CN114504524B - Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof - Google Patents
Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof Download PDFInfo
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- CN114504524B CN114504524B CN202210058856.9A CN202210058856A CN114504524B CN 114504524 B CN114504524 B CN 114504524B CN 202210058856 A CN202210058856 A CN 202210058856A CN 114504524 B CN114504524 B CN 114504524B
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- whitening
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 70
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 69
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 57
- 239000000839 emulsion Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 37
- 229960004135 idebenone Drugs 0.000 claims abstract description 36
- 235000019136 lipoic acid Nutrition 0.000 claims abstract description 36
- 229960002663 thioctic acid Drugs 0.000 claims abstract description 36
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000019198 oils Nutrition 0.000 claims abstract description 34
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 33
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000000787 lecithin Substances 0.000 claims abstract description 33
- 229940067606 lecithin Drugs 0.000 claims abstract description 33
- 235000010445 lecithin Nutrition 0.000 claims abstract description 33
- 150000002632 lipids Chemical class 0.000 claims abstract description 33
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims abstract description 32
- GWHCXVQVJPWHRF-KTKRTIGZSA-N (15Z)-tetracosenoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-KTKRTIGZSA-N 0.000 claims abstract description 24
- XJXROGWVRIJYMO-SJDLZYGOSA-N Nervonic acid Natural products O=C(O)[C@@H](/C=C/CCCCCCCC)CCCCCCCCCCCC XJXROGWVRIJYMO-SJDLZYGOSA-N 0.000 claims abstract description 23
- GWHCXVQVJPWHRF-UHFFFAOYSA-N cis-tetracosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000007787 solid Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000020238 sunflower seed Nutrition 0.000 claims abstract description 19
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 17
- -1 isostearoyl lactyl sodium lactate Chemical compound 0.000 claims abstract description 16
- 244000299461 Theobroma cacao Species 0.000 claims abstract description 14
- 235000009470 Theobroma cacao Nutrition 0.000 claims abstract description 14
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims abstract 6
- 239000012528 membrane Substances 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 21
- 239000003995 emulsifying agent Substances 0.000 claims description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 229940110456 cocoa butter Drugs 0.000 claims description 12
- 235000019868 cocoa butter Nutrition 0.000 claims description 12
- 235000019197 fats Nutrition 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 7
- 230000009471 action Effects 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 229940001447 lactate Drugs 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 2
- 229940046000 sodium isostearoyl lactylate Drugs 0.000 claims 1
- FOSNFLMXYRQNAF-UHFFFAOYSA-M sodium;2-[2-(16-methylheptadecanoyloxy)propanoyloxy]propanoate Chemical compound [Na+].CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O FOSNFLMXYRQNAF-UHFFFAOYSA-M 0.000 claims 1
- 230000007794 irritation Effects 0.000 abstract description 11
- 230000035699 permeability Effects 0.000 abstract description 7
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 30
- 239000002537 cosmetic Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 239000000686 essence Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- HTLOQTJMVHLFOV-UHFFFAOYSA-N C(C(O)C)(=O)O.C(CCCCCCCCCCCCCCC(C)C)[Na] Chemical compound C(C(O)C)(=O)O.C(CCCCCCCCCCCCCCC(C)C)[Na] HTLOQTJMVHLFOV-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000003222 Helianthus annuus Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000013065 commercial product Substances 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
- 239000002047 solid lipid nanoparticle Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
- 241000219226 Acer truncatum Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000208818 Helianthus Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003012 bilayer membrane Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 239000003581 cosmetic carrier Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002634 lipophilic molecules Chemical class 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention relates to a nanoparticle emulsion with whitening and anti-aging effects and a preparation method thereof, and is characterized in that: the whitening and anti-aging composition comprises 5-25% of whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of isostearoyl lactyl sodium lactate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water, wherein the whitening and anti-aging composition comprises N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid according to the mass ratio of 1:1-5:1-3, and the solid lipid comprises nervonic acid and cocoa seed fat according to the mass ratio of 1:3-10; the percentages are mass percentages. The whitening and anti-aging nanoparticle emulsion has the advantages of good whitening and anti-aging effects, good stability, high load, capability of effectively reducing the irritation of hydroxydecyl ubiquinone and lipoic acid and the bad smell of lipoic acid, capability of improving the permeability of N-acetylneuraminic acid and the like.
