CN106853207B - Traditional Chinese medicine composition for treating juvenile myopia and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating juvenile myopia and preparation method thereof Download PDF

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CN106853207B
CN106853207B CN201710102470.2A CN201710102470A CN106853207B CN 106853207 B CN106853207 B CN 106853207B CN 201710102470 A CN201710102470 A CN 201710102470A CN 106853207 B CN106853207 B CN 106853207B
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刘文兰
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Xian Medical University
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Abstract

The invention discloses a traditional Chinese medicine composition for treating juvenile myopia, which is prepared from the following raw materials in parts by weight: 10-20 parts of salvia miltiorrhiza, 6-10 parts of sargassum thunbergii, 6-14 parts of Chinese honeylocust abnormal herb, 11-15 parts of pyrola, 2-4 parts of rhizoma sparganii, 9-13 parts of artemisia anomala, 5-9 parts of astragalus membranaceus, 3-5 parts of catechu, 6-10 parts of semen cuscutae, 10-20 parts of plantain herb, 2-4 parts of creeping oxalis, 1-3 parts of passionflower herb, 4-8 parts of gynostemma pentaphylla and 5-10 parts of paris polyphylla. The traditional Chinese medicine composition has the functions of tonifying qi and activating blood, tonifying deficiency and tonifying kidney, nourishing liver and improving eyesight, and removing dampness and reducing swelling, so that the yin and blood of the liver body are full, the functions of the liver and the kidney are normal, the function of retina photoreceptor cells is strengthened, eyeball tissues are firmed, and neurotrophic factors in the retina and cell layers are increased; the eye system obtains sufficient nutrition, the eye substance and function metabolism are normal, the self-healing capability and the resistance of the organism are enhanced, the myopia of the teenagers is fundamentally treated, the symptoms and the root causes are treated, and no toxic or side effect is caused.

Description

Traditional Chinese medicine composition for treating juvenile myopia and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating juvenile myopia, and a preparation method of the traditional Chinese medicine composition.
Background
Myopia refers to the condition that parallel light rays (light rays emitted by an object with the length of 5 meters) pass through a dioptric system of the eye and are focused in front of the retina under the condition that the eye does not use adjustment, and only a blurred image is formed on the retina. Myopia is marked by blurred vision, near-sightedness or relatively clear vision, and is manifested as visual impairment, asthenopia, etc. Juvenile myopia is one of the eye diseases with the highest incidence rate at present, and the number of myopia patients in China reaches 2 hundred million, wherein: the primary school students account for about 30% and the middle school students account for about 60%. With the progress of modern life, the popularization of televisions, computers and the like and the increase of the burden of students on the classroom, the myopia of children and teenagers is advanced in the onset age and obviously increased in the incidence rate, and becomes a serious public health problem and arouses the high attention of the national ministry of education and the ministry of health. A large number of medical researches prove that as the myopia degree is increased, blindness-causing eye diseases caused by myopia, such as macular degeneration, retinal detachment, open-angle glaucoma and the like, are increased correspondingly.
Since the pathogenesis of myopia is not clear, the prevention and treatment of myopia cannot be satisfied, and various methods for treating myopia are endless. At present, a plurality of methods for treating myopia are available, such as vision correction instruments, small-hole glasses, laser therapy, magnetic therapy, electrotherapy, acupuncture and moxibustion and other therapies. Although each therapy has some efficacy, and some relief, most of them are not consolidated. Currently there is no better treatment for myopia. It is still common practice in society to wear spectacles for near vision. The myopia glasses can correct vision and adjust diopter, but have no treatment effect on eyes and cannot prevent the development of myopia. Currently, medical workers in the technical field of medicine are urgently needed to solve the problems of prevention, treatment, consolidation, radical treatment and the like of the myopia of the teenagers as early as possible.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating juvenile myopia, which can radically treat juvenile myopia, has obvious curative effect, treats both principal and secondary aspect of disease and has no toxic or side effect.
The invention adopts the technical scheme that a traditional Chinese medicine composition for treating juvenile myopia is prepared from the following raw materials in parts by weight: 10-20 parts of salvia miltiorrhiza, 6-10 parts of sargassum thunbergii, 6-14 parts of Chinese honeylocust abnormal herb, 11-15 parts of pyrola, 2-4 parts of rhizoma sparganii, 9-13 parts of artemisia anomala, 5-9 parts of astragalus membranaceus, 3-5 parts of catechu, 6-10 parts of semen cuscutae, 10-20 parts of plantain herb, 2-4 parts of creeping oxalis, 1-3 parts of passionflower herb, 4-8 parts of gynostemma pentaphylla and 5-10 parts of paris polyphylla.
Preferably, the traditional Chinese medicine composition for treating juvenile myopia is prepared from the following raw materials in parts by weight: 15 parts of salvia miltiorrhiza, 8 parts of sargassum thunbergii, 10 parts of Chinese honeylocust herb, 13 parts of pyrola, 3 parts of rhizoma sparganii, 11 parts of artemisia anomala, 7 parts of astragalus membranaceus, 4 parts of catechu, 8 parts of semen cuscutae, 15 parts of plantain herb, 3 parts of creeping oxalis, 2 parts of passionflower herb, 6 parts of gynostemma pentaphylla and 8 parts of paris polyphylla.
The second technical scheme adopted by the invention is that a preparation method of a traditional Chinese medicine composition for treating juvenile myopia is implemented according to the following steps:
step 1, weighing the following components in parts by weight: 10-20 parts of salvia miltiorrhiza, 6-10 parts of sargassum thunbergii, 6-14 parts of Chinese honeylocust, 11-15 parts of pyrola, 2-4 parts of rhizoma sparganii, 9-13 parts of artemisia anomala, 5-9 parts of astragalus membranaceus, 3-5 parts of catechu, 6-10 parts of semen cuscutae, 10-20 parts of plantain herb, 2-4 parts of creeping oxalis, 1-3 parts of passionflower herb, 4-8 parts of gynostemma pentaphylla and 5-10 parts of paris polyphylla;
step 2, mixing the raw materials weighed in the step 1, adding cold water which is 8 times of the total weight of the medicinal materials, soaking for 1 hour, boiling with strong fire, decocting with slow fire for 1 hour, and filtering to obtain filtrate for 1 time;
step 3, adding cold water 4 times of the total weight of the medicinal materials, boiling with strong fire, decocting with slow fire for 30min, and filtering to obtain filtrate for 2 times;
and 4, combining the filtrate obtained in the step 1 and the filtrate obtained in the step 2, and heating and concentrating to obtain the compound.
The traditional Chinese medicine composition for treating the juvenile myopia has the beneficial effects that the medicine compatibility is scientific and reasonable, the preparation process is simple, and the traditional Chinese medicine composition has good effects of tonifying qi and activating blood, tonifying deficiency and tonifying kidney, nourishing liver and improving eyesight, and removing dampness and reducing swelling, so that yin and blood of a liver body are full, the functions of liver and kidney are normal, the function of retina photoreceptor cells is strengthened, eyeball tissues are firm, and neurotrophic factors in retina and cell layers are increased; the eye system obtains sufficient nutrition, the eye substance and function metabolism are normal, the self-healing capability and the resistance of the organism are enhanced, the myopia of the teenagers is fundamentally treated, the curative effect is obvious, both the symptoms and root causes are treated, and no toxic or side effect is caused.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
The invention relates to a traditional Chinese medicine composition for treating juvenile myopia, which is prepared from the following raw materials in parts by weight: 10-20 parts of salvia miltiorrhiza, 6-10 parts of sargassum thunbergii, 6-14 parts of Chinese honeylocust abnormal herb, 11-15 parts of pyrola, 2-4 parts of rhizoma sparganii, 9-13 parts of artemisia anomala, 5-9 parts of astragalus membranaceus, 3-5 parts of catechu, 6-10 parts of semen cuscutae, 10-20 parts of plantain herb, 2-4 parts of creeping oxalis, 1-3 parts of passionflower herb, 4-8 parts of gynostemma pentaphylla and 5-10 parts of paris polyphylla.
The preparation method of the traditional Chinese medicine composition for treating juvenile myopia is specifically implemented according to the following steps:
step 1, weighing the following components in parts by weight: 10-20 parts of salvia miltiorrhiza, 6-10 parts of sargassum thunbergii, 6-14 parts of Chinese honeylocust, 11-15 parts of pyrola, 2-4 parts of rhizoma sparganii, 9-13 parts of artemisia anomala, 5-9 parts of astragalus membranaceus, 3-5 parts of catechu, 6-10 parts of semen cuscutae, 10-20 parts of plantain herb, 2-4 parts of creeping oxalis, 1-3 parts of passionflower herb, 4-8 parts of gynostemma pentaphylla and 5-10 parts of paris polyphylla;
step 2, mixing the raw materials weighed in the step 1, adding cold water which is 8 times of the total weight of the medicinal materials, soaking for 1 hour, boiling with strong fire, decocting with slow fire for 1 hour, and filtering to obtain filtrate for 1 time;
step 3, adding cold water 4 times of the total weight of the medicinal materials, boiling with strong fire, decocting with slow fire for 30min, and filtering to obtain filtrate for 2 times;
and 4, combining the filtrate obtained in the step 1 and the filtrate obtained in the step 2, and heating and concentrating to obtain the compound.
The invention relates to a Chinese medicinal composition for treating juvenile myopia, which has the following application and dosage: the medicine is decocted in water for oral administration, one dose is taken one time a day, two times a day, and 200ml of the medicine is taken 1 hour after breakfast and supper respectively. The treatment course is 10 days, and the disease can be cured after 4-6 treatment courses.
The pharmacology of each raw material is as follows:
red sage root: bitter in taste and slightly cold in nature. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, nourishing blood, tranquilizing mind, cooling blood, and relieving swelling. Can be used for treating blood stasis, headache, chest pain, hypochondrium pain, abdominal pain, menoxenia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal pain, arthralgia, traumatic injury, blood stasis, vexation, blood deficiency, palpitation, pyocutaneous disease, toxic swelling, erysipelas, scabies, and tinea.
And (4) cowtail vegetable: sweet and bitter in flavor and neutral in nature. It enters liver meridian. Invigorating qi, promoting blood circulation, relaxing muscles and tendons, expelling pathogenic wind, activating collateral flow, expelling phlegm, and relieving cough. Can be used for treating rheumatic arthritis, arthralgia and myalgia, traumatic injury, lumbar muscle strain, bronchitis, pulmonary tuberculosis, cough, and hemoptysis.
Noodle dish: sweet taste and cool nature. It enters heart and liver meridians. To nourish yin, clear heat, stop bleeding and regulate menstruation. Can be used for treating hematemesis, epistaxis, cough due to asthenia consumption, hemoptysis, hematuria, and menoxenia.
Herba Pyrolae: sweet and bitter in flavor and warm in nature. It enters lung, stomach, liver and kidney meridians. Has effects in tonifying deficiency, invigorating kidney, expelling pathogenic wind, removing dampness, promoting blood circulation, regulating menstruation, strengthening bone, relieving cough, and stopping bleeding.
Three-edge: pungent and bitter in flavor and mild in nature. It enters liver and spleen meridians. Break blood and move qi, resolve food stagnation and alleviate pain. Has effects in removing blood stasis, promoting qi circulation, removing food stagnation, and relieving pain. Can be used for treating abdominal mass, dysmenorrhea, blood stasis, amenorrhea, thoracic obstruction, heart pain, and pain due to food stagnation.
Diverse wormwood herb: pungent, slightly bitter and warm in nature. It enters heart, liver and spleen meridians. Dispel blood stasis and dredge meridians, stop bleeding and relieve swelling, promote digestion and resolve stagnation.
Astragalus root: sweet in flavor and slightly warm in nature. It enters lung, spleen, liver and kidney meridians. Replenishing qi to strengthen superficies, arresting sweating, promoting granulation, inducing diuresis to alleviate edema. Can be used for treating deficiency of vital energy, asthenia, collapse of middle-warmer energy, chronic diarrhea, proctoptosis, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, carbuncle, cellulitis, intractable ulcer, blood deficiency, sallow complexion, internal heat, diabetes, chronic nephritis, albuminuria, diabetes, etc.
Catechu: bitter and astringent taste, slightly cold in nature. Clear heat and resolve phlegm, promote the production of body fluid to quench thirst, stop bleeding and relieve pain, astringe dampness and heal wound. Can be used for treating phlegm heat cough, dysphoria with smothery sensation, diabetes, pharyngitis, aphtha, ulcerative gingivitis, hemoptysis, hematemesis, epistaxis, hematuria, hematochezia, bloody dysentery, metrorrhagia, traumatic hemorrhage, hemorrhoid swelling and pain, pyocutaneous disease, eczema, and leukorrhagia.
Dodder seed: sweet and pungent in flavor and slightly warm in nature. It enters liver, kidney and spleen meridians. Tonify kidney, replenish essence, nourish liver to improve vision, prevent miscarriage, improve vision, check diarrhea, secure essence and reduce urination.
Turning grass: sweet and bland in flavor, slightly cold in nature. It enters lung, liver, kidney and bladder meridians. Clearing away heat, promoting urination, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm. Can be used for treating dysuria, stranguria with turbid discharge, edema, abdominal distention, summer-heat, dampness, dysentery, conjunctival congestion, nebula, and cough with asthma due to phlegm-heat.
And (3) creeping oxalis: sour in taste and cold in nature. It enters liver, lung and bladder meridians. Clearing away heat, promoting diuresis, cooling blood, removing blood stasis, relieving swelling, and removing toxic substance. It can be used for treating diarrhea, dysentery, jaundice, gonorrhea, leucorrhea with red and white discharge, measles, hematemesis, epistaxis, sore throat, furuncle, carbuncle, scabies, hemorrhoid, proctoptosis, traumatic injury, and fire injury.
Passion flower: bitter taste and warm nature. Dispel wind and clear heat, relieve cough and resolve phlegm. It is indicated for dizziness due to wind-heat, nasal obstruction and nasal discharge.
