CN106963672A - It is a kind of that there is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application - Google Patents

It is a kind of that there is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application Download PDF

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Publication number
CN106963672A
CN106963672A CN201611016268.XA CN201611016268A CN106963672A CN 106963672 A CN106963672 A CN 106963672A CN 201611016268 A CN201611016268 A CN 201611016268A CN 106963672 A CN106963672 A CN 106963672A
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parts
composition
eyes
fatigue
skin cell
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CN106963672B (en
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张静
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Guangzhou Yun Yun Medicine Polytron Technologies Inc
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Guangzhou Yun Yun Medicine Polytron Technologies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin

Abstract

There is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application the invention discloses a kind of.Said composition is made up of grapefruit abstract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, Lavender, chamomile essential oil, taurine and Sodium Hyaluronate; it can be made into the external nursing product such as watery, emulsion form or cream shape; its remarkable advantage is that each raw material not only has obvious effect to alleviating asthenopia, and its synergy can alleviate skin cell fatigue near the eyes.Meanwhile, raw materials used in the present invention is frequently seen plants and vegetable fruit prods, is used for a long time nontoxic, it is adaptable to all kinds of to use the crowd of eye for a long time, containing colonies such as student, working clan, mobile phone family.

Description

It is a kind of that there is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application
Technical field
The present invention relates to a kind of composition, more particularly to it is a kind of have alleviate visual fatigue and the near the eyes tired group of skin cell Compound and its application.
Background technology
In recent years, with the popularization of video display terminal equipment and 3D stereopsis and adding for modern society's Working Life rhythm It hurry up, the scope of visual fatigue crowd is also constantly expanding.According to CNNIC（CNNIC）Data display, cut To 2013, Chinese netizen's scale oneself through reaching 5.64 hundred million；The computer user of the U.S.'s at least 14 % ~ 23% is different degrees of With computer vision syndrome, in Japan, India and Norway, this data has respectively reached 19.6 %, 46. 3% and 62. 5%.The college student of high-tech industry field correlation practitioner's research display 57%, which is tested oneself, has visual fatigue related symptoms；The whole world 90% computer user has the visual fatigue symptom such as dry and astringent eyes, ghost image, headache, livid ring around eye.
Eye visual fatigue mainly includes two kinds of eye fatigue and eye skin cell fatigue.Eye fatigue often shows as eye The eye syndrome that eyeball is swollen, eyes pain, eyes dry, foreign body sensation, photophobia, eye-blurred, ghost image, eyesight are unstable etc.；Eye flesh The problems such as skin cell fatigue can cause periocualr skin dim, relaxation, dry, so cause to occur livid ring around eye, pouch, crow's feet, The skin problem near the eyes such as fat granule.
The content of the invention
The primary and foremost purpose of the present invention is to provide a kind of composition, and said composition has the obvious visual fatigue and near the eyes alleviated The effect of skin cell fatigue.
Another object of the present invention is to provide application of the above-mentioned composition in external nursing product is prepared.
The present invention is realized by following technological means：
A kind of to have alleviation asthenopia and the near the eyes composition of skin cell fatigue, said composition is made up of following raw materials：Shaddock Seed extract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, Lavender, chamomile essential oil, taurine and hyalomitome Sour sodium.
As currently preferred technical scheme, the parts by weight of each raw material are：0.01-0.20 parts of grapefruit abstract is small Careless 0.01-0.20 parts of the extract of rice, 0.05-0.30 parts of kudzu root extract, 0.01-0.10 parts of peppermint oil, Lavender 0.01- 0.05 part, 0.01-0.05 parts of chamomile essential oil, 0.5-2.0 parts of taurine, 0.01-0.10 part of Sodium Hyaluronate.
