CN106924108B - Whitening and freckle removing cream - Google Patents
Whitening and freckle removing cream Download PDFInfo
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- CN106924108B CN106924108B CN201710078627.2A CN201710078627A CN106924108B CN 106924108 B CN106924108 B CN 106924108B CN 201710078627 A CN201710078627 A CN 201710078627A CN 106924108 B CN106924108 B CN 106924108B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The invention discloses a whitening and freckle-removing cream. In the formula of the cream, 2 whitening components of 4-butyl resorcinol and glabridin are reasonably compatible with an ultraviolet absorbent (ethylhexyl methoxycinnamate) and moisturizing and anti-wrinkle components (sodium hyaluronate, biological carbohydrate gum-1 and hydroxydecyl ubiquinone), so that stimulation of excessive ultraviolet radiation to skin is reduced, the formation of melanin is prevented, the skin is effectively protected, and excellent whitening, freckle removing and moisturizing effects are achieved; the formula of the cream disclosed by the invention is free of essence, mineral oil and nipagin ester preservative, has no side effect, and is suitable for all people needing daily skin care.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a whitening and freckle-removing cream.
Background
With the age, the living pressure is getting bigger and bigger, and the damage of ultraviolet rays to the facial skin is getting bigger and bigger due to the pollution of the external environment, so that the melanin is continuously precipitated, and the skin becomes rough, dark yellow and lacks moisture. Currently, a method of applying and protecting cream is popular to perform maintenance and care on the facial skin.
The cream is a carrier of skin care nutrient components, and has various forms, such as oil-in-water type, water-in-oil type and the like, wherein the oil-in-water type is more suitable for daily care of skin. Most of whitening and freckle removing are based on moisture preservation, and the maintenance work of whitening and freckle removing, aging resistance and the like can be more effective on the basis of moisture preservation.
In order to solve the problems, a great deal of exploration-meaningful work is done in the industry; the cream with various functions is also presented in the market, and has certain curative effect on whitening and removing freckles on the face. However, the raw materials of the existing cream mainly or partially adopt more industrially synthesized components, and one part of the industrially synthesized materials can cause irritation to the skin of one group of people, or the other part of the industrially synthesized materials can cause irritation to the skin of another group of people, so that the phenomena of skin allergy and redness and swelling are caused, and the skin becomes more fragile and sensitive.
Disclosure of Invention
The invention aims to provide the cream which can meet the requirements of skin whitening, moisturizing and freckle removing and has no irritation to skin.
The technical scheme adopted by the invention is as follows:
A whitening and freckle-removing cream comprises the following components: ethylhexyl methoxycinnamate, 4-butylresorcinol, glabridin, hydroxydecyl ubiquinone, sodium hyaluronate, biogel-1, tocopherol, dipotassium glycyrrhizinate, peony flower extract, p-hydroxyacetophenone, 1, 2-hexanediol, an emollient, a thickener, an emulsifier, water, and butanediol.
A whitening and freckle-removing cream comprises the following components in parts by weight: 2-10 parts of ethylhexyl methoxycinnamate, 0.1-1 part of 4-butylresorcinol, 0.001-0.01 part of glabridin, 0.2-2 parts of hydroxydecyl ubiquinone, 0.03-0.3 part of sodium hyaluronate, 10.3-4 parts of bioglycan gum, 0.2-2 parts of tocopherol, 0.03-0.3 part of dipotassium glycyrrhizinate, 2-15 parts of peony flower extract, 0.1-0.6 part of p-hydroxyacetophenone, 0.05-0.5 part of 1, 2-hexanediol, 15-35 parts of emollient, 0.5-3 parts of thickener, 1-8 parts of emulsifier, 30-65 parts of water and 1-8 parts of butanediol.