Description
Technical Field
The invention relates to the technical field of cosmetic carriers, in particular to a nanoparticle emulsion with whitening and anti-aging effects and a preparation method thereof.
Background
With the upgrading of consumer consumption concepts and skin care cognition, efficacy skin care has become a new trend of cosmetic consumption, and based on the influence of the traditional Chinese medicine concept of 'medicine and food homology', cosmetic and food homology is also gradually and widely accepted. Cosmetic homology involves, on the one hand, the bringing together of the cosmetic appearance towards the food and, on the other hand, the addition of edible raw materials to give the product a high efficacy.
N-acetylneuraminic acid is a natural carbohydrate which is readily soluble in water, also known as nidus Collocaliae acid, sialic acid, and is originally isolated from bovine submaxillary gland mucin, and therefore known as sialic acid. N-acetylneuraminic acid is formally used as a raw material for the quasi-use of cosmetics, and has the effects of moisturizing, resisting oxidation and whitening. Lipoic acid, at the earliest, is a nutritional supplement for diabetics and can assist in controlling blood glucose. The lipoic acid has strong antioxidant capacity, participates in the progress of various antioxidant reactions in the body, and can repair oxidative damage and remove active oxygen and free radicals. Hydroxydecylubiquinone, idebenone, is a lipophilic compound similar to coenzyme Q10 in structure but smaller in molecular weight, and has effects of scavenging free radicals, inhibiting lipid peroxidation, resisting photoprotection, etc. However, these ingredients have certain application limitations, such as limited permeability of N-acetylneuraminic acid, optimal efficacy in weak acidic environment, low solubility in thiooctanoic acid water, poor stability, and bad smell similar to that of a rotten egg; the hydroxydecylubiquinone has the problems of irritation and stability, so that a suitable carrier technology is required to be sought to improve the application value of the functional components.
Liposome is a carrier technology and has a cell structure of a bilayer membrane, and is widely applied to the fields of medicines, cosmetics and the like, but the traditional Liposome has the problems of limited loading of functional components, easy leakage, high water content of an aqueous dispersion system and the like. The solid lipid nano particles (Solid Lipid Nanoparticles, SLN) take natural or synthetic solid lipid as a carrier, and the functional components are adsorbed or wrapped in the lipid core, and further, the solid lipid is replaced by liquid oil or mixed lipid with a certain proportion, so that the crystallinity of the lipid can be reduced, and the prepared nano particles have high loading quantity of the functional components, are not easy to leak, and can better control the release of the functional components. For lipophilic functional components, if the melting point is higher than that of the lipid material, the functional components can be solidified preferentially to form an active core when cooled, otherwise, the lipid is solidified preferentially to form a lipid core, the functional components are distributed on the outer layer, the encapsulation rate and the loading amount are not equal to those of the former functional components, and the release of the functional components possibly has abrupt release behavior. Therefore, the selection of the lipid material is critical for the lipophilic functional ingredient with a low melting point.
Disclosure of Invention
The invention aims to solve the technical problem of providing a nanoparticle emulsion with whitening and anti-aging effects and a preparation method thereof, which are used for overcoming the defects of traditional liposome loaded functional components, reducing the irritation of the functional components, improving the stability and covering the bad smell.
In order to solve the technical problems, the invention adopts the following technical scheme: the nanoparticle emulsion with the whitening and anti-aging effects is characterized in that: the whitening and anti-aging composition comprises 5-25% of whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of isostearoyl lactyl sodium lactate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water, wherein the whitening and anti-aging composition comprises N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid according to the mass ratio of 1:1-5:1-3, and the solid lipid comprises nervonic acid and cocoa seed fat according to the mass ratio of 1:3-10; the percentages are mass percentages.
A preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
A. weighing 5-25% of whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of isostearyl lactoyl sodium lactate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1:1-5:1-3, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:3-10;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the pressurizing action of nitrogen gas of 30-55kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃, and the flow rate to be 10cm/s-25cm/s, wherein the liquid discharged from the membrane emulsifier is the nanoparticle emulsion with the whitening and anti-aging effects.
The particle size of the nanoparticles in the nanoparticle emulsion with whitening and anti-aging effects is 330-580nm, and the nanoparticle emulsion is stable after centrifugation at 3000rpm for 30 min.