As the further preferred technical scheme of the present invention, the parts by weight of each raw material are：Grapefruit abstract 0.05-0.10 Part, 0.05-0.10 parts of Herba Euphrasiae Regelii extract, 0.10-0.20 parts of kudzu root extract, 0.03-0.05 parts of peppermint oil, Lavender 0.02-0.04 parts, 0.02-0.04 parts of chamomile essential oil, 1.00-1.50 parts of taurine, 0.05-0.10 parts of Sodium Hyaluronate.
Shaddock contains abundant carbohydrate, vitamin B1, vitamin B2, vitamin C, citrin, carrotene, potassium, phosphorus, Chinese holly The compositions such as rafter acid, with the effect such as preferable anti-inflammatory, skin-care and beautifying.In addition, shaddock contains physiological activator skin glycosides, it is possible to decrease The viscosity of blood, reduces the formation of thrombus, to promoting blood flow to have preferable effect.
The root of kudzu vine can effectively improve blood supply and the microcirculation of eye, increase eye oxygen supply, improve cell metabolism, reduce myocyte Oxygen demand, so as to alleviate tonus of ocular muscles, mitigates visual fatigue；Simultaneously its can by adjust ciliary muscle stretch, with strengthen eye self Regulatory function and mitigate visual fatigue.
Eyebright active ingredient eyebright flavones, is a kind of very strong antioxidant, and its antioxidation can be prevented carefully Degeneration, the aging of born of the same parents, anti-eye strain improves eyesight bright eyes and reproduced, and promotes eyesight and eye function, help cut down pouch and Livid ring around eye.Eyebright has been appointed as natural eyeshield tonic by doctor in Europe, the title for having " eyedrops that can be drunk ".
Peppermint contains carrotene, B family vitamin, vitamin C, protein, fat and carbohydrate etc..Peppermint is pungent cool in nature, enters Lung, Liver Channel, there are dissipate wind-heat, head clearing, except analgesic of itching.
Lavender has good antibacterial, antioxidation, can promote cytothesis, balance skin top layer sebum point Secrete.Can also clearing heat and detoxicating, skin of releiving, relax one's muscles, mitigate skin cell sense of fatigue.
Chamomile essential oil, which has, improves eye strain, and the effect of Vitamin K can releive and loosen eye muscle, anti-inflammatory, town It is quiet；Dry, sensitive, fragile skin can be improved again.
Taurine accounts for 50% of free amino acid total amount in retina, safeguards that various kinds of cell, especially haemocyte are anti-oxidant Activity, makes tissue from the damage of oxidation base and free radical.Taurine has the ability for assigning skin cell living simultaneously, can in a steady stream not There is provided disconnectedly young skin quickly with lasting energy supplement and multiple protective.
Sodium Hyaluronate is one of main component in vitreum, can be with collagenous fibres, the common structure of soluble protein Into vitreum, to maintaining corneal surface shape that there is important effect.Rabbit experiment prompting, topical application Sodium Hyaluronate can necessarily journey Degree promotes the healing of corneal epithelial wound, meanwhile, Sodium Hyaluronate has the effect for preventing that isolated rabbit conjunctiva piece from drying, and can delay Eye strain and drying are solved, especially there is preferable curative effect to xerophthalmia.
Therefore, the present invention is with grapefruit abstract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, Lavender, ox Sulfonic acid, Sodium Hyaluronate are primary raw material prescription, mutual Synergistic, with supplement tear component, alleviate inner and external flesh of eyes it is nervous, Nutrition needed for visual cell is supplemented, improves eye microcirculation, while reducing the multiple action of radical damage.Investigate and demonstrate,prove through crowd Bright, the present composition has the obvious effect for alleviating visual fatigue and skin cell fatigue.
Present invention also offers a kind of external nursing product, alleviate asthenopia comprising above-mentioned having and skin is thin near the eyes The composition of born of the same parents' fatigue.
In the having and alleviate asthenopia and the near the eyes composition of skin cell fatigue of the invention described above, do not damaging In the range of invention effect, the composition that generally may be fitted in external nursing product can be arbitrarily coordinated to prepare external nursing Product.This any condition includes preservative, NMF, ultra-violet absorber, antioxidant, pH adjusting agent, emulsifying agent, hydrotropy Agent, thickener etc..Its consumption is the conventional amount used for preparing external nursing product.
The formulation of the external nursing product is watery, emulsion form or cream shape.
The technological merit of the present invention：
