CN108354967A - A kind of anaesthetic of clearing and antitussive and preparation method thereof - Google Patents
A kind of anaesthetic of clearing and antitussive and preparation method thereof Download PDFInfo
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- CN108354967A CN108354967A CN201810412133.8A CN201810412133A CN108354967A CN 108354967 A CN108354967 A CN 108354967A CN 201810412133 A CN201810412133 A CN 201810412133A CN 108354967 A CN108354967 A CN 108354967A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The present invention relates to a kind of drug and manufacturing method, i.e., a kind of anaesthetic of clearing and antitussive and preparation method thereof.A kind of anaesthetic of clearing and antitussive, including bulk pharmaceutical chemicals root of Aucklandia lappa Decne, its main feature is that：The root of Aucklandia lappa Decne is matched with oriental wormwood, Radix Glycyrrhizae, and weight is 75 125 parts of root of Aucklandia lappa Decne, 75 125 parts of oriental wormwood, 75 125 parts of Radix Glycyrrhizae.Preparation method is：Take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get；Or the bulk pharmaceutical chemicals in addition to the beta cyclodextrin clathrate of volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract or root of Aucklandia lappa Decne, the mixture of Herba Artemisiae Scopariae volatile oil or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture are crushed, it sieves with 100 mesh sieve, mixing, be uniformly mixed again with the mixture beta cyclodextrin clathrate of volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract or root of Aucklandia lappa Decne, the mixture of Herba Artemisiae Scopariae volatile oil or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil to get.
Description
Technical field
The present invention relates to a kind of drug and manufacturing method, i.e., a kind of anaesthetic of clearing and antitussive and preparation method thereof.
Background technology
Clearing and antitussive is one of critical treatment means of Mongolian medicine, and pyretic pulmonary syndrome scope, targeted range are belonged in Mongolian medicine
Mainly three dysequilibriums wish and draw flourishing the generating heat, is short of breath caused by intrapulmonary of heat evil, and chest is swollen, pectoralgia, just then cough and nothing
Phlegm or cough spit saline taste yellow foam phlegm, and cough frequency is more immediately, and phlegm color is more yellow, or with color or simultaneous sees peripheral coldness, lip
Blue and blister, arteries and veins and urine are all in thermal image.
Anaesthetic root of Aucklandia lappa Decne Saussurea costus, up to such as, different name sand bubble such as reaches Mongolian name, agate slave such as reaches, and derives from composite family
Plant root of Aucklandia lappa Decne（Aucklandia lappa Decen）Root, be Mongolian medicine's common medicine, in the treatment of above-mentioned disease, play
Larger effect.But it the contained prescription of existing ancient books and records and spreads in civil proved recipe, the raw material pharmacopoeia with root of Aucklandia lappa Decne compatibility
There are many class, and clinical effectiveness is irregular, and pharmacological action is had different versions, due to guiding theory and the direction difference of compatibility, even
There is clinical application to be also not quite similar, it is seen then that rationally appropriate compatibility, the effect of priming enters disease, excavates drug, improve treatment effect
Fruit becomes our Mongolia Medicine workers and urgently solves the problems, such as.In addition, the active ingredient of root of Aucklandia lappa Decne is mostly volatile substance,
Existing anaesthetic is mostly to play powder life to use, and pulverizing process will produce higher temperature, and volatile matter is largely lost, and consumes certain drug effect.
As it can be seen that the anaesthetic urgent need of clearing and antitussive grows with each passing hour, modern science and technology is introduced, improves standardization, standardized level, enhancing treatment effect
Fruit.
Invention content
The purpose of the present invention is find it is more suitable coordinate with root of Aucklandia lappa Decne, removing heat from the lung to relieve cough effect is more notable, to cough with lung heat, in phlegm
Bulk pharmaceutical chemicals with the diseases better efficacy such as purulence, and then be made and have no toxic side effect, it prepares simply, cheap, compatibility is reasonable, convenient for answering
The anaesthetic of clearing and antitussive.
It is a further object of the present invention to provide the preparation methods of above-mentioned anaesthetic.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic of clearing and antitussive, including bulk pharmaceutical chemicals root of Aucklandia lappa Decne are provided,
Its main feature is that：The root of Aucklandia lappa Decne is matched with oriental wormwood, Radix Glycyrrhizae, and weight is 75-125 parts of root of Aucklandia lappa Decne, and 75-125 parts of oriental wormwood is sweet
It is 75-125 parts careless.
The root of Aucklandia lappa Decne is extracted by 7.5-12.5 parts of replacements of volatile oil of Radix Aucklandiae extract, the oriental wormwood by Herba Artemisiae Scopariae volatile oil
7.5-12.5 parts of replacements of object.
The volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract are all made of steam distillation and are made.
The preparation method of the volatile oil of Radix Aucklandiae extract is：Root of Aucklandia lappa Decne bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water,
30min is impregnated, is placed in volatile oil extractor, adds water, past medicinal material liquid level 2-3cm, heating water bath collects root of Aucklandia lappa Decne volatilization
Oil extract；The preparation method of the Herba Artemisiae Scopariae volatile oil extract is：Oriental wormwood bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water,
20min is impregnated, is placed in volatile oil extractor, adds water, past medicinal material liquid level 2-3cm, heating water bath collects oriental wormwood volatilization
Oil extract.
