CN106983848A - A kind of swelling and pain relieving emplastrum and preparation method thereof - Google Patents

A kind of swelling and pain relieving emplastrum and preparation method thereof Download PDF

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Publication number
CN106983848A
CN106983848A CN201710337996.9A CN201710337996A CN106983848A CN 106983848 A CN106983848 A CN 106983848A CN 201710337996 A CN201710337996 A CN 201710337996A CN 106983848 A CN106983848 A CN 106983848A
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swelling
emplastrum
pain relieving
extract
volatile
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CN106983848B (en
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曾利杰
陈丽斯
江涛
彭红英
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GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARMACEUTICAL Co Ltd
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GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of swelling and pain relieving emplastrum, ointment and pharmaceutical plaster substrate are included；The ointment includes traumatic injury and rheumatism liquid extract；The preparing raw material of the traumatic injury and rheumatism liquid extract includes following components：Safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, Kaempferia galanga and Semen Strychni.Swelling and pain relieving emplastrum of the present invention uses supercritical CO in preparation process2Abstraction technique extracts the volatile oil in medicine, improves volatile oil extracting rate, reduces the destruction of active ingredient；Volatile medicine inclusion compound is prepared using inclusion technique, reduce effumability active ingredient Moschus traumatic injury and rheumatism cream prepare and storage process in loss, improve curative effect of medication, to rheumatism, swell and ache, arthralgia has preferable curative effect.

Description

A kind of swelling and pain relieving emplastrum and preparation method thereof
Technical field
The present invention relates to a kind of emplastrum, and in particular to a kind of swelling and pain relieving emplastrum and preparation method thereof.
Background technology
Volatile oil (volatile oils, VO) is also referred to as essential oil, is that the class being present in plant has volatility can be with water Steam distillation and the general name of the not miscible oily liquids of water.The characteristics of volatile oil has strong lipophilicity, low boiling point, existing market On swelling and pain relieving emplastrum preparation method in, volatile oil mainly uses solvent extraction method, conventional molten of solvent extraction method Agent is petroleum ether, ether, carbon tetrachloride etc., and the medicinal material such as schizonepeta, Kaempferia galanga and rhizoma zingiberis is generally used plus 90% ethanol is heated to reflux carrying Take, the polarity of 90% ethanol is big, it is impossible to fully extract the volatile oil in schizonepeta, Kaempferia galanga and rhizoma zingiberis, while extraction process temperature is high, Extraction time is long, easily causes the destruction to thermally labile and oxidizable composition, is unfavorable for playing the curative effect of medicine.In the market Swelling and pain relieving emplastrum preparation method in, ethereal oil is directly mixed and made into coating with host material, carries out painting cream, segment, Lid lining, stripping and slicing easily causes the loss of volatile ingredient, causes curative effect of medication to reduce.Traditional rubber agent uses gasoline slurrying, unfavorable In environmental protection, and take off after and to pull tool pain, easily occur allergic reaction, patient medication compliance is poor.
The content of the invention
It is an object of the invention to overcome prior art exist weak point and provide a kind of swelling and pain relieving emplastrum and its Preparation method.
To achieve the above object, the technical scheme taken of the present invention is：A kind of swelling and pain relieving emplastrum, comprising ointment and medicinal Plaster stroma；The ointment includes traumatic injury and rheumatism liquid extract；The preparing raw material of the traumatic injury and rheumatism liquid extract includes following components： Safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, Kaempferia galanga and Semen Strychni；
The preparation method of the traumatic injury and rheumatism liquid extract comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga, are weighed, is placed in supercritical extracting equipment, CO is carried out2Supercritical extract, is carried Take thing A and dregs of a decoction B；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, it is mixed with dregs of a decoction B Close, then Jia 80~90% ethanol solution heating and refluxing extraction, obtain extract, extract is concentrated to give relatively close at 80 DEG C Spend the thick paste C for 1.2~1.25；
(3), extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
The preparation of traumatic injury and rheumatism liquid extract employs supercritical CO in swelling and pain relieving emplastrum of the present invention2Extraction, is adopted Use supercritical CO2Abstraction technique extracts volatile oil in schizonepeta, Kaempferia galanga and rhizoma zingiberis, is heated back with prior art using 90% ethanol Flow extraction comparison, considerably improve the recovery rate of volatile oil, realize that low temperature extracts volatile oil component, reduce to thermally labile and The destruction of oxidizable composition, extractant used can be recycled and extract no solvent residue, consume energy lower more environmentally friendly.To super The dregs of a decoction B obtained after critical extraction again with safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the medicine such as the root of Dahurain angelica Extracted, further come out the volatile oil extracting in schizonepeta, Kaempferia galanga and rhizoma zingiberis using alcohol reflux.Thick paste C relative density is 1.2~1.25 refer to that the density of water relatively is 1.2~1.25, and relative density refers both to the density of relative water in the present invention.
Preferably, the CO2The condition of supercritical extract is：Extracting pressure is 20~30MPa, and extraction temperature is 40~50 DEG C, parsing pressure is 5~7MPa, and resolution temperature is 30~50 DEG C, and extraction time is 2.5~3.5 hours.
Volatile oil in schizonepeta, Kaempferia galanga and rhizoma zingiberis is in above-mentioned CO2When under conditions of supercritical extract, schizonepeta, Kaempferia galanga and dry The yield of volatile oil in ginger is more than 4.1%.
Preferably, the CO2The condition of supercritical extract is：Extracting pressure is 28MPa, and extraction temperature is 42 DEG C, parsing Pressure is 6MPa, and resolution temperature is 42 DEG C, and extraction time is 3 hours.
