CN106177075A - The cold compress bag for the treatment of allergic skin and preparation method thereof - Google Patents

The cold compress bag for the treatment of allergic skin and preparation method thereof Download PDF

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Publication number
CN106177075A
CN106177075A CN201610568004.9A CN201610568004A CN106177075A CN 106177075 A CN106177075 A CN 106177075A CN 201610568004 A CN201610568004 A CN 201610568004A CN 106177075 A CN106177075 A CN 106177075A
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CN
China
Prior art keywords
bag
weight portion
radix
cold compress
herba
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Pending
Application number
CN201610568004.9A
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Chinese (zh)
Inventor
李鸿雁
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Foshan Langda Information Technology Co Ltd
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Foshan Langda Information Technology Co Ltd
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Priority to CN201610568004.9A priority Critical patent/CN106177075A/en
Publication of CN106177075A publication Critical patent/CN106177075A/en
Pending legal-status Critical Current

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    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
    • A61F2007/0265—Compresses or poultices for effecting heating or cooling medicated antiallergic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M2210/04—Skin

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Abstract

The present invention relates to treat the cold compress bag of allergic skin, including bag, described bag includes medicated bag and the condensation bag being overlapped mutually setting, separated by the nonwoven layer that thickness is 1 5mm between described medicated bag and condensation bag, it is made up of waterproof fabrics outside described medicated bag, described condensation bag is made up of non-woven fabrics, and described medicated bag includes that the content in bag and liquid medicine, described condensation bag include the epoxy resin in bag；Medicated bag and condensation bag are respectively provided with active ingredient of Chinese herbs, make cold compress bag promote vasoconstriction, alleviate pruritus, relief of symptoms, have alleviation pruritus and the effect of detumescence, have the features such as treatment cycle is short, instant effect, expense are low.

Description

The cold compress bag for the treatment of allergic skin and preparation method thereof
Technical field
The invention belongs to Traditional chinese medicine medicament field, particularly to a kind of cold compress bag treating allergic skin and preparation method thereof.
Background technology
In common allergy (allergy) dermatoses, major skin pruritus, urticaria, neurodermatitis, contact Dermatitis and pemphigus etc..Skin pruritus, the traditional Chinese medical science is referred to as " pruritus ".Urticaria, the traditional Chinese medical science claims " urticaria ", is commonly called as " rubella wheal ".God Through property dermatitis, in existing " stubborn dermatitis ", " chronic eczema ", " psoriasis " etc..Contact dermatitis, the traditional Chinese medical science referred to as " pollen skin ulcer ", " dermatitis rhus ", " contact dermatitis from plaster " etc..Pemphigus, the traditional Chinese medical science is referred to as " pemphigus ", " red-fire ulcers, dermatitis herpetiformis ".These dermatosiss belong to skin allergic reaction (mistake Quick) category, the most relatively common and be difficult to thoroughly cure, bring great misery to patient.
Effectively treat allergy (allergy) property disease at present, main employing antiallergic or anti-inflammatory drug treatment, but multiple The rate of sending out is the highest.Key agents have cetirizine, imidazoles this sting, ranitidine, and methylprednisolone etc., Chinese medicine has Thunder God Rattan, Tripterygium hypoglaucum, fangfeng tongsheng pill, YUPINGFENG SAN, WUSHE ZHIYANG WAN, pathogenic wind expelling electuary etc., but existing patient is difficult to accept Hormone and the chemicals toxic and side effects to human body, be more willing to take TCM in Vitro to treat, and present stage be the absence of medicine for external use very much The treatment of thing.And existing external medication method, mostly there is DeGrain, the technical problems such as curative effect of medication is short.
Summary of the invention
Present invention seek to address that technical problem present in prior art.To this end, it is an object of the present invention to propose A kind of cold compress bag treating allergic skin, this cold compress bag is evident in efficacy, external use；This cold compress bag promotes vasoconstriction, subtracts Light pruritus, relief of symptoms, there is alleviation pruritus and the effect of detumescence, there is the features such as treatment cycle is short, instant effect, expense are low, And can the most thoroughly treat allergic skin.
Technical scheme is as follows:
A kind of cold compress bag treating allergic skin, including bag, described bag include being overlapped mutually setting medicated bag and Condensation bag, is separated by the nonwoven layer that thickness is 1-5mm, by the anti-water surface outside described medicated bag between described medicated bag and condensation bag Material is made, and described condensation bag is made up of non-woven fabrics；
Described medicated bag includes that the content in bag and liquid medicine, described content are mainly prepared from by following crude drug: horse Tooth bamboo water pipe 3-12 weight portion, Radix Arnebiae (Radix Lithospermi) 2-6 weight portion, Herba Sonchi Oleracei 3-9 weight portion, Radix Notoginseng 1-5 weight portion, Herba Euphorbiae Helioscopiae 1-5 weight portion, strong wind Sub-0.5-3 weight portion, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 0.5-3 weight portion；
Described liquid medicine is mainly prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 weight portion, Radix Astragali 10-20 weight portion, and one Branch Artemisia 10-20 weight portion, Cortex Phellodendri 5-18 weight portion, Herba Senecionis Scandentis 5-15 weight portion, Indigo Naturalis 5-15 weight portion, Spica Prunellae 3-11 weight Part, Cortex Mori 5-15 weight portion；
Described condensation bag includes the epoxy resin in bag, and described epoxy resin is mainly prepared from by following raw material: methylol is fine Dimension element sodium 50-80 weight portion, hydrogenated wood rosin glycerol ester 10-30 weight portion, menthyl lactate 5-20 weight portion, Oleum menthae 0.5-3 weight Part.
Chinese medicine extract of the present invention passes through kinds of traditional Chinese medicines compatibility, has the effect alleviating pruritus and detumescence, to anaphylaxis skin The treatment of skin has significant curative effect.Wherein epoxy resin is using Carboxymethyl cellulose sodium and hydrogenated wood rosin glycerol ester as gel-type vehicle, has Stronger swelling function, forms space net structure after water suction, can absorb the medicinal liquid of medicated bag well through nonwoven layer, effectively Act on target site；Menthyl lactate and Oleum menthae are collaborative to be used, and improves the cooling blood and removing stasis of medicine, lenitive further Effect, and effect is lasting.