75-125 parts of the root of Aucklandia lappa Decne, the 15-25 parts of replacements of mixture of 75-125 parts of oriental wormwood by root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil.
The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture are made using steam distillation, the root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixing
The preparation method of object is：Root of Aucklandia lappa Decne, the oriental wormwood bulk pharmaceutical chemicals of parts by weight such as take, -5 DEG C or less are ground into coarse powder, add room temperature in distilled water
Sealed soak 30min, is placed in volatile oil extractor, adds water, past medicinal material liquid level 2-3cm, straight fire or heating water bath,
Collect root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture to get.
15-25 parts of the mixture of the root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil is by root of Aucklandia lappa Decne, the beta-cyclodextrin of Herba Artemisiae Scopariae volatile oil mixture
150-250 parts of replacements of inclusion compound.
The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil the preparation method of mixture beta-cyclodextrin be：Beta-cyclodextrin is taken, adds 80-100 times
Parts by weight water is warming up to 60 DEG C and beta-cyclodextrin aqueous solution is made, and under 120-150 turns/min rotating speed stirring conditions, is slowly added into
The weight ratio of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture, root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture and beta-cyclodextrin is 1:10, add volatilization
After oil, 60 DEG C of constant temperature under the conditions of power 100HZ, is ultrasonically treated 2h, and 4 degree placement 15h-20h filter, discard filtrate, and room temperature is done
It is dry, it grinds to get root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound.
Above-mentioned root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound remove β-ring paste with being washed to it under the conditions of 70 DEG C of petroleum ether
The volatile oil that smart surface does not include, drying at room temperature crush.
175-225 parts of santal, 75-125 parts of tabasheer, 75-125 parts of safflower, calculus bovis factitius 75- are added in the bulk pharmaceutical chemicals
125 parts, white grape is 75-125 parts dry.
45-55 parts of Hu Luba, 40-50 parts of rosette thistle herb are added in the bulk pharmaceutical chemicals.
The anaesthetic preparation method of the clearing and antitussive：Take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get.
The anaesthetic preparation method of the clearing and antitussive：Will remove volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract or
Root of Aucklandia lappa Decne, the mixture of Herba Artemisiae Scopariae volatile oil or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture Benexate Hydrochloride other than raw material medicinal powder
It is broken, sieve with 100 mesh sieve, mixing, then with volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil it is mixed
Close object or root of Aucklandia lappa Decne, the mixture Benexate Hydrochloride of Herba Artemisiae Scopariae volatile oil be uniformly mixed to get.
The beneficial effects of the invention are as follows：The drug effect that root of Aucklandia lappa Decne can be given full play to, by rationally appropriate compatibility, priming enters
Disease excavates removing heat from the lung to relieve cough effect of root of Aucklandia lappa Decne, improves therapeutic effect, modern pharmaceutical technology is combined with traditional mongolian medicine, and then is made
It has no toxic side effect, prepares simply, cheap, compatibility is reasonable, convenient for the anaesthetic for the clearing and antitussive taken, meanwhile, flavour of a drug are reduced,
The shortcomings that volatilization for preventing active ingredient, economizes on resources, and overcomes anaesthetic flavour of a drug strong, and most of patients is reluctant to take promotes anaesthetic
Mouthfeel, it is expected to become the typical medicaments of clearing and antitussive.
Specific implementation mode
The first embodiment：A kind of anaesthetic of clearing and antitussive, including bulk pharmaceutical chemicals root of Aucklandia lappa Decne, its main feature is that：The root of Aucklandia lappa Decne and mattress
Old, Radix Glycyrrhizae matches, and weight is 75-125 parts of root of Aucklandia lappa Decne, 75-125 parts of oriental wormwood, 75-125 parts of Radix Glycyrrhizae.It is preferred that root of Aucklandia lappa Decne
100 parts, 100 parts of oriental wormwood, 100 parts of Radix Glycyrrhizae.
Preparation method：
The anaesthetic preparation method of the clearing and antitussive：Take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get.
Bulk pharmaceutical chemicals are analyzed：
Root of Aucklandia lappa Decne, up to such as, different name sand bubble such as reaches Mongolian name, agate slave such as reaches, and derives from feverfew root of Aucklandia lappa Decne（Aucklandia lappa
Decen）Root, acrid flavour, hardship are warm-natured.It imitates greasy, rough, light.Major function：Broken ruffian adjusts member, and eliminating the phlegm, apocenosis, anti-corrosion, Xie He is according to blood
Phase intermal comflict.Pulmonary abscess is cured mainly, is coughed, asthma, ear purulence, packet such as disease, stomach trouble, belch, vomiting, stomach acute diseases such as cholera and sunstroke, diphtheria.Chemical composition：Root contains
Volatile oil contains single China fir alkene, α-and β-costen, constuslactone, 12- methyl oxygen dihydrocostulactones, costic acid, costol in oily
Deng also contain saussurine and synanthrin.
