CN106885915A - A kind of New Blood analyzer and method - Google Patents
A kind of New Blood analyzer and method Download PDFInfo
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- CN106885915A CN106885915A CN201710167506.5A CN201710167506A CN106885915A CN 106885915 A CN106885915 A CN 106885915A CN 201710167506 A CN201710167506 A CN 201710167506A CN 106885915 A CN106885915 A CN 106885915A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
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Abstract
The invention provides a kind of New Blood analyzer and method, instrument includes that sample first draw and buanch unit by dilution unit, leucocyte and hemochrome detection unit, red blood cell and platelets analysis unit, sample.Dilution unit is used to carry out blood sample first time dilution the sample first, and dilution ratio is 1: 11: 10；The leucocyte and hemochrome detection unit, for carrying out second dilution from the part blood sample in sample first dilution unit, and detect to leucocyte and hemochrome；The red blood cell and platelets analysis unit are used to carry out third time dilution to the dilution blood sample that leukocytes and hemochrome detection unit are come in part, and the red blood cell and blood platelet in blood sample are detected.Blood analyser of the invention can substantially reduce dilution and the consumption of other reagents when instrument is detected, reduce testing cost, reduce waste liquid and produce, and mitigate environmental protection pressure.Instrument can also automatically to the dilution blood sample reinspection of dilution unit, it is to avoid repeats to take a blood sample.
Description
Technical field
The invention belongs to medical test detection technique field, particularly a kind of New Blood analyzer and method.
Background technology
Contain various kinds of cell and biochemical in blood, usually needed in clinical diagnosis to the Cell Component in blood and
Hemochrome is detected that commonly referred to blood routine is detected.
The blood analyser that blood routine detection is used in current medical test is all that blood sample is directly added into two detection cups
(leucocyte and hemochrome detection cup；Red blood cell and platelets analysis cup) in directly once, after dilute twice blood sample carry out respectively
Detection, often dilution ratio is little for such dilution process, the dilution liquid measure used required for the dilution that reach higher proportion
It is larger and also larger to the reagent dosage used required for two cleanings of corresponding detection cup upon completion of the assays, therefore operation
Relatively costly, produced waste liquid amount is also larger, increased environmental protection pressure.
Additionally, the blood sample only only a part that existing blood analyser is drawn when detecting is used to detect, and remaining is partly
Almost do not slatterned using just exclusion.It is commonly encountered in clinical position and scientific research and is available for the sample size of detection less, or sampling
Difficulty is big, such as infant, toy, patient with severe symptoms etc., if Instrumental results are suspicious in addition or have examined during instrument failure
The blood sample of survey has been consumed, and generally requires to detect again, or even take a blood sample again.Present invention design can in the case of blood sample amount identical
Actually detected unwanted part dilution blood sample is deposited in diluted cup, when detection process or problematic result, instrument
Device is detected again using the dilution blood sample of this some residual automatically, without taking a blood sample and being manually automatically performed by participation weight again
New detection ensures to obtain satisfied testing result.
The content of the invention
The purpose of invention is to provide a kind of New Blood analyzer and method.
The technical scheme for realizing the object of the invention is：A kind of New Blood analyzer, including sample dilution unit, white first
Cell and hemochrome detection unit, red blood cell and platelets analysis unit, sample are drawn and buanch unit, dilution adding device
5th, hemolytic agent adding device 1, waste liquid deliverying unit, cleaning fluid adding device 4, blending unit and control unit；The control is single
Unit's control sample dilution unit, leucocyte and hemochrome detection unit, red blood cell and platelets analysis unit, sample absorption first
And buanch unit, dilution adding device, hemolytic agent adding device, waste liquid deliverying unit, cleaning fluid adding device and mixing are single
Co-ordination between unit.