Further improve the curative effect of cold compress bag treatment allergic skin, prepare described content and also include following raw material Medicine: Flos Lonicerae 3-9 weight portion, Radix Glycyrrhizae Preparata 1-5 weight portion, Radix Paeoniae Alba 1-5 weight portion, store 0.5-3 weight portion, Periostracum Cicadae 0.5-3 weight Amount part.
Further, prepare described liquid medicine and also include following crude drug: Medulla Junci 5-20 weight portion, Radix Dipsaci 5-15 weight Part, Rhizoma Acori Graminei 5-15 weight portion, Radix Platycodonis 1-5 weight portion, fresh Rhizoma Phragmitis 1-5 weight portion, Fructus Gardeniae 3-9 weight portion.
In further preferred version, prepare described epoxy resin and also include following raw material: sorbitol 2-8 weight portion, pool Luo Shamu 10-20 weight portion.Poloxamer has stronger surface-active action, and in the present invention, it is as surfactant Not only can increase the contact area of penetrating fluid and skin, and be used in conjunction with sorbitol, improve antibacterial ability, extend medicine and protect Deposit the phase；Meanwhile, poloxamer has certain gelatification, improves the molding of epoxy resin further；Additionally, poloxamer and hydrogenation Rosin ester synergism, extends the action time of pharmaceutical through skin, extends curative effect, improves patient compliance.
The present invention is in an improvement project, and described content also includes adjuvant, crude drug and adjuvant in described content Ratio of weight and number be 1:0.1-0.6；Described adjuvant includes linoleic acid 10-30 weight portion, sodium dehydroacetate 8-20 weight portion, water Poplar acid sodium 3-12 weight portion.Linoleic interpolation, is beneficial to improve the osmosis of gel-type vehicle, sodium dehydroacetate and sodium salicylate Adjuvant is used in conjunction with having good Antimicrobial preservative ability, extends the storage life of medicine.
Described adjuvant also includes Bentonite 15-35 weight portion and colloidality silica 1 0-25 weight portion.Both adjuvant is common Using, beneficially content dispersion in liquid medicine suspends, it is to avoid because microgranule is saved bit by bit on nonwoven layer wall, cause obstruction.
Further in scheme, the nonwoven layer thickness between described medicated bag and condensation bag is 2.2mm；This thickness makes liquid medicine Can permeate well and pass through, and can preferable coutroi velocity.
Nonwoven layer surface outside described condensation bag is provided with tearable cover layer, and described cover layer is that polyethylene film covers Cap rock.
It is a further object to provide the preparation method of a kind of above-mentioned cold compress bag, described method includes following step Rapid:
The preparation of (a) content: weigh the Herba portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Caulis et Folium Hyptidis suaveolentis Grass, Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content；
The preparation of (b) liquid medicine:
(b-1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and receive Aqueous solution after collection distillation；
(b-2) Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, Huang are weighed After stilbene, Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (b-1), boiling twice, each 1 hour, Merging decoction liquor, filter, after filtration, the aqueous solution with step (b-1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol Making alcohol content is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, obtains liquid medicine；
C (), by the content of step (a) of preparation and the liquid medicine mixing and stirring of step (b), adds the Asia of formula ratio Oleic acid, Bentonite, colloidality silicon dioxide, sodium dehydroacetate and sodium salicylate, after mix homogeneously, obtain medicated bag mixture, standby；
The preparation of (d) epoxy resin
(d-1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester and poloxamer, add appropriate deionization Water mix homogeneously, obtains mixed liquor, standby；
(d-2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(d-3) weigh Oleum menthae and the sorbitol of formula ratio, and add the mixed liquor of step (d-1) and step (d-2) Menthyl lactate ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin；
The preparation of (e) condensation bag: epoxy resin prepared for step (d-3) is spread evenly across non-woven fabrics inner face, then by nothing Spin together with cloth side and medicated bag inside edge sew, outside non-woven fabrics, press polyethylene film cover, non-fill medicine The cold compress bag of bag；
F medicated bag mixture prepared for step (c) is poured in step (e) in the medicated bag of cold compress bag by (), sealing, packaging, i.e. The cold compress bag of allergic skin must be treated.
The present invention treats the cold compress bag of allergic skin, can be by connecting adhesive tape in the outside of medicated bag, by cold compress bag Paste and be fixed on target site.Cold compress bag can promote vasoconstriction, alleviates contrafluxion, eases the pain, and relief of symptoms has very Good alleviation pruritus and detumescence effect, the good effect for the treatment of allergic skin.Additionally, this cold compress bag changes tradition directly by medicine It is blended in the preparation method of gel layer, is spaced apart by medicated bag and gel pockets, improves medicine stability, it is to avoid in some medicines easily The inefficacy of oxidizing component, it is ensured that drug effect, and extend storage life；In use, medicinal liquid slowly oozes out, and further increases cold compress bag The drug effect phase.The processing preparation process of cold compress bag of the present invention is simple, easy to use, has good market prospect.
The source of the raw material of Chinese medicine composition of the present invention:
Herba Portulacae: this product is portulacaceous plant Herba Portulacae Portulaca oleracea L..
Radix Arnebiae (Radix Lithospermi): this product is comfrey lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst., Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb.et Zucc. or arnebia guttata Bunge Arnebia guttata Bunge is dried Root.
Herba Sonchi Oleracei: the herb of Compositae sonchus plant Herba Sonchi Arvensis Sonchus Brachyotus DC..
Radix Notoginseng: this product is the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.
Herba Euphorbiae Helioscopiae: Euphorbiaceae euphorbia Herba Euphorbiae Helioscopiae Euphorbia helioscopia L., with all herbal medicine.