Oriental wormwood, Mongolian name A Rong, different name Ah lattice are flourish.For the seedling of feverfew artemisia scoparia and Artemisia capillaris.Fresh oriental wormwood is containing volatilization
Oil, chlorogenic acid, scoparone.Oriental wormwood with fruit ear contains volatile oil.Contain capillarisin, 6,7- diformazan butylcoumariiis again.Still contain hydroxyl
Base benzene, folic acid.Scoparone master is containing green former ketone, flavone compound, volatile oil, scoparone, cumarin, different legumin, capillarin, tan
Matter etc..Pharmacological action：The decoction tablet of resisting pathogenic microbes effect 100% burrows method, to staphylococcus aureus, A type hammer
Bacterium, corynebacterium diphtheriae, pseudomonas aeruginosa, Escherichia coli, staphylococcus, typhoid bacillus, paratyphosum Bacterium, hay bacillus, dysentery
Bacillus, diplococcus meningitidis etc. have different degrees of inhibiting effect；Also antipyretic, analgesia and the pharmacological actions such as anti-inflammatory.Pharmacological property：Taste
It is bitter, pungent, cool in nature.Major function：Jaundice is gone in clearing lung-heat heat, cough-relieving, apocenosis.Lung heat is cured mainly, is panted, lung shouting pain, pulmonary abscess, flu,
Cough, phlegm product, larynx flu, jaundice.
Radix Glycyrrhizae, the western Hull crow Buss of Mongolian name, Xing A.For glycyrrhizic legume（Glycyrrrhiza uralensis
Fisch）, swollen fruit Radix（Glycyrrrhiza inflate.Bat.）Or glycyrrhiza glabra（Glycyrrrhiza glabral.）'s
Dry root and rhizome.This product is sweet in flavor, cool in nature, dilute and soft, light, and function is cough-relieving, eliminating the phlegm, opens lung key, antiemetic, nourishes, quenches the thirst,
Heat-clearing, removing toxic substances.For：To cough with lung heat, cough Huang phlegm is uncomfortable in chest, asthma, the diseases such as lung heat shouting pain.
Prescription compatibility of medicines is analyzed：In above-mentioned prescription, root of Aucklandia lappa Decne, broken ruffian, tune are first, eliminating the phlegm, apocenosis, anti-corrosion, and Xie He matches according to blood phase intermal comflict
With oriental wormwood clearing lung-heat heat, while Radix Glycyrrhizae mediation property of medicine, lung key is opened in cough-relieving, eliminating the phlegm, enhances the cough suppressing effect of said medicine.It is above-mentioned
Three tastes complement each other, the effect of playing the hot cough-relieving of clearing lung-heat altogether.
Usage and dosage：It is oral.2-3g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add under the guidance of doctor pharmacist
Subtract.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2012, voluntary in patient
In the case of, patient 40 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.20 patients are taken to take the drug of the present invention, as reality
Group is tested, another 20 patients take the common pectoral ambroxol hydrochloride oral solution of daily life（Sunflower medicine company group (Jizhou City)
The clear boards of Hua Weili of Co., Ltd's production）It for control group, treated for 1 week, recovers and stop medicine.Observe therapeutic effect.In vain：Cough
It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever almost disappear
It loses, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：The cure rate of control group be 55%, experimental group or cure rate be 60%, hence it is evident that be higher than control group,
And the total effective rate of control group is 80%, the total effective rate of experimental group is 85%, hence it is evident that is higher than control group.As it can be seen that the present invention receives
Unexpected therapeutic effect.
Second of embodiment：On the basis of the first embodiment, the root of Aucklandia lappa Decne is by volatile oil of Radix Aucklandiae extract 7.5-
12.5 parts of replacements, the oriental wormwood is by 7.5-12.5 parts of replacements of Herba Artemisiae Scopariae volatile oil extract.Press its weight：Root of Aucklandia lappa Decne is waved
7.5-12.5 parts of hair oil extract, 7.5-12.5 parts of Herba Artemisiae Scopariae volatile oil extract, 75-125 parts of Radix Glycyrrhizae.It is preferred that volatile oil of Radix Aucklandiae carries
Take 10 parts of object, 10 parts of Herba Artemisiae Scopariae volatile oil extract, 100 parts of Radix Glycyrrhizae.
The extracting method of the volatile oil of Radix Aucklandiae extract, preferably steam distillation are made.
The preparation method of the volatile oil of Radix Aucklandiae extract is：Root of Aucklandia lappa Decne bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water,
30min is impregnated, is placed in volatile oil extractor, adds water, past medicinal material liquid level 2-3cm, heating water bath collects root of Aucklandia lappa Decne volatilization
Oil extract.
The Herba Artemisiae Scopariae volatile oil extract extracting method, preferably steam distillation are made.
The preparation method of the Herba Artemisiae Scopariae volatile oil extract is：Oriental wormwood bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water,
20min is impregnated, is placed in volatile oil extractor, adds water, past medicinal material liquid level 2-3cm, heating water bath collects oriental wormwood volatilization
Oil extract.