Dilution unit includes diluted cup C0 to the sample first, and for carrying out first time dilution to blood sample, blood sample is in the cup
In do not carry out the direct detection of any project；
The leucocyte and hemochrome detection unit include the first detection cup, the colorimetric detection on the first detection cup
Device and the first grain count detection means, for being diluted again to the part blood sample from diluted cup, and in cup
Blood sample carries out hemochrome and white blood cell detection；
The red blood cell and platelets analysis unit include the second detection cup and second on the second detection cup
Grain counting and detecting device, for being diluted again by the part blood sample after dilute twice from the first detection cup, and
Carry out red blood cell and platelets analysis；
The sample is drawn and buanch unit primary structure quantitatively extracts syringe, connecting line including suction needle, first
And dilution liquid level, mixed for drawing quantitative blood sample from sample cell, and blood sample being transferred into diluted cup dilution, then by diluted cup
The blood sample that middle dilution is mixed, is transferred in the first detection cup, and is diluted again in the first detection cup；Then from the first detection cup
It is middle to draw the blood sample that part of dilution is mixed, it is transferred in the second detection cup, blood sample carries out third time dilution in the second detection cup
After mixing, red blood cell and platelets analysis are carried out.
The dilution adding device include dilution liquid level, the 5th quantitatively extract syringe, the 6th quantitatively extract syringe,
Connecting line and valve, for respectively to first detection cup and second detection cup in quantitatively add dilution.
The hemolytic agent adding device includes that hemolytic agent position, second quantitatively extract syringe, connecting line and valve, is used for
To first detection cup in add hemolytic agent.
The cleaning fluid adding device includes that cleaning liquid level, the 9th quantitatively extract syringe, connecting line and valve, is used for
To first detection cup in add cleaning fluid.
The blending unit is by respectively to leucocyte and the first detection cup and red blood cell and blood of hemochrome detection unit
Second detection cup bottom air-blowing of platelet detection unit, detects the aqueous agitation in cup to mix diluted sample to each.
Further, the instrument diluted cup and each detection cup put in order it is unrestricted.
Further, dilution unit also includes diluted cup bit transition mechanism and more than one diluted cup to the sample first,
Instrument often detects that a sample uses a diluted cup, the diluted cup that diluted cup bit transition mechanism will just use after the completion of detection
Remove, a new diluted cup is separately moved to working position C0w.When the diluted cup on sample first dilution unit has all been used
Afterwards, instrument points out the diluted cup for more renewing automatically.
Further, the Sample Dilution cup is loaded with cleaning device, and diluted cup is automatic to dilution using rear cleaning device
Cup is cleaned, and diluted cup is reused.
Further, the sample first by sample drawn and the suction needle of buanch unit and first quantitative by dilution unit
Syringe is extracted to inhale the blood sample diluted for the first time in diluted cup repeatedly, push away mixing sample；The detection cup of each detection unit
In dilution blood sample it is each detection cup bottom air-blowing by way of mix it is each detection cup in diluted sample.
Further, the analyzer has diluted cup apparatus for automatic change, for automatically by the diluted cup after use from
Removed on diluted cup disk, and new diluted cup is loaded automatically on diluted cup disk relevant position, diluted cup is changed without artificial.
Further, there is a special dilution addition mouth 10 the diluted cup position of the analyzer Sample Dilution unit,
For the dilution needs according to sample to be tested, dilution is quantified to being added in the diluted cup of working position.
A kind of New Blood analyzer and method, it is characterised in that analysis method is comprised the following steps：
In step 1, the sample cell by sample absorption and buanch unit suction needle from outside instrument, draw quantitative to be checked complete
Blood blood sample, injecting sample is first in the diluted cup of dilution unit；
Step 2, by sample draw and buanch unit suction needle and first quantitatively extract syringe it is dilute first to sample
A certain amount of dilution is injected in the diluted cup for releasing unit, suction needle is sucked, pushed away repeatedly under the cooperation of the first fixed-quantity injector
Go out blood sample after dilution, realize first time dilution and mixing to blood sample；
Step 3, sample are drawn and buanch unit is by suction needle, quantitative to draw the part blood sample that dilution is mixed for the first time,
In transfer distribution to the first detection cup, mix to the quantitative dilution added in the first detection cup with dilution adding device.With
Air pump is roused by the first detection cup bottom connecting line of leucocyte and hemochrome detection unit to the first detection cup bottom afterwards
Gas, mixes blood sample in detection cup；
Step 4, sample are drawn and buanch unit suction needle, the first of leucocyte and hemochrome detection unit from step 3
The blood sample that second dilution in part is mixed is drawn in detection cup, the second detection cup of red blood cell and platelets analysis unit is transferred to
In, the quantitative dilution added with dilution adding device mixes, and air pump detects cup bottom air-blowing by pipeline to second, right
Blood sample in cup is mixed.Blood sample is examined after being mixed through third time dilution during second detects cup by the second grain count
Device is surveyed to detect the quantity and volume of blood platelet in blood sample and red blood cell.