Semen Hydnocarpi: for Flacourtiaceae plant Semen Hydnocarpi, the mature seed of Hydnocarpus hainanensis (Merr.) Sleum..
Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan: for the herb of labiate Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan.
Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi): for root and the leaf of euphorbia plant comospore Fructus glochidionis puberi(Herba Glochidii Puberi).
The Radix Astragali: this product is leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao's or Radix Astragali Astragalus membranaceus (Fisch.) Bge. Dry root.
Herba Achilleae: for feverfew Millefolium or the herb of southwest achillea millefolium.
Cortex Phellodendri: this product is rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri The dry bark of Phellodendron amurense Rupr..
Herba Senecionis Scandentis: this product is Compositae Senecio plant Herba Senecionis Scandentis Senecio scandens Buch.-Ham., with herb It is used as medicine.
Indigo Naturalis: this product is acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia (Nees) Bremek., polygonaceae plant knotweed Blue Polygonum tinctorium Ait. or the leaf of cruciferae isatis Isatis indigotica Fort. or stem The processed prepared dried powder of leaf or agglomerate.
Spica Prunellae: this product is the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..
Cortex Mori: this product is the dry root bark of moraceae plants Mulberry Morus alba L..
Flos Lonicerae: this product is caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera Hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera The flower that the dry flower of dasystyla Rehd. or band are just opened.
Radix Glycyrrhizae Preparata: this product is the Preparation process product of Radix Glycyrrhizae.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..
Store: for the Herb of polygonaceae plant axillary flower knotweed.
Periostracum Cicadae: when this product is the larva emergence of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius Exuviae shell.
Medulla Junci: the dry stem pith of rush family plant Medulla Junci Juncus effusus L..
Radix Dipsaci: this product is Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C.Y.Cheng et T.M.Ai The dry root of (or Dipsacus asper Wall).
Rhizoma Acori Graminei: this product is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC..
Fresh Rhizoma Phragmitis: this product is liliaceous plant Aloe vulgaris Aloe barbadensis Miller, Aloe ferox Miller Aloe ferox Miller or other belong to the fresh root of kindred plant leaf together.
Fructus Gardeniae: this product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of cold compress bag of the present invention；
Fig. 2 is the cross sectional representation of cold compress bag of the present invention.
Detailed description of the invention
A kind of cold compress bag treating allergic skin of the present invention, as shown in Figure 1-2, including bag 1, described bag 1 includes It is overlapped mutually medicated bag 2 and the condensation bag 3 of setting, by nonwoven layer 4 that thickness is 1-5mm between described medicated bag 2 and condensation bag 3 Separating, preferred thickness is 2.2mm；Being made up of waterproof fabrics outside described medicated bag 2, described condensation bag 3 is made up of non-woven fabrics.Described Medicated bag 2 includes that the content in bag and liquid medicine, described condensation bag 3 include the epoxy resin in bag；Activity one-tenth in medicated bag 2 of the present invention The detailed description of the invention of the epoxy resin composition dividing and condensing bag 3 is as follows.
Embodiment 1
The prescription of the present embodiment bag is:
Medicated bag:
Content is mainly prepared from by following crude drug: Herba Portulacae 30g, Radix Arnebiae (Radix Lithospermi) 20g, Herba Sonchi Oleracei 30g, Radix Notoginseng 10g, pool Paint 10g, Semen Hydnocarpi 5g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 5g.
Liquid medicine is mainly prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 100g, Radix Astragali 100g, Herba Achilleae 100g, Cortex Phellodendri 50g, Herba Senecionis Scandentis 50g, Indigo Naturalis 50g, Spica Prunellae 30g, Cortex Mori 50g.
Condensation bag:
Carboxymethyl cellulose sodium 500g, hydrogenated wood rosin glycerol ester 100g, menthyl lactate 50g, Oleum menthae 5g.
Embodiment 2
The prescription of the present embodiment bag is:
Medicated bag:
Content is mainly prepared from by following crude drug: Herba Portulacae 120g, Radix Arnebiae (Radix Lithospermi) 60g, Herba Sonchi Oleracei 90g, Radix Notoginseng 50g, Herba Euphorbiae Helioscopiae 50g, Semen Hydnocarpi 30g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 30g.
Liquid medicine is mainly prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 200g, Radix Astragali 200g, Herba Achilleae 200g, Cortex Phellodendri 180g, Herba Senecionis Scandentis 150g, Indigo Naturalis 150g, Spica Prunellae 110g, Cortex Mori 150g.
Condensation bag:
Carboxymethyl cellulose sodium 800g, hydrogenated wood rosin glycerol ester 300g, menthyl lactate 200g, Oleum menthae 30g.
Embodiment 3
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug: Herba Portulacae 45g, Radix Arnebiae (Radix Lithospermi) 30g, Herba Sonchi Oleracei 60g, Radix Notoginseng 30g, Herba Euphorbiae Helioscopiae 30g, Semen Hydnocarpi 20g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 20g, Flos Lonicerae 30g, Radix Glycyrrhizae Preparata 10g, Radix Paeoniae Alba 10g, store 5g, Periostracum Cicadae 5g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 150g, Radix Astragali 150g, Herba Achilleae 150g, Cortex Phellodendri 100g, a thousand li Light 100g, Indigo Naturalis 100g, Spica Prunellae 60g, Cortex Mori 100g, Medulla Junci 50g, Radix Dipsaci 50g, Rhizoma Acori Graminei 50g, Radix Platycodonis 10g, fresh reed Root 10g, Fructus Gardeniae 30g.Condensation bag:
Carboxymethyl cellulose sodium 600g, hydrogenated wood rosin glycerol ester 200g, menthyl lactate 100g, Oleum menthae 20g.
