CN106905324B - 具有咪唑并吡嗪酮骨架的pde9抑制剂 - Google Patents
具有咪唑并吡嗪酮骨架的pde9抑制剂 Download PDFInfo
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- CN106905324B CN106905324B CN201710247417.1A CN201710247417A CN106905324B CN 106905324 B CN106905324 B CN 106905324B CN 201710247417 A CN201710247417 A CN 201710247417A CN 106905324 B CN106905324 B CN 106905324B
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| CN201280076285.6A CN104703987B (zh) | 2011-10-10 | 2012-10-09 | 具有咪唑并吡嗪酮骨架的pde9抑制剂 |
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| MY183499A (en) | 2014-02-13 | 2021-02-22 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
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| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| TW201629064A (zh) | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之三唑並吡酮 |
| MA51438A (fr) | 2015-04-03 | 2021-04-14 | Incyte Corp | Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1 |
| JO3627B1 (ar) * | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| EP4335497A3 (en) * | 2015-07-07 | 2024-05-01 | H. Lundbeck A/S | Pde9 inhibitor with imidazo pyrazinone backbone for treatment of peripheral diseases |
| TW201717948A (zh) * | 2015-08-10 | 2017-06-01 | Ｈ 朗德貝克公司 | 包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療 |
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| JP6877423B2 (ja) * | 2015-11-09 | 2021-05-26 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | がんの処置において有用なジヒドロイミダゾピラジノン誘導体 |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| CR20180553A (es) | 2016-04-22 | 2019-02-01 | Incyte Corp | Formulaciones de un inhibidor de lsd1 |
| CA3025586A1 (en) * | 2016-07-06 | 2018-01-11 | Imara, Inc. | Pde9 inhibitors for treatment of peripheral diseases |
| CN109843884B (zh) | 2016-10-18 | 2022-03-04 | H.隆德贝克有限公司 | 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮 |
| RS60716B1 (sr) | 2016-10-28 | 2020-09-30 | H Lundbeck As | Kombinovane terapije koje obuhvataju imidazopirazinone za lečenje psihijatrijskih i/ili kognitivnih poremećaja |
| MX2019004859A (es) | 2016-10-28 | 2019-06-20 | H Lundbeck As | Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas. |
| CN110325535A (zh) * | 2017-02-27 | 2019-10-11 | 詹森药业有限公司 | 经哌啶、吗啉或哌嗪取代的作为oga抑制剂的[1,2,4]-三唑[1,5-a]-嘧啶基衍生物 |
| MX2019014049A (es) * | 2017-05-26 | 2020-07-28 | Imara Inc | Metodos de fabricacion y uso de inhibidores de pde9. |
| KR20200013758A (ko) | 2017-06-08 | 2020-02-07 | 머크 샤프 앤드 돔 코포레이션 | 피라졸로피리미딘 pde9 억제제 |
| US11147275B2 (en) | 2017-11-23 | 2021-10-19 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| MX2020012636A (es) | 2018-05-25 | 2021-01-29 | Imara Inc | Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2- ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8- ona. |
| WO2019243528A1 (en) * | 2018-06-20 | 2019-12-26 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| BR112021003686A2 (pt) | 2018-08-31 | 2021-05-18 | Imara Inc. | inibidores de pde9 para tratar doença falciforme |
| JP2022527630A (ja) * | 2019-04-05 | 2022-06-02 | イマラ インク． | 鎌状赤血球症を治療するためのｐｄｅ９阻害剤 |
| TW202108585A (zh) * | 2019-05-07 | 2021-03-01 | 美商伊馬拉公司 | 用於治療地中海型貧血之pde9抑制劑 |
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