Modern medicine study achievement reasonable combination have developed a kind of composition suitable for visual fatigue crowd by the present invention.With showing There is technology to compare, its remarkable advantage is that each raw material not only has protective effect to alleviating asthenopia, and its synergy can be simultaneously Alleviate skin cell fatigue near the eyes.
Effect of this formula to human body show it is following some：
1st, toxic side effect is small：In contained component of the invention, taurine is not only one of aminoacid ingredient main in retina, and And the nutriment required for human body, participate in internal cystine, the metabolism of cysteine；During hyaluronic acid is vitreum Main component, to maintaining corneal surface shape to play an important roll.And other compositions all can be edible and nutritive value is very high Common natural plants and vegetable fruit prods, long-term use are nontoxic, safely and effectively;
2nd, synergistic function：Emphasis of the present invention is that lacrimal secretion is reduced, inner and external flesh of eyes continues tightly for the origin cause of formation of visual fatigue , nutrition supply is not enough, microcirculation disorder and the broad aspect of oxidative damage five, science selection prescription, with artificial tears（Hyaluronic acid Sodium）For matrix components, while adding grapefruit abstract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, Lavender, ocean Camomile essential oil and taurine etc. are provided simultaneously with the functional component Synergistic of beauty, eyeshield, to reach the battalion needed for supplement eye Form point, alleviate flesh constant tension inside and outside the ball of eyeball, improve eye microcirculation, remove free radical and alleviate the dry comprehensive work of eye With.
Embodiment：
Invention is described further by the following examples：
The raw material that the embodiment of the present invention is used is as follows：
It is gloomy not that grapefruit abstract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, taurine and Sodium Hyaluronate are purchased from Shaanxi Natural product Co., Ltd, Lavender is purchased from Guangzhou Tai Le Chemical Industry Science Co., Ltd with chamomile essential oil.
Embodiment 1：
With alleviating asthenopia and the near the eyes tired composition of skin cell, the parts by weight of each raw material are：Grapefruit abstract 0.05 part, 0.05 part of Herba Euphrasiae Regelii extract, 0.10 part of kudzu root extract, 0.02 part of peppermint oil, 0.01 part of Lavender, ocean is sweet 0.01 part of chrysanthemum essential oil, 0.5 part of taurine, 0.02 part of Sodium Hyaluronate.
Embodiment 2
With alleviating asthenopia and the near the eyes tired composition of skin cell, the parts by weight of each raw material are：Grapefruit abstract 0.10 part, 0.10 part of Herba Euphrasiae Regelii extract, 0.20 part of kudzu root extract, 0.05 part of peppermint oil, 0.03 part of Lavender, ocean is sweet 0.03 part of chrysanthemum essential oil, 1.5 parts of taurine, 0.05 part of Sodium Hyaluronate.
Embodiment 3：
With alleviating asthenopia and the near the eyes tired composition of skin cell, the percentage by weight of each raw material is：Shaddock is extracted 0.20 part of thing, 0.20 part of Herba Euphrasiae Regelii extract, 0.30 part of kudzu root extract, 0.10 part of peppermint oil, 0.05 part of Lavender, ocean 0.05 part of camomile essential oil, 2.0 parts of taurine, 0.10 part of Sodium Hyaluronate.
Application examples 1：With alleviating visual fatigue and the near the eyes tired watery external nursing product of skin cell
Formula composition is as follows：
It is separate Raw material is numbered Material name Percentage by weight/%
A 1 APEO（35）Castor oil（EL-35） 1.00
2 Tween-80（Tween-80） 1.00
3 Glycerine 0.40
4 Peppermint oil 0.03
5 Lavender 0.01
6 Chamomile essential oil 0.01
B 7 Sodium chloride 0.85
8 Disodium hydrogen phosphate 0.22
9 Sodium dihydrogen phosphate 0.046
10 Taurine 0.50
11 Grapefruit abstract 0.05
12 Herba Euphrasiae Regelii extract 0.05
13 Kudzu root extract 0.10
14 Deionized water To 100
C 15 Sodium Hyaluronate 0.02
D 16 Phenoxyethanol 0.80
17 Glycerine 0.80
Preparation technology is as follows：
（1）By 45 DEG C of heating water baths of A phases, constant temperature stirring 20min, entirely molten to extract powder, A phases are in clarification shape；
（2）Weigh each material of B phases to be dissolved in deionized water, filter；
（3）C is added in B phases, 45 DEG C of heating water baths, stirring to dissolving is swelled completely；
（4）Kept for 45 DEG C, A phases are rapidly joined in blended complete B, C two-phase, magnetic agitation 10min；
（5）D phase materials are weighed to be uniformly mixed；
（6）D phases are added into ABC three-phase mixing liquids, after stirring, discharging.