Preparation method:
The preparation of (a) content: weigh the Herba Portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Caulis et Folium Hyptidis suaveolentis Grass, Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content, take 100g standby；
The preparation of (b) liquid medicine:
(b-1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and receive Aqueous solution after collection distillation；
(b-2) Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, Huang are weighed After stilbene, Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (b-1), boiling twice, each 1 hour, Merging decoction liquor, filter, after filtration, the aqueous solution with step (b-1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol Making alcohol content is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, and cold cut, obtain liquid medicine, take 250g standby；
C (), by the content of step (a) of preparation and the liquid medicine mixing and stirring of step (b), obtains medicated bag mixture, standby With；
The preparation of (d) epoxy resin
(d-1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester, add appropriate deionized water mixing all Even, obtain mixed liquor, standby；
(d-2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(d-3) weigh the Oleum menthae of formula ratio, and add mixed liquor and the lactic acid Herba Menthae of step (d-2) of step (d-1) Ester ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin, take 120g standby；
The preparation of (e) condensation bag: epoxy resin prepared for step (d-3) is spread evenly across non-woven fabrics inner face, then by nothing Spin together with cloth side and medicated bag inside edge sew, outside non-woven fabrics, press polyethylene film cover, non-fill medicine The cold compress bag of bag；
F medicated bag mixture prepared for step (c) is poured in step (e) in the medicated bag of cold compress bag by (), sealing, packaging, i.e. The cold compress bag of allergic skin must be treated.
Embodiment 4
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug: Herba Portulacae 45g, Radix Arnebiae (Radix Lithospermi) 30g, Herba Sonchi Oleracei 60g, Radix Notoginseng 30g, Herba Euphorbiae Helioscopiae 30g, Semen Hydnocarpi 20g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 20g, Flos Lonicerae 30g, Radix Glycyrrhizae Preparata 10g, Radix Paeoniae Alba 10g, store 5g, Periostracum Cicadae 5g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 150g, Radix Astragali 150g, Herba Achilleae 150g, Cortex Phellodendri 100g, a thousand li Light 100g, Indigo Naturalis 100g, Spica Prunellae 60g, Cortex Mori 100g, Medulla Junci 50g, Radix Dipsaci 50g, Rhizoma Acori Graminei 50g, Radix Platycodonis 10g, fresh reed Root 10g, Fructus Gardeniae 30g.Condensation bag:
Carboxymethyl cellulose sodium 600g, hydrogenated wood rosin glycerol ester 200g, menthyl lactate 100g, Oleum menthae 20g, sorbitol 20g, Poloxamer 100g.
Preparation method:
The preparation of (a) content: weigh the Herba Portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Caulis et Folium Hyptidis suaveolentis Grass, Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content, take 100g standby；
The preparation of (b) liquid medicine:
(b-1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and receive Aqueous solution after collection distillation；
(b-2) Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, Huang are weighed After stilbene, Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (b-1), boiling twice, each 1 hour, Merging decoction liquor, filter, after filtration, the aqueous solution with step (b-1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol Making alcohol content is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, obtains liquid medicine, takes 250g standby；
C (), by the content of step (a) of preparation and the liquid medicine mixing and stirring of step (b), obtains medicated bag mixture, standby With；
The preparation of (d) epoxy resin
(d-1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester and poloxamer, add appropriate deionization Water mix homogeneously, obtains mixed liquor, standby；
(d-2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(d-3) weigh Oleum menthae and the sorbitol of formula ratio, and add the mixed liquor of step (d-1) and step (d-2) Menthyl lactate ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin, take 120g standby；
The preparation of (e) condensation bag: epoxy resin prepared for step (d-3) is spread evenly across non-woven fabrics inner face, then by nothing Spin together with cloth side and medicated bag inside edge sew, outside non-woven fabrics, press polyethylene film cover, non-fill medicine The cold compress bag of bag；
F medicated bag mixture prepared for step (c) is poured in step (e) in the medicated bag of cold compress bag by (), sealing, packaging, i.e. The cold compress bag of allergic skin must be treated.
Embodiment 5
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug: Herba Portulacae 80g, Radix Arnebiae (Radix Lithospermi) 40g, Herba Sonchi Oleracei 70g, Radix Notoginseng 35g, Herba Euphorbiae Helioscopiae 25g, Semen Hydnocarpi 25g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 25g, Flos Lonicerae 90g, Radix Glycyrrhizae Preparata 50g, Radix Paeoniae Alba 50g, store 30g, Periostracum Cicadae 30g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 180g, Radix Astragali 180g, Herba Achilleae 180g, Cortex Phellodendri 120g, a thousand li Light 120g, Indigo Naturalis 120g, Spica Prunellae 80g, Cortex Mori 120g, Medulla Junci 200g, Radix Dipsaci 150g, Rhizoma Acori Graminei 150g, Radix Platycodonis 50g, Fresh Rhizoma Phragmitis 50g, Fructus Gardeniae 90g.
Condensation bag:
Carboxymethyl cellulose sodium 650g, hydrogenated wood rosin glycerol ester 150g, menthyl lactate 100g, Oleum menthae 15g, sorbitol 60g, Poloxamer 150g.
Preparation method: preparation method as described in Example 4.
Embodiment 6
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug and adjuvant:
Crude drug: Herba Portulacae 60g, Radix Arnebiae (Radix Lithospermi) 35g, Herba Sonchi Oleracei 50g, Radix Notoginseng 25g, Herba Euphorbiae Helioscopiae 25g, Semen Hydnocarpi 15g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 25g, Flos Lonicerae 55g, Radix Glycyrrhizae Preparata 25g, Radix Paeoniae Alba 25g, store 15g, Periostracum Cicadae 15g；
Adjuvant: linoleic acid 100g, sodium dehydroacetate 80g, sodium salicylate 30g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 120g, Radix Astragali 120g, Herba Achilleae 120g, Cortex Phellodendri 80g, a thousand li Light 80g, Indigo Naturalis 70g, Spica Prunellae 70g, Cortex Mori 70g, Medulla Junci 120g, Radix Dipsaci 100g, Rhizoma Acori Graminei 100g, Radix Platycodonis 30g, fresh reed Root 30g, Fructus Gardeniae 50g.