The membrane emulsifier used in the invention is an external pressure type high flux membrane emulsifier, the model is KH-125, and the manufacturer is Japanese SPG Co.
The N-acetylneuraminic acid has CAS number of 131-48-6, and the purity is required to be not lower than 98 percent and is purchased from Guangdong Green biotechnology Co., ltd.
The hydroxydecylubiquinone of the present invention is available from Shanghai Bilai chemical industry under the serial number 05256 in China, catalog of used cosmetic raw Material names (2021 edition).
The lipoic ACID of the invention has a serial number of 04403 in the name catalog of used cosmetics raw materials (2021 edition) in China, and a commercial product such as lipoic ACID with a trademark of THIOCTIC ACID of KTFC company.
The lecithin of the present invention is required to have a phosphatidylcholine content of not less than 75%, and has a serial number of 04456 in the name catalog of used cosmetic raw materials (2021 edition) in China, and a commercially available product such as lecithin having a name of SOYA SPL 75P of the company Neuropei.
The isostearyl sodium lactate provided by the invention has a serial number of 07890 in the name catalog of used cosmetic raw materials (2021 edition) in China, and a commercial product such as isostearyl sodium lactate with a chemical trademark of ISL-P in Chinese lion.
The nervonic acid disclosed by the invention has the CAS number of 506-37-6, is extracted from Acer truncatum seed oil, has the purity of not less than 98%, and is purchased from Shaanxi morning-xi biological Co.
The cocoa (Theobroma CACAO) seed fat of the present invention has a serial number of 04118 in China (catalog of used cosmetic raw materials names (2021 edition)), and a commercially available product such as cocoa seed fat with a trade name of organic white cocoa butter from Jiaji company.
The sunflower (HELIANTHUS ANNUUS) seed oil disclosed by the invention has a serial number of 07074 in China (catalog of used cosmetic raw materials names (2021 edition)), and is commercially available, such as sunflower seed oil with the trade name of Bota-Valley 80 of Jiaji company.
The lipid material of the nanoparticles in the nanoparticle emulsion with the whitening and anti-aging effects is composed of nervonic acid, cocoa butter and sunflower seed oil, wherein the melting points of the nervonic acid and the cocoa butter are 39-40 ℃ and 30-34 ℃ respectively, the prepared nanoparticles can preferentially form active cores of hydroxydecyl ubiquinone and lipoic acid, and the nervonic acid and the cocoa butter form lipid shells to effectively protect functional components and mask bad smell.
According to the invention, the cosmetic and food homology concept is used as guidance, and the nanoparticle emulsion capable of simultaneously loading N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid is prepared by a membrane emulsification method, and furthermore, the specific proportion of nervonic acid and cocoa butter are innovatively used as lipid materials of the nanoparticles, so that the obtained nanoparticles have the advantages of high content of functional components, low irritation, good stability, low bad smell and mild slow release.
The invention has the beneficial effects that: 1) The nanometer particle can simultaneously load N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid in specific proportion, has good stability, high load and synergistic effect of the effective components, and has the effects of whitening and resisting aging; 2) The invention uses the nervonic acid and the cocoa seed fat as lipid materials to prepare the nano particles, which can effectively reduce the irritation of hydroxydecyl ubiquinone and lipoic acid and the bad smell of lipoic acid, and improve the permeability of N-acetylneuraminic acid.
To demonstrate the beneficial effects of the present invention, the following experiments were further conducted.
1. The experiment for verifying the stability of nanoparticle emulsion is as follows:
the nanoparticle emulsion prepared in example 1 (particle diameter 413nm, whitening and anti-aging composition content 10%, wherein hydroxydecylubiquinone content 4.5%) was taken as sample a, and stability experiments were performed by placing the above samples at 5 ℃, 25 ℃ and 38 ℃ respectively, measuring the content of hydroxydecylubiquinone as a marker at 1,2,4 weeks, and observing the appearance change of the samples, and the results are shown in table 1.