Volatile oil in schizonepeta, Kaempferia galanga and rhizoma zingiberis is in above-mentioned CO2When under conditions of supercritical extract, schizonepeta, Kaempferia galanga and dry The yield of volatile oil in ginger can reach 4.2%.
Preferably, the safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, Kaempferia galanga and raw Strychnos nux-vomica Son weight ratio be：Safflower：It is windproof：Rhizoma zingiberis：Radix Aconiti Kusnezoffii：Schizonepeta：Radix Aconiti：The root of Dahurain angelica：Line grass：Kaempferia galanga：Semen Strychni=0.8 ~1.2：3.8~4.2：5.8~6.2：1.8~2.2：3.8~4.2：1.8~2.2：5.8~6.2：3.8~4.2：5.8~ 6.2：1.8~2.2.
Safflower, with promoting blood circulation and removing blood stasis, effect of dissipate wet effect going to swell；It is windproof, with expelling pathogenic wind from the body surface, the work(of expel endogenous wind to relieve convulsion, only convulsion Effect；Rhizoma zingiberis, with warming spleen and stomach for dispelling cold, Back to Yang Tongmai, the effect of Wenfei of drink；Radix Aconiti Kusnezoffii, warming channel and expelling cold with dispelling wind and eliminating dampness, detumescence The effect of analgesic；Schizonepeta, there is town phlegm, wind-dispelling, the effect of cool blood；Radix Aconiti, with dispelling wind and eliminating dampness, the effect of antalgic；The root of Dahurain angelica, It is used as medicine with root, the effects such as the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain；Line grass, the effect of with subdhing swelling and detoxicating；Kaempferia galanga, tool There is cold dispelling, dry, warm taste ward off the function of bad odor；Semen Strychni, with removing obstruction in channels to relieve pain, effect of mass dissipating and swelling eliminating.Using above-mentioned Each compatibility of drugs, can make swelling and pain relieving emplastrum of the present invention play swelling and pain relieving and the wet effect of wind dispelling.
Preferably, the ointment includes the component of following parts by weight：280~320 parts of traumatic injury and rheumatism liquid extract, volatility medicine 110~130 parts of 280~320 parts of 500~550 parts of inclusion compound, belladonna liquid extract, the camphor of thing and muscone 0.35~0.45 Part；
Wherein, the inclusion compound of the volatile medicine includes volatile medicine, and the volatile medicine includes following components： Borneol, peppermint oil, basil oil, cinnamon oil and gaultherolin；Borneol, peppermint oil, basil oil, cinnamon oil and bigcatkin willow The weight ratio of sour methyl esters is：Borneol：Peppermint oil：Basil oil：Cinnamon oil：Gaultherolin=6:6:1:2:10.
Borneol has volatility, there is anti-inflammatory analgetic effect；Peppermint oil is volatile oil, with spasmolysis, anti-inflammatory and antalgic, promotees infiltration etc. Effect；Basil oil is volatile oil, containing trans-anethole (C10H12O 80.0%) is no less than, with analgesic effect；Cinnamon oil For volatile oil, containing cinnaldehydrum (C9H8O 75.0%) is no less than, with effects such as anti-inflammatory, antiallergy, wind-damp dispelling analgesias；Salicylic acid first Ester has volatility, can promote local blood circulation, and external application or local embrocate can produce that cutaneous vasodilation, the colour of skin are rubescent etc. to stimulate Reaction, and reflectivity influence skin, muscle, nerve and the joint of corresponding site, rise subside a swelling, anti-inflammatory and analgesic activity.Each medicine Thing, than compatibility, can increase the curative effect of swelling and pain relieving emplastrum by above-mentioned weight.
Preferably, the preparation method of the inclusion compound of the volatile medicine comprises the following steps：
(a) volatile medicine, is weighed by formula, the volatile medicine and ethanol is miscible, obtain the second of volatile materials Alcoholic solution, weighs beta-schardinger dextrin, and the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：5~7, by β-ring Dextrin is made into supersaturated solution, obtains the supersaturated solution of beta-schardinger dextrin；
(b), by the ethanol solution of the volatile materials with 3~5mL/min speed be added to 40~70 DEG C the β- In cyclodextrin supersaturated solution, 2~4h is stirred, rotating speed is 600~1000r/min, stop continuing to stir 4~6h after liquid feeding, obtain Volatile medicine mixed liquor；
(c) volatile medicine mixed liquor obtained by step (b), is placed in 2~5 DEG C of environment and freezes 12~24h, filtering must be filtered Slag；
(d), filter residue is placed at 30~50 DEG C and dried, the inclusion compound of volatile medicine is obtained.
Use of the volatile medicine in swelling and pain relieving emplastrum, may cause emplastrum to be volatilized in preparation and storage process, So that curative effect is reduced.Above-mentioned borneol, peppermint oil, basil oil, cinnamon oil and salicylic acid are included by using inclusion technique The taste effumability medicine of methyl esters 5, can reduce loss of the effumability active ingredient in the preparation of emplastrum and storage process, improve Curative effect of medication.
When the gross mass of volatile medicine and the mass ratio of beta-schardinger dextrin are less than 1:When 7, the volatility medicine of unit mass Volatile medicine is less in thing inclusion compound, includes thicker, it is more difficult to given play to the effect of volatile medicine；It is total when volatile medicine Quality and the mass ratio of beta-schardinger dextrin are more than 1:When 5, volatile medicine can not completely by beta-cyclodextrin inclusion compound, inclusion effect compared with Difference.Therefore, when the gross mass of volatile medicine and the mass ratio of beta-schardinger dextrin are 1：When 5~7, volatile medicine can be preferably In beta-schardinger dextrin, and the volatile medicine inclusion compound of unit mass can play preferable effect.
