UA102693C2 - Phenylimidazole derivatives as pde10a enzyme inhibitors - Google Patents

Phenylimidazole derivatives as pde10a enzyme inhibitors

Info

Publication number
UA102693C2
UA102693C2 UAA201015420A UAA201015420A UA102693C2 UA 102693 C2 UA102693 C2 UA 102693C2 UA A201015420 A UAA201015420 A UA A201015420A UA A201015420 A UAA201015420 A UA A201015420A UA 102693 C2 UA102693 C2 UA 102693C2
Authority
UA
Ukraine
Prior art keywords
subject
compound
formula
effective amount
therapeutically effective
Prior art date
Application number
UAA201015420A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Андреас Ритсен
Ян Кехлер
Мортен Ланггор
Якоб Нильсен
Джон Пол Килберн
Мохамед Эм. Фарах
Original Assignee
Х. Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Луннбек А/С filed Critical Х. Луннбек А/С
Priority claimed from PCT/DK2009/050134 external-priority patent/WO2009152825A1/en
Publication of UA102693C2 publication Critical patent/UA102693C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).
UAA201015420A 2008-06-20 2009-06-19 Phenylimidazole derivatives as pde10a enzyme inhibitors UA102693C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200800855 2008-06-20
PCT/DK2009/050134 WO2009152825A1 (en) 2008-06-20 2009-06-19 Novel phenylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number Publication Date
UA102693C2 true UA102693C2 (en) 2013-08-12

Family

ID=42321053

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201015420A UA102693C2 (en) 2008-06-20 2009-06-19 Phenylimidazole derivatives as pde10a enzyme inhibitors
UAA201200499A UA106378C2 (en) 2009-06-19 2010-06-17 Phenylimidazole derivative as pde10a enzyme inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201200499A UA106378C2 (en) 2009-06-19 2010-06-17 Phenylimidazole derivative as pde10a enzyme inhibitor

Country Status (27)

Country Link
EP (1) EP2443105B1 (en)
JP (1) JP5768044B2 (en)
AR (1) AR077144A1 (en)
AU (1) AU2010262190B2 (en)
CA (1) CA2765750A1 (en)
CR (1) CR20110654A (en)
CY (1) CY1115971T1 (en)
DK (1) DK2443105T3 (en)
DO (1) DOP2011000397A (en)
ES (1) ES2527216T3 (en)
GE (1) GEP20146100B (en)
GT (1) GT201100322A (en)
HR (1) HRP20141222T1 (en)
IL (1) IL216684A (en)
MA (1) MA33367B1 (en)
MX (1) MX2011013400A (en)
MY (1) MY156785A (en)
NZ (1) NZ597203A (en)
PL (1) PL2443105T3 (en)
PT (1) PT2443105E (en)
SG (1) SG176680A1 (en)
SI (1) SI2443105T1 (en)
SM (1) SMT201500003B (en)
TW (1) TW201100430A (en)
UA (2) UA102693C2 (en)
WO (1) WO2010145668A1 (en)
ZA (1) ZA201109271B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (en) 2008-06-20 2015-10-01 Lundbeck & Co As H Novel phenylimidazole derivatives as pde10a enzyme inhibitors
TWI485151B (en) 2009-12-17 2015-05-21 Lundbeck & Co As H Heteroaromatic phenylimidazole derivatives as pde 10a enzyme inhibitors
JO3089B1 (en) * 2010-11-19 2017-03-15 H Lundbeck As Imidazole derivatives as PDE10A enzyme inhibitors
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
RU2013142364A (en) 2011-02-18 2015-03-27 Аллерган, Инк. SUBSTITUTED DERIVATIVES OF 6,7-DIALCOXY-3-ISOQUINOLINE AS PHOSPHODYESTERASE 10 (PDE10A) INHIBITORS
CN103874701A (en) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 Pyridine compounds and uses thereof
WO2013034761A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Pyridine compounds and uses thereof
WO2013034758A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
WO2013034755A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
AR089361A1 (en) 2011-12-21 2014-08-20 Lundbeck & Co As H DERIVATIVES OF QUINOLINE AS INHIBITORS OF THE ENZYME PDE10A
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
BR112020013697A2 (en) * 2018-11-06 2020-12-01 H. Lundbeck A/S compounds to treat negative symptoms and cognitive impairments
BR112020013743A2 (en) * 2018-11-06 2020-12-01 H. Lundbeck A/S 5,8-dimethyl-2- [2- (1-methyl-4-phenyl-1h-imidazol-2-yl) -ethyl] - [1,2,4] triazolo [1,5-a] pyrazine hemiadipate