In the first detection cup of step 5, hemolytic agent adding device to leucocyte and hemochrome detection unit, inject quantitative
Hemolytic agent, carries out leucocyte and hemochrome detection to blood sample in cup after mixing；
After the completion of step 6, detection, instrument respectively detects that the valve of glass bottom is opened, the waste liquid pump startup of waste liquid deliverying unit
Work and exclude the waste liquid after being detected in each detection cup；Cleaning fluid adding device to first detection cup in add cleaning fluid, waste liquid
The waste drains pump of deliverying unit is again started up, and the cleaning fluid after being detected in each detection cup is excluded；Subsequent dilution adding device to
Dilution is added in first detection cup and the second detection cup；The waste drains pump of waste liquid deliverying unit is again started up, by each detection cup
Cleaning fluid after detection is excluded, and instrument completes a detection cleaning process；
Step 7, the diluted cup after is transitioned off diluted cup working position to the sample of instrument by dilution unit first, and is incited somebody to action
Another clean diluted cup is transferred to diluted cup working position.
The states to be detected such as step 8, instrument entrance, detect again when new command is obtained according to step 1-7.
Further, if instrument is in step 1-6 detection process is performed, mistake and other occur needs to sample again
During the situation of detection, instrument can respectively detection cup be cleaned according to step 6 pair, is then drawn again from Sample Dilution cup automatically
Part mixes sample, is detected and is run according to step 1-8.
Further, step 2 to the dilution ratio of blood sample in diluted cup between 1: 1-1: 10.
Further, in the detection of step 3 pair first cup the dilution ratio of blood sample between 1: 20-1: 300.
Further, in the detection of step 4 pair second cup the dilution ratio of blood sample between 1: 20-1: 300.
Compared with prior art, remarkable result of the invention is：(1) present invention is by increasing a dilution device and dilution
Cup, detects after three dilutions are carried out to blood sample, is compared compared to the only secondary dilution detection of more existing blood analyser, dilution ratio
Increase, required dilution liquid measure reduces about 40%, and the testing result of acquisition is more accurate.(2) analyzer of the present invention is detected only every time
Using only part blood sample, remaining dilutes blood sample and is retained in Sample Dilution cup for the first time, is needed when mistake and other occurs in instrument
During situation about being detected again to sample, instrument enables remaining dilution blood sample in Sample Dilution cup automatically, is detected again,
Ensure to obtain accurate result in the case that blood sample amount is few, it is to avoid repetition is taken a blood sample, improves operating efficiency and work quality.(3)
The analyzer general structure that the present invention is used is simple, and the waste liquid produced by detection is less, is conducive to environmental protection.
Brief description of the drawings
Fig. 1 is that sample of the invention is drawn and buanch unit structural representation.
Fig. 2 is dilution adding device structural representation of the invention.
Fig. 3 is hemolytic agent adding device structural representation of the invention.
Fig. 4 is cleaning fluid adding device structural representation of the invention.
Fig. 5 is that waste liquid of the invention is excluded and blending unit structural representation.
Fig. 6 is the sample of the invention rail that the diluted cup of dilution unit is moved with the layout and sample pin of each detection cup first
Mark figure.
Fig. 7 be sample of the invention dilution unit first diluted cup be double cups structural representation.
Fig. 8 be sample of the invention first dilution unit diluted cup for bar shaped rail mounted arrangement many cup structures illustrate
Figure.
Fig. 9 is that the diluted cup of sample of the invention dilution unit first is that many cup structures of discoid rail mounted arrangement are illustrated
Figure.
Figure 10 is diluted cup loading attachment side view of the invention.
Figure 11 is diluted cup apparatus for automatic change top view of the invention.
Figure 12 unloads device side view for diluted cup of the invention.