The anaesthetic preparation method of the clearing and antitussive：Will remove volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract with
Outer bulk pharmaceutical chemicals（That is Radix Glycyrrhizae）It crushes, sieves with 100 mesh sieve, mixing, then is mixed with volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract
Close uniformly to get.
The anaesthetic preparation method of the clearing and antitussive：Take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get；Or
Person：Bulk pharmaceutical chemicals in addition to volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract are crushed, are sieved with 100 mesh sieve, mixing, then with
Volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract be uniformly mixed to get.
Prescription analysis：In prescription, volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract, pharmacological property dissipate, and priming enters lung,
Clearing and antitussive is equipped with Radix Glycyrrhizae, the effect of enhancing its clearing lung-heat hot cough-relieving, and three medicine phases are matched, compared with root of Aucklandia lappa Decne, oriental wormwood, three taste bulk pharmaceutical chemicals of Radix Glycyrrhizae
Match, drug effect is stronger, and taking dose is reduced, and mitigates the pressure of patient's medication.
Usage and dosage：It is oral.1-2g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add under the guidance of doctor pharmacist
Subtract.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2013, voluntary in patient
In the case of, patient 20 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.It treated for 1 week, recovers and stop medicine.Observe therapeutic effect.
In vain：It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever
It almost disappears, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：Using the patient of the drug, through statistics, cure rate 60%, total effective rate 90%, total effective rate is obviously high
In the first embodiment.As it can be seen that " root of Aucklandia lappa Decne is substituted by volatile oil of Radix Aucklandiae extract, and oriental wormwood is extracted by Herba Artemisiae Scopariae volatile oil
Object substitutes " have received unexpected therapeutic effect.Patient is set to be more easy to due to the reduction of each medication dose through follow-up investigation
In receiving, it is big to avoid traditional mongolian medicine medication metering, and patient refuses in take the shortcomings that.
The third embodiment：On the basis of the first embodiment, 75-125 parts of the root of Aucklandia lappa Decne, 75-125 parts of oriental wormwood by
15-25 parts of replacements of mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil.Press its weight：The mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
15-25 parts, 75-125 parts of Radix Glycyrrhizae.It is preferred that 20 parts of the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil, 100 parts of Radix Glycyrrhizae.
The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture are made using steam distillation.
The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture preparation method be：Root of Aucklandia lappa Decne, the oriental wormwood bulk pharmaceutical chemicals of parts by weight such as take, -5
It is ground into coarse powder below degree, adds room temperature sealed soak 30min in distilled water, is placed in volatile oil extractor, adds water, be allowed to super
Cross medicinal material liquid level 2-3cm, straight fire or heating water bath, collect root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture to get.
Test result is shown, takes root of Aucklandia lappa Decne, the oriental wormwood of identical weight, the root of Aucklandia lappa Decne extracted in aforementioned manners, Herba Artemisiae Scopariae volatile oil mixed
It closes object and more individually extracts volatile oil of Radix Aucklandiae, Herba Artemisiae Scopariae volatile oil respectively with steam distillation（As described in second of embodiment
Method）More, the recovery rate of volatile oil increases 2%-3%, though temporarily not yet it can determine that using " root of Aucklandia lappa Decne, oriental wormwood made from the above method
The ratio of component in mixture of volatile oil ", but test result is stablized, and have received unexpected clinical therapeutic efficacy.
The anaesthetic preparation method of the clearing and antitussive：By the bulk pharmaceutical chemicals in addition to the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
（That is Radix Glycyrrhizae）Crush, sieve with 100 mesh sieve, mixing, then be uniformly mixed with the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil to get.
Prescription analysis：
Usage and dosage：It is oral.1-2g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add and subtract under the guidance of doctor pharmacist.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2013, voluntary in patient
In the case of, patient 20 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.It treated for 1 week, recovers and stop medicine.Observe therapeutic effect.
In vain：It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever
It almost disappears, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：Using the patient of the drug, through statistics, cure rate 65%, total effective rate 90% is cured by contrast
Rate is apparently higher than first and second kind of embodiment.As it can be seen that " root of Aucklandia lappa Decne, oriental wormwood are replaced by the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
In generation ", has received unexpected clinical therapeutic efficacy.
4th kind of embodiment：On the basis of the third embodiment, the root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture 15-
25 parts of 150-250 parts of replacements of Benexate Hydrochloride by root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture.Press its weight：Wood
Fragrant, Herba Artemisiae Scopariae volatile oil mixture 150-250 parts of Benexate Hydrochloride, 75-125 parts of Radix Glycyrrhizae.It is preferred that root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
200 parts of the Benexate Hydrochloride of mixture, 100 parts of Radix Glycyrrhizae.