Preferably, the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：6.
Drawn through inventor's repeated tests, when volatile medicine gross mass and beta-schardinger dextrin mass ratio be 1： When 6, volatile medicine fully can be incorporated in beta-schardinger dextrin, and the effect of volatile medicine can be given full play of again.
Preferably, the pharmaceutical plaster substrate includes the component of following parts by weight：1400~1600 parts of rubber, tongued bell barium white 0 ~100 parts, 180~200 parts of zinc oxide, 900~1100 parts of rosin, 2650~2800 parts of liquid paraffin and vaseline 240~320 Part.
Preferably, the preparation method of the pharmaceutical plaster substrate is：
(i), rubber stripping and slicing, broken, plus gasoline are dipped to rubber and fully swollen and obtains A；
(ii), B is obtained after rosin heating dissolving；
(iii), A, B, tongued bell barium white, zinc oxide, liquid paraffin and vaseline are mixed to stir and produces emplastrum base Matter.
Present invention also offers a kind of preparation method of above-mentioned swelling and pain relieving emplastrum, the preparation side of the swelling and pain relieving emplastrum Method is：Belladonna liquid extract is weighed by constituent content, is concentrated, it is the thick of 1.2~1.3 belladonna to obtain relative density at 65~70 DEG C Cream；Then the thick paste of belladonna, traumatic injury and rheumatism liquid extract, the inclusion compound of volatile medicine, resina liquidamberis, camphor and muscone are added Enter into pharmaceutical plaster substrate, be coated on after being well mixed on nonwoven cloth material, dry, produce the swelling and pain relieving emplastrum.
The beneficial effects of the present invention are：The invention provides a kind of swelling and pain relieving emplastrum and preparation method thereof, the present invention The swelling and pain relieving emplastrum uses supercritical CO in preparation process2Abstraction technique extracts the volatile oil in medicine, improves and waves Hair oil recovery rate, reduces the destruction of active ingredient；Volatile medicine inclusion compound is prepared using inclusion technique, reducing effumability has Imitate composition Moschus traumatic injury and rheumatism cream prepare and storage process in loss, improve curative effect of medication, to rheumatism, swell and ache, arthritis Pain has preferable curative effect.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.
Embodiment 1
The ointment includes the component of following parts by weight：320 parts of traumatic injury and rheumatism liquid extract, the inclusion compound of volatile medicine 0.45 part of 550 parts, 320 parts of belladonna liquid extract, 130 parts of camphor and muscone；
The traumatic injury and rheumatism liquid extract includes following components：It is safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, white The root of Dahurian angelica, line grass, mountain and Semen Strychni；The safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, Kaempferia galanga Weight ratio with Semen Strychni is：Safflower：It is windproof：Rhizoma zingiberis：Radix Aconiti Kusnezoffii：Schizonepeta：Radix Aconiti：The root of Dahurain angelica：Line grass：Kaempferia galanga：Raw horse Money=1.2：4.2：6.2：2.2：4.2：2.2：6.2：4.2：6.2：2.2；
The inclusion compound of the volatile medicine includes volatile medicine, and the volatile medicine includes following components：Borneol, Peppermint oil, basil oil, cinnamon oil and gaultherolin；The borneol, peppermint oil, basil oil, cinnamon oil and bigcatkin willow The weight ratio of sour methyl esters is：Borneol：Peppermint oil：Basil oil：Cinnamon oil：Gaultherolin=6:6:1:2:10；
The pharmaceutical plaster substrate includes the component of following parts by weight：1400 parts of rubber, 180~200 parts of zinc oxide, rosin 240 parts of 900 parts, 2650 parts of liquid paraffin and vaseline.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga that medicinal material water content is less than 5%, are weighed by formula, 40~50 mesh is crushed to, is placed in In supercritical extracting equipment, CO is carried out2Supercritical extract, extraction conditions is：Extracting pressure is 20MPa, and extraction temperature is 40 DEG C, Parsing pressure is 5MPa, and resolution temperature is 30 DEG C, and extraction time is 3.5 hours, obtains extract A and dregs of a decoction B；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, it is mixed with dregs of a decoction B Close, then Jia 80~90% ethanol solution heating and refluxing extraction, obtain extract, extract is concentrated to give relatively close at 80 DEG C Spend the thick paste C for 1.2~1.25；
(3) extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
The preparation method of the inclusion compound of volatile medicine described in the present embodiment comprises the following steps：
(a) volatile medicine, is weighed by formula, the volatile medicine and ethanol is miscible, obtain the second of volatile materials Alcoholic solution, weighs beta-schardinger dextrin, and the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：7, β-ring is pasted Essence is made into supersaturated solution, obtains the supersaturated solution of beta-schardinger dextrin；
(b), the β-ring that the ethanol solution of the volatile materials is added into 70 DEG C with 3~5mL/min speed is pasted In smart supersaturated solution, 2h is stirred, rotating speed is 600r/min, stop continuing to stir 4h after liquid feeding, obtain volatile medicine mixed liquor；
(c) volatile medicine mixed liquor obtained by step (b), is placed in 2 DEG C of environment and freezes 12h, filtering obtains filter residue；
(d), filter residue is placed at 30 DEG C and dried, the inclusion compound of volatile medicine is obtained.