TABLE 1 nanoparticle emulsion stability test results
As can be seen from Table 1, the nanoparticle emulsion with whitening and anti-aging effects prepared by the invention is placed for 4 weeks at 5 ℃, 25 ℃ and 38 ℃, the content of effective components, the particle size and the appearance smell are not obviously changed, and the nanoparticle emulsion prepared by the invention can effectively improve the stability of hydroxydecyl ubiquinone and lipoic acid and mask the bad smell of lipoic acid and has the characteristic of good stability.
2. The nanoparticle emulsion permeability test was validated as follows:
the nanoparticle emulsion prepared in example 1 (10% of the whitening and anti-aging composition, wherein the content of N-acetylneuraminic acid is 2.5%) was taken as sample a, the untreated whitening and anti-aging composition having the same concentration as that in sample a was simultaneously and directly dispersed in a glycerin/water (50:50) solution to be taken as sample B, modified Franz Chi Fa was adopted to simulate the artificial stratum corneum membrane as a transdermal barrier, the sample a and the sample B were uniformly added into a supply tank in equal amounts respectively, and were sampled in parallel with 6 parts at a predetermined time point, and the measurement and analysis were carried out by using hydroxydecylubiquinone and N-acetylneuraminic acid as markers respectively, and the results are shown in fig. 1.
As shown in FIG. 1, FIG. 1 is a graph showing the cumulative release rate of sample A-hydroxydecylubiquinone; 2 is a cumulative release rate curve of sample B-hydroxydecyl ubiquinone; 3 is a cumulative release rate curve of the sample A-N-acetylneuraminic acid; 4 is a cumulative release rate curve of the sample B-N-acetylneuraminic acid, and the nanoparticle emulsion prepared by the invention can improve the permeability of the water-soluble functional component N-acetylneuraminic acid, effectively control the release of the fat-soluble functional component, ensure stable integral release, effectively reduce the irritation and avoid skin sensitivity caused by sudden release.
3. The nanoparticle emulsion irritation test was verified as follows:
in order to verify the irritation of the nanoparticle emulsion prepared by the invention, refer to cosmetic safety technical Specification 2015 edition-human skin patch test, the specific steps are as follows: selecting 34 volunteers 18-60 years old, adding the sample into a spot tester, then applying the spot tester with the sample to the back of a subject by using a non-irritating adhesive tape, and uniformly applying the spot tester to the skin by using palm light pressure for 24 hours; the test piece plaque tester was removed, the test piece residue at the test site was gently rubbed off with a moist absorbent cotton ball, and after 0.5H, the skin reaction was observed after the indentation disappeared. If the result is negative, the spot patch is removed and observed again 24 hours after the spot patch is removed. The reaction results were recorded according to a grading standard.
The samples used were the essence added with the whitening and anti-aging composition, wherein sample a was the essence added with the nanoparticle emulsion prepared in example 1, and sample B was the essence directly added with the whitening and anti-aging composition in the same proportion as in example 1, more specifically, the two groups of essences contained the following active ingredients in mass percent: 0.25% N-acetylneuraminic acid, 0.45% hydroxydecylubiquinone, 0.3% lipoic acid.
The effective results of the human skin patch test are shown in table 2.
TABLE 2 results of irritation test (effective volunteer 32)
As can be seen from Table 2, the nanoparticle emulsion prepared by the invention can effectively reduce the irritation of hydroxydecyl ubiquinone and lipoic acid under the condition that the adding amount ratio of the whitening and anti-aging composition is consistent.
4. The human efficacy test of the nanoparticle emulsion is verified as follows:
in order to further prove the synergistic effect of the whitening anti-aging composition selected by the invention, the human body efficacy test is carried out, and the specific steps are as follows: 48 female volunteers aged 30-65 years were selected and divided into four groups of 12 people each. In the test period, volunteers respectively use essence added with whitening and anti-aging nanoparticle emulsion in the whole face of the early and late twice, the compositions, the grease and the like of the essence used in each group are the same, the preparation method and the like, the addition amount of the whitening and anti-aging nanoparticle emulsion in each group is 10%, the whitening and anti-aging nanoparticle emulsion added with the essence used in the group 1 is a sample prepared in the embodiment 1, the whitening and anti-aging nanoparticle emulsion added with the essence used in the groups 2-4 is a nanoparticle emulsion which is consistent with the preparation method in the embodiment 1, and the composition and the proportion of the whitening and anti-aging composition are different, and the specific compositions and the proportions of the whitening and anti-aging compositions in each group are shown in the table 3.