Figure 13 is semicircle dilution of the invention even cup front elevation.
Specific embodiment
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
Embodiment 1
With reference to Fig. 1, in sample cell S of the present embodiment by sample absorption and buanch unit suction needle N1 from outside instrument,
Quantitative whole blood blood sample to be checked is drawn, injecting sample is first in the diluted cup C0 of dilution unit；Concrete operations are the second valve of closing
V2, the first valve V1, the first fixed-quantity injector S1 is drop-down for opening, and blood sample enters in suction needle N1 in sample cell, and sample is inhaled afterwards
Take and buanch unit suction needle is moved to N1-1, the first fixed-quantity injector S1 is above pushed away, by sample injection diluted cup C0；Close
First valve V1, the second valve V2, the first fixed-quantity injector S1 is drop-down for opening, and dilution R1 enters in the first fixed-quantity injector,
The second valve V2 is closed afterwards, the first valve V1 is opened, and the first fixed-quantity injector S1 is above pushed away, and quantitative dilution injecting sample is first
In the diluted cup of secondary dilution unit, afterwards by the drop-down of the first fixed-quantity injector S1 and above push it is dynamic, repeatedly suction release it is dilute
Rear blood sample is released, first time dilution and mixing to blood sample is realized；First fixed-quantity injector S1 is drop-down to dilute mixed for the first time by part
Even blood sample is sucked in the first fixed-quantity injector, and suction needle N1 is moved to N1-2, and the first fixed-quantity injector is above pushed away, will be dilute for the first time
Blood sample is released quantitatively to inject in the first detection cup C1；Suction needle N1 is moved to N1-3, and the first fixed-quantity injector is above pushed away, will be for the first time
Dilution blood sample is quantitatively injected in the second detection cup C2；
With reference to Fig. 2, the tenth valve V10 is closed, open the 11st valve V11, the 12nd valve V12, the 13rd valve
V13, the 5th fixed-quantity injector S5 and the 6th fixed-quantity injector S6 are drop-down, and quantitative dilution is respectively enterd in each syringe；Afterwards
The 11st valve V11 and the 13rd valve V13 is closed, the tenth valve V10 and the 12nd valve V12, the 5th calibrated shot is opened
Device and the 6th fixed-quantity injector are above pushed away, and quantitative dilution is respectively enterd in the first detection detection cups of cup C1 and second C2；Close the
Eight valve V8, open the 3rd valve V3, the 4th valve V4 and the 5th valve V5, and air pump P1 is by pipeline to each detection cup bottom
Air-blowing, mixes blood sample in each cup；
Sample is drawn and buanch unit suction needle N1, and the blood that second dilution in part is mixed is drawn from the first detection cup
Sample, is transferred in the second detection cup, mixes with the quantitative dilution added in this glass；The 8th valve V8 is closed, the 3rd valve is opened
Door V3 and the 5th valve V5, air pump, to the second detection cup bottom air-blowing, is mixed by pipeline to the blood sample in cup.Blood sample
Mixed through third time dilution in the second detection cup, afterwards by the second grain count detection means to blood platelet in blood sample and red
Cell quantity, volume are detected.
With reference to Fig. 3, the 18th valve V18 is closed, open the 19th valve V19, the second fixed-quantity injector S2 is drop-down, it is quantitative
Hemolytic agent R2 is sucked in the second fixed-quantity injector S2；The 19th valve V19 is closed, the 18th valve V18, the second quantitative note is opened
Pushed away in emitter, Quantitative Haemolytic agent R2 injections first are detected in cup, and part blood cell in blood sample is detected after mixing；
With reference to Fig. 4, after the completion of detection, the 3rd valve V3 is closed, open the 4th valve V4, the 5th valve V5 and the 8th valve
V8, the waste drains pump P2 of waste liquid deliverying unit starts work, and the waste liquid after being detected in each detection cup is excluded；Close the 24th valve
Door V24, opens the 25th valve V25, and the 9th fixed-quantity injector S9 is drop-down, and cleaning fluid R5 is sucked into the 9th fixed-quantity injector S9
In, the 25th valve V25 is closed afterwards, the 24th valve V24 is opened, the 9th fixed-quantity injector S9 is above pushed away, by cleaning fluid
R5 injections first detect in cup that the waste drains pump of waste liquid deliverying unit is again started up, the cleaning fluid row after being detected in each detection cup
Remove；Subsequent dilution adding device adds dilution, the waste liquid of waste liquid deliverying unit in detecting cup to the first detection cup and second
Pump is again started up, and the cleaning fluid after being detected in each detection cup is excluded, and so far instrument completes a detection cleaning process.