The preparation method of pharmaceutical plaster substrate described in the present embodiment is：
(i), rubber stripping and slicing, broken, plus gasoline are dipped to rubber and fully swollen and obtains A；
(ii), B is obtained after rosin heating dissolving；
(iii), A, B, zinc oxide, liquid paraffin and vaseline are mixed to stir and produces plaster stroma.
The preparation method of swelling and pain relieving emplastrum is described in the present embodiment：Belladonna liquid extract is weighed by constituent content, concentrates, obtains Relative density is the thick paste of 1.2~1.3 belladonna at 65~70 DEG C；Then by the thick paste of belladonna, traumatic injury and rheumatism liquid extract, volatilization Property medicine inclusion compound, resina liquidamberis, camphor and muscone add into pharmaceutical plaster substrate, it is well mixed after be coated on nonwoven On cloth material, dry, produce swelling and pain relieving emplastrum.
Embodiment 2
A kind of embodiment of swelling and pain relieving emplastrum of the present invention, includes ointment and pharmaceutical plaster substrate；
The ointment includes the component of following parts by weight：280 parts of traumatic injury and rheumatism liquid extract, the inclusion compound of volatile medicine 0.35 part of 500 parts, 280 parts of belladonna liquid extract, 110 parts of camphor and muscone；
The traumatic injury and rheumatism liquid extract includes following components：It is safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, white The root of Dahurian angelica, line grass, Kaempferia galanga and Semen Strychni；The safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, mountain The weight ratio of a kind of apple and Semen Strychni is：Safflower：It is windproof：Rhizoma zingiberis：Radix Aconiti Kusnezoffii：Schizonepeta：Radix Aconiti：The root of Dahurain angelica：Line grass：Kaempferia galanga：It is raw Vomiting nut=0.8：3.8：5.8：1.8：3.8：1.8：5.8：3.8：5.8：1.8；
The inclusion compound of the volatile medicine includes volatile medicine, and the volatile medicine includes following components：Borneol, Peppermint oil, basil oil, cinnamon oil and gaultherolin；The borneol, peppermint oil, basil oil, cinnamon oil and bigcatkin willow The weight ratio of sour methyl esters is：Borneol：Peppermint oil：Basil oil：Cinnamon oil：Gaultherolin=6:6:1:2:10；
The pharmaceutical plaster substrate includes the component of following parts by weight：1600 parts of rubber, 100 parts of tongued bell barium white, zinc oxide 320 parts of 1200 parts, 1100 parts of rosin, 2800 parts of liquid paraffin and vaseline.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga that medicinal material water content is less than 5%, are weighed by formula, 40~50 mesh are crushed to, carried out CO2Supercritical extract, extraction conditions is：Extracting pressure is 30MPa, and extraction temperature is 50 DEG C, and parsing pressure is 7MPa, parsing temperature Spend for 50 DEG C, extraction time is 2.5 hours, obtains extract A and dregs of a decoction B；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, it is mixed with dregs of a decoction B Close, then Jia 80~90% ethanol solution heating and refluxing extraction, obtain extract, extract is concentrated to give relatively close at 80 DEG C Spend the thick paste C for 1.2~1.25；
(3), extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
The preparation method of the inclusion compound of volatile medicine described in the present embodiment comprises the following steps：
(a) volatile medicine, is weighed by formula, the volatile medicine and ethanol is miscible, obtain the second of volatile materials Alcoholic solution, weighs beta-schardinger dextrin, and the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：5, β-ring is pasted Essence is made into supersaturated solution, obtains the supersaturated solution of beta-schardinger dextrin；
(b), the β-ring that the ethanol solution of the volatile materials is added into 40 DEG C with 3~5mL/min speed is pasted In smart supersaturated solution, 2h is stirred, rotating speed is 1000r/min, stop continuing to stir 6h after liquid feeding, obtain volatile medicine mixing Liquid；
(c) volatile medicine mixed liquor obtained by step (b), is placed in 5 DEG C of environment and freezes 24h, filtering obtains filter residue；
(d), filter residue is placed at 50 DEG C and dried, the inclusion compound of volatile medicine is obtained.
The preparation method of pharmaceutical plaster substrate described in the present embodiment is：
(i), rubber stripping and slicing, broken, plus gasoline are dipped to rubber and fully swollen and obtains A；
(ii), B is obtained after rosin heating dissolving；
(iii), A, B, tongued bell barium white, zinc oxide, liquid paraffin and vaseline are mixed to stir and produces emplastrum base Matter.
The preparation method of swelling and pain relieving emplastrum is described in the present embodiment：Belladonna liquid extract is weighed by constituent content, concentrates, obtains Relative density is the thick paste of 1.2~1.3 belladonna at 65~70 DEG C；Then by the thick paste of belladonna, traumatic injury and rheumatism liquid extract, volatilization Property medicine inclusion compound, resina liquidamberis, camphor and muscone add into pharmaceutical plaster substrate, it is well mixed after be coated on nonwoven On cloth material, dry, produce swelling and pain relieving emplastrum.
