CN106974936A - A kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof - Google Patents
A kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof Download PDFInfo
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- CN106974936A CN106974936A CN201610033951.8A CN201610033951A CN106974936A CN 106974936 A CN106974936 A CN 106974936A CN 201610033951 A CN201610033951 A CN 201610033951A CN 106974936 A CN106974936 A CN 106974936A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/105—Aliphatic or alicyclic compounds
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/111—Aromatic compounds
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/20—Inorganic substances, e.g. oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
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Abstract
The present invention relates to a kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof, the component and its ratio of weight and number of said composition are：10-40 parts of activated carbon；10-40 parts of kaolin；10-20 parts of sucrose；0.01-0.02 parts of sodium chloride；10-30 parts of niacinamide.Inventive formulation composition is scientific and reasonable; technique is simple; it is easy to use; cost is relatively low; vaccine miospore egg capsule can be improved to discharge sporangium rapidly, zygoblast is rapidly entered enterocyte progress schizogamy and zoogamy; destruction of the schizogamy stage to epithelial cell is reduced simultaneously; impaired intestinal mucosa can quickly be repaired, energy needed for more nutriments supplement body in time is absorbed by suction-operated; discharge rate of the vaccine miospore egg capsule in chicken body is reduced, protective rate of the coccidial vaccine to whole chicken group is improved.
Description
Technical field
It is especially a kind of to improve broiler chicken coccidial vaccine immune effect the invention belongs to veterinary biologics field
Composition and preparation method thereof.
Background technology
Chicken coccidiasis is a kind of parasitic disease of global infringement poultry intestinal tract, be to aquaculture harm compared with
One of big disease, usually in Outbreak, after chicken coccidiasis occurs, not only influences the production of chicken
Performance, reduces the price of deed, causes chick growth to be obstructed, and a large amount of chickens can be caused dead, once
Outburst will result in the economic loss that can not be made up, and its incidence of disease is up to 50%-70%, and the death rate is
20-30%, severe patient is up to 80%, and the indirect loss that application chemical drug preventing and treating etc. is caused at present is difficult to estimate,
The medicament residue of such as drug induced animal derived food is into the maximum barrier of outlet broiler chicken, while medicine
Production also bring the outstanding problems such as environmental pollution to environmental protection；China some areas and major in recent years
Cultivate group and use anticoccidial vaccine, economical and practical, beneficial to environmental protection, but the toxicity of external vaccine is too strong
Be not suitable for the use of China poultry, the country uses Precocious Strains vaccine immunity, immune response often occurs, cause
Chicken body band worm, influences the digestibility of feed, increased weight is slow, and protective rate is not high, discharge egg capsule amount compared with
It is many.So it is vital thing to develop a kind of composition that can improve coccidial vaccine immune effect.
The content of the invention
It is an object of the invention to provide a kind of composition for improving broiler chicken coccidial vaccine immune effect, this hair
Bright formula composition is scientific and reasonable, and easy to use, cost is relatively low, can improve vaccine miospore egg capsule fast
Quick-release releases sporangium, zygoblast is rapidly entered enterocyte progress schizogamy and zoogamy,
Destruction of the schizogamy stage to epithelial cell is reduced simultaneously, can quickly be repaired impaired intestinal mucosa, be led to
Cross the more nutriments of suction-operated absorption and supplement energy needed for body in time, reduce vaccine miospore ovum
Discharge rate of the capsule in chicken body, improves protective rate of the coccidial vaccine to whole chicken group.
It is another object of the present invention to provide a kind of composition for improving broiler chicken coccidial vaccine immune effect
Preparation method.
