HRP20220570A1 - Formulation of resveratrol-based functional cosmetic ingredient, procedure for its preparation and usage - Google Patents

Abstract

<IMAGE NAME="20220570_01" TYPE="JPG" CENTER=TRUE/><BR/>The invention discloses a functional cosmetic ingredient based on liposomal resveratrol (<B>1</B>) in a phospholipid (PL) base such as soy lecithin and which is homogenized in an aqueous solution of xanthan gum hydrocolloid (XG). Furthermore, the invention discloses a procedure for the preparation of the cosmetic ingredient in question by dissolving said phospholipids and resveratrol (<B>1</B>) in an organic solvent such as ethyl acetate and evaporating the organic solvent in a vacuum, with the formation of liposomal resveratrol which is homogenized in the XG solution with the addition of suitable auxiliary substances such as preservatives and antioxidants. The formulation according to the invention is used as a finished cosmetic product for direct application on the skin or as a raw material for the production of various cosmetic products based on resveratrol because it enables easy incorporation into different types of formulations, increasing its solubility and stability. The product according to the invention is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory and depigmentation agent, to prevent and reduce wrinkles, to treat stretch marks, to tighten and rejuvenate the skin, and to improve the barrier function of the skin.<IMAGE NAME="20220570_01" TYPE="JPG" CENTER=TRUE/><BR/>The invention discloses a functional cosmetic ingredient based on liposomal resveratrol (<B>1</B>) in a phospholipid (PL) base such as soy lecithin, which is homogenised in an aqueous hydrocolloid solution xanthan gum (XG). Furthermore, the invention discloses the preparation process of the related cosmetic ingredient by dissolving said phospholipids and resveratrol (<B>1</B>) in an organic solvent such as ethyl acetate and evaporating the organic solvent in a vacuum, with the formation of liposomal resveratrol which is homogenised in the XG solution with the addition of suitable auxiliary substances such as preservatives and antioxidants. The formulation according to the invention is used as a finished cosmetic product for direct application on the skin or as raw material for the production of various cosmetic products based on resveratrol because it enables easy incorporation into different types of formulations, increasing its solubility and stability. The product according to the invention is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory and depigmentation agent, for the prevention and mitigation of wrinkles, for the treatment of stretch marks, for tightening and rejuvenating the skin, and for improving the barrier function of the skin.

Description

The field of technology

The present invention relates to a functional cosmetic ingredient based on liposomal resveratrol (1) stabilized by a hydrocolloid system based on xanthan gum (XG), its preparation process and application.

[image]

Technical problem

The technical problem relates to the technology of incorporating the well-known active cosmetic substance resveratrol (1) into various cosmetic products. Resveratrol (1) is poorly soluble in water and is susceptible to oxidation once dissolved in the aqueous phase, which is relatively richer in dissolved oxygen.

The subject invention solves said technical problem with the application of a complex cosmetic ingredient containing encapsulated resveratrol in liposomes based on lecithin or its derivatives, which is stabilized in a hydrocolloid system based on xanthan gum (XG).

The use of the complex ingredient according to the invention enables simple incorporation of resveratrol into various cosmetic formulations, which simplifies the technology of their production and obtains stable products.

Prior art

Resveratrol (1), 3,5,4'-trihydroxy-trans-stilbene or 5-[(E)-2-(4-hydroxyphenyl)ethen-1-yl]benzene-1,3-diol is a known natural compound widely represented in the plant world. It is used as an active nutritional and cosmetic substance. The richest source of natural resveratrol is the root of the Japanese gorse plant (Polygonum cuspidatum Siebold & Zucc.), which is mainly grown in China and Japan. Resveratrol shows a preventive effect on the occurrence of skin cancer, anti-cancer and antioxidant effect, protects the skin from damage caused by UV rays, then anti-inflammatory and depigmentation effect, prevents the occurrence and cures acne, accelerates wound healing and helps with psoriasis, eczema and other exfoliative skin disorders; see literature reference 1:

1) R.R. Watson, S. Zibadi (Editors): Bioactive Dietary Factors and Plant Extracts in dermatology; Chapter 18: D. K. Das, H. Vasanthi: Resveratrol in Dermal Health, 177-187; Humana Press (2013).

Xanthan gum (XG) is a natural polysaccharide obtained as a fermentation product from the bacteria Xanthomonas campestris [(Pammel 1895) Dowson 1939]:

[image]

It is used as a valuable hydrocolloid in the food industry, as an E415 food additive in the thickener category, and as a thickener in the cosmetic, pharmaceutical and chemical industries; see literature reference 2:

2) N. Z. Nordin, A. R. Rashidi, D. J. Dailin, R. A. Malek, N. I. W. Azelee, N. H. A. Manas, S. Selvamani, D. N. A. Zaidel, R. A. A. Alsaheb, D. Sukmawati, H. El Enshasy: Xanthan Biopolymer in Pharmaceutical and Cosmeceutical Applications: Critical Review, Biosci. Crisp. 17 (2020) 205-220.

The main technical problems associated with the use of resveratrol (1) in cosmetic formulations are low solubility in water and sensitivity to oxidation in the dissolved state, and thus a tendency to oxidative decay.

The state of the art describes certain solutions for the mentioned technical problem through different methods of resveratrol encapsulation into different micro- and nano-sized particles that increase the solubility of resveratrol and its stability according to the oxidation process.

For example, Chen and Liao described nano-particles of resveratrol encapsulated in lecithin. Their process involves mixing a lecithin solution and a resveratrol solution to form a solution that is then added to the aqueous phase, presumably to precipitate nanoparticles. The latter are subjected to a purification process, whereby lecithin-encapsulated resveratrol particles of nano-dimensions are obtained; see literature reference 3:

3) CN112773728A; W. Chen, W. Liao: Nano resveratrol-coated compound as well as preparation method and application thereof; holder: Jiangxi Normal Sci&Tech University and Sun Yat Sen University; China (CN); priority date: 31 December 2020

A related technical solution is disclosed by the Saar et al. patent, which describes a method of solubilizing poorly water-soluble cosmetic active substances; see literature reference 4:

4) US11207256B2; I. Saar, W. Brysch, J. von Wegerer: Method for solubilizing poorly water-soluble cosmetic agents; holder: Athenion AG (CH); priority date: 06/30/2017

Their procedure is based on dissolving cosmetic active substances such as resveratrol (1) in a complex system:

(i) at least one lecithin derivative from the class of phosphatidyl choline (PC), 20-80% m/m,

(ii) medium chain triglyceride (MCT), 10-70% m/m, with a ratio of PC : MCT = 80 : 1 – 1.33 : 1 m/m,

(iii) ethanol, 1-20% m/m, i

(iv) oleic acid, 0.5-10% m/m,

at 30-120 °C with the formation of a clear and stable system of significantly improved solubility of resveratrol in cosmetic products in which said complex cosmetic ingredient is incorporated. Such a formulation of a complex cosmetic ingredient may additionally contain excipients from other classes, including stabilizers (thickeners) such as xanthan gum.

The subject invention solves the defined technical problem in a new and inventive way as described in the chapter Detailed description of the invention.

The essence of invention

The subject invention discloses a complex functional cosmetic ingredient consisting of the following ingredients:

(a) resveratrol (1), 0.50-2.50% m/m,

[image]

(b) phospholipids (PL) such as various lecithins or their derivatives, 2.50-4.50% m/m,

(c) xanthan gum (XG), 0.05-1.00% m/m,

(d) preservative (PR), 0.10-2.00% m/m,

(e) optional, antioxidant (AO), 0.00-0.20% w/w, i

(f) purified water, up to 100% m/m formulation,

wherein the ingredient (b) forms liposomal particles in which the molecules of the ingredients (a) are placed, where said liposomal particles are additionally stabilized in the hydrocolloid gel of xanthan gum (XG).

Preferably, the functional cosmetic ingredient according to the invention contains ingredients (a)-(c) in mass proportions as follows:

(a) resveratrol (1), 1.75-2.00% w/w,

(b) phospholipid (PL), 3.00-3.25% w/w, i

(c) xanthan gum (XG), 0.10-0.50% w/w.

The present invention discloses the preparation process of said liposomal form of resveratrol, which is based on dissolving phospholipids (PL) in a suitable organic solvent such as ethyl acetate (EtOAc), then dissolving resveratrol (1) in the thus prepared solution, and then evaporating the organic solvent under mild conditions in a vacuum. After that, the obtained liposomal resveratrol (1) is additionally stabilized by homogenization in a preserved aqueous solution of hydrocolloid based on xanthan gum (XG), whereby the formulation according to the invention is obtained.

The cosmetic formulation according to the invention is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol (1) in forms selected from the group consisting of: lotion solutions, water-in-oil (W-O) emulsion lotions, oil-in-water (O-W) emulsion lotions ), water-in-oil (W-O) emulsion creams, oil-in-water (O-W) emulsion creams, solution serums, water-in-oil (W-O) emulsion serums, oil-in-water (O-W) emulsion serums, cosmetic masks, sticks for underarm care, lip care lipsticks, solution gels or oil-in-water (O-W) emulsion gels.

In addition, the formulation according to the invention is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, anti-wrinkle agent, anti-wrinkle agent, stretch mark treatment agent, skin tightening and rejuvenation agent, eye area care agent and as a means of improving the barrier function of the skin.

Also, the formulation according to the invention is used as a cosmetic product, in the form of a serum formulation, for direct application on the skin, which acts as an antioxidant, anti-inflammatory agent, depigmentation agent, wrinkle prevention agent, wrinkle softener, stretch mark treatment agent, tightening agent and skin rejuvenation and as a means of improving the barrier function of the skin.

Detailed description of the invention

The subject invention discloses a complex functional cosmetic ingredient consisting of the following ingredients:

(a) resveratrol (1), 0.50-2.50% w/w,

[image]

(b) phospholipid (PL), 2.50-4.50% m/m,

(c) xanthan gum (XG), 0.05-1.00% w/w,

[image]

(d) preservative (PR), 0.10-2.00% m/m,

(e) optional, antioxidant (AO), 0.00-0.20% w/w, i

(f) purified water up to 100% m/m formulation,

whereby the ingredient (b) forms liposomal particles in which the molecules of the ingredients (a) are placed. The liposomal particles formed in this way were additionally stabilized in a hydrocolloid system based on xanthan gum (XG).

Ingredient (b), phospholipid (PL), used in the formulation according to the invention is selected from the group consisting of:

A. phosphatidyl choline (PC), phosphatidyl inositol (PI), phosphatidyl ethanolamine (PE), phosphatidyl serine (PS),

B. hydrogenated phosphatidyl choline (HPC), hydrogenated phosphatidyl inositol (HPI), hydrogenated phosphatidyl ethanolamine (HPE), hydrogenated phosphatidyl serine (HPS),

C. lecithin <L> isolated from sunflower (Helianthus annuus L.), soybean (Glycine max L.), canola (Brasica napus L.), canola (Brassica rapa L.), cotton (Gossypium spp L.) or chicken ( Gallus gallus domesticus) eggs,

D. hydrogenated lecithin (HGL) obtained from sunflower, soybean, rapeseed, canola or cotton lecithin or lecithin from chicken eggs,

E. hydrolyzed lecithin (HL) obtained from sunflower, soybean, rapeseed, cannolin or cotton lecithin or lecithin from chicken eggs,

or mixtures of these substances.

As ingredient (c), xanthan gum (XG), all commercially available products containing xanthan gum can be used provided they are of food, cosmetic or pharmaceutical grade purity.

Ingredient (d), preservative (PR), used in the formulation according to the invention is selected from the group consisting of: phenoxyethanol, caprylyl glycol, benzyl alcohol, dehydroacetic acid, benzoic acid, sorbic acid, ethyl hexylglycerol or mixtures of the above substances.

Optional ingredient (e), antioxidant (AO), used in the formulation of the present invention is selected from the group consisting of: ascorbic acid, tocopherols such as α-tocopherol, propyl gallate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiary butylhydroquinone (TBHQ) or mixtures of these substances.

In the preferred embodiment of the present invention, the functional cosmetic ingredient contains the ingredients (a)-(c) in the mass proportions as follows:

(a) resveratrol (1), 1.75-2.00% w/w,

(b) phospholipid (PL), 3.00-3.25% w/w, i

(c) xanthan gum (XG), 0.10-0.50% w/w.

Preparation of the formulation according to the invention

The functional cosmetic ingredient according to the invention is prepared according to a manufacturing process that includes the following steps:

(i) dissolution of phospholipids (PL) in organic solvent (OS), by stirring at temperatures from room temperature to reflux temperature for 10-60 minutes, with a mass ratio of phospholipids (PL) to organic solvent as follows:

PL : OS = 1 : 1-10, m/m,

(ii) adding resveratrol (1) to the solution from step (i) and dissolving it by stirring at room temperature to reflux temperature for 10-60 minutes;

(iii) evaporation of the solution from step (ii) in a vacuum at a pressure of 0.01-0.1 mbar, at temperatures of 10-25 °C, while controlling the content of the remaining organic solvent from step (i) below the level of 0.5 % m/m,

(iv) separately dissolving xanthan gum (XG), preservatives and, optionally, antioxidants in the prescribed amount of water, by mixing at temperatures of 20-50 °C for 15-60 minutes;

(v) adding the vapor residue from step (iii) to the solution from step (iv) and swelling the resulting mixture at temperatures of 10-30 °C for 30-120 minutes, and

(vi) homogenization of the resulting mixture at 10,000-20,000 rpm for 5-30 minutes;

whereby the formulation according to the invention is formed in the form of a homogeneous cloudy liquid.

The organic solvent (OS) in step (i) was selected from the group consisting of: methyl formate (HCOOMe), methyl acetate (MeOAc), ethyl acetate (EtOAc), propyl acetate (n-PrOAc), isopropyl acetate (i- PrOAc) or mixtures of said solvents.

Ethyl acetate is preferably used in step (i) as an organic solvent (OS) for dissolving phospholipids (PL) with the mass ratio:

PL : EtOAc = 1 : 1-1.5, m/m,

at temperatures of 20-25 °C, while in step (ii), the dissolution of resveratrol (1) is carried out at temperatures of 20-25 °C.

Typical examples of the procedure for preparing the cosmetic ingredient according to the invention are described in Examples 1 and 2.

Use of the formulation according to the invention

The cosmetic formulation according to the invention is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol (1) in forms selected from the group consisting of: lotion solutions, water-in-oil (W-O) emulsion lotions, oil-in-water (O-W) emulsion lotions ), water-in-oil (W-O) emulsion creams, oil-in-water (O-W) emulsion creams, solution serums, water-in-oil (W-O) emulsion serums, oil-in-water (O-W) emulsion serums, cosmetic masks, sticks for underarm care, lip care lipsticks, solution gels or oil-in-water (O-W) emulsion gels.

In addition, the formulation according to the invention is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, anti-wrinkle agent, anti-wrinkle agent, stretch mark treatment agent, skin tightening and rejuvenation agent, eye area care agent , and as a means of improving the barrier function of the skin.

Exemplary examples of cosmetic products obtained with the application of a functional cosmetic product according to the invention are described in Examples 3-5.

Alternatively, given the known spectrum of useful cosmetic and pharmacological topical effects of resveratrol (1), the formulation according to the invention is used as a cosmetic product, in the form of a serum, for direct application on the skin, which acts as an antioxidant, anti-inflammatory agent, depigmentation agent, and anti-aging agent wrinkle, wrinkle softener, stretch mark treatment, skin tightening and rejuvenating agent, and as a means to improve the skin's barrier function.

Examples of embodiments of the invention

General notes

All quantitative compositions are expressed in percentages of the mass fraction (% m/m) of an individual ingredient in a specific formulation. The term "room temperature" (r.t.) refers to the temperature interval of 20-25 °C. The mixing speed is expressed in the number of revolutions of the mixing element per minute (rpm). All procedures for the preparation of the functional cosmetic ingredient according to the invention and sample recipes of cosmetic products based on it were carried out on a scale of 100 g.

Example 1. Preparation of a functional cosmetic ingredient according to the invention

[image]

Procedure:

(1) Phase A was stirred at room temperature for 30 minutes resulting in a clear solution;

(2) Then B was added to the solution from step (1) and stirred at room temperature for 15 minutes until a clear solution was formed;

(3) The solution from step (2) was then evaporated to dryness on a rotary evaporator at 20-25 °C under vacuum; the mass fraction of ethyl acetate was controlled and lowered below 0.5% m/m by evaporation;

(4) Optionally, additional drying of the residual ethyl acetate from the finished product can be carried out in a deep vacuum at an oil pump vacuum of 0.001-0.01 mbar.

(5) Phase C was then added to the vapor residue and allowed to bubble at room temperature for 30 minutes.

(6) The mixture was then homogenized by stirring at 15,000 rpm for 10 minutes.

The finished functional ingredient according to the invention had the form of a homogeneous opaque liquid, milky yellow in color. The smell is slightly intense, characteristic. pH value = 6.0-7.5. Analysis: 0.90-1.10% resveratrol (1).

and BergaSom Soy 90 from Berg+Schmidt Functional Lipids GmbH&Co. KG, Germany. b Ethyl acetate, anhydrous 99.8%; product of Sigma-Aldrich, USA; c To dissolve lecithin and resveratrol, ethyl acetate was used in the mass ratio lecithin : EtOAc = 1 : 1.5 m/m; d Biotive® Resveratrol, min 99%; product of Symrise AG, Germany. e Keltrol® CG-SFT, product of the company CP Kelco, USA; f Product of EVONIK Dr. Straetmans, Germany.

Example 2. Preparation of a functional cosmetic ingredient according to the invention

[image]

Procedure:

(1) Phase A was stirred at room temperature for 30 minutes resulting in a clear solution;

(2) Then B was added to the solution from step (1) and stirred at room temperature for 15 minutes until a clear solution was formed;

(3) The solution from step (2) was then evaporated to dryness on a rotary evaporator at 20-25 °C under vacuum; the mass fraction of ethyl acetate was controlled and lowered below 0.5% m/m by evaporation;

(4) Phase C was then added to the vapor residue and allowed to bubble at room temperature for 120 minutes.

(5) The mixture was then homogenized by stirring at 15,000 rpm for 30 minutes.

The finished functional ingredient according to the invention had the form of a homogeneous opaque viscous liquid, milky yellow in color. The smell is slightly intense, characteristic. pH value = 6.0-7.5. Analysis: 1.80-2.20% resveratrol (1).

and BergaSom Soy 90 from Berg+Schmidt Functional Lipids GmbH&Co. KG, Germany. b Ethyl acetate, anhydrous 99.8%; product of Sigma-Aldrich, USA; c To dissolve lecithin and resveratrol, ethyl acetate was used in the mass ratio lecithin : EtOAc = 1 : 1.5 m/m; d Biotive® Resveratrol, min 99%; product of Symrise AG, Germany. e Keltrol® CG-SFT, product of the company CP Kelco, USA; f Product of EVONIK Dr. Straetmans, Germany.

Example 3. Preparation of a cosmetic product in the form of an anti-aging cream with resveratrol (1) with the use of a functional ingredient according to the invention

[image]

Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C for 30 minutes while stirring with an anchor mixer at 50 rpm.

(4) Separately weigh C and leave to swell in a dark place at room temperature for 30 minutes. Then homogenize by mixing at 10,000 rpm for 5 minutes.

(5) Add C to A+B at 50 °C. Then add D to A+B+C and homogenize by mixing at 10,000 rpm for 1 minute.

(6) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(7) Adjust the pH to about 6.0 with E stirring at 50 rpm for 15 minutes.

The finished cosmetic product is a semi-solid emulsion of ivory color with a glossy shine. The smell is neutral. pH = 5.5-6.5. Analysis: 0.09-0.11% resveratrol (1).

and Ph.Eur.10; b Product of EVONIK Dr. Straetmans, Germany; c Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; d D-Panthenol Care, product of BASF AG, Germany; e Product of BASF AG, Germany; f Keltrol® CG-SFT, product of the company CP Kelco, USA; g Product of the company Henry Lamotte, Germany; h Carbopol® 980 polymer, product of Lubrizol, USA; and Product of Givaudan, Switzerland; j Blanova Active Sodium Hyaluronate 8,000-50,000 Yes, product of DeWold Chemical, USA; k Product of SEPPIC SA, France; l Product of IOI Oleo GmbH, Germany; m Bioxan E 1300 IU, product of the company BTSA, Spain; n Product from Example 1.

Example 4. Preparation of a cosmetic product in the form of a serum for acne-prone skin with resveratrol (1) with the use of a functional ingredient according to the invention

[image]

Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C while stirring with an anchor mixer at 50 rpm for 30 minutes.

(4) Separately weigh C and add to A+B at 50 °C and homogenize by stirring at 10,000 rpm for 1 minute.

(5) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(6) Adjust the pH to about 6.0 with D stirring at 50 rpm for 15 minutes.

The finished cosmetic product is an ivory-colored liquid emulsion with a glossy sheen. The smell is neutral. pH = 5.5-6.5. Analysis: 0.18-0.22% resveratrol (1).

and Ph.Eur.10; b Activonol, product of the Activon company, Korea; c Niacinamide PC, product of DSM Nutritional Products, The Netherlands; d D-Panthenol Care, product of the company BASF, Germany; e Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; f Product of EVONIK Dr. Straetmans, Germany; g Product of SEPPIC SA, France; h Product of the company BASF, Germany; and Product of the company IOI Oleo GmbH, Germany; j Keltrol® CG-SFT, product of the company CP Kelco, USA; k Product of DSM Nutritional Products, The Netherlands; l Carbopol® 980 polymer, product of Lubrizol, USA; m Product from Example 2; n Product of the company Jungbunzlauer, Switzerland, dissolved in water before preparation.

Example 5. Preparation of a cosmetic product in the form of an antioxidant serum for the face with resveratrol (1) with the use of a functional ingredient according to the invention

[image]

Procedure:

(1) Heat previously weighed phases A and B to 80 °C.

(2) Add B to A at 80 °C and homogenize by stirring at 10,000 rpm for 2 minutes.

(3) Cool to 50 °C while stirring with an anchor mixer at 50 rpm for 30 minutes.

(4) Separately weigh C and add to A+B at 50 °C and homogenize by stirring at 10,000 rpm for 1 minute.

(5) Cool the product to 30 °C while stirring with an anchor mixer at 50 rpm for approx. 30 minutes.

(6) Adjust the pH to about 6.0 with D stirring at 50 rpm for 15 minutes.

The finished cosmetic product is a liquid emulsion, ivory in color and shiny; the smell is neutral. pH = 5.5-6.5. Analysis: 0.09-0.11% resveratrol (1).

and Ph.Eur.10; b Activonol, product of the Activon company, Korea; c D-Panthenol Care, product of BASF AG, Germany; d Dermofeel® PA-12, product of Evonik Dr. Straetmans, Germany; e Product of EVONIK Dr. Straetmans, Germany; f Product of SEPPIC SA, France; g Product of BASF AG, Germany; h Product of the company Henry Lamotte, Germany; and Product of the company IOI Oleo GmbH, Germany; j Keltrol® CG-SFT, product of the company CP Kelco, USA; k Product of DSM Nutritional Products, The Netherlands; l Carbopol® 980 polymer, product of Lubrizol, USA; m Product from Example 1.

Industrial applicability

The present invention is used for the production of a functional cosmetic ingredient that is used in the cosmetic industry for the production of various types of cosmetic products based on resveratrol (1). Therefore, the industrial applicability of this invention is obvious.

Claims (11)

1. Complex functional cosmetic ingredient, characterized by the fact that it consists of the following ingredients: (a) resveratrol <1>, 0.50-2.50% w/w, [image] (b) phospholipid <PL>, 2.50-4.50% m/m, (c) xanthan gum <XG>, 0.05-1.00% m/m, (d) preservative <PR>, 0.10-2.00% m/m, (e) optionally, antioxidant <AO>, 0.00-0.20% w/w, and (f) purified water up to 100% m/m formulation, whereby the ingredient (b) forms liposomal particles in which the molecules of the ingredients (a) are placed. 2. Functional cosmetic ingredient according to claim 1, characterized in that ingredient (b), phospholipid <PL>, is selected from the group consisting of: A. phosphatidyl choline <PC>, phosphatidyl inositol <PI>, phosphatidyl ethanolamine <PE>, phosphatidyl serine <PS>, B. hydrogenated phosphatidyl choline <HPC>, hydrogenated phosphatidyl inositol <HPI>, hydrogenated phosphatidyl ethanolamine <HPE>, hydrogenated phosphatidyl serine <HPS>, C. lecithin <L> isolated from sunflower <Helianthus annuus>, soybean <Glycine max>, rapeseed <Brasica napus>, canola <Brassica rapa>, cotton <Gossypium spp> or chicken <Gallus gallus domesticus> eggs, D. hydrogenated lecithin <HGL> obtained from sunflower, soy, rapeseed, canola or cotton lecithin or lecithin from chicken eggs, E. hydrolyzed lecithin <HL> obtained from sunflower, soybean, rapeseed, cannolin or cotton lecithin or lecithin from chicken eggs, or mixtures of these substances. 3. Functional cosmetic ingredient according to claims 1 and 2, indicated by the fact that ingredient (d), preservative <PR>, is selected from the group consisting of: phenoxyethanol, caprylyl glycol, benzyl alcohol, dehydroacetic acid, benzoic acid, sorbic acid, ethyl hexylglycerol or mixtures of the above substances. 4. Functional cosmetic ingredient according to any of the preceding claims, characterized in that the ingredient (e), antioxidant <AO>, is selected from the group consisting of: ascorbic acid, tocopherols such as α-tocopherol, propyl gallate, butylated hydroxyanisole <BHA> , butylated hydroxytoluene <BHT>, tertiary butylhydroquinone <TBHQ> or mixtures of these substances. 5. A functional cosmetic ingredient according to any of the previous claims, characterized in that it contains ingredients (a)-(c) in the mass proportions as follows: (a) resveratrol <1>, 1.75-2.00% w/w, (b) phospholipid <PL>, 3.00-3.25% w/w, i (c) xanthan gum <XG>, 0.10-0.50% w/w. 6. The procedure for preparing a functional cosmetic ingredient according to any of the previous requirements, characterized by the fact that it consists of the following steps: (i) dissolving the phospholipid <PL> in the organic solvent <OS>, by stirring at temperatures from room temperature to the return temperature of the solvent for 10-60 minutes, with the mass ratio of the phospholipid <PL> to the organic solvent as follows: PL : OS = 1 : 1-10, m/m, (ii) adding resveratrol <1> to the solution from step (i) and dissolving it by stirring at room temperature to reflux temperature for 10-60 minutes; (iii) evaporation of the solution from step (ii) in a vacuum at a pressure of 0.01-0.1 mbar, at temperatures of 10-25 °C, while controlling the content of the remaining organic solvent from step (i) below the level of 0.5 % m/m, (iv) separate dissolution of xanthan gum <XG>, preservatives and, optionally, antioxidants in the prescribed amount of water, by mixing at temperatures of 20-50 °C for 15-60 minutes; (v) adding the vapor residue from step (iii) to the solution from step (iv) and swelling the resulting mixture at temperatures of 10-30 °C for 30-120 minutes, and (vi) homogenization of the resulting mixture at 10,000-20,000 rpm for 5-30 minutes; whereby the formulation according to the invention is formed in the form of a homogeneous cloudy liquid. 7. The method of preparing a functional cosmetic ingredient according to claim 6, characterized in that the organic solvent <OS> in step (i) is selected from the group consisting of: methyl formate <HCOOMe>, methyl acetate <MeOAc>, ethyl acetate <EtOAc>, propyl acetate <n-PrOAc>, isopropyl acetate <i-PrOAc> or mixtures of said solvents. 8. The procedure for preparing a functional cosmetic ingredient according to claims 6 and 7, characterized in that: - in step (i), ethyl acetate is used as the organic solvent <OS>, which with the mass ratio: PL : EtOAc = 1 : 1-1.5, m/m, at temperatures of 20-25 °C, and - in step (ii), dissolution of resveratrol <1> is carried out at temperatures of 20-25 °C. 9. The use of a cosmetic ingredient according to claims 1-5, characterized by the fact that it is used as a functional cosmetic ingredient for the preparation of various cosmetic formulations based on resveratrol <1> in forms selected from the group consisting of: lotion solutions, water-in-oil emulsion lotions < W-O>, oil-in-water emulsion lotions <O-W>, water-in-oil emulsion creams <W-O>, oil-in-water emulsion creams <O-W>, solution serums, water-in-oil emulsion serums <W-O>, oil emulsion serums in water <O-W>, cosmetic masks, underarm care sticks, lip care lipsticks, solution gels or oil-in-water emulsion gels <O-W>. 10. Use of a cosmetic ingredient according to claims 1-5, characterized in that it is used as an active cosmetic ingredient that acts as an antioxidant, anti-inflammatory agent, depigmentation agent, agent for preventing the formation of wrinkles, agent for reducing wrinkles, agent for the treatment of stretch marks, agent for tightening and rejuvenating the skin, a means of care for the eye area, and as a means of improving the barrier function of the skin. 11. Use of the formulation according to claims 1-5, characterized by the fact that it is used as a cosmetic product, in the form of a serum formulation, for direct application on the skin, which acts as an antioxidant, anti-inflammatory agent, depigmentation agent, wrinkle prevention agent, wrinkle mitigation agent , a means for the treatment of stretch marks, a means for tightening and rejuvenating the skin, and as a means for improving the barrier function of the skin.