Embodiment 3
A kind of embodiment of swelling and pain relieving emplastrum of the present invention, includes ointment and pharmaceutical plaster substrate；
The ointment includes the component of following parts by weight：300 parts of traumatic injury and rheumatism liquid extract, the inclusion compound of volatile medicine 0.4 part of 500 parts, 300 parts of belladonna liquid extract, 225 parts of resina liquidamberis, 120 parts of camphor and muscone；
The traumatic injury and rheumatism liquid extract includes following components：It is safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, white The root of Dahurian angelica, line grass, Kaempferia galanga and Semen Strychni；The safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, Radix Aconiti, the root of Dahurain angelica, line grass, mountain The weight ratio of a kind of apple and Semen Strychni is：Safflower：It is windproof：Rhizoma zingiberis：Radix Aconiti Kusnezoffii：Schizonepeta：Radix Aconiti：The root of Dahurain angelica：Line grass：Kaempferia galanga：It is raw Vomiting nut=1：4：6：2：4：2：6：4：6：2；
The inclusion compound of the volatile medicine includes volatile medicine, and the volatile medicine includes following components：Borneol, Peppermint oil, basil oil, cinnamon oil and gaultherolin；The borneol, peppermint oil, basil oil, cinnamon oil and bigcatkin willow The weight ratio of sour methyl esters is：Borneol：Peppermint oil：Basil oil：Cinnamon oil：Gaultherolin=6:6:1:2:10；
The pharmaceutical plaster substrate includes the component of following parts by weight：1500 parts of rubber, 50 parts of tongued bell barium white, zinc oxide 190 Part, 1000 parts of rosin, 2700 parts of liquid paraffin and 300 parts of vaseline.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga that medicinal material water content is less than 5%, are weighed by formula, 40~50 mesh are crushed to, carried out CO2Supercritical extract, condition is：Extracting pressure is 28MPa, and extraction temperature is 42 DEG C, and parsing pressure is 6MPa, and resolution temperature is 42 DEG C, extraction time is 3 hours；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, it is mixed with dregs of a decoction B Close, then Jia 80~90% ethanol solution heating and refluxing extraction, obtain extract, extract is concentrated to give relatively close at 80 DEG C Spend the thick paste C for 1.2~1.25；
(3), extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
The preparation method of the inclusion compound of volatile medicine described in the present embodiment comprises the following steps：
(a) volatile medicine, is weighed by formula, the volatile medicine and ethanol is miscible, obtain the second of volatile materials Alcoholic solution, weighs beta-schardinger dextrin, and the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：6, β-ring is pasted Essence is made into supersaturated solution, obtains the supersaturated solution of beta-schardinger dextrin；
(b), the β-ring that the ethanol solution of the volatile materials is added into 50 DEG C with 3~5mL/min speed is pasted In smart supersaturated solution, 3h is stirred, rotating speed is 800r/min, stop continuing to stir 5h after liquid feeding, obtain volatile medicine mixed liquor；
(c) volatile medicine mixed liquor obtained by step (b), is placed in 4 DEG C of environment and freezes 18h, filtering obtains filter residue；
(d), filter residue is placed at 40 DEG C and dried, the inclusion compound of volatile medicine is obtained.
The preparation method of pharmaceutical plaster substrate described in the present embodiment is：
(i), rubber stripping and slicing, broken, plus gasoline are dipped to rubber and fully swollen and obtains A；
(ii), B is obtained after rosin heating dissolving；
(iii), A, B, tongued bell barium white, zinc oxide, liquid paraffin and vaseline are mixed to stir and produces emplastrum base Matter.
The preparation method of swelling and pain relieving emplastrum is described in the present embodiment：Belladonna liquid extract is weighed by constituent content, concentrates, obtains Relative density is the thick paste of 1.2~1.3 belladonna at 65~70 DEG C；Then by the thick paste of belladonna, traumatic injury and rheumatism liquid extract, volatilization Property medicine inclusion compound, resina liquidamberis, camphor and muscone add into pharmaceutical plaster substrate, it is well mixed after be coated on nonwoven On cloth material, dry, produce swelling and pain relieving emplastrum.
Embodiment 4
A kind of embodiment of swelling and pain relieving emplastrum of the present invention, swelling and pain relieving emplastrum traditional Chinese medicinal ointment and medicine described in the present embodiment It is same as Example 3 with the composition of plaster stroma.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment the difference is that only CO with embodiment 32It is super The difference of the condition of critical extraction, difference is that extraction conditions is in the present embodiment：Extracting pressure is 26MPa, extraction temperature Spend for 45 DEG C, parsing pressure is 6MPa, resolution temperature is 42 DEG C, and extraction time is 3 hours；
The preparation method of the inclusion compound of volatile medicine described in the present embodiment, pharmaceutical plaster substrate and swelling and pain relieving emplastrum It is same as Example 3.
Embodiment 5
A kind of embodiment of swelling and pain relieving emplastrum of the present invention, swelling and pain relieving emplastrum traditional Chinese medicinal ointment and medicine described in the present embodiment It is same as Example 3 with the composition of plaster stroma.
The preparation method of the inclusion compound of volatile medicine and embodiment 3 the difference is that only volatility in the present embodiment The gross mass of medicine is different from the mass ratio of beta-schardinger dextrin, the gross mass of volatile medicine and beta-schardinger dextrin in the present embodiment Mass ratio is 1：5.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment, pharmaceutical plaster substrate and swelling and pain relieving emplastrum with Embodiment 3 is identical.
Embodiment 6
A kind of embodiment of swelling and pain relieving emplastrum of the present invention, swelling and pain relieving emplastrum traditional Chinese medicinal ointment and medicine described in the present embodiment It is same as Example 3 with the composition of plaster stroma.
The preparation method of the inclusion compound of volatile medicine and embodiment 3 the difference is that only volatility in the present embodiment The gross mass of medicine is different from the mass ratio of beta-schardinger dextrin, the gross mass of volatile medicine and beta-schardinger dextrin in the present embodiment Mass ratio is 1：7.
The preparation method of traumatic injury and rheumatism liquid extract described in the present embodiment, pharmaceutical plaster substrate and swelling and pain relieving emplastrum with Embodiment 3 is identical.