Condensation bag:
Carboxymethyl cellulose sodium 750g, hydrogenated wood rosin glycerol ester 250g, menthyl lactate 150g, Oleum menthae 25g, sorbitol 80g, Poloxamer 200g.
Preparation method:
The preparation of (a) content: weigh the Herba Portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Caulis et Folium Hyptidis suaveolentis Grass, Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content, take 150g standby；
The preparation of (b) liquid medicine:
(b-1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and receive Aqueous solution after collection distillation；
(b-2) Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, Huang are weighed After stilbene, Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (b-1), boiling twice, each 1 hour, Merging decoction liquor, filter, after filtration, the aqueous solution with step (b-1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol Making alcohol content is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, obtains liquid medicine, takes 200g standby；
C (), by the content of step (a) of preparation and the liquid medicine mixing and stirring of step (b), adds the Asia of formula ratio Oleic acid, sodium dehydroacetate and sodium salicylate, after mix homogeneously, obtain medicated bag mixture, standby；
The preparation of (d) epoxy resin
(d-1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester and poloxamer, add appropriate deionization Water mix homogeneously, obtains mixed liquor, standby；
(d-2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(d-3) weigh Oleum menthae and the sorbitol of formula ratio, and add the mixed liquor of step (d-1) and step (d-2) Menthyl lactate ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin, take 200g standby；
The preparation of (e) condensation bag: epoxy resin prepared for step (d-3) is spread evenly across non-woven fabrics inner face, then by nothing Spin together with cloth side and medicated bag inside edge sew, outside non-woven fabrics, press polyethylene film cover, non-fill medicine The cold compress bag of bag；
F medicated bag mixture prepared for step (c) is poured in step (e) in the medicated bag of cold compress bag by (), sealing, packaging, i.e. The cold compress bag of allergic skin must be treated.
Embodiment 7
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug and adjuvant:
Crude drug: Herba Portulacae 60g, Radix Arnebiae (Radix Lithospermi) 35g, Herba Sonchi Oleracei 50g, Radix Notoginseng 25g, Herba Euphorbiae Helioscopiae 25g, Semen Hydnocarpi 15g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 25g, Flos Lonicerae 55g, Radix Glycyrrhizae Preparata 25g, Radix Paeoniae Alba 25g, store 15g, Periostracum Cicadae 15g；
Adjuvant: linoleic acid 100g, sodium dehydroacetate 80g, sodium salicylate 30g, Bentonite 150g, colloidality silica 1 00g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 120g, Radix Astragali 120g, Herba Achilleae 120g, Cortex Phellodendri 80g, a thousand li Light 80g, Indigo Naturalis 70g, Spica Prunellae 70g, Cortex Mori 70g, Medulla Junci 120g, Radix Dipsaci 100g, Rhizoma Acori Graminei 100g, Radix Platycodonis 30g, fresh reed Root 30g, Fructus Gardeniae 50g.
Condensation bag:
Carboxymethyl cellulose sodium 750g, hydrogenated wood rosin glycerol ester 250g, menthyl lactate 150g, Oleum menthae 25g, sorbitol 80g, Poloxamer 200g.
Preparation method:
The preparation of (a) content: weigh the Herba Portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Caulis et Folium Hyptidis suaveolentis Grass, Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content, take 150g standby；
The preparation of (b) liquid medicine:
(b-1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and receive Aqueous solution after collection distillation；
(b-2) Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, Huang are weighed After stilbene, Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (b-1), boiling twice, each 1 hour, Merging decoction liquor, filter, after filtration, the aqueous solution with step (b-1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol Making alcohol content is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, obtains liquid medicine, takes 200g standby；
C (), by the content of step (a) of preparation and the liquid medicine mixing and stirring of step (b), adds the Asia of formula ratio Oleic acid, Bentonite, colloidality silicon dioxide, sodium dehydroacetate and sodium salicylate, after mix homogeneously, obtain medicated bag mixture, standby；
The preparation of (d) epoxy resin
(d-1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester and poloxamer, add appropriate deionization Water mix homogeneously, obtains mixed liquor, standby；
(d-2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(d-3) weigh Oleum menthae and the sorbitol of formula ratio, and add the mixed liquor of step (d-1) and step (d-2) Menthyl lactate ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin, take 200g standby；
The preparation of (e) condensation bag: epoxy resin prepared for step (d-3) is spread evenly across non-woven fabrics inner face, then by nothing Spin together with cloth side and medicated bag inside edge sew, outside non-woven fabrics, press polyethylene film cover, non-fill medicine The cold compress bag of bag；
F medicated bag mixture prepared for step (c) is poured in step (e) in the medicated bag of cold compress bag by (), sealing, packaging, i.e. The cold compress bag of allergic skin must be treated.
Embodiment 8
The prescription of the present embodiment bag is:
Medicated bag:
Content is prepared from by following crude drug and adjuvant:
Crude drug: Herba Portulacae 70g, Radix Arnebiae (Radix Lithospermi) 38g, Herba Sonchi Oleracei 55g, Radix Notoginseng 20g, Herba Euphorbiae Helioscopiae 20g, Semen Hydnocarpi 16g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 26g, Flos Lonicerae 50g, Radix Glycyrrhizae Preparata 26g, Radix Paeoniae Alba 26g, store 16g, Periostracum Cicadae 16g；
Adjuvant: linoleic acid 150g, sodium dehydroacetate 120g, sodium salicylate 50g, Bentonite 350g, colloidality silicon dioxide 250g.
Liquid medicine is prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 140g, Radix Astragali 140g, Herba Achilleae 140g, Cortex Phellodendri 80g, a thousand li Light 80g, Indigo Naturalis 80g, Spica Prunellae 80g, Cortex Mori 80g, Medulla Junci 100g, Radix Dipsaci 120g, Rhizoma Acori Graminei 120g, Radix Platycodonis 15g, fresh reed Root 30g, Fructus Gardeniae 60g.
Condensation bag:
Carboxymethyl cellulose sodium 650g, hydrogenated wood rosin glycerol ester 220g, menthyl lactate 180g, Oleum menthae 14g, sorbitol 40g, Poloxamer 150g.