Table 3 composition and ratio of whitening and anti-aging composition in nanoparticle emulsion used in each group
The cheek of the volunteer is selected as a test part, and is followed up once before use and 4 and 8 weeks after use respectively for 3 times, and the skin color value and the wrinkle depth and the number of the same part are measured by the same person by using a German PROMIS PICO wrinkle measuring instrument and a spectrocolorimeter Meida CM-700d, wherein the skin color value measuring index is L * The larger the skin brightness is, the lower the melanin content is, the larger the wrinkle measurement index is SEW, and the deeper the wrinkle is, the deeper the depth is. Let ΔE= [ (ΔL) 2 +(ΔSEW) 2 ] 1/2 The whitening and anti-aging effects of each group are measured, the anti-aging effects are more remarkable as the numerical value is larger, and the results are shown in Table 4.
Table 4 shows the results of the whitening anti-aging efficacy test
As shown in table 4, when the addition ratio of the nanoparticle emulsion is consistent, the optimal whitening and anti-aging effect can be achieved only when the functional components carried by the nanoparticle emulsion are combined in a specific ratio, and if any one of the components is absent, the effect is inferior to that of the whitening and anti-aging nanoparticle emulsion.
In conclusion, the whitening and anti-aging nanoparticle emulsion prepared by the invention can simultaneously load N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid in a specific proportion, has good whitening and anti-aging effects, good stability and high load, can effectively reduce the irritation of hydroxydecyl ubiquinone and lipoic acid and the bad smell of lipoic acid, and can improve the permeability of N-acetylneuraminic acid.
Drawings
FIG. 1 shows the results of nanoparticle emulsion permeability experiments.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below.
Example 1: a preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
A. weighing 10% of a whitening and anti-aging composition, 24.2% of solid lipid, 1.2% of lecithin, 0.1% of isostearyl lactoyl sodium lactate, 8.5% of sunflower seed oil, 20% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid according to the mass ratio of 1:1.8:1.2, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:10;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the action of nitrogen pressurization of 45kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃ and the flow rate to be 20cm/s, and obtaining the nano particle emulsion with the whitening and anti-aging effects from the liquid discharged from the membrane emulsifier.
Example 2: a preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
weighing 5% of a whitening and anti-aging composition, 10% of solid lipid, 0.8% of lecithin, 0.1% of isostearyl lactoyl sodium lactate, 1% of sunflower seed oil, 30% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1:5:1.5, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:3;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the action of nitrogen pressurization of 30kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃ and the flow rate to be 10cm/s, and obtaining the nano particle emulsion with the whitening and anti-aging effects from the liquid discharged from the membrane emulsifier.
Example 3: a preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
A. weighing 25% of whitening and anti-aging composition, 35% of solid lipid, 1.5% of lecithin, 0.3% of isostearyl lactoyl sodium lactate, 10% of sunflower seed oil, 10% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1:4:3, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:6;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the action of nitrogen pressurization of 55kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃ and the flow rate to be 20cm/s, and obtaining the nano particle emulsion with the whitening and anti-aging effects from the liquid discharged from the membrane emulsifier.
Example 4: a preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
A. weighing 15% of a whitening and anti-aging composition, 20% of solid lipid, 2% of lecithin, 0.15% of isostearyl lactoyl sodium lactate, 5.6% of sunflower seed oil, 18% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1:1.5:2.5, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:7;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the action of nitrogen pressurization of 40kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃ and the flow rate to be 16.5cm/s, and obtaining the nano particle emulsion with the whitening and anti-aging effects from the liquid discharged from the membrane emulsifier.
Example 5: a preparation method of nanoparticle emulsion with whitening and anti-aging effects is characterized by comprising the following steps: the method comprises the following steps:
A. weighing 6% of a whitening and anti-aging composition, 15% of solid lipid, 0.5% of lecithin, 0.2% of isostearyl lactoyl sodium lactate, 5% of sunflower seed oil, 22.5% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1:1:1, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:9;
B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase;
C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase;
D. and B, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the action of nitrogen pressurization of 55kPa, entering the continuous mobile phase obtained in the step C, setting the temperature to be not higher than 25 ℃ and the flow rate to be 25cm/s, and obtaining the nano particle emulsion with the whitening and anti-aging effects from the liquid discharged from the membrane emulsifier.
Claims (1)
1. The nanoparticle emulsion with the whitening and anti-aging effects is characterized in that: the whitening and anti-aging composition comprises 5-25% of whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of isostearoyl lactyl sodium lactate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water, wherein the whitening and anti-aging composition comprises N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid according to the mass ratio of 1:1-5:1-3, and the solid lipid comprises nervonic acid and cocoa seed fat according to the mass ratio of 1:3-10; the nanoparticle emulsion is prepared by the following steps of A, weighing 5-25% of whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of sodium isostearoyl lactylate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water according to the mass ratio, wherein the whitening and anti-aging composition consists of N-acetylneuraminic acid, hydroxydecylubiquinone and lipoic acid according to the mass ratio of 1:1-5:1-3, and the solid lipid consists of nervonic acid and cocoa seed fat according to the mass ratio of 1:3-10; B. mixing the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa butter and sunflower seed oil weighed in the step A, heating to 40-50 ℃ and stirring for dissolution to obtain an oil phase; C. adding the lecithin weighed in the step A into a mixed solution of butanediol and water, stirring and dissolving, continuously adding N-acetylneuraminic acid and sodium isostearyl lactoyl lactate, and stirring until the lecithin is completely dissolved, and taking the lecithin as a continuous mobile phase; D. b, taking the oil phase obtained in the step B as a disperse phase, adding the disperse phase into a storage tank of a membrane emulsifier, preserving heat at 40-50 ℃, allowing the disperse phase to penetrate through an SPG membrane with the average pore diameter of 0.1-0.2 mu m under the pressurizing action of nitrogen gas of 30-55kPa, and entering a continuous mobile phase obtained in the step C, wherein the set temperature is not higher than 25 ℃, the flow rate is 10cm/s-25cm/s, and the liquid discharged from the membrane emulsifier is the nanoparticle emulsion with the whitening and anti-aging effects; the percentages are mass percentages.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083291A (en) * | 2014-06-16 | 2014-10-08 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics |
| CN106924108A (en) * | 2017-02-14 | 2017-07-07 | 广州天玺生物科技有限公司 | A kind of whitening spot-removing creams |
| CN107837204A (en) * | 2017-11-09 | 2018-03-27 | 苏州纳康生物科技有限公司 | A kind of narrow ditribution particle diameter emulsion with skin anti-aging effect and preparation method thereof |
| CN108186407A (en) * | 2018-02-24 | 2018-06-22 | 珀莱雅化妆品股份有限公司 | A kind of preparation method for the solid dispersions for having effects that whitening is anti-ageing |
| CN111467284A (en) * | 2020-04-29 | 2020-07-31 | 泉后(广州)生物科技研究院有限公司 | Anti-aging nano composition and preparation method and application thereof |
| CN112294701A (en) * | 2020-11-24 | 2021-02-02 | 泉后(广州)生物科技研究院有限公司 | Low-irritation whitening nano composition and preparation method and application thereof |
-
2022
- 2022-01-19 CN CN202210058856.9A patent/CN114504524B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083291A (en) * | 2014-06-16 | 2014-10-08 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics |
| CN106924108A (en) * | 2017-02-14 | 2017-07-07 | 广州天玺生物科技有限公司 | A kind of whitening spot-removing creams |
| CN107837204A (en) * | 2017-11-09 | 2018-03-27 | 苏州纳康生物科技有限公司 | A kind of narrow ditribution particle diameter emulsion with skin anti-aging effect and preparation method thereof |
| CN108186407A (en) * | 2018-02-24 | 2018-06-22 | 珀莱雅化妆品股份有限公司 | A kind of preparation method for the solid dispersions for having effects that whitening is anti-ageing |
| CN111467284A (en) * | 2020-04-29 | 2020-07-31 | 泉后(广州)生物科技研究院有限公司 | Anti-aging nano composition and preparation method and application thereof |
| CN112294701A (en) * | 2020-11-24 | 2021-02-02 | 泉后(广州)生物科技研究院有限公司 | Low-irritation whitening nano composition and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| "老药抗衰老新用综述";温正如;《金华职业技术学院学报》;第第12卷卷(第第3期期);80-81页 * |
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