Application examples 2：With alleviating visual fatigue and the near the eyes tired emulsion form external nursing product of skin cell
Formula composition is as follows：
It is separate Raw material is numbered Material name Mass fraction/%
A 1 Tristerin（A165） 0.50
2 PEG-40 castor oil（RH-40） 1.50
3 Monoglyceride 0.50
4 GTCC 2.00
5 Peppermint oil 0.05
6 Lavender 0.03
7 Chamomile essential oil 0.03
B 8 Glycerine 4.00
9 Butanediol 2.00
10 Xanthan gum 0.10
11 Carbomer U20 0.15
12 Sodium Hyaluronate 0.05
13 Kudzu root extract 0.20
14 Herba Euphrasiae Regelii extract 0.10
15 Grapefruit abstract 0.10
16 Taurine 1.50
17 EDTA 0.05
18 Deionized water To100
C 19 Triethanolamine In right amount
D 20 It is double（Methylol）Imidazolidinyl urea IPBC（IPBC）(Jie Ma-BP) 0.40
21 Essence In right amount
Preparation technology is as follows：
（1）A phase each components are weighed successively, are stirred, are warming up to 75 ~ 80 DEG C, heat preservation for standby use；
（2）First weigh glycerine, butanediol and disperse xanthan gum, add other components, stirring and dissolving in B phases, be heated to 85 DEG C, Obtain B phases, heat preservation for standby use；
（3）When A, B two-phase are completely dissolved and temperature difference is little（Typically>80℃）, A is added to B phases, at a high speed（> 3000rpm）Homogeneous 3min, is stirred for 1min；
（4）Addition C phases after 50 DEG C are cooled to, is approximately equal to 7.0 to pH value, stirs；
（5）Addition D phases after 45 DEG C are cooled to, are stirred, are stood, bottling.
Application examples 3：With alleviating visual fatigue and the near the eyes tired cream shape external nursing product of skin cell
Formula composition is as follows：
It is separate Raw material is numbered Material name Mass fraction/%
A 1 Sorbitan trioleate (Span80) 1.00
2 Albolene 2.00
3 Lanolin derivative 1.00
5 GTCC 3.00
6 Peppermint oil 0.10
7 Lavender 0.05
8 Chamomile essential oil 0.05
B 9 Glycerine 4.00
10 Butanediol 2.00
11 Tween-80（Tween-80） 2.00
12 Carbomer U20 0.20
13 Sodium Hyaluronate 0.10
14 Kudzu root extract 0.30
15 Herba Euphrasiae Regelii extract 0.20
16 Grapefruit abstract 0.20
17 Taurine 2.00
18 EDTA 0.05
19 Deionized water To100
C 20 Triethanolamine In right amount
D 21 It is double（Methylol）Imidazolidinyl urea IPBC（IPBC）(Jie Ma-BP) 0.40
22 Essence In right amount
Preparation technology is as follows：
（1）A phase each components are weighed successively, are stirred, are heated to 85 DEG C, obtain A phases, heat preservation for standby use；
（2）B phase each components are weighed successively, and stirring and dissolving is heated to 80 DEG C, obtains B phases, heat preservation for standby use；
（3）When A, B two-phase are completely dissolved and temperature difference is little（Typically>80℃）, A is added to B phases, at a high speed（> 3000rpm）Homogeneous 3min, is stirred for 1min；
（4）Addition C phases after 50 DEG C are cooled to, is approximately equal to 7.0 to pH value, stirs；
（5）Addition D phases after 45 DEG C are cooled to, are stirred, are stood, bottling.
Application examples 4：Normal individual trial is tested
Normal individual trial is tested（Alleviate visual fatigue evaluation）：The watery external nursing product of application examples 1 is taken to be applied to subject（Number No less than 100）Side eyes around skin, be used as own control using the opposite side eyes that do not process.Respectively on probation After 10min, and after continuous on probation 15 days, care product is to the related indication improvement degree of visual fatigue and scores for record, with this Evaluate mitigation of the product to visual fatigue.Result of the test shows that the externally applied product, which has, preferably alleviates visual fatigue effect.Knot Fruit is as shown in table 1：
Note：By 0-3 points of scales, wherein, " 0 point " indicates no related symptoms；" 1 point " represents random thoughts（1-2 times/2 days）There is phase Close symptom；" 2 points " have when representing（1-3 times/day）Related symptoms；" 3 points " expressions often have（>3 times/day）Related symptoms.
Normal individual trial is tested（Moisturizing moisturizing effect assessment）：Take application examples 1 watery external nursing product be applied to it is tested Person（Number is no less than 100）Side eyes around skin, be used as own control using the opposite side eyes that do not process.Respectively In after 10min on probation, and it is continuous it is on probation 15 days after, improvement degree of the record care product to periocualr skin skin state near the eyes And score, protective effect of the product to skin near the eyes is evaluated with this.Result of the test shows that the externally applied product, which has, preferably to be moistened The effect of skin, reduction microgroove and Vitamin K near the eyes.As a result it is as shown in table 2：