The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil the preparation method of mixture beta-cyclodextrin be：The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
The preparation method of mixture beta-cyclodextrin is：Beta-cyclodextrin is taken, adds 80-100 times to measure water, 60 DEG C is warming up to and beta-cyclodextrin water is made
Solution, under 120-150 turns/min rotating speed stirring conditions, preferably 130 turns/min is slowly added into root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixing
The weight ratio of object, root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture and beta-cyclodextrin is 1:10, after adding volatile oil, 60 DEG C of constant temperature, power
Under the conditions of 100HZ, it is ultrasonically treated 2h, 4 degree are placed 15h-20h, preferably 18h, are filtered, and filtrate is discarded, and drying at room temperature is ground, i.e.,
Obtain root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound.
Further, by above-mentioned root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound, with being washed to it under the conditions of 70 degree of petroleum ether
It washs, removes the volatile oil that beta-cyclodextrin surface does not include, drying at room temperature crushes.
Preparation method：
By the bulk pharmaceutical chemicals in addition to the mixture Benexate Hydrochloride of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil（That is Radix Glycyrrhizae）It crushes, crosses 100 mesh
Sieve, mixing, then be uniformly mixed with the mixture Benexate Hydrochloride of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil to get.
Further：Above-mentioned raw materials medicine is placed in breaking-wall cell pulverizer progress broken wall crushing, then with root of Aucklandia lappa Decne, oriental wormwood
Volatile oil clathrate compound mixing to get.
Prescription analysis：Verified the mixture of Herba Artemisiae Scopariae volatile oil " root of Aucklandia lappa Decne, " be equipped with Radix Glycyrrhizae have to cough symptom it is positive
Curative effect carries out specific beta-cyclodextrin inclusion compound technology, purpose one in the present embodiment to the mixture of Herba Artemisiae Scopariae volatile oil " root of Aucklandia lappa Decne, "：
It is to take medicine convenient for patient to cover smell, the generation for the phenomenon that avoids refusing to take medicine, purpose two：" the mixing of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
After inclusion, the Radix Glycyrrhizae understood slow release under one's belt, and be mixed with first contacts with gastric juice object ", and one layer of protection is formed in stomach
Film reduces the stimulation of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil to throat and stomach, eliminates adverse reaction, purpose three：Avoid waving for active ingredient
Hair, economizes on resources, extends the term of validity of drug, and have received good therapeutic effect.And wall breaking technology powder is used to Radix Glycyrrhizae
Broken method is more normally crushed to be mixed with root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound, is compared under equal conditions, cure rate improves 2%.
Usage and dosage：It is oral.1-2g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add under the guidance of doctor pharmacist
Subtract.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2014, voluntary in patient
In the case of, patient 20 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.It treated for 1 week, recovers and stop medicine.Observe therapeutic effect.
In vain：It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever
It almost disappears, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：Using the patient of the drug, through statistics, cure rate 70%, total effective rate 90% is cured by contrast
Rate is apparently higher than first, second and third kind of embodiment.
5th kind of embodiment：On the basis of previous embodiment, 175-225 parts of santal, India are added in the bulk pharmaceutical chemicals
It is 75-125 parts yellow, 75-125 parts of safflower, 75-125 parts of calculus bovis factitius, dry 75-125 parts of white grape.It is preferred that 200 parts of santal, India
100 parts of Huang, 100 parts of safflower, 10 parts of calculus bovis factitius, white grape are 100 parts dry.
Form formula as below：
Formula（1）：100 parts of root of Aucklandia lappa Decne, 100 parts of oriental wormwood, 100 parts of Radix Glycyrrhizae, 200 parts of santal, 100 parts of tabasheer, 100 parts of safflower, people
100 parts of work cow-bezoar, white grape are 100 parts dry.
Formula（2）：10 parts of volatile oil of Radix Aucklandiae extract, 10 parts of Herba Artemisiae Scopariae volatile oil extract, 100 parts of Radix Glycyrrhizae, santal 200
Part, 100 parts of tabasheer, 100 parts of safflower, 100 parts of calculus bovis factitius, white grape are 100 parts dry.
Formula（3）：20 parts of the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil, 100 parts of Radix Glycyrrhizae, 200 parts of santal, 100 parts of tabasheer,
100 parts of safflower, 100 parts of calculus bovis factitius, white grape are 100 parts dry.
Formula（4）：200 parts of the Benexate Hydrochloride of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture, 100 parts of Radix Glycyrrhizae, santal 200
Part, 100 parts of tabasheer, 100 parts of safflower, 100 parts of calculus bovis factitius, white grape are 100 parts dry.
Preparation method：
The anaesthetic preparation method of the clearing and antitussive：Take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get；Or：It will
Except root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture extract in addition to bulk pharmaceutical chemicals crush, sieve with 100 mesh sieve, mixing, then with root of Aucklandia lappa Decne, oriental wormwood
The mixture of volatile oil be uniformly mixed to get.
Above-mentioned prescription has received unexpected therapeutic effect in a large amount of clinical tests, before the present embodiment drug is added
After compare, cure rate or total effective rate improve 3% or more, now with（1）For a formula, above-mentioned raw materials medicine is taken, i.e.,：Wood
It is 100 parts fragrant, 100 parts of oriental wormwood, 100 parts of Radix Glycyrrhizae, 200 parts of santal, 100 parts of tabasheer, 100 parts of safflower, 100 parts of calculus bovis factitius, in vain
100 parts of raisins, crush, cross 80 mesh sieve, mixing to get.
