IN2015DN02829A - - Google Patents
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- Publication number
- IN2015DN02829A IN2015DN02829A IN2829DEN2015A IN2015DN02829A IN 2015DN02829 A IN2015DN02829 A IN 2015DN02829A IN 2829DEN2015 A IN2829DEN2015 A IN 2829DEN2015A IN 2015DN02829 A IN2015DN02829 A IN 2015DN02829A
- Authority
- IN
- India
- Prior art keywords
- compound
- formula
- effective amount
- therapeutically effective
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 101100407341 Drosophila melanogaster Pde9 gene Proteins 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention is directed to compounds , which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011001692 | 2011-10-10 | ||
| PCT/EP2012/069936 WO2013053690A1 (en) | 2011-10-10 | 2012-10-09 | Pde9i with imidazo pyrazinone backbone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02829A true IN2015DN02829A (en) | 2015-09-11 |
Family
ID=47019007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2829DEN2015 IN2015DN02829A (en) | 2011-10-10 | 2012-10-09 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9643970B2 (en) |
| EP (2) | EP2906562B1 (en) |
| JP (1) | JP2015531401A (en) |
| CN (2) | CN104703987B (en) |
| AU (2) | AU2012323085B2 (en) |
| BR (1) | BR112015007731B1 (en) |
| CA (1) | CA2886885C (en) |
| HK (1) | HK1211023A1 (en) |
| IL (2) | IL237836A (en) |
| IN (1) | IN2015DN02829A (en) |
| MA (1) | MA37958B1 (en) |
| MX (2) | MX381326B (en) |
| SG (1) | SG11201502728WA (en) |
| TN (1) | TN2015000100A1 (en) |
| WO (1) | WO2013053690A1 (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA37958B1 (en) * | 2011-10-10 | 2018-10-31 | H Lundbeck As | Pde9i having an imidazo pyrazinone skeleton |
| JP6602779B2 (en) | 2014-02-13 | 2019-11-06 | インサイト・コーポレイション | Cyclopropylamines as LSD1 inhibitors |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| EP3626713B1 (en) | 2014-02-13 | 2021-09-29 | Incyte Corporation | Cyclopropylamines for use as lsd1 inhibitors |
| WO2015123408A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| TW201629064A (en) | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | Triazolopyrainones as PDE1 inhibitors |
| MA51438A (en) | 2015-04-03 | 2021-04-14 | Incyte Corp | HETEROCYCLIC COMPOUNDS USED AS LSD1 INHIBITORS |
| JO3627B1 (en) * | 2015-04-30 | 2020-08-27 | H Lundbeck As | Imidazopyrazinones as PDE1 inhibitors |
| CN107810187B (en) * | 2015-07-07 | 2020-09-15 | H.隆德贝克有限公司 | PDE9 inhibitors with imidazotriazinone backbone and imidazopyrazinone backbone for the treatment of peripheral diseases |
| TW201717948A (en) * | 2015-08-10 | 2017-06-01 | Ｈ 朗德貝克公司 | Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines |
| SI3334709T1 (en) | 2015-08-12 | 2025-03-31 | Incyte Holdings Corporation | LSD1 INHIBITOR SALTS |
| TWI730012B (en) * | 2015-11-09 | 2021-06-11 | 瑞典商阿斯特捷利康公司 | Chemical compounds |
| TWI729109B (en) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-c]PYRIDIN-4-ONES AS PDE1 INHIBITORS |
| MA44725A (en) | 2016-04-22 | 2019-02-27 | Incyte Corp | LSD1 INHIBITOR FORMULATIONS |
| CA3025586A1 (en) * | 2016-07-06 | 2018-01-11 | Imara, Inc. | Pde9 inhibitors for treatment of peripheral diseases |
| US10633382B2 (en) | 2016-10-18 | 2020-04-28 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors |
| MA46621A (en) | 2016-10-28 | 2021-06-02 | H Lundbeck As | COMBINATION TREATMENTS INCLUDING THE ADMINISTRATION OF IMIDAZOPYRAZINONES |
| ME03821B (en) * | 2016-10-28 | 2021-04-20 | H Lundbeck As | COMBINATION TREATMENTS WITH IMIDAZOPYRAZONES FOR THE TREATMENT OF PSYCHIATRIC AND / OR COGNITIVE DISORDERS |
| CA3045745A1 (en) * | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazin as oga inhibitors |
| RS65143B1 (en) * | 2017-05-26 | 2024-02-29 | Cardurion Pharmaceuticals Inc | Methods of making and using pde9 inhibitors |
| AU2018281131B2 (en) | 2017-06-08 | 2022-01-20 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine PDE9 inhibitors |
| WO2019101511A1 (en) | 2017-11-23 | 2019-05-31 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| EP4349403A3 (en) * | 2018-05-25 | 2024-06-05 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one |
| US20210115040A1 (en) * | 2018-06-20 | 2021-04-22 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| BR112021003686A2 (en) | 2018-08-31 | 2021-05-18 | Imara Inc. | pde9 inhibitors to treat sickle cell disease |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| CN114302724A (en) * | 2019-04-05 | 2022-04-08 | 伊马拉公司 | PDE9 inhibitors for the treatment of sickle cell disease |