Claims (6)

1. a kind of have alleviation asthenopia and the near the eyes composition of skin cell fatigue, it is characterised in that said composition is under Raw material is stated to be made：Grapefruit abstract, Herba Euphrasiae Regelii extract, kudzu root extract, peppermint oil, Lavender, chamomile essential oil, ox Sulfonic acid and Sodium Hyaluronate.
2. according to claim 1 have alleviation asthenopia and the near the eyes composition of skin cell fatigue, its feature exists In：The parts by weight of each raw material are：0.01-0.20 parts of grapefruit abstract, 0.01-0.20 parts of Herba Euphrasiae Regelii extract, the root of kudzu vine is extracted 0.05-0.30 parts of thing, 0.01-0.10 parts of peppermint oil, 0.01-0.05 parts of Lavender, 0.01-0.05 parts of chamomile essential oil, 0.5-2.0 parts of taurine, 0.01-0.10 part of Sodium Hyaluronate.
3. according to claim 2 have alleviation asthenopia and the near the eyes composition of skin cell fatigue, its feature exists In：The parts by weight of each raw material are：0.05-0.10 parts of grapefruit abstract, 0.05-0.10 parts of Herba Euphrasiae Regelii extract, the root of kudzu vine is extracted 0.10-0.20 parts of thing, 0.03-0.05 parts of peppermint oil, 0.02-0.04 parts of Lavender, 0.02-0.04 parts of chamomile essential oil, 1.00-1.50 parts of taurine, 0.05-0.10 parts of Sodium Hyaluronate.
4. application of the composition according to claim any one of 1-3 in external nursing product is prepared.
5. a kind of external nursing product, includes the composition described in claim any one of 1-3.
6. external nursing product according to claim 5, it is characterised in that the formulation of the external nursing product is water Shape, emulsion form or cream shape.
CN201611016268.XA 2016-11-18 2016-11-18 Composition capable of relieving visual fatigue and periocular skin cell fatigue and application thereof Active CN106963672B (en)

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CN109745404A (en) * 2019-03-28 2019-05-14 陕西中美天顺药业有限公司 A kind of anti-visual fatigue and the Essence for nursing periocualr skin

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379169A (en) * 2018-05-04 2018-08-10 无限极（中国）有限公司 A kind of composition and its application in preparing the cosmetics for releiving fatigue
CN109745404A (en) * 2019-03-28 2019-05-14 陕西中美天顺药业有限公司 A kind of anti-visual fatigue and the Essence for nursing periocualr skin

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