CN101129698A - Eye drops containing turmeric extractive and preparation method thereof - Google Patents
Eye drops containing turmeric extractive and preparation method thereof Download PDFInfo
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- CN101129698A CN101129698A CNA2007100302976A CN200710030297A CN101129698A CN 101129698 A CN101129698 A CN 101129698A CN A2007100302976 A CNA2007100302976 A CN A2007100302976A CN 200710030297 A CN200710030297 A CN 200710030297A CN 101129698 A CN101129698 A CN 101129698A
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Abstract
Disclosed is an eye drop containing turmeric extract which is prepared from the following constituents (by weight ratio): turmeric extract 0. 15-0. 45, taurine 0. 07, sodium hyaluronate 0. 033, vitamin B6 0. 033, boracic acid 0. 8-1. 2, borax 0. 8-1. 2, polyoxyethylene hydrogenated castor oil 1. 5-4. 5 and balancing distilled water. The invention also relates to the process for preparing the eye drop, which contains the precursor of human body hormones, and is capable of facilitating auto-regulated hormones in human body, increasing lacrimal gland secretion, increasing eye cells vitality, improving eye microcirculation, and alleviating symptoms of dry-eye patients.
Description
Technical field
The present invention relates to a kind of collyrium, particularly a kind of eye drop that contains HUANGJIANG extract.The invention still further relates to the preparation method of above-mentioned eye drop.
Background technology
Xerophthalmia is meant that a variety of causes causes a kind of disease of tear film relevant with ophthalmic uncomfortable and eye surface abnormalities.It comprises the unusual equal generation that causes xerophthalmia of unusual and tear kinetics of the tear film quality and quantity that any reason causes.The normal main suit of xerophthalmia patient eye is dry and astringent, foreign body sensation, photophobia are shed tears, asthenopia etc., has had a strong impact on patient's life, working and learning.According to a case load of the U.S. is that 2520 people's xerophthalmia Epidemiological studys show, prevalence is 14.6% among the crowd in 65-84 year, and promptly 4,300,000 populations suffer from xerophthalmia.And China does not still have report, the diagnosis of epidemiology aspect so far because the research of xerophthalmia is started late.
Xerophthalmia is known as modern's civilization, the symptom of xerophthalmia comprise twinge, scorching hot, have in the harsh feeling, eyes or on every side and occur thread mucus, stimulated by wind and smoke easily, of short duration reading is tired easily and be difficult to wear contact lens.The origin cause of formation that influences the xerophthalmia symptom can be divided into oil layer deficiency, water layer deficiency and slime layer deficiency according to composition part of tear, usually test to check whether the xerophthalmia situation is arranged with tear clinically, it is exactly dry eye symptoms that the testing standard lacrimal secretion is less than 5mm, but this is not to be unique foundation of diagnosis xerophthalmia, even some patient's tear test is normal clinically sometimes, even surpass the 5mm standard, but in the daily life extremely uncomfortable xerophthalmia symptom appears still.
Clinical data is pointed out, ophthalmic patient has two to three one-tenth the uncomfortable problem of xerophthalmia is all arranged, person in middle and old age more than 20 years old young student to 55 year old have, wherein in the majority with climacteric women and gerontal patient again, the patient wants to improve the xerophthalmia symptom, must know the xerophthalmia origin cause of formation, if the xerophthalmia symptom that blepharitis causes will be paid attention to the cleaning of eyes, if water deficient causes then suitably replenishing the artificial tears, if the middle severe xerophthalmia that inflammation causes is depended an artificial tears alone and still can't be releived, tradition then can select anti-inflammatory drug such as steroid to treat, and then is probably can cause glaucoma but its effect is a life-time service, ocular disease such as high intraocular pressure or cataract.
For middle severe xerophthalmia patient, can use the medicine that suppresses the inflammation of xerophthalmia eye cell long-period in fact, promote tear to produce naturally, the discomfort of making the life better.The lacrimal secretion of xerophthalmia is undesired, and inflammation has very big related with eye table cell long-period, and in the past the Therapeutic Method of xerophthalmia only at the symptom of oligodacrya, moisten or tear plug pipe is temporarily releived with the artificial tears, but needing for a long time to associate with the artificial tears is suitable inconvenience in life, if can suit the remedy to the case, can improve meeting person's inconvenience greatly at the xerophthalmia origin cause of formation.
Summary of the invention
First purpose of the present invention, just provide a kind of eye drop that contains HUANGJIANG extract, HUANGJIANG extract contains human hormone's precursor, the secretion that can promote human body self to regulate hormone improves the endocrine of human eye, increases lacrimal secretion, by regulating body balance, strengthen the eye cell viability, improve the eye microcirculation, have nutrition, lubricated effect, alleviating dry eye disease patient's ophthalmic uncomfortable symptom.
Another object of the present invention is to provide a kind of preparation method of above-mentioned eye drop.
For realizing above-mentioned first purpose, the eye drop that contains HUANGJIANG extract of the present invention is made by following component: (following unit all be weight percentage wt%)
HUANGJIANG extract 0.15~0.45 taurine 0.07
Hyaluronate sodium 0.033 vitamin B 60.033
Boric acid 0.8~1.2 Borax 0.8~1.2
Polyoxyethylene castor oil 1.5~4.5
All the other are distilled water.
HUANGJIANG has another name called Rhizoma Dioscoreae Zingiberensis, is list plant Dioscoreaceae Wild yam, is the important source material of ideal extraction steroid hormone class medicine, and its steroidal structural compounds is transformed, and just can obtain various steroid hormone class medicine.With the HUANGJIANG is raw material, therefrom extracts and can synthesize series of products such as being converted into gonadal hormone, protein anabolic hormone and 17-hydroxy-11-dehydrocorticosterone.Have beauty treatment, increase hormone secretion, regulate body balance.
Clinical verification shows that HUANGJIANG extract has good biological action to tarsal glands, and the excretory oils and fats of tarsal glands can cover on the tear, prevents the evaporation of tear.HUANGJIANG extract can promote the lacrimal secretion tear and have moistening cornea and the effect of washing foreign body.The active substance that the prompting HUANGJIANG extract can be used as the treatment xerophthalmia is applied in the collyrium.
Taurine, chemical name: 2-aminoethyl sulfonic acid, a kind of white, needle-shaped crystals or crystalloid powder, odorless, little acid of distinguishing the flavor of is dissolved in water.
Taurine is a kind of sulfur-containing amino acid with multiple physiologically active and physiological function.The fields such as medicine, food, milk product, beverage, bean product, tonic, nutritional solution, compound monosodium glutamate that are widely used in are as nutrition enhancer.Have and protect the liver, function of gallbladder promoting, detoxifcation, promotion metabolism, promote infant intelligent development, safeguard normal visual function and improve effects such as immune function of human body.Be the indispensable seed amino acid of human body,, can be used for the control of various oculopathy because of having good analgesic and antiinflammation; Playing an important role aspect the homergy of keeping eye,, retina generation pathologic is being changed, may cause at last losing one's sight if lack taurine.
Chondroitin sulfate, chemical name are the D-glucuronic acid, and 2-hexanamido-2-deoxidation-sulphuric acid-D-galactose has another name called hyaluronic acid sodium, hyaluronate sodium, are colourless or yellowish clear liquid.
Chondroitin sulfate is from the acidic mucopolysaccharide class material that animal tissue extracts, purification prepares, and is the main component that constitutes intercellular substance, and relative stability and the normal function of keeping cellular environment had important function.But accelerating wound healing, reduce the generation of scar tissue, by promoting the generation of substrate, for the migration of cell provides framework, help the migration of corneal epithelial cell, thereby promote the healing of corneal wound, chondroitin sulfate can improve blood circulation, quicken metabolism, promote the absorption of transudate and the elimination of inflammation.Chondroitin sulfate is up-to-date natural moisture preserving agent, have extremely strong preserve moisture, lubricity, the some back is comfortable; Have high viscoelasticity, prolonged medicinal liquid action time within the eye, increased drug effect, reduced the sense of discomfort that causes because of the easy inflow entrance of medicinal liquid, nasal cavity simultaneously.
Vitamin B6 is the indispensable a kind of water miscible vitamin of human body, has Nutrition; The blurred vision that can anti-eye strain causes; Promote the vigor of cornea and retina cell, prevent the cornea drying;
The above-mentioned preparation method that contains the eye drop of HUANGJIANG extract can prepare successively according to the following steps:
1) with HUANGJIANG extract and polyoxyethylene castor oil are conventional mixes thawing aseptic filtration after, put sterile chamber;
2) under aseptic condition, taurine, hyaluronate sodium, vitamin B6 gradation are added in the sterile chamber;
3) the boric acid adding distil water is made into 100ml solution;
4) the Borax adding distil water is made into 100ml solution,
5) use 3 respectively), 4) gained solution is 2) pH value of gained is adjusted within 5.5~7.8 scopes, osmotic pressure should be adjusted in the scope that is equivalent to 0.8%~1.2% sodium chloride solution osmotic pressure;
6) adding distil water is to ormal weight, and routine mixes that 120 ℃ of heat sterilizations promptly got product in 1 hour in the rearmounted hermetic container.
Beneficial effect: the eye drop that contains HUANGJIANG extract of the present invention can increase hormone secretion, regulate body balance, strengthens the eye cell viability, improves the eye microcirculation, have nutrition, lubricated, antibacterial, itching relieving effect, and preparation method is simple.
The specific embodiment
The present invention is described in further detail below by embodiment.
Embodiment 1
Prepare raw material by following component (in percentage by weight wt%):
HUANGJIANG extract 0.15 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 0.8 Borax 0.8
Polyoxyethylene castor oil 1.5
All the other are distilled water.
Preparation according to the following steps contains the eye drop of HUANGJIANG extract:
1) with HUANGJIANG extract and polyoxyethylene castor oil are conventional mixes thawing aseptic filtration after, put sterile chamber;
2) under aseptic condition, taurine, hyaluronate sodium, vitamin B6 gradation are added in the sterile chamber;
3) the boric acid adding distil water is made into 100ml solution;
4) the Borax adding distil water is made into 100ml solution;
5) use 3 respectively), 4) gained solution is 2) pH value of gained is adjusted within 5.5~7.8 scopes, osmotic pressure should be adjusted in the scope that is equivalent to 0.8%~1.2% sodium chloride solution osmotic pressure;
6) adding distil water is to ormal weight, and routine mixes that 120 ℃ of heat sterilizations promptly got product in 1 hour in the rearmounted hermetic container.
Embodiment 2
Prepare raw material by following component (in percentage by weight wt%):
HUANGJIANG extract 0.3 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 1.2 Boraxs 1.2
Polyoxyethylene castor oil 2.5
All the other add to 100 for distilled water.
Preparation process is with embodiment 1.
Embodiment 3
Prepare raw material by following component (in percentage by weight wt%):
HUANGJIANG extract 0.45 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 1.0 Boraxs 1.0
Polyoxyethylene castor oil 4.5
All the other add to 100 for distilled water.
Preparation process is with embodiment 1.
HUANGJIANG extract eye drop of the present invention is contained that all the components all can be buied steady sources from regular pharmaceuticals such as Dalian Fu Sheng pharmaceutical Co. Ltd, Wuhan Yuancheng Technology Development Co., Ltd..
The present invention relates to a kind of ophthalmic preparation and preparation method thereof, said preparation is by solubilizing agent, osmotic pressure regulator, pH value regulator, distilled water preparation, be prepared from by the standard sterile preparation production technique, preparation of the present invention is to eye nonirritant and toxic and side effects, advantages such as the quality of the pharmaceutical preparations is stable are suitable as artificial tears's succedaneum.
Ophthalmic solution should strictly be controlled its pH value, generally should be within 5.5~7.8 scopes.For keeping the ophthalmic solution pH value stable, HUANGJIANG extract eye drop of the present invention uses borate buffer solution: be made into 1%~1.25% solution with boric acid, Borax is made into 1%~1.25% solution.Face the time spent, two liquid mix by different proportion can get the buffer that pH6.7~9.1 scopes are bigger.
The osmotic pressure of ophthalmic solution should be adjusted in the scope that is equivalent to 0.8%~1.2% sodium chloride solution osmotic pressure.The accent osmotic pressure material that HUANGJIANG extract eye drop of the present invention uses has: boric acid, Borax.
The product specification of this eye drop: every<0.5g 0.4ml.
Usage and consumption: drip in eyelid, one time 1,3 times on the one; Can increase as one sees fit in case of necessity.
Storage: airtight, put cool dark place.
HUANGJIANG extract eye drop purposes of the present invention:
1, alleviate long-time computation, read a book, see the blurred vision that TV, driving etc. cause;
2, alleviate the eyes acid account and the vision decline of bringing out because of asthenopia due to the excess eye-using;
3, prevent and reduce wear the eyes that contact lens causes dried, puckery, itch, bitterly, foreign body sensation and complication.
4, be specially adapted to student, computer operation person, financial staff, driver and the heavier personnel's of other eyes burden long-term eye health protection.
Claims (4)
1. an eye drop that contains HUANGJIANG extract is characterized in that, is made by all the be weight percentage component of wt% meter of following following unit:
HUANGJIANG extract 0.15~0.45 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 0.8~1.2 Borax 0.8~1.2
Polyoxyethylene castor oil 1.5~4.5
All the other are distilled water.