Preferably, the whitening and freckle-removing cream comprises the following components in parts by weight: 3-7 parts of ethylhexyl methoxycinnamate, 0.2-0.6 part of 4-butylresorcinol, 0.002-0.006 part of glabridin, 0.3-1.8 parts of hydroxydecyl ubiquinone, 0.05-0.25 part of sodium hyaluronate, 10.5-3.5 parts of biogan gum, 0.3-1.8 parts of tocopherol, 0.05-0.25 part of dipotassium glycyrrhizinate, 3-12 parts of peony flower extract, 0.2-0.5 part of p-hydroxyacetophenone, 0.1-0.5 part of 1, 2-hexanediol, 20-30 parts of emollient, 1-2.5 parts of thickener, 2-6 parts of emulsifier, 35-60 parts of water and 2-6 parts of butanediol.
further preferably, the whitening and freckle-removing cream comprises the following components in parts by weight: 4-6 parts of ethylhexyl methoxycinnamate, 0.3-0.5 part of 4-butylresorcinol, 0.003-0.005 part of glabridin, 0.5-1.5 parts of hydroxydecyl ubiquinone, 0.1-0.2 part of sodium hyaluronate, 11-3 parts of biogan gum, 0.5-1.5 parts of tocopherol, 0.1-0.2 part of dipotassium glycyrrhizinate, 5-10 parts of peony flower extract, 0.3-0.4 part of p-hydroxyacetophenone, 0.2-0.4 part of 1, 2-hexanediol, 22.5-28.5 parts of emollient, 1.5-2.25 parts of thickener, 3-5 parts of emulsifier, 40-55 parts of water and 3-5 parts of butanediol.
The emollient is composed of the following components in parts by weight: 2-6 parts of propylene glycol, 2-6 parts of shea butter, 2-6 parts of squalane, 5-8 parts of isohexadecane, 2-6 parts of cyclopenta dimethyl silicone polymer, 0.3-1.2 parts of dimethyl silicone polymer and 1-3 parts of cetostearyl alcohol.
preferably, the emollient is composed of the following components in parts by weight: 3-5 parts of propylene glycol, 3-5 parts of shea butter, 3-5 parts of squalane, 6-7 parts of isohexadecane, 3-5 parts of cyclopenta dimethyl silicone polymer, 0.5-1 part of dimethyl silicone polymer and 1.5-2.5 parts of cetostearyl alcohol.
The thickener is at least one of xanthan gum, hydroxyethyl cellulose and SIMULGEL TM NS thickener.
The invention has the beneficial effects that:
(1) The whitening component of the invention is reasonably compatible with the 2 whitening components of 4-butyl resorcinol and glabridin, namely the ethylhexyl methoxycinnamate, and the three moisturizing and anti-wrinkle components (sodium hyaluronate, biological carbohydrate gum-1 and hydroxydecyl ubiquinone), so that the stimulation of excessive ultraviolet radiation to the skin is reduced, the formation of melanin is prevented, the skin is effectively protected, and the excellent whitening, freckle removing and moisturizing effects are achieved;
(2) The formula of the cream disclosed by the invention is not added with essence, mineral oil or a paraben preservative, and has no side effect.
Detailed Description
A whitening and freckle-removing cream comprises the following components: ethylhexyl methoxycinnamate, 4-butylresorcinol, glabridin, hydroxydecyl ubiquinone, sodium hyaluronate, biogel-1, tocopherol, dipotassium glycyrrhizinate, peony flower extract, p-hydroxyacetophenone, 1, 2-hexanediol, an emollient, a thickener, an emulsifier, water, and butanediol.
A whitening and freckle-removing cream comprises the following components in parts by weight: 2-10 parts of ethylhexyl methoxycinnamate, 0.1-1 part of 4-butylresorcinol, 0.001-0.01 part of glabridin, 0.2-2 parts of hydroxydecyl ubiquinone, 0.03-0.3 part of sodium hyaluronate, 10.3-4 parts of bioglycan gum, 0.2-2 parts of tocopherol, 0.03-0.3 part of dipotassium glycyrrhizinate, 2-15 parts of peony flower extract, 0.1-0.6 part of p-hydroxyacetophenone, 0.78-0.5 part of 1, 2-hexanediol 0.0.5, 15-35 parts of emollient, 0.5-3 parts of thickener, 1-8 parts of emulsifier, 30-65 parts of water and 1-8 parts of butanediol.