Embodiment 2
With reference to Fig. 5, the analyzer and the difference of embodiment 1 of the present embodiment are that the present embodiment diluted cup C0 is not once
Property use cup, after can cleaning reuse.
Embodiment 3
With reference to Fig. 6, the diluted cup of the analyzer sample of the present embodiment dilution unit first is one cup C0, the movement of sample pin
Track is sample cell S → diluted cup C0 → leucocyte/hemochrome detection cup C1 → red blood cell/platelets analysis cup C2.
Embodiment 4
With reference to Fig. 7, the diluted cup of the analyzer sample of the present embodiment dilution unit first is double cups, and two cups are in motor 7
Working position C0w is moved under driving in turn, for diluting blood sample for the first time.
Embodiment 5
With reference to Fig. 8, the diluted cup of the analyzer sample of the present embodiment dilution unit first is the arrangement of bar shaped rail mounted, first
Diluted cup bit transition mechanism 8 is unidirectionally mobile, after instrument often detects that a sample uses a diluted cup, diluted cup bit transition mechanism
The diluted cup that will just use is removed, and new diluted cup is moved into working position.
Embodiment 6
With reference to Fig. 9, the present embodiment is with the difference of embodiment 5, the analyzer sample of the present embodiment dilution unit first
Diluted cup be discoid arrangement, the second diluted cup bit transition mechanism 9 moves in a circle in one direction, and transfer one is dilute every time
Release cup to working position.
Embodiment 7
The analyzer of the present embodiment also has diluted cup apparatus for automatic change, i.e., automatically remove the diluted cup after,
Then new diluted cup is loaded in corresponding diluted cup position.The apparatus for automatic change includes that diluted cup storage warehouse, diluted cup are unloaded
Underarm 16 and diluted cup loading arm 11, and diluted cup is semicircle even cup 15.The diluted cup disk 9 of instrument often completes one in instrument
Detection just rotates a cup position to same direction, so when used diluted cup is pass on unloads underarm position to diluted cup,
Diluted cup unloads underarm and automatically removes used diluted cup；When diluted cup disk goes to diluted cup loading arm position, diluted cup
Loading arm then loads a diluted cup, so as to realize that diluted cup is unloaded and loaded automatically.After the diluted cup of storage has been used, instrument
Device diluted cup storage warehouse detector can be detected automatically, and by instrumentation control system alarm artificial supplementation diluted cup, together
When take out used diluted cup.
When loading semicircle even cup, as shown in Figure 10 and Figure 11, the 5th motor M5 drives the first handgrip 14 by semicircle
Shape connects cup 15 and clamps, and the first motor M1 drives the first transfer arm 11 to move horizontally, and the second motor drives first to move
Arm 11 is moved up and down, and semicircle even cup is taken out from diluted cup storage warehouse and diluted cup position is positioned over, and the 5th drives electricity afterwards
Machine M5 drives the first handgrip 14 to extend out.
When unloading lower semi-circular and connecting cup, as is illustrated by figs. 11 and 12, it is dilute that the 6th motor M6 drives the second handgrip 17 to clamp
The semicircle even cup on disk 9 is released, while the 3rd motor M3 drives the second transfer arm 16 to move horizontally, the 4th motor M4
Drive the second transfer arm 16 to move up and down, semicircle even cup is removed from diluted cup position, be moved to waste and old diluted cup collector
Top, the second handgrip 17 of the 6th motor M6 drivings afterwards is extended out.
Embodiment 8
The analyzer of the present embodiment is with the difference of embodiment 7, dilute in the present embodiment diluted cup apparatus for automatic change
Cup is released for linear connects cup.
Embodiment 9
The analyzer of the present embodiment is with the difference of embodiment 7, dilute in the present embodiment diluted cup apparatus for automatic change
It is fan-shaped even cup or single diluted cup to release cup.
Claims (10)
1. a kind of New Blood analyzer and method, it is characterised in that instrument includes：Sample first dilution unit, leucocyte and
Hemochrome detection unit, red blood cell and platelets analysis unit, sample draws and buanch unit, dilution adding device (5), molten
Blood agent adding device (1), waste liquid deliverying unit, cleaning fluid adding device (4), blending unit and control unit；The control is single
Unit's control sample dilution unit, leucocyte and hemochrome detection unit, red blood cell and platelets analysis unit, sample absorption first
And buanch unit, dilution adding device, hemolytic agent adding device, waste liquid deliverying unit, cleaning fluid adding device and mixing are single
Co-ordination between unit；
Dilution unit includes diluted cup (C0) to the sample first, and for carrying out first time dilution to blood sample, blood sample is in the cup
The direct detection of any project is not carried out；
The leucocyte and hemochrome detection unit include the first detection cup, the colour comparison detection apparatus on the first detection cup
With the first grain count detection means, for being diluted again to the part blood sample from diluted cup, and to the blood sample in cup
Carry out hemochrome and white blood cell detection；
The red blood cell and platelets analysis unit include the second detection cup and the second particle meter on the second detection cup
Number detection means, for being diluted again by the part blood sample after dilute twice from the first detection cup, and are carried out
Red blood cell and platelets analysis；
The sample is drawn and buanch unit primary structure quantitatively extracts syringe, connecting line and dilute including suction needle, first
Liquid level is released, is mixed for drawing quantitative blood sample from sample cell, and blood sample being transferred into diluted cup dilution, then will be dilute in diluted cup
The blood sample of mixing is released, is transferred in the first detection cup, and diluted again in the first detection cup；Then inhaled from the first detection cup
The blood sample of part of dilution mixing is taken, is transferred in the second detection cup, blood sample carries out third time dilution and mixes in the second detection cup
Afterwards, red blood cell and platelets analysis are carried out；
The dilution adding device includes that dilution liquid level, the 5th quantitatively extract syringe, the 6th and quantitatively extract syringe, connection
Pipeline and valve, for respectively to first detection cup and second detection cup in quantitatively add dilution；
The hemolytic agent adding device includes that hemolytic agent position, second quantitatively extract syringe, connecting line and valve, for the
Hemolytic agent is added in one detection cup；
The cleaning fluid adding device includes that cleaning liquid level, the 9th quantitatively extract syringe, connecting line and valve, for the
Cleaning fluid is added in one detection cup；
The blending unit is by respectively to leucocyte and the first detection cup and red blood cell and blood platelet of hemochrome detection unit
Second detection cup bottom air-blowing of detection unit, detects the aqueous agitation in cup to mix diluted sample to each.
2. a kind of New Blood analyzer according to claim 1 and method, it is characterised in that：The instrument diluted cup and
Putting in order for each detection cup is unrestricted.
3. a kind of New Blood analyzer according to claim 1 and method, it is characterised in that the sample dilutes first
Unit also includes diluted cup bit transition mechanism and more than one diluted cup, and instrument often detects that a sample uses a diluted cup,
The diluted cup that diluted cup bit transition mechanism will just use after the completion of detection is removed, and a new diluted cup separately is moved into working position
(C0w)；After the diluted cup on sample first dilution unit has all been used, instrument points out the diluted cup for more renewing automatically.
4. a kind of New Blood analyzer according to claim 1 and method, it is characterised in that the Sample Dilution cup
Cleaning device is loaded with, diluted cup is cleaned to diluted cup automatically using rear cleaning device, diluted cup is reused.
5. a kind of New Blood analyzer according to claim 1 and method, it is characterised in that：The analyzer has dilute
A glass apparatus for automatic change is released, for automatically removing the diluted cup after from diluted cup disk, and in diluted cup disk corresponding positions
The new diluted cup of automatic loading is put, diluted cup is changed without artificial.