Further：The anaesthetic preparation method of the clearing and antitussive：Above-mentioned raw materials medicine is placed in breaking-wall cell to crush
In machine carry out broken wall crushing, mixing to get.
Newly-increased bulk pharmaceutical chemicals analysis：
Santal, Mongolian name look into dry-Zan Dan, praise red loud, high-pitched sound boolean, Sa Chaoge, craze for Japanese pop culture praise pellet.For sandalwood plants santal（Santalum
album L.）Dry duramen.This product puckery is cold in nature, light, blunt, dry, soft.Have it is clear disturb heat, the effect of nourishing.For lung heat cough
It coughs, the diseases such as pectoralgia asthma.
Tabasheer also known as Concretio Silicea Bambusae, Mongolian name Hu Lusen bamboos ridge.For grass bambusa texlitis（Bambusatoxtilis
Mc Clure）After because stinging hole by parasitic tabasheer bee, juice is stored up in internode, through block made of dry condensation.This product
Taste micro-sweet, it is cool in nature, soft and again, it is blunt.Function is heat-clearing, cough-relieving, slit phlegm, cool heart arresting convulsion.Cough with lung heat is cured mainly, the old heat of lung is hidden
Latent heat, pyreticosis coma, apoplectic coma in silence, twitch, epilepsy by child convulsion.For lung liver heat, blood-head, the such as latent pyrexia
Calculus bovis factitius is by processing systems such as bilein, cholic acid, hyodesoxycholic acid, taurine, bilirubin, cholesterol, trace elements
At.Clear away heart-fire, slit phlegm is had one's ideas straightened out, cool liver, ceases wind, removing toxic substances.For pyreticosis coma, stroke and phlegm confusing heart, twitch, epilepsy goes mad, throat
Swelling and pain, aphthae, carbuncle swells furunculosis.
White grape is dry, replenishing blood and vital energy, and the iron in raisins and calcium content very abundant also contain several mineral materials and Wei Sheng
Element, amino acid.
Safflower, Mongolian name Gu Gu wood, E Ligeneisai mattresses are the dry flower of feverfew safflower.This product is sweet in flavor, micro-
Hardship, it is cool in nature, again, it is blunt, soft soft, solid；There is removing heat from the liver, menstruation regulating, promoting blood circulation, hemostasis, analgesic, detumescence, nourish the effect of positive essence.
Prescription analysis：On the basis of previous embodiment, santal, tabasheer, safflower, artificial ox are added in the bulk pharmaceutical chemicals
Huang, white grape are dry.Santal is cold in nature, light, blunt, dry, soft.Have it is clear disturb heat, the effect of nourishing, tabasheer, taste micro-sweet, it is cool in nature, soft,
With again, it is blunt, function is heat-clearing, cough-relieving, slit phlegm, the arresting convulsion of the cool heart, and calculus bovis factitius clears away heart-fire, and slit phlegm is had one's ideas straightened out, cool liver, ceases wind, solution
Poison.Safflower, sweet in flavor, slight bitter, it is cool in nature, again, it is blunt, soft soft, solid, positive essence is nourished in analgesic, detumescence, and white grape is dry, replenishing blood and vital energy, mesh
Be enhance its clearing and antitussive eliminating the phlegm the effect of, especially to cough the middle and later periods patient it is especially suitable, benefit let out proper, institute's shape
At above-mentioned 4 prescriptions, therapeutic effect has received unexpected therapeutic effect obviously higher than previous embodiment.In addition,
Its therapeutic effect of drug after being crushed using wall breaking technology improves 2% or more compared with the drug cure rate crushed without broken wall.Below with
Formula（1）For.
Usage and dosage：It is oral.2-3g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add under the guidance of doctor pharmacist
Subtract.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2014, voluntary in patient
In the case of, patient 20 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.It treated for 1 week, recovers and stop medicine.Observe therapeutic effect.
In vain：It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever
It almost disappears, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：Using the patient of the drug, through statistics, cure rate 75%, total effective rate 95% is cured by contrast
Rate is apparently higher than the above embodiment, has received good therapeutic effect.
6th kind of embodiment：On the basis of the 5th kind of embodiment, 45-55 parts of Hu Luba, lotus are added in the bulk pharmaceutical chemicals
40-50 parts of Ji of seat.It is preferred that 50 parts of Hu Luba, 45 parts of rosette thistle herb.
Form formula as below：
Formula（1）：100 parts of root of Aucklandia lappa Decne, 100 parts of oriental wormwood, 100 parts of Radix Glycyrrhizae, 200 parts of santal, 100 parts of tabasheer, 100 parts of safflower, people
100 parts of work cow-bezoar, white grape is 100 parts, 50 parts of Hu Luba dry, 45 parts of rosette thistle herb.
Formula（2）：10 parts of volatile oil of Radix Aucklandiae extract, 10 parts of Herba Artemisiae Scopariae volatile oil extract, 100 parts of Radix Glycyrrhizae, santal 200
Part, 100 parts of tabasheer, 100 parts of safflower, 100 parts of calculus bovis factitius, white grape is 100 parts, 50 parts of Hu Luba dry, 45 parts of rosette thistle herb.