Preferably, the whitening and freckle-removing cream comprises the following components in parts by weight: 3-7 parts of ethylhexyl methoxycinnamate, 0.2-0.6 part of 4-butylresorcinol, 0.002-0.006 part of glabridin, 0.3-1.8 parts of hydroxydecyl ubiquinone, 0.05-0.25 part of sodium hyaluronate, 10.5-3.5 parts of biogan gum, 0.3-1.8 parts of tocopherol, 0.05-0.25 part of dipotassium glycyrrhizinate, 3-12 parts of peony flower extract, 0.2-0.5 part of p-hydroxyacetophenone, 0.1-0.5 part of 1, 2-hexanediol, 20-30 parts of emollient, 1-2.5 parts of thickener, 2-6 parts of emulsifier, 35-60 parts of water and 2-6 parts of butanediol.
further preferably, the whitening and freckle-removing cream comprises the following components in parts by weight: 4-6 parts of ethylhexyl methoxycinnamate, 0.3-0.5 part of 4-butylresorcinol, 0.003-0.005 part of glabridin, 0.5-1.5 parts of hydroxydecyl ubiquinone, 0.1-0.2 part of sodium hyaluronate, 11-3 parts of biogan gum, 0.5-1.5 parts of tocopherol, 0.1-0.2 part of dipotassium glycyrrhizinate, 5-10 parts of peony flower extract, 0.3-0.4 part of p-hydroxyacetophenone, 0.2-0.4 part of 1, 2-hexanediol, 22.5-28.5 parts of emollient, 1.5-2.25 parts of thickener, 3-5 parts of emulsifier, 40-55 parts of water and 3-5 parts of butanediol.
According to the invention, 4-butyl resorcinol, glabridin and ethylhexyl methoxycinnamate are reasonably compatible, so that the stimulation of excessive ultraviolet radiation to the skin can be reduced, the formation of melanin is prevented, the skin is effectively protected, and the effects of whitening and removing freckles are achieved. 4-butylresorcinol is effective in inhibiting tyrosinase and TRP-1 enzyme, and blocking activation site, thereby preventing melanin formation. The glabridin can penetrate into skin, maintain high activity, whiten skin, resist oxidation effectively, and inhibit activity of various enzymes in melanin generation process, especially tyrosinase activity. The ethylhexyl methoxycinnamate is a good absorbent in an ultraviolet UVB region, can effectively prevent ultraviolet rays of 280-310 nm, is high in absorptivity, and has no stimulation to skin and good safety.
on the basis of the whitening components, the whitening skin-care product is reasonably compatible with sodium hyaluronate, biological carbohydrate gum-1 and hydroxydecyl ubiquinone, so that the effects of brightening skin and moisturizing, moisturizing and repairing are achieved. The sodium hyaluronate has extremely high moisture retention, viscoelasticity and lubricity, can not only make the skin smooth and moist, but also has a strong wrinkle removing function, can increase the skin elasticity and delay the skin aging. The biogel-1 is a special polysaccharide in brown algae, is a humectant from natural sources, has strong water binding capacity, shows good water absorption effect even in a low-humidity environment, and simultaneously forms a breathable sugar film on the surface layer of skin to prevent the moisture of the skin from evaporating again and enhance the moisturizing effect; biogel-1 can reduce allergic reactions by competitively inhibiting macrophage migration inhibitory factor to promote the removal of inert macrophages from the infected site and slow down the production of inflammation. Hydroxydecyl ubiquinone is coenzyme Q10, has remarkable effects of resisting oxidation and delaying aging, can penetrate into cells, enhance the metabolism function of the cells, and tighten and combine the cells in the collaterals, and can repair wrinkles caused by water loss in the elastic reticular structure of the epidermis layer, thereby achieving the real moisturizing effect.
The peony extract mainly contains flavonoid compounds and polysaccharide media, can nourish blood and liver, dispel stagnation and remove stasis, and is produced by a farmer: seaanrauert Biotechnology, Inc.
The emollient is composed of the following components by weight: 2-6 parts of propylene glycol, 2-6 parts of shea butter, 2-6 parts of squalane, 5-8 parts of isohexadecane, 2-6 parts of cyclopenta dimethyl silicone polymer, 0.3-1.2 parts of dimethyl silicone polymer and 1-3 parts of cetostearyl alcohol.