Preparation method: preparation method as described in Example 7.
Comparative examples
The prescription of the present embodiment bag is:
Active component is prepared from by following crude drug: Herba Portulacae 60g, Radix Arnebiae (Radix Lithospermi) 35g, Herba Sonchi Oleracei 50g, Radix Notoginseng 25g, Herba Euphorbiae Helioscopiae 25g, Semen Hydnocarpi 15g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 25g, Flos Lonicerae 55g, Radix Glycyrrhizae Preparata 25g, Radix Paeoniae Alba 25g, store 15g, Periostracum Cicadae 15g, and liquid medicine is by such as Lower crude drug is prepared from: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 120g, Radix Astragali 120g, Herba Achilleae 120g, Cortex Phellodendri 80g, Herba Senecionis Scandentis 80g, Indigo Naturalis 70g, the summer Hay 70g, Cortex Mori 70g, Medulla Junci 120g, Radix Dipsaci 100g, Rhizoma Acori Graminei 100g, Radix Platycodonis 30g, fresh Rhizoma Phragmitis 30g, Fructus Gardeniae 50g.
Epoxy resin: Carboxymethyl cellulose sodium 500g, hydrogenated wood rosin glycerol ester 100g, menthyl lactate 50g, Oleum menthae 5g.
Preparation method:
(1) weigh each crude drug in active component, boiling three times, each 1 hour, merge decoction liquor, filter, filter After be concentrated into magma shape, be cooled to room temperature, add ethanol and make alcohol content be 65%, stirring, stands 24 hours, takes supernatant recovery second After alcohol, obtain liquid medicine；
(2) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester, add appropriate deionized water mix homogeneously, Obtain mixed liquor, standby；The menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；Weigh The Oleum menthae of formula ratio, and add mixed liquor and menthyl lactate ethanol solution, add liquid medicine regulation viscosity, stir, i.e. Obtain the epoxy resin of band liquid medicine.
Test example 1 stability test
The sample of above-described embodiment 1, embodiment 3-4, embodiment 6-7 and comparative examples 1 is carried out temperature, humidity and Infiltrative influence factor tests, with the outward appearance of epoxy resin for reference index 1；Medicated bag is taken apart, with the dose of medicated bag as reference Index 2；Cold compress bag is placed on sponge, with the medicated bag dose after 1h and outward appearance for reference index 3；The results are shown in Table 1.
Table 1 is the Acceleration study result of the test of test specimen
Condition: temperature40℃±2DEG C, under the conditions of humidity 75 ± 5%
Table 2 absorbs the result of the test of dose for sponge
Condition: under room temperature, humidity 60% ± 10%
The above results shows, embodiment 1,3-4,6-7 stability under the conditions of temperature 40 DEG C ± 2 DEG C, humidity 75 ± 5% is equal Good than comparative examples 1, the wherein optimal stability of embodiment 7.The result of comparing embodiment 3 and embodiment 4 understands, and moors Lip river The interpolation of husky nurse and sorbitol has moisturizing, promotees gelatification；The result of comparing embodiment 6 and embodiment 7 understands, Bentonite and glue Property silicon dioxide add be beneficial to content dispersion, have suspending effect.
Test example 2 pharmacological toxicity is tested
Acute toxicity testing data
1, experimental technique
Depilatory is uniformly coated with by guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory Returning cage to observe 24 hours, often group Cavia porcellus loses money in a business the cold compress bag of inventive embodiments 1, embodiment 3 and embodiment 7 respectively (by cold compress bag Make 20 square centimeters of sizes), another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, is put to death by Cavia porcellus, The heart, liver, kidney and depilation skin do pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunks depilation district, has no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, Liver, kidney and depilation skin compare also no significant difference with compareing word.
Result is pointed out, and Chinese medicine cold compress bag of the present invention, without local irritant effect, also has no that general toxicity shows.Show the present invention Chinese medicine cold compress bag uses safety.
Long term toxicity test data
1, experimental technique
Random for Cavia porcellus part is become 4 groups, often group 15.In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is de- Hair scope about 40 square centimeters.Clean depilatory, often organize Cavia porcellus after observing 24 hours and lose money in a business respectively inventive embodiments 1, embodiment 3 With the cold compress bag of embodiment 7, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observes the ordinary circumstance of Cavia porcellus, experiment Put to death animal after end and carry out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunks go to hair-fields, have no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group and control animals chroma of hair, ingest, matched group no significant difference, blood biochemistry checking, the medication such as extremity are movable Group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious disease Become.
Cold compress bag long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Test Result shows, cold compress bag experiment safety of the present invention.
The pharmacodynamics test of test example 4 cold compress bag
1. experiment material
1.1 test medicine: the sample 1-3 of embodiment 1,3,7 preparation, make epoxy resin the thin slice of 2mm thickness, are immersed in Medication after 5min in medicinal liquid.
1.2 laboratory animals: BALB/c mouse, ICR mice, body weight is 18 ± 1g, male and female half and half.
2. experimental technique
2.1 therapeutic administratp itching-relieving action to dextran induced mice whole skin pruritus
ICR mice is randomly divided into 4 groups by body weight grade, respectively model control group, sample 1-3 group, often group 10.With I.e. observe to each group of mouse tail vein injection 0.025% dextran 0.05ml/10g (1.25mg/kg).Mice after half an hour Skin plays unhairing at erythema, returns after cleaning, and group 1-3 carries out cold compress to mice erythema position, and matched group does not processes；With mice fore paw Scratch trunk, mouth of head, rear solid end of scratching stings each position of whole body as pruritus indication.In observed and recorded 1h, 6h, mice is scratched where it itches number of times And scratch where it itches the persistent period.