Formula（3）：20 parts of the mixture of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil, 100 parts of Radix Glycyrrhizae, 200 parts of santal, 100 parts of tabasheer,
100 parts of safflower, 100 parts of calculus bovis factitius, white grape is 100 parts, 50 parts of Hu Luba dry, 45 parts of rosette thistle herb.
Formula（4）：200 parts of the Benexate Hydrochloride of root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture, 100 parts of Radix Glycyrrhizae, santal 200
Part, 100 parts of tabasheer, 100 parts of safflower, 100 parts of calculus bovis factitius, white grape is 100 parts, 50 parts of Hu Luba dry, 45 parts of rosette thistle herb.
Newly-increased bulk pharmaceutical chemicals analysis：
Hu Luba, An Helumolebaoerchu grams of Mongolian name, refined wood Sa, letter A Tubaoerchuke.For legume Hu Luba
（Trigonella foenum graecum L.）Dry mature seed.This product bitter, property weight are put down, greasy, dry, puckery.Function is
Dry lung purulence, antidiarrheal, suppression it is conspicuous according to.Cure mainly lung abscess, hot dysentery, diarrhea.
Rosette thistle herb, Mongolian name Ta Bu celebratings figure, the Cannes A Jier, letter such as lattice Nyingma.For feverfew rosette thistle herb（Cirsium
esculentum (Sievers) C.A.Mey.）Drying herb.This product is sweet in flavor, cool in nature.Function is that purulence is held back in eliminating the phlegm, controls carbuncle and is cured
Wound.Cure mainly pulmonary abscess, sore and toxic, skin disease, liver heat, various bleedings.For coughing with a lot of sputum, pulmonary abscess.
Prescription analysis：On the basis of previous embodiment, add dry lung purulence, suppression it is conspicuous according to Hu Luba, eliminating the phlegm holds back purulence
Rosette thistle herb, the effect of enhancing drug clearing and antitussive, cooperate with other drugs and play effect.
Preparation method：
Above-mentioned prescription has received unexpected therapeutic effect in a large amount of clinical tests, and it is right before and after the present embodiment drug to be added
Than cure rate or total effective rate improve 3% or more, and above-mentioned prescription has received unexpected in a large amount of clinical tests
Therapeutic effect is especially formulated（4）, now for it, take above-mentioned raw materials medicine, crush, cross 80 mesh sieve, mixing to get.
Further：The anaesthetic preparation method of the clearing and antitussive：Above-mentioned raw materials medicine is placed in breaking-wall cell to crush
In machine carry out broken wall crushing, mixing to get.
Usage and dosage：It is oral.1-2g, 1-2 times on the one.According to the state of an illness, can take the circumstances into consideration to add under the guidance of doctor pharmacist
Subtract.
Clinical test：On the basis of a large amount of pharmacological toxicology experiment obtains support, since 2015, voluntary in patient
In the case of, patient 20 is randomly selected, men and women is fifty-fifty, and the age is in 12-60 one full year of life, symptom：Cough, fever, short of breath, chest
It is swollen, pectoralgia, just then cough and spit saline taste yellow foam phlegm without phlegm or cough, immediately cough frequency it is more, phlegm color is more yellow, or with color, or
It is simultaneous to see peripheral coldness, cyanotic lips and blister, arteries and veins and urine all be in thermal image.It treated for 1 week, recovers and stop medicine.Observe therapeutic effect.
In vain：It coughs or chest is swollen or asthma symptom is without alleviation, improve：Cough symptom frequency halving, the simultaneous disease such as asthma, chest is swollen, fever
It almost disappears, cures：Cough symptom disappears, and the simultaneous disease such as asthma, chest is swollen, fever disappears.
Cure rate（%）=【It cures（People）/ total number of cases（People）】*100%；
Total effective rate（%）={【Total number of cases（People）It is invalid（People）】/ total number of cases（People）}*100%.
From table：Using the patient of the drug, through statistics, cure rate 80%, total effective rate 95% is cured by contrast
Rate is apparently higher than the above embodiment.Have received unexpected therapeutic effect.
Claims (13)
1. a kind of anaesthetic of clearing and antitussive, including bulk pharmaceutical chemicals root of Aucklandia lappa Decne, it is characterised in that：The root of Aucklandia lappa Decne is matched with oriental wormwood, Radix Glycyrrhizae,
Its weight is 75-125 parts of root of Aucklandia lappa Decne, 75-125 parts of oriental wormwood, 75-125 parts of Radix Glycyrrhizae.
2. a kind of anaesthetic of clearing and antitussive according to claim 1, it is characterised in that：The root of Aucklandia lappa Decne is by volatile oil of Radix Aucklandiae
7.5-12.5 parts of replacements of extract, the oriental wormwood is by 7.5-12.5 parts of replacements of Herba Artemisiae Scopariae volatile oil extract.