Preferably, the emollient is composed of the following components in parts by weight: 3-5 parts of propylene glycol, 3-5 parts of shea butter, 3-5 parts of squalane, 6-7 parts of isohexadecane, 3-5 parts of cyclopenta dimethyl silicone polymer, 0.5-1 part of dimethyl silicone polymer and 1.5-2.5 parts of cetostearyl alcohol.
In the components, the thickening agent is at least one of xanthan gum, hydroxyethyl cellulose and SIMULGEL TM NS thickening agent.
The invention is further illustrated by the following examples.
Examples 1-5 whitening and freckle-removing cream
The whitening and freckle-removing cream disclosed by the embodiments 1-5 is prepared according to a formula shown in a table 1.
table 1 examples 1-5 whitening and freckle removing cream formula
Examples 1-5 preparation method of whitening and freckle-removing cream
According to the formula of the embodiment 1-5, the whitening and freckle-removing cream is prepared according to the following steps:
(1) Dispersing and dissolving glabridin and 4-butyl resorcinol with butanediol for later use;
(2) Heating the water phase material in a water phase pot of a homogenizing emulsifying pot to 75-85 ℃, and stirring for dissolving; the water phase material comprises deionized water, propylene glycol, xanthan gum, hydroxyethyl cellulose, sodium hyaluronate and dipotassium glycyrrhizinate;
(3) heating oil phase materials in a homogenizing emulsifying pot to 75-85 ℃, stirring and melting, wherein the oil phase materials comprise MONTANOV TM 68 emulsifier, SIMUSOL TM 165 emulsifier, shea butter, squalane, isohexadecane, cyclopenta dimethyl silicone, cetearyl alcohol, tocopherol, ethylhexyl methoxycinnamate and p-hydroxyacetophenone;
(4) after complete dissolution, adding SIMULGEL TM NS thickener, stirring for 3-5 minutes, and uniformly mixing;
(5) Adding the liquid obtained in the step (2) into a water phase under stirring, homogenizing in vacuum for 3-5 minutes at intervals of 5-10 minutes, homogenizing for 3-5 minutes, and then slowly stirring and cooling to 50-45 ℃;
(6) Adding the solution obtained in the step (1), biological carbohydrate gum-1, hydroxydecyl ubiquinone, 1, 2-hexanediol and a peony extract;
(7) Stirring evenly and discharging.
Test example 1 test of whiteness and humidity
Test objects: the skin and the face are dark yellow, the pigmentation is obvious, and the dry volunteer subjects are divided into 6 groups, and 10 subjects are in each group; before use, there was no significant difference in facial moisture and whiteness of each group of subjects.
The using method comprises the following steps: each group was applied with the whitening and spot-removing cream prepared in examples 1-5 and a commercially available foreign product (lankok whitening cream) every morning and evening, and then the cream was applied to the face for 2 months.
The test method comprises the following steps: after washing the face, the intelligent whitening detector (Shenzhen Meili Zhi science and technology Co., Ltd.) was used to read the whiteness and humidity of the skin without applying any cosmetic product.
TABLE 2 degree of fair and humidity (mean) on the face before and after application of cream to each group of subjects
As shown in table 2, the cream of example 3 has the best whitening effect, which is significantly better than the commercial product, and the cream of example 2 has the best moisturizing effect, which is significantly better than the commercial product; and it was observed that: the facial pigmentation was significantly improved before and after use by the subjects of examples 1 to 3, and was less improved before and after use by the subjects of examples 4 to 5 and the commercial products. Therefore, the cream has excellent whitening, freckle removing and moisturizing effects, and is suitable for repairing the skin of dry people with dark yellow skin and face, obvious pigmentation; meanwhile, as the formula of the cream is not added with essence, mineral oil and nipagin ester preservative, the cream has no side effect and is also suitable for all people needing daily skin care.
The foregoing is for the purpose of illustrating the invention only and various simple changes and modifications within the spirit of the invention made by those skilled in the art should fall within the scope of the invention.
Claims (4)
1. a whitening and freckle-removing cream comprises the following components in parts by weight: 4-6 parts of ethylhexyl methoxycinnamate, 0.3-0.5 part of 4-butylresorcinol, 0.003-0.005 part of glabridin, 0.5-1.5 parts of hydroxydecyl ubiquinone, 0.1-0.2 part of sodium hyaluronate, 11-3 parts of biogan gum, 0.5-1.5 parts of tocopherol, 0.1-0.2 part of dipotassium glycyrrhizinate, 5-10 parts of peony flower extract, 0.3-0.4 part of p-hydroxyacetophenone, 0.2-0.4 part of 1, 2-hexanediol, 22.5-28.5 parts of emollient, 1.5-2.25 parts of thickener, 3-5 parts of emulsifier, 40-55 parts of water and 3-5 parts of butanediol.
2. The whitening and freckle-removing cream according to claim 1, wherein the whitening and freckle-removing cream comprises the following components in percentage by weight: the emollient is composed of the following components in parts by weight: 2-6 parts of propylene glycol, 2-6 parts of shea butter, 2-6 parts of squalane, 5-8 parts of isohexadecane, 2-6 parts of cyclopenta dimethyl silicone polymer, 0.3-1.2 parts of dimethyl silicone polymer and 1-3 parts of cetostearyl alcohol.
3. The whitening and freckle-removing cream according to claim 2, wherein the whitening and freckle-removing cream comprises the following components in percentage by weight: the emollient is composed of the following components in parts by weight: 3-5 parts of propylene glycol, 3-5 parts of shea butter, 3-5 parts of squalane, 6-7 parts of isohexadecane, 3-5 parts of cyclopenta dimethyl silicone polymer, 0.5-1 part of dimethyl silicone polymer and 1.5-2.5 parts of cetostearyl alcohol.
4. The cream of claim 1, wherein the thickener is at least one of xanthan gum, hydroxyethyl cellulose, and SIMULGEL TM NS thickener.
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Families Citing this family (11)
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CN107296764B (en) * | 2017-06-28 | 2020-06-26 | 深圳市永济泰科技有限公司 | Cream and preparation method thereof |
CN108096096B (en) * | 2017-12-27 | 2020-07-24 | 珠海伊斯佳科技股份有限公司 | Composition with long-acting moisturizing and whitening functions |
CN108324589A (en) * | 2018-05-11 | 2018-07-27 | 广东省中药研究所 | A kind of composition for whitening skin and preparation method thereof |
CN108420749A (en) * | 2018-05-11 | 2018-08-21 | 广东省中药研究所 | A kind of skin care item and preparation method thereof with anti-aging effects |
CN110200874A (en) * | 2019-07-08 | 2019-09-06 | 卢琛 | A kind of whitening and spot eliminating cream and preparation method thereof |
CN110327247A (en) * | 2019-08-15 | 2019-10-15 | 广州栢汇生物科技有限公司 | Whitening and spot eliminating cream |
CN110538107A (en) * | 2019-09-16 | 2019-12-06 | 安婕妤化妆品科技股份有限公司 | cosmetic containing vitamin components |
CN110960478A (en) * | 2019-12-04 | 2020-04-07 | 广州博科健康科技集团有限公司 | Freckle-removing cream containing umbilical cord extract and preparation method thereof |
CN113318030B (en) * | 2021-06-18 | 2021-12-03 | 广州恒芳生物科技有限公司 | Whitening and freckle removing cream and preparation method thereof |
CN113679629A (en) * | 2021-08-31 | 2021-11-23 | 珀莱雅化妆品股份有限公司 | Whitening composition for cosmetics and preparation method thereof |
CN114504524B (en) * | 2022-01-19 | 2024-01-26 | 珀莱雅化妆品股份有限公司 | Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof |
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JP2011195494A (en) * | 2010-03-19 | 2011-10-06 | Pola Chemical Industries Inc | Composition containing proton pump inhibitor |
CN106361620A (en) * | 2016-11-28 | 2017-02-01 | 宁浩 | Skin whitening cream |
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CN101365414A (en) * | 2006-01-05 | 2009-02-11 | 西姆莱斯有限责任两合公司 | Stabilized preparations comprising phenolic compounds and benzophenones |
JP2011195494A (en) * | 2010-03-19 | 2011-10-06 | Pola Chemical Industries Inc | Composition containing proton pump inhibitor |
CN106361620A (en) * | 2016-11-28 | 2017-02-01 | 宁浩 | Skin whitening cream |
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