The present invention is achieved by the following technical solutions：
A kind of composition for improving broiler chicken coccidial vaccine immune effect, the component and its parts by weight of its composition
Counting ratio is：
Moreover, said composition component and its optimal ratio of weight and number are respectively：
A kind of preparation method for the composition for improving broiler chicken coccidial vaccine immune effect, the step of its preparation method
Suddenly it is：
(1) activated carbon, kaolin, sucrose, sodium chloride, niacinamide is weighed respectively according to weight proportion to carry out
Crush and cross 200 mesh sieves；
(2) the activated carbon after sieving, kaolin, sucrose, sodium chloride, niacinamide are respectively put into mixing dry
65 degree of dryings 2 hours in dry case；
(3) batch mixing is put into after mixing dried activated carbon, kaolin, sucrose, sodium chloride, niacinamide
In tank, uniform mixing 25 minutes, that is, obtain a kind of composition for improving broiler chicken coccidial vaccine immune effect into
Product.
Advantages of the present invention and beneficial effect are：
Formed 1. the present invention makes the zygoblast of release rapidly enter epithelial cell by the suction-operated of activated carbon
Trophozoite carries out schizogamy, reduces the destruction to cell, and increase zygoblast enters the ability of cell.
2. inventive formulation composition is scientific and reasonable, technique is simple, and easy to use, cost is relatively low, can be effective
The immunity of broiler chicken coccidia is improved, the egg capsule quantity in excrement is detected after attacking poison by an immune cycle
It is substantially zeroed, chicken group is set up powerful immune system.
3. the niacinamide in the present invention can repair impaired enteron aisle facial mask rapidly, the pain of body is set to delay
Solution, recovers feeding, promotes the sound of body Liver immunity system and epithelial cell.
Embodiment
The present invention is described in further detail by following examples.It should be noted that：Following embodiments are explanations
Property, it is not limited, it is impossible to limit protection scope of the present invention with following embodiments.
Activated carbon, kaolin, sucrose, sodium chloride, niacinamide in instant component can be in markets
On be commercially available.
Embodiment 1
A kind of composition for improving broiler chicken coccidial vaccine immune effect, the component and its weight point of its composition
It is not：Activated carbon 30kg, kaolin 30kg, sucrose 20kg, sodium chloride 0.01kg, niacinamide 20kg.
A kind of preparation method for the composition for improving broiler chicken coccidial vaccine immune effect, be the step of its preparation method：
(1) activated carbon, kaolin, sucrose, sodium chloride, niacinamide is weighed respectively according to weight proportion to carry out
Crush and cross 200 mesh sieves；
(2) the activated carbon after sieving, kaolin, sucrose, sodium chloride, niacinamide are respectively put into mixing dry
65 degree of dryings 2 hours in dry case；
(3) batch mixing is put into after mixing dried activated carbon, kaolin, sucrose, sodium chloride, niacinamide
In tank, uniform mixing 25 minutes, that is, obtain a kind of composition for improving broiler chicken coccidial vaccine immune effect into
Product.
Embodiment 2
A kind of composition for improving broiler chicken coccidial vaccine immune effect, the component and its weight point of its composition
It is not：Activated carbon 10kg, kaolin 10kg, sucrose 10kg, sodium chloride 0.01kg, niacinamide 10kg.
The step be the same as Example 1 of its preparation method.
Embodiment 3
A kind of composition for improving broiler chicken coccidial vaccine immune effect, the component and its weight point of its composition
It is not：Activated carbon 40kg, kaolin 40kg, sucrose 20kg, sodium chloride 0.02kg, niacinamide 30kg.
The step be the same as Example 1 of its preparation method.
Clinical practice
Test site Weifang broiler breeding company of China Oil and Food Import and Export Corporation, 60 5 Japanese instar chicklings of AA broiler chicken are taken to be divided into 3
Group, every group 20, be put into isolator raise.A groups be an immune group, B groups be immune group of the present invention,
C groups are blank group, and the consumption that the present invention is organized uses for 50g/1000 plumage seedlings；By only weighing during packet, respectively
Group distribution uniform in size.Vaccine selects the plumage part/chicken of trivalent seedling 1 of the positive allusion quotation in Foshan, is said according to product
It is bright to use, it is finished and carries out within the after vaccine the 8th day attacking a malicious 50000 egg capsule/chicken.The 4th day is attacked after poison to young bird
Chicken is cooked clinical observation, record excrement OPG and chicken group's protective rate, and is recorded in detail.(refer to Experimental Comparison
Table)
Table immune effect contrast test of the present invention
Conclusion：Show that B groups immune group chicken group excrement OPG i.e. of the present invention only has 128 by above-mentioned conclusion (of pressure testing)
Individual/g, hence it is evident that better than the immune effect that A groups list vaccine, from the state of mind, the feeding for majoring in rear chicken group
From the point of view of amount, jumpbogroup protective rate, of the present invention group notable in coccidial vaccine protecting effect.