3. a kind of anaesthetic of clearing and antitussive according to claim 2, it is characterised in that：The volatile oil of Radix Aucklandiae extraction
Object, Herba Artemisiae Scopariae volatile oil extract are all made of steam distillation and are made.
4. a kind of anaesthetic of clearing and antitussive according to claim 3, it is characterised in that：The volatile oil of Radix Aucklandiae extract
Preparation method be：Root of Aucklandia lappa Decne bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water, 30min is impregnated, is placed in volatile oil extractor, adds
Water, past medicinal material liquid level 2-3cm, heating water bath collects volatile oil of Radix Aucklandiae extract, the Herba Artemisiae Scopariae volatile oil extract
Preparation method be：Oriental wormwood bulk pharmaceutical chemicals are taken, coarse powder is ground into, add distilled water, 20min is impregnated, is placed in volatile oil extractor, adds
Water, past medicinal material liquid level 2-3cm, heating water bath collects Herba Artemisiae Scopariae volatile oil extract.
5. a kind of anaesthetic of clearing and antitussive according to claim 1, it is characterised in that：75-125 parts of the root of Aucklandia lappa Decne, mattress
Old 75-125 parts 15-25 parts of replacements of mixture by root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil.
6. a kind of anaesthetic of clearing and antitussive according to claim 5, it is characterised in that：The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil are mixed
Close object using steam distillation be made, the root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture preparation method be：The wood of parts by weight such as take
Fragrant, oriental wormwood bulk pharmaceutical chemicals, are ground into coarse powder, add distilled water immersion 30min, be placed in volatile oil extractor, add water, past
Medicinal material liquid level 2-3cm, straight fire or heating water bath, collect root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture to obtain the final product.
7. a kind of anaesthetic of clearing and antitussive according to claim 5, it is characterised in that：The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
15-25 parts of mixture by root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil mixture 150-250 parts of replacements of Benexate Hydrochloride.
8. a kind of anaesthetic of clearing and antitussive according to claim 7, it is characterised in that：The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil are mixed
The preparation method of beta-cyclodextrin for closing object is：The beta-cyclodextrin for taking 10 times of parts by weight of volatile oil adds 80-100 times to measure water, is warming up to
60 DEG C are made beta-cyclodextrin aqueous solution, under 120-150 turns/min rotating speed stirring conditions, are slowly added into root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
Mixture after adding volatile oil, at 60 DEG C, under the conditions of 100HZ, is ultrasonically treated 2h, 4 degree of placement 15h-20h filter, discard filter
Liquid, drying at room temperature grind to get root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil inclusion compound.
9. a kind of anaesthetic of clearing and antitussive according to claim 8, it is characterised in that：The root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
Inclusion compound removes the volatile oil that beta-cyclodextrin surface does not include with being washed to it under the conditions of 70 degree of petroleum ether, and room temperature is dry
It is dry, it crushes.
10. a kind of anaesthetic of clearing and antitussive according to claims 1 or 2 or 5 or 7, it is characterised in that：In the bulk pharmaceutical chemicals
175-225 parts of santal is added, 75-125 parts of tabasheer, 75-125 parts of safflower, 75-125 parts of calculus bovis factitius, white grape does 75-125
Part.
11. a kind of anaesthetic of clearing and antitussive according to claim 10, it is characterised in that：Hu Lu is added in the bulk pharmaceutical chemicals
Bars 45-55 parts, 40-50 parts of rosette thistle herb.
12. a kind of anaesthetic preparation method of clearing and antitussive according to claim 1 or 10, it is characterised in that：Take above-mentioned original
Expect medicine, crush, cross 80 mesh sieve, mixing to get.
13. a kind of preparation method of the anaesthetic of clearing and antitussive as described in claim 2 or 5 or 7 or 10：It is characterized in that：It will
Except volatile oil of Radix Aucklandiae extract, Herba Artemisiae Scopariae volatile oil extract or root of Aucklandia lappa Decne, the mixture of Herba Artemisiae Scopariae volatile oil or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
Bulk pharmaceutical chemicals other than the Benexate Hydrochloride of mixture crush, and sieve with 100 mesh sieve, mixing, then with volatile oil of Radix Aucklandiae extract, mattress
The mixture beta-cyclodextrin inclusion compound of old extractive of volatile oil or root of Aucklandia lappa Decne, the mixture of Herba Artemisiae Scopariae volatile oil or root of Aucklandia lappa Decne, Herba Artemisiae Scopariae volatile oil
Object be uniformly mixed to get.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201036A (en) * | 2019-07-04 | 2019-09-06 | 内蒙古民族大学附属医院 | A kind of anaesthetic and its preparation process for clearing lung and relieving cough |
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| CN103638347A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Children heat clearing compound powder and preparation method thereof |
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2018
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638347A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Children heat clearing compound powder and preparation method thereof |
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| 蒙医学编辑委员会: "《中国医学百科全书 蒙医学》", 31 December 1992, 上海科学技术出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110201036A (en) * | 2019-07-04 | 2019-09-06 | 内蒙古民族大学附属医院 | A kind of anaesthetic and its preparation process for clearing lung and relieving cough |
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