Comparative example 1
The composition of swelling and pain relieving emplastrum traditional Chinese medicinal ointment and pharmaceutical plaster substrate is same as Example 3 described in this comparative example.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example the difference is that only CO with embodiment 32It is super The difference of the condition of critical extraction, difference is that extraction conditions is in this comparative example：Extracting pressure is 18MPa, extraction temperature Spend for 35 DEG C, parsing pressure is 6MPa, resolution temperature is 42 DEG C, and extraction time is 2 hours；
The preparation method of the inclusion compound of volatile medicine described in this comparative example, pharmaceutical plaster substrate and swelling and pain relieving emplastrum It is same as Example 3.
Comparative example 2
The composition of swelling and pain relieving emplastrum traditional Chinese medicinal ointment and pharmaceutical plaster substrate is same as Example 3 described in this comparative example.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example the difference is that only CO with embodiment 32It is super The difference of the condition of critical extraction, difference is that extraction conditions is in this comparative example：Extracting pressure is 33MPa, extraction temperature Spend for 53 DEG C, parsing pressure is 6MPa, resolution temperature is 42 DEG C, and extraction time is 2 hours；
The preparation method of the inclusion compound of volatile medicine described in this comparative example, pharmaceutical plaster substrate and swelling and pain relieving emplastrum It is same as Example 3.
Comparative example 3
The composition of swelling and pain relieving emplastrum traditional Chinese medicinal ointment and pharmaceutical plaster substrate is same as Example 3 described in this comparative example.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga that medicinal material water content is less than 5%, are weighed by formula, 40~50 mesh are crushed to, carried out CO2Supercritical extract, condition is：Extracting pressure is 28MPa, and extraction temperature is 42 DEG C, and parsing pressure is 6MPa, and resolution temperature is 42 DEG C, extraction time is 3 hours, obtains extract A and dregs of a decoction B；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, then Jia 80~ 90% ethanol solution heating and refluxing extraction, obtains extract, and it is 1.2~1.25 that extract is concentrated to give into relative density at 80 DEG C Thick paste C；
(3), extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
The preparation method of the inclusion compound of volatile medicine described in this comparative example, pharmaceutical plaster substrate and swelling and pain relieving emplastrum It is same as Example 3.
Comparative example 4
The composition of swelling and pain relieving emplastrum traditional Chinese medicinal ointment and pharmaceutical plaster substrate is same as Example 3 described in this comparative example.
The preparation method of the inclusion compound of volatile medicine and embodiment 3 the difference is that only volatility in this comparative example The gross mass of medicine is different from the mass ratio of beta-schardinger dextrin, the gross mass of volatile medicine and beta-schardinger dextrin in this comparative example Mass ratio is 1：8.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example, pharmaceutical plaster substrate and swelling and pain relieving emplastrum with Embodiment 3 is identical.
Comparative example 5
The composition of swelling and pain relieving emplastrum traditional Chinese medicinal ointment and pharmaceutical plaster substrate is same as Example 3 described in this comparative example.
The preparation method of the inclusion compound of volatile medicine and embodiment 3 the difference is that only volatility in this comparative example The gross mass of medicine is different from the mass ratio of beta-schardinger dextrin, the gross mass of volatile medicine and beta-schardinger dextrin in this comparative example Mass ratio is 1：4.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example, pharmaceutical plaster substrate and swelling and pain relieving emplastrum with Embodiment 3 is identical.
Comparative example 6
Composition in swelling and pain relieving emplastrum traditional Chinese medicinal ointment described in this comparative example the difference is that only volatility with embodiment 3 The inclusion compound of medicine is different, and this comparative example directly uses borneol, peppermint oil, basil oil, cinnamon oil and salicylic acid first Pharmaceutical plaster substrate is replaced using traditional rubber mass in ester five tastes volatile medicine, this comparative example.
The preparation method of traumatic injury and rheumatism liquid extract described in this comparative example is：Safflower, Semen Strychni, sward are weighed by formula Crow, Radix Aconiti, schizonepeta, Longtube Ground Ivy Herb, the windproof, root of Dahurain angelica, Kaempferia galanga, rhizoma zingiberis, are ground into coarse powder, plus 90% ethanol heating and refluxing extraction two Secondary, extraction time first time is 4 hours, and second extraction time is 2 hours, and obtained extract solution and second will be extracted for the first time The secondary obtained extract solution that extracts merges, and filtering reclaims ethanol, the extract solution after merging is concentrated into relative density at 20~30 DEG C For 1.05~1.15 medicinal extract, traumatic injury and rheumatism liquid extract described in this comparative example is produced.
The preparation method of swelling and pain relieving emplastrum is described in this comparative example：Belladonna liquid extract will be weighed by constituent content, will be concentrated, Obtain the thick paste for the belladonna that relative density at 65~70 DEG C is 1.2~1.3；Then by the thick paste of belladonna, traumatic injury and rheumatism liquid extract, wave Hair property medicine, camphor and muscone are added into rubber mass, are coated on after being well mixed on nonwoven cloth material, are dried, i.e., Obtain swelling and pain relieving emplastrum described in this comparative example.
Embodiment 7
The yield of volatile oil in embodiment 1~4, comparative example 1,2,6 in schizonepeta, Kaempferia galanga and rhizoma zingiberis is shown in Table 1.
The yield of volatile oil in the embodiment 1~4 of table 1, comparative example 1,2,6 in schizonepeta, Kaempferia galanga and rhizoma zingiberis
Group Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Comparative example 1 Comparative example 2 Comparative example 6
Yield 4.2% 4.1% 4.5% 4.3% 2.5% 3.1% 1.1%
As it can be seen from table 1 compared to the complete comparative example 6 using solvent extraction method, using in CO of the present invention2It is super to face Under conditions of boundary's extraction, the yield of the volatile oil in schizonepeta, Kaempferia galanga and rhizoma zingiberis is significantly improved.