2.2 therapeutic administratp cause the antiallergic effect of mouse skin allergy to histamine
By body weight grade, BALB/c mouse is randomly divided into 4 groups, and respectively model control group, sample 1-3 group, often organize 10 Only.To each group of mouse tail vein injection 0.5% azovan blue normal saline solution 5mg/kg.In mouse web portion center in advance immediately The intradermal injection 0.1% histamine phosphate 0.1ml/ at skin that lost hair or feathers only, forms a cuticle mound.Little Corium Mus mound portion is carried out by group 1-3 Cold compress, matched group does not processes；After 2h, mice is taken off cervical vertebra lethal, cuts abdominal part open, cut skin of abdomen, be laid on glass plate, Measure the longest diameter of injection site locus coeruleus and major diameter normal thereto, calculate the face of skin locus coeruleus by oval area formula Long-pending (S=π AB).Peel abdominal part indigo plant dye skin, shred with operating scissors and put in test tube, add 4ml acetone-normal saline (7: 3) and mix Close liquid, shaking.After soaking 24h, 2000r/min is centrifuged 10min, takes supernatant colorimetric at spectrophotometer 610nm, records OD Value.Locus coeruleus area and OD value result represent with mean ± standard deviation (x ± s), compare employing one factor analysis of variance and carry out between group Statistical procedures.
Suppression ratio=(model comparison class value-intervention class value)/model comparison class value × 100%.
3, experimental result
Table 2 cold compress bag itching-relieving action to dextran induced mice whole skin pruritus
Note:--represent that number of times is too much, disregard.
After using tail vein injection dextran method to cause mouse systemic skin pruritus, mice occurs that pruritus is reacted, can To observe that scratch head, rear solid end of fore paw is scratched trunk, mouth stings the action of systemic sites.As seen from Table 2, sample 1-3 is given cold After Fuing, pruritus number of times and pruritus persistent period substantially reduce, and have pole significant difference (P ＜ 0.01) with model control group, wherein The effect of sample 3 is the most obvious.
Table 3 cold compress bag causes the impact of mice subcutaneous locus coeruleus area to histamine
Group Number of animals Locus coeruleus area (mm2) Suppression ratio (%)
Model control group 10 504.32±150.6 0
1 group of sample 10 375.42±110.64 35.25
2 groups of sample 10 294.20±58.41 54.46
3 groups of sample 10 265.78±61.04 65.15
After tail vein injection azovan blue, hypodermic histamine phosphate may result in mouse skin allergy reaction, forms skin Lower locus coeruleus.As seen from Table 3, after giving cold compress bag cold compress, after 2h, the backboard area of sample 1-3 all reduces, and has with model control group Significant difference (P ＜ 0.01), and backboard area suppression ratio all reaches more than 35%, the wherein best results of sample 3, suppression ratio Reach 65.16%.
Model case
Case 1: Chen, man, 34 years old, suffer from skin allergy, went to chronic dermatosis well because anaphylactogen is untreated the year before last, Show as chronic eczema, the cold compress bag of the cold compress embodiment of the present invention 73 days after half a year, every day cold compress 4h, effect is notable, continues again About cold compress two weeks, eczema disappears；Eczema of recurrence the most after two months, cold compress disappeared after 7 days；The most not multiple Send out.
Case 2: Lee, man, 23 years old, it to be engaged in slaughtering industry, suffer from skin pruritus for many years, skin lines thickens, and is dried, office Portion is red and swollen, the cold compress bag of the cold compress embodiment of the present invention 46 days, and every day, cold compress was not less than 4h, was almost recovered, and red and swollen disappearance, skin is extensive Compound light pool.
Case 3: Wang, female, 38 years old, scabies pruritus had 10 years, uses various Chinese and western medicine and hormone therapy, and symptom fails to delay Solution increases the weight of on the contrary, for a long time and Folium Styracis Suberifoliae increases the weight of, day and night scratch and itch very, agonizing.After cold compress bag of the present invention is carried out cold compress to affected part, Every day, cold compress was not less than 3h, and within 7 days, the state of an illness significantly alleviates, and when 15 days, whole body pruritus, lamellar prurigo, all diseases all alleviate, and spot is basic Disappearing, the place of skin darkening has reduced, after two months, and transference cure, with side after 1 year, does not recurs.
Case 4: Zhang, 56 years old, urticaria: whole body is very itched, lamellar redness shape antisensitizer flickering, long-term is invalid, Doctor is invalid for a long time.Affected part is carried out cold compress by cold compress bag of the present invention, and every day, cold compress was not less than 5h, continues 5 days state of an illness of medication and significantly subtracts Gently, after 20 days, whole body pruritus, lamellar erythema disappear substantially, urticaria Periostracum Cicadae when 2 months, continue the drug of topical application pull out again whole body it Poison, skin surface is smooth, and color is identical with surrounding, and latter 6 months without recurrence.

Claims (9)

1. treat a cold compress bag for anaphylaxis dermatosis, including bag, it is characterised in that described bag includes being overlapped mutually and sets The medicated bag put and condensation bag, separated by the non-woven fabrics that thickness is 1-5mm, outside described medicated bag between described medicated bag and condensation bag Being made up of waterproof fabrics, described condensation bag is made up of non-woven fabrics；
Described medicated bag includes that the content in bag and liquid medicine, described content are mainly prepared from by following crude drug: Herba portulacae 3-12 weight portion, Radix Arnebiae (Radix Lithospermi) 2-6 weight portion, Herba Sonchi Oleracei 3-9 weight portion, Radix Notoginseng 1-5 weight portion, Herba Euphorbiae Helioscopiae 1-5 weight portion, Semen Hydnocarpi 0.5-3 weight portion, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 0.5-3 weight portion；
Described liquid medicine is mainly prepared from by following crude drug: Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 weight portion, Radix Astragali 10-20 weight portion, Herba Achilleae 10-20 weight portion, Cortex Phellodendri 5-18 weight portion, Herba Senecionis Scandentis 5-15 weight portion, Indigo Naturalis 5-15 weight portion, Spica Prunellae 3-11 weight portion, Cortex Mori 5-15 weight portion；
Described condensation bag includes that epoxy resin, described epoxy resin are mainly prepared from by following raw material: Carboxymethyl cellulose sodium 50-80 Weight portion, hydrogenated wood rosin glycerol ester 10-30 weight portion, menthyl lactate 5-20 weight portion, Oleum menthae 0.5-3 weight portion.