Claims (3)
1. a kind of composition for improving broiler chicken coccidial vaccine immune effect, it is characterised in that：Should
The component and its ratio of weight and number of composition be：
2. a kind of group for improving broiler chicken coccidial vaccine immune effect according to claim 1
Compound, it is characterised in that：Said composition component and its optimal ratio of weight and number are respectively：
3. a kind of a kind of raising broiler chicken coccidial vaccine immune effect as claimed in claim 1
The preparation method of composition, it is characterised in that：The step of preparation method is：
(1) activated carbon, kaolin, sucrose, sodium chloride, cigarette are weighed respectively according to weight proportion
Acid amides is crushed and crosses 200 mesh sieves；
(2) the activated carbon after sieving, kaolin, sucrose, sodium chloride, niacinamide are put respectively
Enter in combination drying case 65 degree of dryings 2 hours；
(3) put after mixing dried activated carbon, kaolin, sucrose, sodium chloride, niacinamide
Enter in mixing tank, uniform mixing 25 minutes, that is, obtain a kind of broiler chicken coccidial vaccine that improves and be immunized
The composition finished product of effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610033951.8A CN106974936A (en) | 2016-01-19 | 2016-01-19 | A kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610033951.8A CN106974936A (en) | 2016-01-19 | 2016-01-19 | A kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106974936A true CN106974936A (en) | 2017-07-25 |
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| CN201610033951.8A Pending CN106974936A (en) | 2016-01-19 | 2016-01-19 | A kind of composition for improving broiler chicken coccidial vaccine immune effect and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108060085A (en) * | 2017-12-31 | 2018-05-22 | 天津赫莱恩特生物科技有限公司 | It is a kind of to improve the method for poisoning eimeria tenella egg capsule purifying success rate |
| WO2023110658A1 (en) * | 2021-12-13 | 2023-06-22 | Dsm Ip Assets B.V. | Use of oligosaccharide preparation to increase performance of animal vaccinated against coccidiosis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5122829A (en) * | 1974-08-14 | 1976-02-23 | Sankyo Co | KOKOKUSHIJIUMUZAI |
| CN104083767A (en) * | 2014-07-02 | 2014-10-08 | 湖南尔康制药股份有限公司 | Vaccine protective agent premixing auxiliary material and preparation method thereof |
-
2016
- 2016-01-19 CN CN201610033951.8A patent/CN106974936A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5122829A (en) * | 1974-08-14 | 1976-02-23 | Sankyo Co | KOKOKUSHIJIUMUZAI |
| CN104083767A (en) * | 2014-07-02 | 2014-10-08 | 湖南尔康制药股份有限公司 | Vaccine protective agent premixing auxiliary material and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 朱晓波: "球虫疫苗稀释剂的制备及其对疫苗免疫效果的影响", 《中国优秀硕士学位论文全文数据库 农业科技辑》 * |
| 王洪鹏: "鸡球虫病的辅助性治疗措施", 《当代畜牧》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108060085A (en) * | 2017-12-31 | 2018-05-22 | 天津赫莱恩特生物科技有限公司 | It is a kind of to improve the method for poisoning eimeria tenella egg capsule purifying success rate |
| WO2023110658A1 (en) * | 2021-12-13 | 2023-06-22 | Dsm Ip Assets B.V. | Use of oligosaccharide preparation to increase performance of animal vaccinated against coccidiosis |
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