Embodiment 8
Swelling and pain relieving emplastrum described in embodiment 1~6 and comparative example 1~6 is subjected to hot-plate, specific experiment side to mouse Method is as follows：
SPF grades of Kunming mouses are taken, female under 22 DEG C of room temperature conditions, opens hot plate type analgesic experiment instrument, temperature is determined In (55 ± 0.5) DEG C, 10min is preheated, then 1 mouse of input records mouse from putting into there is pain reaction with stopwatch every time The time of (lick metapedes, kick back leg or jump), survey 2 times altogether, per minor tick 5min, average (using average value no more than 30s as It is qualified).
Qualified mouse 120 is screened, every group 10,12 groups, respectively A, B, C, D, E, F, a, b, c, d, e, f are randomly divided into Group, 24h bellies depilation before administration.Every mouse of A, B, C, D, E, F group gives swelling and pain relieving described in embodiment 1~6 and pasted respectively Cream (such as A groups mouse gives swelling and pain relieving emplastrum described in embodiment 1, and B group mouse give swelling and pain relieving emplastrum described in embodiment 2, By that analogy), external application；Every mouse of a, b, c, d, e, f group gives (such as a groups of swelling and pain relieving emplastrum described in comparative example 1~6 Mouse gives swelling and pain relieving emplastrum described in comparative example 1, and b group mouse give swelling and pain relieving emplastrum described in comparative example 2, by that analogy), External application；60 after administration, 90,120,180min determine pain reaction time 2 times, average.If mouse 60s in instrument is still painless Reaction, then stop test, mouse taken out immediately, is calculated by 60s, tests the threshold of pain after terminating as measured by different time and is averaged Value, calculates the threshold of pain and improves percentage.Hot-plate the results are shown in Table 2.
Wherein, average pain before percentage=(average pain threshold before average pain threshold-medication after medication)/medication is improved in the threshold of pain Threshold value × 100%.
The hot-plate result of table 2
Note：* represent that there is significant difference (P compared with f groups<0.05).
From above hot-plate result, swelling and pain relieving emplastrum described in the embodiment of the present invention 1~6 and comparative example 1~6 Analgesic activity occur in 60min after administration, compared with f groups (using swelling and pain relieving emplastrum described in comparative example 6), A, B, C, D, E, F group (using swelling and pain relieving emplastrum described in embodiment 1~6) have significant difference (P in 180min<0.05) this, is illustrated The analgesic activity for inventing the swelling and pain relieving emplastrum is notable.
Embodiment 9
Swelling and pain relieving emplastrum described in embodiment 1~6 and comparative example 1~6 is subjected to swelling of auricle caused by dimethylbenzene to mouse Swollen experiment, specific experiment method is as follows：
Take SPF grades of Kun Ming mices, 120, male and female half and half, are divided 12 groups by body weight at random by every group 10, respectively A, B, C, D, E, F, a, b, c, d, e, f group, 24h bellies depilation before administration.Every mouse of A, B, C, D, E, F group is given respectively implements (such as A groups mouse gives swelling and pain relieving emplastrum described in embodiment 1 to swelling and pain relieving emplastrum described in example 1~6, and B group mouse, which are given, implements Swelling and pain relieving emplastrum described in example 2, by that analogy), external application；Every mouse of a, b, c, d, e, f group is given described in comparative example 1~6 (such as a groups mouse gives swelling and pain relieving emplastrum described in comparative example 1 to swelling and pain relieving emplastrum, and b group mouse are given to disappear described in comparative example 2 Swollen pain-stopping plaster, by that analogy), external application；After the preceding fasting in 12 hours of experiment, free water, last dose 60min, by dimethylbenzene Two sides before and after mouse right ear is applied to, mouse cervical dislocation only, is put to death, two ears are cut along auricle baseline by 50ul/ after 30min, is used 9mm card punch lays round auricle at same position respectively, and precise weighing is distinguished with electronic balance, calculates swelling inhibiting rate, experiment It the results are shown in Table 3.Wherein, swelling=auris dextra sheet weight-left auricle weight.
Ear swelling test result caused by the dimethylbenzene of table 3
Note：* represent that there is significant difference (P compared with f groups<0.05).It is of the present invention to disappear it was found from the result of upper table Swollen pain-stopping plaster can substantially suppress dimethylbenzene induced mice ear swelling, with f groups (using swelling and pain relieving emplastrum described in comparative example 6) phase Than A, B, C, D, E, F group (using swelling and pain relieving emplastrum described in embodiment 1~6) have significant difference (P in 180min< 0.05), illustrate that swelling and pain relieving emplastrum of the present invention has obvious detumescence effect.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention And scope.

Claims (10)

1. a kind of swelling and pain relieving emplastrum, it is characterised in that include ointment and pharmaceutical plaster substrate；The ointment includes traumatic injury and rheumatism Liquid extract；The preparing raw material of the traumatic injury and rheumatism liquid extract includes following components：Safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, schizonepeta, life Monkshood, the root of Dahurain angelica, line grass, Kaempferia galanga and Semen Strychni；
The preparation method of the traumatic injury and rheumatism liquid extract comprises the following steps：
(1) schizonepeta, rhizoma zingiberis and kaempferia galamga, are weighed, is placed in supercritical extracting equipment, CO is carried out2Supercritical extract, obtains extract A With dregs of a decoction B；
(2), weigh that safflower, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti, line be careless, windproof and the root of Dahurain angelica, crush, mixed with dregs of a decoction B, so Plus 80 afterwards~90% ethanol solution heating and refluxing extraction, obtain extract, extract is concentrated to give into relative density at 80 DEG C is 1.2~1.25 thick paste C；
(3), extract A is well mixed with thick paste C and produces traumatic injury and rheumatism liquid extract.