2. the eye drop that contains HUANGJIANG extract according to claim 1 is characterized in that: made by all the be weight percentage component of wt% meter of following following unit:
HUANGJIANG extract 0.2~0.4 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 0.9~1.1 Borax 0.9~1.1
Polyoxyethylene castor oil 2.0~3.5
All the other are distilled water.
3. the eye drop that contains HUANGJIANG extract according to claim 2 is characterized in that: made by all the be weight percentage component of wt% meter of following following unit:
HUANGJIANG extract 0.35 taurine 0.07
Hyaluronate sodium 0.033 vitamin B6 0.033
Boric acid 1.0 Boraxs 1.0
Polyoxyethylene castor oil 3.0
All the other are distilled water.
4. prepare the preparation method that contains the eye drop of HUANGJIANG extract as claimed in claim 1, step is as follows:
1) with HUANGJIANG extract and polyoxyethylene castor oil are conventional mixes thawing aseptic filtration after, put sterile chamber;
2) under aseptic condition, taurine, hyaluronate sodium, vitamin B6 gradation are added in the sterile chamber;
3) the boric acid adding distil water is made into 100ml solution;
4) the Borax adding distil water is made into 100ml solution,
5) use 3 respectively), 4) gained solution is 2) pH value of gained is adjusted within 5.5~7.8 scopes, osmotic pressure should be adjusted in the scope that is equivalent to 0.8%~1.2% sodium chloride solution osmotic pressure;
6) adding distil water is to ormal weight, and routine mixes that 120 ℃ of heat sterilizations promptly got product in 1 hour in the rearmounted hermetic container.
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CN200710030297A CN101129698B (en) | 2007-09-18 | 2007-09-18 | Eye drops containing turmeric extractive and preparation method thereof |
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CN200710030297A CN101129698B (en) | 2007-09-18 | 2007-09-18 | Eye drops containing turmeric extractive and preparation method thereof |
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CN101129698A true CN101129698A (en) | 2008-02-27 |
CN101129698B CN101129698B (en) | 2010-05-19 |
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CN200710030297A Expired - Fee Related CN101129698B (en) | 2007-09-18 | 2007-09-18 | Eye drops containing turmeric extractive and preparation method thereof |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105148118A (en) * | 2015-09-30 | 2015-12-16 | 张晰 | Traditional Chinese medicine composition medicament for treating xerophthalmia and preparation method thereof |
CN106963672A (en) * | 2016-11-18 | 2017-07-21 | 广州宏韵医药科技股份有限公司 | It is a kind of that there is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application |
CN109260460A (en) * | 2018-11-12 | 2019-01-25 | 陈业国 | It is a kind of for preventing and treating the pharmaceutical composition of eye illness and rhinitis |
CN109718245A (en) * | 2019-03-20 | 2019-05-07 | 嘉兴力山明朗生物医药科技有限公司 | A kind of collyrium and preparation method thereof for asthenopia of releiving |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100494217C (en) * | 2006-01-06 | 2009-06-03 | 北京大学 | Method for extracting Chinese yam saponin from turmeric |
-
2007
- 2007-09-18 CN CN200710030297A patent/CN101129698B/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105148118A (en) * | 2015-09-30 | 2015-12-16 | 张晰 | Traditional Chinese medicine composition medicament for treating xerophthalmia and preparation method thereof |
CN105148118B (en) * | 2015-09-30 | 2018-11-02 | 张晰 | A kind of Chinese medicine composition medicament and preparation method thereof for treating xerophthalmia |
CN106963672A (en) * | 2016-11-18 | 2017-07-21 | 广州宏韵医药科技股份有限公司 | It is a kind of that there is alleviation visual fatigue and the near the eyes composition of skin cell fatigue and its application |
CN106963672B (en) * | 2016-11-18 | 2020-03-31 | 广州宏韵医药科技股份有限公司 | Composition capable of relieving visual fatigue and periocular skin cell fatigue and application thereof |
CN109260460A (en) * | 2018-11-12 | 2019-01-25 | 陈业国 | It is a kind of for preventing and treating the pharmaceutical composition of eye illness and rhinitis |
CN109718245A (en) * | 2019-03-20 | 2019-05-07 | 嘉兴力山明朗生物医药科技有限公司 | A kind of collyrium and preparation method thereof for asthenopia of releiving |
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CN101129698B (en) | 2010-05-19 |
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Granted publication date: 20100519 Termination date: 20130918 |