2. the cold compress bag treating anaphylaxis dermatosis as claimed in claim 1, it is characterised in that prepare described content and also wrap Include following crude drug: Flos Lonicerae 3-9 weight portion, Radix Glycyrrhizae Preparata 1-5 weight portion, Radix Paeoniae Alba 1-5 weight portion, store 0.5-3 weight portion, Cicadae Slough off 0.5-3 weight portion.
3. the cold compress bag treating anaphylaxis dermatosis as claimed in claim 2, it is characterised in that prepare described liquid medicine and also include Following crude drug: Medulla Junci 5-20 weight portion, Radix Dipsaci 5-15 weight portion, Rhizoma Acori Graminei 5-15 weight portion, Radix Platycodonis 1-5 weight portion is fresh Rhizoma Phragmitis 1-5 weight portion, Fructus Gardeniae 3-9 weight portion.
4. the cold compress bag treating anaphylaxis dermatosis as claimed in claim 1, it is characterised in that prepare described condensation bag and also wrap Include following raw material: sorbitol 2-8 weight portion, poloxamer 10-20 weight portion.
5. the cold compress bag of the treatment anaphylaxis dermatosis as according to any one of claim 1-4, it is characterised in that described content Thing also includes adjuvant, and in described content, the ratio of weight and number of crude drug and adjuvant is 1:0.5-3；Described adjuvant includes linoleic acid 10-30 weight portion, sodium dehydroacetate 8-20 weight portion, sodium salicylate 3-12 weight portion.
6. the cold compress bag treating anaphylaxis dermatosis as claimed in claim 5, it is characterised in that described adjuvant also includes Bentonite 15-35 weight portion and colloidality silica 1 0-25 weight portion.
7. the as claimed in claim 1 cold compress bag treating anaphylaxis dermatosis, it is characterised in that described medicated bag and condensation bag it Between nonwoven thickness be 2.2mm.
8. the cold compress bag treating anaphylaxis dermatosis as claimed in claim 1, it is characterised in that the nothing outside described condensation bag Spinning layer of cloth surface and be provided with tearable cover layer, described cover layer is polyethylene film cover.
9. a preparation method for the cold compress bag for the treatment of anaphylaxis dermatosis as claimed in claim 6, comprises the steps:
(1) preparation of content: weigh the Herba portulacae of formula ratio, Radix Arnebiae (Radix Lithospermi), Herba Sonchi Oleracei, Radix Notoginseng, Herba Euphorbiae Helioscopiae, Semen Hydnocarpi, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan, gold Flos Lonicerae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, storage and Periostracum Cicadae, pulverize, and crosses 60 mesh sieves, obtains content；
(2) preparation of liquid medicine:
(2.1) take the Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) of described weight portion, Radix Platycodonis, Spica Prunellae, fresh Rhizoma Phragmitis distillation extraction, obtain volatile oil, and collect steaming Aqueous solution after evaporating；
(2.2) weigh the Herba Achilleae of formula ratio, Cortex Phellodendri, Herba Senecionis Scandentis, Indigo Naturalis, Cortex Mori, Medulla Junci, Radix Dipsaci, Rhizoma Acori Graminei, the Radix Astragali, After Fructus Gardeniae boiling 3 hours, add the medicinal residues after distillation in step (2.1), boiling twice, each 1 hour, merge Decoction liquor, filters, and after filtration, the aqueous solution with step (2.1) merges, and is concentrated into magma shape, is cooled to room temperature, adds ethanol and makes to contain Alcohol amount is 65%, stirring, stands 24 hours, after taking supernatant recovery ethanol, obtains liquid medicine；
(3) by the content of step (1) and the liquid medicine mixing and stirring of step (2) of preparation, add formula ratio linoleic acid, Bentonite, colloidality silicon dioxide, sodium dehydroacetate and sodium salicylate, after mix homogeneously, obtain medicated bag mixture, standby；
(4) preparation of epoxy resin
(4.1) weigh the Carboxymethyl cellulose sodium of formula ratio, hydrogenated wood rosin glycerol ester and poloxamer, add appropriate deionized water and mix Close uniformly, obtain mixed liquor, standby；
(4.2) menthyl lactate weighing formula ratio is dissolved in ethanol, obtains menthyl lactate ethanol solution, standby；
(4.3) weigh Oleum menthae and the sorbitol of formula ratio, and add mixed liquor and the lactic acid of step (4.2) of step (4.1) Menthyl ester ethanol solution, adds suitable quantity of water regulation viscosity, stirs, obtain epoxy resin；
(5) preparation of bag is condensed: the epoxy resin that step (4.3) prepares is spread evenly across non-woven fabrics inner face, then by non-woven fabrics Side presses polyethylene film outside non-woven fabrics and covers together with sewing with medicated bag inside edge, obtains non-fill medicated bag Cold compress bag；
(6) the medicated bag mixture that step (3) prepares is poured in step (5) in the medicated bag of cold compress bag, sealing, packaging, must control Treat the cold compress bag of anaphylaxis dermatosis.
CN201610568004.9A 2016-07-17 2016-07-17 The cold compress bag for the treatment of allergic skin and preparation method thereof Pending CN106177075A (en)

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Publication number Priority date Publication date Assignee Title
CN109700862A (en) * 2019-03-13 2019-05-03 山东朱氏药业集团有限公司 Photon epoxy resin and manufacture the photon epoxy resin complete production line

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109700862A (en) * 2019-03-13 2019-05-03 山东朱氏药业集团有限公司 Photon epoxy resin and manufacture the photon epoxy resin complete production line
CN109700862B (en) * 2019-03-13 2022-02-01 山东朱氏药业集团有限公司 Photon condensate and matched production line for manufacturing photon condensate

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