2. swelling and pain relieving emplastrum as claimed in claim 1, it is characterised in that the CO2The condition of supercritical extract is：Extraction pressure Power is 20~30MPa, and extraction temperature is 40~50 DEG C, and parsing pressure is 5~7MPa, and resolution temperature is 30~50 DEG C, during extraction Between be 2.5~3.5 hours.
3. swelling and pain relieving emplastrum as claimed in claim 2, it is characterised in that the CO2The condition of supercritical extract is：Extraction pressure Power is 28MPa, and extraction temperature is 42 DEG C, and parsing pressure is 6MPa, and resolution temperature is 42 DEG C, and extraction time is 3 hours.
4. swelling and pain relieving emplastrum as described in the appended claim 1, it is characterised in that the safflower, windproof, rhizoma zingiberis, Radix Aconiti Kusnezoffii, chaste tree Mustard, Radix Aconiti, the root of Dahurain angelica, line grass, the weight ratio of Kaempferia galanga and Semen Strychni are：Safflower：It is windproof：Rhizoma zingiberis：Radix Aconiti Kusnezoffii：Schizonepeta：It is raw Monkshood：The root of Dahurain angelica：Line grass：Kaempferia galanga：Semen Strychni=0.8~1.2：3.8~4.2：5.8~6.2：1.8~2.2：3.8~4.2： 1.8~2.2：5.8~6.2：3.8~4.2：5.8~6.2：1.8~2.2.
5. swelling and pain relieving emplastrum as claimed in claim 4, it is characterised in that the ointment includes the component of following parts by weight：Fall Beat 280~320 parts of rheumatism liquid extract, 280~320 parts of 500~550 parts of inclusion compound, belladonna liquid extract, the camphor of volatile medicine 110~130 parts and 0.35~0.45 part of muscone；
Wherein, the inclusion compound of the volatile medicine includes volatile medicine, and the volatile medicine includes following components：Ice Piece, peppermint oil, basil oil, cinnamon oil and gaultherolin；The borneol, peppermint oil, basil oil, cinnamon oil and water Poplar acid methyl esters weight ratio be：Borneol：Peppermint oil：Basil oil：Cinnamon oil：Gaultherolin=6:6:1:2:10.
6. swelling and pain relieving emplastrum as claimed in claim 5, it is characterised in that the preparation method of the inclusion compound of the volatile medicine Comprise the following steps：
(a) volatile medicine, is weighed by formula, the volatile medicine and ethanol is miscible, and the ethanol for obtaining volatile materials is molten Liquid, weighs beta-schardinger dextrin, and the gross mass of the volatile medicine and the mass ratio of beta-schardinger dextrin are 1：5~7；By beta-schardinger dextrin Supersaturated solution is made into, the supersaturated solution of beta-schardinger dextrin is obtained；
(b), the β-ring that the ethanol solution of the volatile materials is added into 40~70 DEG C with 3~5mL/min speed is pasted In smart supersaturated solution, 2~4h is stirred, rotating speed is 600~1000r/min, stop continuing to stir 4~6h after liquid feeding, must volatilize Property medicine mixed liquor；
(c) volatile medicine mixed liquor obtained by step (b), is placed in 2~5 DEG C of environment and freezes 12~24h, filtering obtains filter residue；
(d), filter residue is placed at 30~50 DEG C and dried, the inclusion compound of volatile medicine is obtained.
7. swelling and pain relieving emplastrum as claimed in claim 6, it is characterised in that the gross mass and beta-schardinger dextrin of the volatile medicine Mass ratio be 1：6.
8. swelling and pain relieving emplastrum as claimed in claim 1, it is characterised in that the pharmaceutical plaster substrate includes following parts by weight Component：1400~1600 parts of rubber, 0~100 part of tongued bell barium white, 180~200 parts of zinc oxide, 900~1100 parts of rosin, liquid stone 240~320 parts of 2650~2800 parts of wax and vaseline.
9. swelling and pain relieving emplastrum as claimed in claim 8, it is characterised in that the preparation method of the pharmaceutical plaster substrate is：
(i), rubber stripping and slicing, broken, plus gasoline are dipped to rubber and fully swollen and obtains A；
(ii), B is obtained after rosin heating dissolving；
(iii), A, B, tongued bell barium white, zinc oxide, liquid paraffin and vaseline are mixed to stir and produces plaster stroma.
10. a kind of preparation method of the swelling and pain relieving emplastrum as any one of claim 5~9, it is characterised in that described to disappear The preparation method of swollen pain-stopping plaster is：Belladonna liquid extract is weighed by constituent content, is concentrated, obtaining relative density at 65~70 DEG C is 1.2~1.3 thick paste containing belladonna；Then by the thick paste containing belladonna, traumatic injury and rheumatism liquid extract, the inclusion compound of volatile medicine, Resina liquidamberis, camphor and muscone are added into pharmaceutical plaster substrate, are coated on after being well mixed on nonwoven cloth material, are dried, Produce the swelling and pain relieving emplastrum.
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CN104606656A (en) * 2015-01-23 2015-05-13 九寨沟天然药业集团有限责任公司 Preparation process of traditional Chinese medicine rubber electuary medicine and paste
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