CN1069733A - 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 - Google Patents

6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 Download PDF

Info

Publication number
CN1069733A
CN1069733A CN92108977A CN92108977A CN1069733A CN 1069733 A CN1069733 A CN 1069733A CN 92108977 A CN92108977 A CN 92108977A CN 92108977 A CN92108977 A CN 92108977A CN 1069733 A CN1069733 A CN 1069733A
Authority
CN
China
Prior art keywords
group
formula
compound
alkyl group
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92108977A
Other languages
English (en)
Chinese (zh)
Inventor
W·本森
K·V·查尔多博
P·C·格雷戈里
K·U·沃尔福
u·普罗舍夫
M·图泊
T·赫肯伯格
I·V·威格登
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Publication of CN1069733A publication Critical patent/CN1069733A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
CN92108977A 1991-07-31 1992-07-30 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 Pending CN1069733A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4125292.6 1991-07-31
DE4125292A DE4125292A1 (de) 1991-07-31 1991-07-31 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN96100699A Division CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Publications (1)

Publication Number Publication Date
CN1069733A true CN1069733A (zh) 1993-03-10

Family

ID=6437366

Family Applications (2)

Application Number Title Priority Date Filing Date
CN92108977A Pending CN1069733A (zh) 1991-07-31 1992-07-30 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用
CN96100699A Pending CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN96100699A Pending CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Country Status (21)

Country Link
US (1) US5272143A (cg-RX-API-DMAC7.html)
EP (1) EP0525584B1 (cg-RX-API-DMAC7.html)
JP (1) JP3174158B2 (cg-RX-API-DMAC7.html)
KR (1) KR930002353A (cg-RX-API-DMAC7.html)
CN (2) CN1069733A (cg-RX-API-DMAC7.html)
AT (1) ATE161012T1 (cg-RX-API-DMAC7.html)
AU (1) AU649153B2 (cg-RX-API-DMAC7.html)
CA (1) CA2075102A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ239392A3 (cg-RX-API-DMAC7.html)
DE (2) DE4125292A1 (cg-RX-API-DMAC7.html)
ES (1) ES2110454T3 (cg-RX-API-DMAC7.html)
FI (1) FI923440A7 (cg-RX-API-DMAC7.html)
HU (2) HU211105B (cg-RX-API-DMAC7.html)
IE (1) IE922310A1 (cg-RX-API-DMAC7.html)
IL (1) IL102503A (cg-RX-API-DMAC7.html)
MX (1) MX9204457A (cg-RX-API-DMAC7.html)
NO (1) NO300375B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ243715A (cg-RX-API-DMAC7.html)
RU (1) RU2078765C1 (cg-RX-API-DMAC7.html)
TW (1) TW207541B (cg-RX-API-DMAC7.html)
ZA (1) ZA925093B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100418967C (zh) * 1999-01-11 2008-09-17 阿古龙制药公司 聚(adp-核糖)聚合酶的三环抑制剂

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414130A (en) * 1993-12-23 1995-05-09 The Dow Chemical Company Process for the preparation of diaminoresorcinol
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
AU2005286190A1 (en) * 2004-09-22 2006-03-30 Cancer Research Technology Ltd. Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
WO2006033003A1 (en) * 2004-09-22 2006-03-30 Pfizer, Inc. Method of preparing poly(adp-ribose) polymerases inhibitors
WO2009155054A2 (en) * 2008-05-29 2009-12-23 Albany Molecular Research, Inc. 5-ht3 receptor modulators, methods of making, and use thereof
PT2534153T (pt) * 2010-02-12 2016-12-27 Pfizer Sais e polimorfos de 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
CA3106239A1 (en) 2018-07-27 2020-01-30 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100418967C (zh) * 1999-01-11 2008-09-17 阿古龙制药公司 聚(adp-核糖)聚合酶的三环抑制剂

Also Published As

Publication number Publication date
CN1141773A (zh) 1997-02-05
NO923004L (no) 1993-02-01
CZ239392A3 (en) 1993-04-14
RU2078765C1 (ru) 1997-05-10
IL102503A (en) 1995-12-31
HU210217A9 (en) 1995-02-28
KR930002353A (ko) 1993-02-23
AU2067792A (en) 1993-02-04
FI923440A0 (fi) 1992-07-30
ZA925093B (en) 1993-04-28
IL102503A0 (en) 1993-01-14
EP0525584B1 (de) 1997-12-10
AU649153B2 (en) 1994-05-12
HU211105B (en) 1995-10-30
TW207541B (cg-RX-API-DMAC7.html) 1993-06-11
HUT65453A (en) 1994-06-28
ATE161012T1 (de) 1997-12-15
EP0525584A1 (de) 1993-02-03
IE922310A1 (en) 1993-02-10
DE59209055D1 (de) 1998-01-22
HU9202430D0 (en) 1992-10-28
NO923004D0 (no) 1992-07-30
JPH05202052A (ja) 1993-08-10
DE4125292A1 (de) 1993-02-04
JP3174158B2 (ja) 2001-06-11
ES2110454T3 (es) 1998-02-16
MX9204457A (es) 1993-05-01
US5272143A (en) 1993-12-21
NZ243715A (en) 1995-03-28
CA2075102A1 (en) 1993-02-01
NO300375B1 (no) 1997-05-20
FI923440A7 (fi) 1993-02-01

Similar Documents

Publication Publication Date Title
CN1041420C (zh) Ｎ－酰基－２，３－苯并环二氮杂䓬衍生物的制备方法
CN1289499C (zh) 吡嗪并(氮杂)吲哚衍生物
CN1070490C (zh) 吲哚衍生物
CN1361779A (zh) 新化合物
CN1072219C (zh) 二氮杂䓬酮、其生产和用途
CN1094727A (zh) 5-芳基吲哚衍生物
CN1107467A (zh) 1-苯磺酰基-1，3-二氢-吲哚-2-酮衍生物，其制备及含有它们的药物组合物
CN1230432C (zh) 取代的苯基－哌嗪衍生物及其制备和用途
CN1043766C (zh) 吲哚衍生物及其制法和它们在制备药物中的应用
CN1620290A (zh) 作为5－羟色胺－6配体的吲哚基烷基胺衍生物
CN87103504A (zh) 杂环羧酰胺
CN1668585A (zh) 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
CN1244577C (zh) 4－苯基－1－哌嗪基、－哌啶基和－四氢吡啶基衍生物
CN1068328A (zh) 吡咯并吡嗪
CN1022322C (zh) 稠合吡唑3-氧代-丙腈衍生物的制备方法
CN1926098A (zh) 新的脲衍生物及其医药应用
CN1069733A (zh) 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用
CN1148355C (zh) 哒嗪-3-酮衍生物和含有该类化合物的药物
CN1205704A (zh) 2,7－取代的八氢－吡咯并[1,2－a]吡嗪衍生物
CN1037895A (zh) 杂脂族羧酰胺类化合物
CN1027536C (zh) 4，5，6，7-四氢化苯并咪唑衍生物制备方法
CN1437598A (zh) 新吲哚衍生物
CN1304403A (zh) 用于治疗抑郁症的n－芳氧基乙基－吲哚基－烷基胺(5－ht1a受体活化剂)
CN1871013A (zh) 作为mao－b抑制剂的苯并氮杂䓬衍生物
CN1173177A (zh) 6－甲氧基－1h－苯并三唑－5－甲酰胺衍生物、其制造方法及含有该衍生物的医药组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned