HRP20220568A1 - Formulation of a functional cosmetic ingredient, procedure of its preparation and use - Google Patents

Abstract

The invention reveals a functional cosmetic ingredient based on liposomal resveratrol (1) in a base of phospholipids selected from the group consisting of: phosphatidyl choline, phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, native lecithins or their derivatives, or mixtures of the aforementioned substances. The invention also discloses the procedure for preparing the cosmetic ingredient in question by dissolving said phospholipids in an organic solvent such as ethyl acetate, dissolving resveratrol (1) in the solution thus obtained, and evaporating the organic solvent in a vacuum, whereby the cosmetic ingredient according to the invention is formed in liposomal form, as a semi-solid homogeneous mass. The cosmetic ingredient according to the invention is used as a raw material for the production of various cosmetic products based on resveratrol because it enables easy incorporation into different types of formulations, increasing its solubility. It is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory and depigmentation agent, for the prevention and mitigation of wrinkles, for the treatment of stretch marks, for tightening and rejuvenating the skin, and for improving the barrier function of the skin. The invention reveals a functional cosmetic ingredient based on liposomal resveratrol (1) in a base of phospholipids selected from the group consisting of: phosphatidyl choline, phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, native lecithins or their derivatives, or mixtures of the aforementioned substances . The invention also discloses the procedure for preparing the related cosmetic ingredient by dissolving said phospholipids in an organic solvent such as ethyl acetate, dissolving resveratrol (1) in the solution thus obtained, and evaporating the organic solvent in a vacuum, whereby the cosmetic ingredient according to the invention is formed in liposomal form, as a semi-solid homogeneous mass. The cosmetic ingredient according to the invention is used as raw material for the production of various cosmetic products based on resveratrol because it enables easy incorporation into different types of formulations, increasing its solubility. It is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory and depigmentation agent, for the prevention and mitigation of wrinkles, for the treatment of stretch marks, for tightening and rejuvenating the skin, and for improving the barrier function of the skin.

Description

The field of technology

The present invention relates to a functional cosmetic ingredient based on liposomal resveratrol (1), its preparation and application.

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Technical problem

The technical problem relates to the technology of incorporating the well-known and valuable active cosmetic substance resveratrol (1) into various cosmetic products. Resveratrol (1) is poorly soluble in water and, as a resorcinol derivative, is sensitive to oxidation once dissolved in the aqueous phase, which is relatively richer in dissolved oxygen.

The subject invention solves said technical problem with the application of a complex cosmetic ingredient containing encapsulated resveratrol in liposomes based on lecithin or its derivatives.

The use of the complex ingredient according to the invention enables simple incorporation of resveratrol into various cosmetic formulations, which simplifies the technology of their production and obtains stable products.

Prior art

Resveratrol (1), 3,5,4'-trihydroxy-trans-stilbene or 5-[(E)-2-(4-hydroxyphenyl)ethen-1-yl]benzene-1,3-diol is a known natural compound that is widely represented in the plant world. It is used as an active nutritional and cosmetic substance. The richest source of natural resveratrol is the root of the Japanese gorse plant (Polygonum cuspidatum Siebold & Zucc.), which is mainly grown in China and Japan. Resveratrol shows a preventive effect on the occurrence of skin cancer, anti-cancer and antioxidant effect, protects the skin from damage caused by UV rays, then anti-inflammatory and depigmentation effect, prevents the occurrence and cures acne, accelerates wound healing and helps with psoriasis, eczema and other exfoliative skin disorders; see literature reference 1:

1) R.R. Watson, S. Zibadi (Editors): Bioactive Dietary Factors and Plant Extracts in dermatology; Chapter 18: D. K. Das, H. Vasanthi: Resveratrol in Dermal Health, 177-187; Humana Press (2013).

The main technical problems associated with the use of resveratrol (1) in cosmetic formulations are low solubility in water and sensitivity to oxidation in the dissolved state, and thus a tendency to oxidative decay.

The state of the art describes certain solutions for the mentioned technical problem through different methods of resveratrol encapsulation in different micro- and nano-sized particles, which increase the solubility of resveratrol and its stability according to the oxidation process.

For example, Chen and Liao described nano-particles of resveratrol encapsulated in lecithin. Their process involves mixing a lecithin solution and a resveratrol solution to form a solution that is then added to the aqueous phase, presumably to precipitate nanoparticles. The latter are subjected to a purification process, whereby lecithin-encapsulated resveratrol particles of nano-dimensions are obtained; see literature reference 2:

2) CN112773728A; W. Chen, W. Liao: Nano resveratrol-coated compound as well as preparation method and application thereof; holder: Jiangxi Normal Sci&Tech University and Sun Yat Sen University; China (CN).

A similar solution via resveratrol encapsulation was described by Che et al., which is based on the use of lecithin and phytosterols and polyethylene glycol (PEG)-polypeptide as coating agents in the resveratrol encapsulation process and vitamins as additional active substances. In doing so, an encapsulated form of resveratrol is obtained, which is used as an active substance for functional food; see literature reference 3:

3) CN111955730A; F. Che, D. Wang, C. Che, Y. Guo, C. Bai, L. Peng: Health-care food containing natural resveratrol and preparation method of health-care food; holder: Dongming Growth Biotechnology Co. Ltd., China (CN).

Furthermore, a similar solution was described by Li, and it is based on the application of a mixture of phosphatidyl choline, soy lecithin, cholesterol, polyvinyl pyrrolidone (PVP), hydroxypropyl cellulose and surfactants Tween-80 and Tween 85 and phosphonate buffer as agents for encapsulating resveratrol in liposomes; see literature reference 4:

4) CN1951368A; W. Li: Oral resveratrol multi-phase liposome and preparation method thereof; holder: Wanzhong Li, China (CN).

To the best of our knowledge, the closest state-of-the-art document to the invention in question is the patent by Wu et al. which discloses liposomal resveratrol particles of nano-dimensions, which are based on the use of soy lecithin and cholesterol in the presence of antioxidants as agents for the formation of liposomes in which resveratrol is incorporated (1) ; see literature reference 5:

5) CN111920771; Y. Wu, Z. Sun, J. Chang, P. Fu, J. Li: Resveratrol nano-liposome as well as preparation method and application thereof; host: Henan University, China (CN).

The subject invention solves the defined technical problem in a new and inventive way as described in the chapter Detailed description of the invention.

The essence of invention

The subject invention discloses a complex functional cosmetic ingredient consisting of the following ingredients:

(a) phospholipids (PL) such as various lecithins or their derivatives, 50-90% m/m,

(b) resveratrol (1), 10-50% m/m,

[image]

and, optionally,

(c) antioxidant (AO), 0-0.2% m/m,

whereby ingredient (a) forms liposomal particles in which the molecules of ingredients (b) and (c) are placed.

Preferably, the functional cosmetic ingredient according to the invention contains ingredients (a) and (b) in mass proportions as below:

(a) phospholipid (PL), 60-65% m/m,

(b) resveratrol (1), 35-40% w/w.

In a special case of application of the subject invention, the functional cosmetic ingredient contains ingredients (a) and (b) in mass proportions as stated below:

(a) phospholipid (PL), 63% w/w, i

(b) resveratrol (1), 37% w/w.

The present invention discloses the preparation process of said liposomal form of resveratrol, which is based on dissolving phospholipids (PL) in a suitable organic solvent such as ethyl acetate (EtOAc), then dissolving resveratrol (1) in the thus prepared solution, and then evaporating the organic solvent under mild conditions in a vacuum.

The functional cosmetic ingredient according to the invention is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol (1) in forms selected from the group consisting of: lotion solutions, water-in-oil emulsion lotions (W-O), oil-in-water emulsion lotions ( O-W), water-in-oil (W-O) emulsion creams, oil-in-water (O-W) emulsion creams, solution serums, water-in-oil (W-O) emulsion serums, oil-in-water (O-W) emulsion serums, cosmetic masks, sticks for underarm care, lip care lipsticks, solution gels or oil-in-water (O-W) emulsion gels.

The functional cosmetic ingredient according to the invention is used as an active cosmetic ingredient (ACI) that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, wrinkle prevention agent, wrinkle softener, stretch mark treatment agent, skin tightening and rejuvenation agent, and as a to improve the barrier function of the skin.

Detailed description of the invention

The subject invention discloses a complex functional cosmetic ingredient consisting of the following ingredients:

(a) phospholipids (PL), 50-90% m/m,

(b) resveratrol (1) or 3,4',5-trihydroxystilbene, 10-50% m/m,

[image]

and, optionally,

(c) antioxidant (AO), 0-0.2% m/m,

whereby ingredient (a) forms liposomal particles in which the molecules of ingredients (b) and (c) are placed.

Ingredient (a), phospholipid (PL), in the formulation of the subject functional cosmetic ingredient, is selected from the group consisting of:

(i) phosphatidyl choline (PC), phosphatidyl inositol (PI), phosphatidyl ethanolamine (PE), phosphatidyl serine (PS),

(ii) hydrogenated phosphatidyl choline (HPC), hydrogenated phosphatidyl inositol (HPI), hydrogenated phosphatidyl ethanolamine (HPE), hydrogenated phosphatidyl serine (HPS),

(iii) lecithin (L) isolated from sunflower (Helianthus annuus L.), soybean (Glycine max L.), rapeseed (Brasica napus L.), canola (Brassica rapa L.), cotton (Gossypium spp L.) or chicken (Gallus gallus domesticus) eggs,

(iv) hydrogenated lecithin (HGL) obtained from sunflower, soybean, rapeseed, canola or cotton lecithin, or lecithin from chicken eggs,

(v) hydrolyzed lecithin (HL) obtained from sunflower, soybean, rapeseed, cannolin or cotton lecithin, or lecithin from chicken eggs,

or mixtures of these substances.

The active substance of resveratrol (1) is synthetic or natural resveratrol isolated from various enriched plant extracts that contain it. The most well-known source is the extract of the Japanese gorse plant (Polygonum cuspidatum Siebold & Zucc.).

The antioxidant (AO) in the formulation of the cosmetic ingredient in question is selected from the group consisting of: ascorbic acid, tocopherols such as α-tocopherol, propyl gallate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiary butylhydroquinone (TBHQ), or mixtures of the aforementioned substances .

Preferably, the functional cosmetic ingredient according to the invention contains ingredients (a) and (b) in mass proportions as below:

(a) phospholipid (PL), 60-65% m/m,

(b) resveratrol (1), 35-40% w/w.

In a special case of application of the subject invention, the functional cosmetic ingredient contains ingredients (a) and (b) in mass proportions as stated below:

(a) phospholipid (PL), 63% w/w, i

(b) resveratrol (1), 37% w/w.

The functional cosmetic ingredient according to the invention is a semi-solid homogeneous mixture of yellow-brown color and a slightly intense, characteristic "herbal" smell due to phospholipids.

Preparation of the formulation of the functional cosmetic ingredient according to the invention

The procedure for preparing a functional cosmetic ingredient according to the invention consists of the following steps:

(i) dissolution of phospholipids (PL) in organic solvent (OS), by stirring at temperatures from room temperature to reflux temperature for 10-60 minutes, with a mass ratio of phospholipids (PL) to organic solvent as follows:

PL : OS = 1 : 1-10, m/m,

(ii) adding resveratrol (1) to the solution from step (i) and dissolving it by stirring at room temperature to reflux temperature for 10-60 minutes;

(iii) evaporation of the solution from step (ii) in a vacuum at a pressure of 0.01-0.1 mbar, at temperatures of 10-25 °C, while controlling the content of the remaining organic solvent from step (i) below the level of 0.5 % m/m and

(iv) optional, additional drying of the steam residue in a deep vacuum at a pressure of 0.001-0.01 mbar, at temperatures of 10-25 °C for 30-120 minutes,

whereby the functional cosmetic ingredient according to the invention is created in the form of a semi-solid homogeneous mixture.

As organic solvent (OS) in step (i) can be used: methyl formate (HCOOMe), methyl acetate (MeOAc), ethyl acetate (EtOAc), propyl acetate (n-PrOAc), isopropyl acetate (i-PrOAc) or mixtures the mentioned substances.

Ethyl acetate is preferably used as the organic solvent (OS) in step (i) with the mass ratio:

PL : EtOAc = 1 : 1-1.5, m/m,

at temperatures of 20-25 °C, while in step (ii), the dissolution of resveratrol (1) is carried out at temperatures of 20-25 °C.

Optionally, the dissolution of resveratrol (1) and possibly the entire process of preparing the cosmetic ingredient according to the invention is carried out in an inert gas atmosphere such as nitrogen (N2) or argon (Ar).

Typical examples of the procedure for preparing the cosmetic ingredient according to the invention are described in Examples 1 and 2.

Use of the formulation of the functional cosmetic ingredient according to the invention

The cosmetic ingredient according to the invention is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol (1) in forms selected from the group consisting of: solution lotions, water-in-oil (W-O) emulsion lotions, oil-in-water (O-W) emulsion lotions ), water-in-oil (W-O) emulsion creams, oil-in-water (O-W) emulsion creams, solution serums, water-in-oil (W-O) emulsion serums, oil-in-water (O-W) emulsion serums, cosmetic masks, sticks for underarm care, lip care lipsticks, solution gels or oil-in-water (O-W) emulsion gels.

Exemplary examples of cosmetic products obtained with the application of a functional cosmetic product according to the invention are described in Examples 3-5.

Considering the spectrum of biological action, the functional cosmetic ingredient according to the invention is used as an active cosmetic ingredient (ACI) that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, anti-wrinkle agent, anti-wrinkle agent, stretch mark treatment agent, tightening agent and skin rejuvenation and as a means of improving the barrier function of the skin.

Examples of embodiments of the invention

General notes

All quantitative compositions are expressed in percentages of the mass fraction (% m/m) of an individual ingredient in a specific formulation. The term "room temperature" (r.t.) refers to the temperature interval of 20-25 °C. The mixing speed is expressed in the number of revolutions of the mixing element per minute (rpm). All procedures for the preparation of the functional cosmetic ingredient according to the invention and sample recipes of cosmetic products based on it were carried out on a scale of 100 g.

Example 1. Preparation of a functional cosmetic ingredient according to the invention

[image]

Procedure:

(1) Phase A was stirred at room temperature for 30 minutes resulting in a clear solution;

(2) Then B was added to the solution from step (1) and stirred at room temperature for 15 minutes until a clear solution was formed;

(3) The solution from step (2) was then evaporated to dryness on a rotary evaporator at 20-25 °C under vacuum; the mass fraction of ethyl acetate was controlled and lowered below 0.5% m/m by evaporation;

(4) Optionally, additional drying of the residual ethyl acetate from the finished product can be carried out in a deep vacuum at an oil pump vacuum of 0.001-0.01 mbar.

The finished functional ingredient according to the invention had the form of a semi-solid homogeneous mass of yellow-brown color. Analysis: 36.50-37.00% resveratrol (1).

aBergaSom Soy 90 from Berg+Schmidt Functional Lipids GmbH&Co. KG, Germany. b Ethyl acetate, anhydrous 99.8%; product of Sigma-Aldrich, USA. c Biotive® Resveratrol, min 99%; product of Symrise AG, Germany.

Example 2. Preparation of a functional cosmetic ingredient according to the invention

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Procedure:

(1) Phase A was stirred at room temperature for 30 minutes resulting in a clear solution;

(2) Then B was added to the solution from step (1) and stirred at room temperature for 15 minutes until a clear solution was formed;

(3) The solution from step (2) was then evaporated to dryness on a rotary evaporator at 20-25 °C under vacuum; the mass fraction of ethyl acetate was controlled and lowered below 0.5% m/m by evaporation.

The finished functional ingredient according to the invention had the form of a semi-solid homogeneous mass of yellow-brown color. Analysis: 24.50-25.00% resveratrol (1).

and BergaSom Soy 90 from Berg+Schmidt Functional Lipids GmbH&Co. KG, Germany.

b Ethyl acetate, anhydrous 99.8%; product of Sigma-Aldrich, USA.

c Biotive® Resveratrol, min 99%; product of Symrise AG, Germany.

Example 3. Preparation of a cosmetic product in the form of a serum for acne-prone skin with resveratrol (1) with the use of a functional ingredient according to the invention

[image]

Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C for 30 minutes while stirring with an anchor mixer at 50 rpm.

(4) Separately weigh C and leave to swell in a dark place at room temperature for 30 minutes. Then homogenize by mixing at 10,000 rpm for 5 minutes.

(5) Add C to A+B at 50 °C and homogenize by stirring at 10,000 rpm for 1 minute.

(6) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(7) Adjust the pH to about 6.0 with D stirring at 50 rpm for 15 minutes.

The finished cosmetic product is a liquid emulsion, ivory in color and shiny; the smell is neutral. pH = 5.5-6.5. Analysis: 0.167-0.204% resveratrol (1).

and Ph.Eur.10; b Activonol, product of the Activon company, Korea; c Niacinamide PC, product of DSM Nutritional Products, The Netherlands; d D-Panthenol Care, product of the company BASF, Germany; e Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; f Product of EVONIK Dr. Straetmans, Germany; g Product of SEPPIC SA, France; h Product of the company BASF, Germany; and Product of the company IOI Oleo GmbH, Germany; j Keltrol® CG-SFT, product of the company CP Kelco, USA; k Product of DSM Nutritional Products, The Netherlands; l Carbopol® 980 polymer, product of Lubrizol, USA; m Product from Example 1; n Product of the company Jungbunzlauer, Switzerland, dissolved in water before preparation.

Example 4. Preparation of a cosmetic product in the form of an antioxidant serum for the face with resveratrol (1) with the use of a functional ingredient according to the invention

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Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C for 30 minutes while stirring with an anchor mixer at 50 rpm.

(4) Separately weigh C and leave to swell in a dark place at room temperature for 30 minutes. Then homogenize by mixing at 10,000 rpm for 5 minutes.

(5) Add C to A+B at 50 °C and homogenize by stirring at 10,000 rpm for 1 minute.

(6) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(7) Adjust the pH to about 6.0 with D stirring at 50 rpm for 15 minutes.

The finished cosmetic product is a liquid emulsion, ivory in color and shiny; the smell is neutral. pH = 5.5-6.5. Analysis: 0.167-0.204% resveratrol (1).

and Ph.Eur.10; b Activonol, product of the Activon company, Korea; c D-Panthenol Care, product of the company BASF, Germany; d Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; f Product of EVONIK Dr. Straetmans, Germany; f Product of SEPPIC SA, France; g Product of the company BASF, Germany; h Product of the company Henry Lamotte, Germany; and Product of the company IOI Oleo GmbH, Germany; j Keltrol® CG-SFT, product of the company CP Kelco, USA; k Product of DSM Nutritional Products, The Netherlands; l Carbopol® 980 polymer, product of Lubrizol, USA; m Product from Example 1.

Example 5. Preparation of a cosmetic product in the form of an anti-aging cream with resveratrol (1) with the use of a functional ingredient according to the invention

[image]

Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C for 30 minutes while stirring with an anchor mixer at 50 rpm.

(4) Separately weigh C and leave to swell in a dark place at room temperature for 30 minutes. Then homogenize by mixing at 10,000 rpm for 5 minutes.

(5) Add C to A+B at 50 °C. Then add D to A+B+C and homogenize by mixing at 10,000 rpm for 1 minute.

(6) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(7) Adjust the pH to about 6.0 with E stirring at 50 rpm for 15 minutes.

The finished cosmetic product is a semi-solid emulsion, ivory in color and shiny; the smell is neutral. pH = 5.5-6.5. Analysis: 0.167-0.204% resveratrol (1).

and Ph.Eur.10; b Product of EVONIK Dr. Straetmans, Germany; c Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; d D-Panthenol Care, product of BASF Company, Germany; e Product of BASF AG, Germany; f Keltrol® CG-SFT, product of the company CP Kelco, USA; g Product of the company Henry Lamotte, Germany; h Carbopol® 980 polymer, product of Lubrizol, USA; and Product of Givaudan, Switzerland; j Blanova Active Sodium Hyaluronate 8,000-50,000 Yes, product of DeWold Chemical, USA; k Product of SEPPIC SA, France; l Product of IOI Oleo GmbH, Germany; m Bioxan E 1300 IU, BTSA, Spain; n Product from Example 1.

Industrial applicability

The subject invention is used for the production of a functional cosmetic ingredient that is used in the cosmetic industry for the production of various types of cosmetic products. Therefore, the industrial applicability of this invention is obvious.

Claims (10)

1. Complex functional cosmetic ingredient, characterized by the fact that it consists of the following ingredients: (a) phospholipid <PL>, 50-90% m/m, (b) resveratrol <1>, 10-50% m/m, [image] and, optionally, (c) antioxidant <AO>, 0-0.2% m/m, whereby ingredient (a) forms liposomal particles in which the molecules of ingredients (b) and (c) are placed. 2. Functional cosmetic ingredient according to claim 1, characterized in that ingredient (a), phospholipid <PL>, is selected from the group consisting of: (i) phosphatidyl choline <PC>, phosphatidyl inositol <PI>, phosphatidyl ethanolamine <PE>, phosphatidyl serine <PS>, (ii) hydrogenated phosphatidyl choline <HPC>, hydrogenated phosphatidyl inositol <HPI>, hydrogenated phosphatidyl ethanolamine <HPE>, hydrogenated phosphatidyl serine <HPS>, (iii) lecithin <L> isolated from sunflower <Helianthus annuus>, soybean <Glycine max>, rapeseed <Brasica napus>, canola <Brassica rapa>, cotton <Gossypium spp> or chicken <Gallus gallus domesticus> eggs, (iv) hydrogenated lecithin <HGL> obtained from sunflower, soybean, rapeseed, canola or cotton lecithin, or lecithin from chicken eggs, (v) hydrolyzed lecithin <HL> obtained from sunflower, soybean, rapeseed, cannolin or cotton lecithin, or lecithin from chicken eggs, or mixtures of these substances. 3. Functional cosmetic ingredient according to claims 1 and 2, characterized by the fact that ingredient (c), antioxidant <AO>, is selected from the group consisting of: ascorbic acid, tocopherols such as α-tocopherol, propyl gallate, butylated hydroxyanisole <BHA>, butylated hydroxytoluene <BHT>, tertiary butylhydroquinone <TBHQ>, or mixtures of these substances. 4. Functional cosmetic ingredient according to claims 1-3, characterized in that it contains ingredients (a) and (b) in mass fractions as below: (a) phospholipid <PL>, 60-65% m/m, (b) resveratrol <1>, 35-40% w/w. 5. Functional cosmetic ingredient according to claims 1-3, characterized in that it contains ingredients (a) and (b) in mass fractions as below: (a) phospholipid <PL>, 63% w/w, i (b) resveratrol <1>, 37% w/w. 6. The procedure for preparing a functional cosmetic ingredient according to any of the previous requirements, characterized by the fact that it consists of the following steps: (i) dissolving the phospholipid <PL> in the organic solvent <OS>, by stirring at temperatures from room temperature to the return temperature of the solvent for 10-60 minutes, with the mass ratio of the phospholipid <PL> to the organic solvent as follows: PL : OS = 1 : 1-10, m/m, (ii) adding resveratrol <1> to the solution from step (i) and dissolving it by stirring at room temperature to reflux temperature for 10-60 minutes; (iii) evaporation of the solution from step (ii) in a vacuum at a pressure of 0.01-0.1 mbar, at temperatures of 10-25 °C, while controlling the content of the remaining organic solvent from step (i) below the level of 0.5 % m/m, and (iv) optional, additional drying of the steam residue in a deep vacuum at a pressure of 0.001-0.01 mbar, at temperatures of 10-25 °C for 30-120 minutes, whereby the functional cosmetic ingredient according to the invention is created in the form of a semi-solid homogeneous mixture. 7. The method of preparing a functional cosmetic ingredient according to claim 6, characterized in that the organic solvent <OS> in step (i) is selected from the group consisting of: methyl formate <HCOOMe>, methyl acetate <MeOAc>, ethyl acetate <EtOAc>, propyl acetate <n-PrOAc>, isopropyl acetate <i-PrOAc> or mixtures of these substances. 8. The procedure for preparing a functional cosmetic ingredient according to claims 6 and 7, characterized in that: - in step (i), ethyl acetate is used as the organic solvent <OS>, which with the mass ratio: PL : EtOAc = 1 : 1-1.5, m/m, at temperatures of 20-25 °C and - in step (ii), dissolution of resveratrol <1> is carried out at temperatures of 20-25 °C. 9. The use of a cosmetic ingredient according to claims 1-5, indicated by the fact that it is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol <1> in forms selected from the group consisting of: lotions, solutions, lotions, water-in-oil emulsions < W-O>, oil-in-water emulsion lotions <O-W>, water-in-oil emulsion creams <W-O>, oil-in-water emulsion creams <O-W>, solution serums, water-in-oil emulsion serums <W-O>, oil emulsion serums in water <O-W>, cosmetic masks, underarm care sticks, lip care lipsticks, solution gels or oil-in-water emulsion gels <O-W>. 10. Use of a cosmetic ingredient according to claims 1-5, characterized in that it is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, wrinkle prevention agent, wrinkle softener, stretch mark treatment agent, tightening and rejuvenating the skin, and as a means of improving the barrier function of the skin.