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
FR2824065A1 (en) 2001-04-26 2002-10-31 Neuro3D COMPOUNDS INHIBITORS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES
WO2004024705A1 (en) 2002-09-10 2004-03-25 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
ES2315546T3 (en) 2002-10-30 2009-04-01 Via Pharmaceuticals, Inc. PHOSPHODESTERASE INHIBITORS OF CYCLIC NUCLEOTIDES, WHICH PRESENT A BENZODIAZEPIN STRUCTURE, AND ITS USE IN THERAPY.
BRPI0411897A (en) * 2003-06-30 2006-08-29 Altana Pharma Ag pyrroldhydroisoquinolines as pde10 inhibitors
CA2530114A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
JP2007508241A (en) 2003-07-31 2007-04-05 バイエル・フアーマシユーチカルズ・コーポレーシヨン Method for treating diabetes and related disorders using PDE10A inhibitors
BRPI0507839A (en) * 2004-02-18 2007-05-08 Pfizer Prod Inc tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
FR2870539B1 (en) 2004-05-19 2006-08-04 Greenpharma Sa Sa NEW METHODS AND MEDICINES
BRPI0511854A (en) 2004-06-07 2008-01-15 Pfizer Prod Inc phosphodiestearase 10 inhibition as a treatment for obesity-related and metabolic syndrome-related conditions
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
WO2006028957A1 (en) 2004-09-03 2006-03-16 Memory Pharmaceuticals Corporation 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
US20060183763A1 (en) * 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
JP2009527560A (en) * 2006-02-21 2009-07-30 アムゲン インコーポレイティッド Cinnoline derivatives as phosphodiesterase 10 inhibitors
TWI501965B (en) * 2008-06-20 2015-10-01 Lundbeck & Co As H Novel phenylimidazole derivatives as pde10a enzyme inhibitors

Also Published As

Publication number Publication date
IL216684A0 (en) 2012-02-29
PL2443105T3 (en) 2015-03-31
HRP20141222T1 (en) 2015-02-27
EP2443105A1 (en) 2012-04-25
EP2443105B1 (en) 2014-10-29
AU2010262190B2 (en) 2013-01-31
UA106378C2 (en) 2014-08-26
AR077144A1 (en) 2011-08-03
CA2765750A1 (en) 2010-12-23
JP5768044B2 (en) 2015-08-26
AU2010262190A1 (en) 2012-01-19
GT201100322A (en) 2014-02-06
MX2011013400A (en) 2012-02-21
SG176680A1 (en) 2012-01-30
IL216684A (en) 2016-03-31
WO2010145668A1 (en) 2010-12-23
ZA201109271B (en) 2013-02-27
MY156785A (en) 2016-03-31
TW201100430A (en) 2011-01-01
MA33367B1 (en) 2012-06-01
SMT201500003B (en) 2015-03-05
NZ597203A (en) 2013-03-28
CY1115971T1 (en) 2017-01-25
GEP20146100B (en) 2014-05-27
ES2527216T3 (en) 2015-01-21
DOP2011000397A (en) 2012-07-15
DK2443105T3 (en) 2015-01-12
SI2443105T1 (en) 2015-02-27
JP2012530086A (en) 2012-11-29
CR20110654A (en) 2012-03-09
PT2443105E (en) 2015-01-14

Similar Documents

Publication Publication Date Title
MY152949A (en) Novel phenylimidazole derivatives as pde10a enzyme inhibitors
UA102693C2 (en) Phenylimidazole derivatives as pde10a enzyme inhibitors
TN2012000287A1 (en) 2-arylimidazole derivatives as pde10a enzyme inhibitors
TN2012000271A1 (en) Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
TN2012000278A1 (en) Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
IN2015DN02829A (en)
JO3089B1 (en) Imidazole derivatives as PDE10A enzyme inhibitors
PH12014501695B1 (en) Pde9 inhibitors with imidazo triazinone backbone
MX336915B (en) Imidazole derivatives as pde10a enzyme inhibitors.
TN2013000200A1 (en) Imidazole derivatives as pde 10a enzyme inhibitors
CY1116689T1 (en) Imidazole derivatives as inhibitors of the PDE10A enzyme
TN2014000288A1 (en) Pde9 inhibitors with imidazo triazinone backbone