6. based on a kind of New Blood analyzer and method described in claim 1, it is characterised in that analysis method includes following
Step：
In step 1, the sample cell by sample absorption and buanch unit suction needle from outside instrument, quantitative whole blood blood to be checked is drawn
Sample, injecting sample is first in the diluted cup of dilution unit；
Step 2, by sample draw and buanch unit suction needle and first quantitatively extract syringe dilute list first to sample
Unit diluted cup in inject a certain amount of dilution, suction needle under the cooperation of the first fixed-quantity injector, suck repeatedly, release it is dilute
Rear blood sample is released, first time dilution and mixing to blood sample is realized；
Step 3, sample are drawn and buanch unit is by suction needle, quantitative to draw the part blood sample that dilution is mixed for the first time, transfer
In distribution to the first detection cup, mix to the quantitative dilution added in the first detection cup with dilution adding device；It is then empty
Air pump, to the first detection cup bottom air-blowing, is mixed by the first detection cup bottom connecting line of leucocyte and hemochrome detection unit
Blood sample in even detection cup；
Step 4, sample are drawn and buanch unit suction needle, first detection of leucocyte and hemochrome detection unit from step 3
The blood sample that second dilution in part is mixed is drawn in cup, is transferred in the second detection cup of red blood cell and platelets analysis unit,
The quantitative dilution added with dilution adding device mixes, and air pump detects cup bottom air-blowing by pipeline to second, to cup
In blood sample mixed；Blood sample is detected after being mixed through third time dilution during second detects cup by the second grain count
Device is detected to the quantity and volume of blood platelet in blood sample and red blood cell；
In the first detection cup of step 5, hemolytic agent adding device to leucocyte and hemochrome detection unit, quantitative haemolysis is injected
Agent, carries out leucocyte and hemochrome detection to blood sample in cup after mixing；
After the completion of step 6, detection, instrument respectively detects that the valve of glass bottom is opened, the waste liquid pump startup work of waste liquid deliverying unit
Waste liquid after being detected in each detection cup is excluded；Cleaning fluid adding device to adding cleaning fluid in the first detection cup, waste liquid discharge
The waste drains pump of unit is again started up, and the cleaning fluid after being detected in each detection cup is excluded；Subsequent dilution adding device is to first
Dilution is added in detection cup and the second detection cup；The waste drains pump of waste liquid deliverying unit is again started up, and will be detected in each detection cup
Cleaning fluid afterwards is excluded, and instrument completes a detection cleaning process；
Step 7, the diluted cup after is transitioned off diluted cup working position to the sample of instrument by dilution unit first, and will be another
Individual clean diluted cup is transferred to diluted cup working position；
The states to be detected such as step 8, instrument entrance, detect again when new command is obtained according to step 1-7.
7. a kind of New Blood analyzer according to claim 9 and method, it is characterised in that：If instrument is performing step
In rapid 1-6 detection process, occur mistake and other when needing situation about being detected again to sample, instrument can be each according to step 6 pair
Detection cup is cleaned, and then drawing part again from Sample Dilution cup automatically mixes sample, is detected according to step 1-8
And operation.
8. a kind of New Blood analyzer according to claim 6 and method, it is characterised in that：Step 2 is in diluted cup
The dilution ratio of blood sample be 1: 1-1: 10 between.
9. a kind of New Blood analyzer according to claim 6 and method, it is characterised in that：Step 3 pair first is detected
The dilution ratio of blood sample is between 1: 20-1: 300 in cup.
10. a kind of New Blood analyzer according to claim 6 and method, it is characterised in that：Step 4 pair second is detected
The dilution ratio of blood sample is between 1: 20-1: 300 in cup.
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| CN201710167506.5A CN106885915A (en) | 2017-03-16 | 2017-03-16 | A kind of New Blood analyzer and method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108844906A (en) * | 2018-06-04 | 2018-11-20 | 江苏柯伦迪医疗技术有限公司 | A kind of blood cell component analyzer and method |
| CN110887971A (en) * | 2018-09-10 | 2020-03-17 | 深圳迈瑞生物医疗电子股份有限公司 | Blood analysis method and blood analyzer |
| CN113777332A (en) * | 2020-06-09 | 2021-12-10 | 深圳迈瑞生物医疗电子股份有限公司 | Immunoassay instrument and autoimmune analysis method |
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Application publication date: 20170623 |