 20-30 ℃, the accuracy of the sample measurement result is facilitated, the pre-heating tube 44 contains the pre-treatment column and the chromatographic column, the pre-treatment column prevents the sample from blocking the chromatographic column, the chromatographic column is protected, and the chromatographic column is separated from the sample.
A back flushing flow passage 47 is also connected between the reagent pump 43 and the chromatographic column 46, a positive and negative electromagnetic valve is arranged on the back flushing flow passage 47, and the eluent is pumped by the reagent pump 43 to reversely flush the pre-warming pipe 44, the pretreatment column 45 and the chromatographic column 46, and the eluent is pumped into a waste liquid bottle after repeated flushing.
Further, a filter 48 and a line booster 49 are sequentially provided on the outlet pipe of the optical system 42 along the flow direction of the sample to be measured, and the sample is discharged into the waste liquid bottle 8 through the filter 48 and the line booster 49.
Further, a second sample pump 411 is installed on a pipeline between the sample injection needle 31 and the hemolytic agent reagent bottle 5, and the sample pump 411 is used for sucking the sample to be detected or the hemolytic agent in the hemolytic agent reagent bottle 5; and a second bubble detector 412 is installed on the pipeline in front of the second sample pump 411, and the second bubble detector 412 detects whether the hemolytic agent entering the second sample pump 411 contains bubbles.
The above description is only illustrative of the preferred embodiments of the present utility model and is not intended to limit the scope of the present utility model, and any alterations and modifications made by those skilled in the art based on the above disclosure shall fall within the scope of the appended claims.
Claims (10)
1. The full-automatic double-channel glycosylated hemoglobin analyzer is characterized by comprising an analyzer body (1), wherein a sample injection disc assembly (2) for loading a sample tube to be measured is arranged outside the analyzer body (1);
a sample injection needle assembly (3) is arranged in the analyzer body (1), a sample to be detected is sucked through a sample injection needle (31) of the sample injection needle assembly (3) for detection, and the sample injection needle (31) is also connected with a hemolytic agent reagent bottle (5) for sucking a hemolytic agent and cleaning the sample injection needle;
and two sets of glycosylated hemoglobin analysis assemblies (4), wherein one end of each glycosylated hemoglobin analysis assembly (4) is connected with a hemolysis tank (6) so that the hemolysis agent sucked by the sample injection needle (31) and the sample to be tested are uniformly mixed in the hemolysis tank (6);
the other end of the glycosylated hemoglobin analysis assembly (4) is connected with a plurality of eluent reagent bottles (7), a sample to be tested is eluted through the eluent, single-wavelength visible light is emitted by an optical system, passes through a photocell after passing through a colorimetric pool, and a detection result of converting a light signal into an electric signal by the photocell is transmitted to a processing unit of the analyzer.
2. The full-automatic dual-channel glycosylated hemoglobin analyzer as claimed in claim 1, wherein two sets of glycosylated hemoglobin analysis assemblies (4) are symmetrically installed at the left and right sides in the analyzer body (1), and the two sets of glycosylated hemoglobin analysis assemblies (4) share the sample injection needle (31), the hemolysis tank (6), the eluent reagent bottle (7) and the waste liquid bottle (8) for collecting waste liquid.
3. A fully automatic two channel glycosylated hemoglobin analyzer according to claim 2, characterized in that the glycosylated hemoglobin analysis assembly (4) comprises a sample pump one (41) arranged below the hemolysis tank (6), and that a sample to be measured is pumped into an optical system (42) for detection by means of the sample pump one (41).
4. The full-automatic dual-channel glycosylated hemoglobin analyzer as claimed in claim 2, wherein a reagent pump (43) is installed on a pipeline between the eluent reagent bottle (7) and the optical system (42), and the eluent is pumped by the reagent pump (43) to elute the sample to be measured.
5. The fully automatic two-channel glycosylated hemoglobin analyzer according to claim 4, wherein a first bubble detector (410) is installed on a pipeline in front of the reagent pump (43), and whether the reagent entering the reagent pump (43) contains bubbles is detected by the first bubble detector (410).
6. The fully automatic two-channel glycosylated hemoglobin analyzer as claimed in claim 4, characterized in that a pre-temperature tube (44), a pre-treatment column (45) and a chromatography column (46) are sequentially arranged in the sample feeding pipeline of the optical system (42) along the flow direction of the sample to be measured, for the separation treatment of the sample to be measured before entering the optical system (42).
7. The full-automatic double-channel glycosylated hemoglobin analyzer according to claim 6, further comprising a back flushing flow channel (47) connected between the reagent pump (43) and the chromatographic column (46), wherein a back flushing solenoid valve is installed on the back flushing flow channel (47), and an eluent back flushing pre-warming tube (44), a pre-treatment column (45) and the chromatographic column (46) are pumped by the reagent pump (43).
8. The full-automatic double-channel glycosylated hemoglobin analyzer according to claim 2, characterized in that a filter (48) and a pipeline pressurizer (49) are sequentially arranged on the outlet pipe of the optical system (42) along the flow direction of the sample to be measured, and the waste liquid is discharged into the waste liquid bottle (8) through the filter (48) and the pipeline pressurizer (49).
9. The full-automatic dual-channel glycosylated hemoglobin analyzer as claimed in claim 2, wherein a second sample pump (411) is installed on a pipeline between the sample injection needle (31) and the hemolytic agent reagent bottle (5), and the hemolytic agent in the sample to be measured or the hemolytic agent reagent bottle (5) is sucked by the second sample pump (411).
10. The fully automatic two-channel glycosylated hemoglobin analyzer according to claim 9, wherein a second bubble detector (412) is installed on a line before the second sample pump (411), and whether the hemolytic agent entering the second sample pump (411) contains bubbles is detected by the second bubble detector (412).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320591610.8U CN219391938U (en) | 2023-03-23 | 2023-03-23 | Full-automatic binary channels glycosylated hemoglobin analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320591610.8U CN219391938U (en) | 2023-03-23 | 2023-03-23 | Full-automatic binary channels glycosylated hemoglobin analyzer |
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| Publication Number | Publication Date |
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| CN219391938U true CN219391938U (en) | 2023-07-21 |
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| CN202320591610.8U Active CN219391938U (en) | 2023-03-23 | 2023-03-23 | Full-automatic binary channels glycosylated hemoglobin analyzer |
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| CN (1) | CN219391938U (en) |
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- 2023-03-23 CN CN202320591610.8U patent/CN219391938U/en active Active
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