| EP3965768A1 (en) * | 2019-05-07 | 2022-03-16 | Imara Inc. | Pde9 inhibitors for treating thalassemia |
| WO2022036111A1 (en) * | 2020-08-13 | 2022-02-17 | Imara Inc. | Methods and compositions for treating sickle cell disease |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287161B6 (en) | 1997-11-12 | 2010-02-08 | Bayer Healthcare Ag | 2-Phenyl substituted imidazotriazinones, method for their preparation, pharmaceuticals containing the same and their use |
| EA200100792A1 (en) | 1999-01-20 | 2002-10-31 | Арцнаймиттельверк Дрезден Гмбх | APPLICATION OF IMIDAZO [1,5-A] -PYRIDO [3,2-E] -PYRASINONES AS A MEDICINE |
| HN2002000317A (en) | 2001-11-02 | 2003-05-21 | Pfizer | PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS |
| BR0213817A (en) | 2001-11-02 | 2004-10-19 | Pfizer Prod Inc | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
| GB2388111A (en) | 2002-05-01 | 2003-11-05 | Bayer Ag | Novel imidazotriazinone compounds |
| US20040220186A1 (en) | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
| EP1686998A1 (en) | 2003-10-31 | 2006-08-09 | Pfizer Products Inc. | Phosphodiesterase 9 inhibition as treatment for obesity-related conditions |
| CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| TW200815436A (en) | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| EP2123801A4 (en) | 2006-09-08 | 2011-01-19 | Tokuyama Corp | METHOD AND EQUIPMENT FOR PRODUCING A NITRIDE OF A GROUP III ELEMENT |
| EP2848620B1 (en) | 2006-12-13 | 2016-09-28 | ASKA Pharmaceutical Co., Ltd. | Quinoxaline derivatives |
| WO2008072778A1 (en) | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | Therapeutic agent for urinary tract disease |
| ES2377849T3 (en) | 2007-05-11 | 2012-04-02 | Pfizer Inc. | Amino-heterocyclic compounds |
| DE102007032349A1 (en) | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo, pyrazolopyrazines and imidazotriazines and their use |
| TWI404721B (en) | 2009-01-26 | 2013-08-11 | Pfizer | Amino-heterocyclic compounds |
| WO2011028820A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
| CN103313988B (en) | 2010-09-20 | 2016-06-08 | 论坛医药有限公司 | imidazotriazinone compound |
| EP2769980B1 (en) | 2011-10-07 | 2016-02-03 | Eisai R&D Management Co., Ltd. | Pyrazoloquinoline derivative as pde9 inhibitors |
| MA37958B1 (en) * | 2011-10-10 | 2018-10-31 | H Lundbeck As | Pde9i having an imidazo pyrazinone skeleton |
| BR112014018199A8 (en) | 2012-01-26 | 2021-03-02 | H Lundbeck As | pde9 inhibitors with imidazo triazinone main chain, pharmaceutical composition comprising them, use of said inhibitors and process for their preparation |
| EP2828262A4 (en) | 2012-03-19 | 2015-09-23 | Forum Pharmaceuticals Inc | Imidazotriazinone compounds |
-
2012
- 2012-10-09 MA MA37958A patent/MA37958B1/en unknown
- 2012-10-09 MX MX2019014982A patent/MX381326B/en unknown
- 2012-10-09 EP EP12772769.1A patent/EP2906562B1/en active Active
- 2012-10-09 US US14/434,308 patent/US9643970B2/en active Active
- 2012-10-09 CA CA2886885A patent/CA2886885C/en active Active
- 2012-10-09 CN CN201280076285.6A patent/CN104703987B/en active Active
- 2012-10-09 EP EP16185105.0A patent/EP3121178B1/en active Active
- 2012-10-09 MX MX2015004422A patent/MX370433B/en active IP Right Grant
- 2012-10-09 CN CN201710247417.1A patent/CN106905324B/en active Active
- 2012-10-09 AU AU2012323085A patent/AU2012323085B2/en active Active
- 2012-10-09 WO PCT/EP2012/069936 patent/WO2013053690A1/en active Application Filing
- 2012-10-09 IN IN2829DEN2015 patent/IN2015DN02829A/en unknown
- 2012-10-09 HK HK15111740.3A patent/HK1211023A1/en unknown
- 2012-10-09 BR BR112015007731-5A patent/BR112015007731B1/en active IP Right Grant
- 2012-10-09 SG SG11201502728WA patent/SG11201502728WA/en unknown
- 2012-10-09 JP JP2015535994A patent/JP2015531401A/en active Pending
-
2015
- 2015-03-16 TN TNP2015000100A patent/TN2015000100A1/en unknown
- 2015-03-19 IL IL237836A patent/IL237836A/en active IP Right Grant
-
2017
- 2017-03-08 US US15/452,827 patent/US9993477B2/en active Active
- 2017-03-20 AU AU2017201873A patent/AU2017201873C1/en active Active
- 2017-07-12 IL IL253448A patent/IL253448A0/en unknown
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