Gynostemma pentaphylla: sweet and bitter in flavor, slightly cold in nature. It enters lung, spleen and kidney meridians. Replenishing qi, tranquilizing the mind, lowering blood pressure, clearing away heat and toxic material, relieving cough and eliminating phlegm.
Rhizoma paridis: bitter taste and cool nature. It enters heart, liver, lung, stomach and large intestine meridians. Has toxic materials clearing away, anticancer, repercussive, analgesic, heat clearing away, convulsion arresting, cough relieving, and asthma relieving effects. It is used for clearing away heat and toxic materials, relieving swelling and pain, treating epidemic encephalitis B, gastralgia, appendicitis, tuberculous lymphadenitis, tonsillitis, parotitis, mastitis, venomous snake bite, insect bite, pyocutaneous disease, and pyogenic infections.
In the invention, the salvia miltiorrhiza and the boletus are monarch, so that the effects of tonifying qi, promoting blood circulation, dispelling wind and activating collaterals are achieved, the blood circulation of an organism is enhanced, the metabolism function of the organism is promoted, and the function of retina photoreceptor cells is increased; the Chinese medicinal composition has the effects of tonifying deficiency, tonifying kidney, promoting qi circulation and relieving pain, assisting monarch drugs in enhancing the metabolic function of organisms, strengthening the function of retina photoreceptor cells, regulating the function of an immune system and enhancing the toughness of scleral tissues; the astragalus, the catechu, the dodder and the plantain are used as assistants, so that the effects of nourishing the liver, improving eyesight, tonifying qi, strengthening exterior, clearing heat and promoting urination are achieved, deficiency heat of a retinal pigment cell layer is eliminated, eyeball tissues are firmed, and neurotrophic factors in the retina and the cell layer are increased; the creeping oxalis, passion flower, gynostemma pentaphylla and paris polyphylla have the effects of clearing away heat and toxic materials, tonifying qi, soothing the nerves, promoting diuresis, relieving swelling, removing deficiency heat in vivo, inhibiting scleral deformation and enhancing the self-healing capability and resistance of the organism.
Example 1
A traditional Chinese medicine composition for treating juvenile myopia is prepared from the following raw materials in parts by weight: 20 parts of salvia miltiorrhiza, 6 parts of sargassum thunbergii, 6 parts of Chinese cabbage, 11 parts of pyrola, 4 parts of rhizoma sparganii, 13 parts of artemisia anomala, 9 parts of astragalus membranaceus, 3 parts of catechu, 10 parts of semen cuscutae, 20 parts of plantain herb, 2 parts of creeping oxalis, 1 part of passionflower herb, 4 parts of gynostemma pentaphylla and 5 parts of paris polyphylla.
The traditional Chinese medicine composition for treating juvenile myopia is prepared by the following steps:
(1) weighing the raw materials according to the parts by weight, adding the raw materials into a marmite, adding cold water which is 8 times of the total weight of the decocted medicinal materials, soaking for 1 hour, boiling with strong fire, decocting with slow fire for 1 hour, and filtering to obtain filtrate for 1 time;
(2) adding cold water 4 times the total weight of the decocted medicinal materials into casserole, boiling with strong fire, decocting with slow fire for 30min, and filtering to obtain filtrate for 2 times;
(3) mixing the filtrate obtained in 1 time and the filtrate obtained in 2 times, and heating and concentrating to 400 ml.
Example 2
A traditional Chinese medicine composition for treating juvenile myopia is prepared from the following raw materials in parts by weight: 15 parts of salvia miltiorrhiza, 8 parts of sargassum thunbergii, 10 parts of Chinese honeylocust herb, 13 parts of pyrola, 3 parts of rhizoma sparganii, 11 parts of artemisia anomala, 7 parts of astragalus membranaceus, 4 parts of catechu, 8 parts of semen cuscutae, 15 parts of plantain herb, 3 parts of creeping oxalis, 2 parts of passionflower herb, 6 parts of gynostemma pentaphylla and 8 parts of paris polyphylla.
The rest is the same as example 1.
Example 3
A traditional Chinese medicine composition for treating juvenile myopia is prepared from the following raw materials in parts by weight: 10 parts of salvia miltiorrhiza, 10 parts of boenninghausenia, 14 parts of Chinese honeylocust abnormal fruit, 15 parts of pyrola, 2 parts of rhizoma sparganii, 9 parts of artemisia anomala, 5 parts of astragalus membranaceus, 5 parts of catechu, 6 parts of semen cuscutae, 10 parts of plantain herb, 4 parts of creeping oxalis, 3 parts of passionflower herb, 8 parts of gynostemma pentaphylla and 10 parts of paris polyphylla.
The rest is the same as example 1.
Clinical data
General data: 140 cases of teenager myopia patients in outpatient service of a hospital are selected and randomly divided into two groups; treatment group 70 patients with 136 eyes, wherein 36 men and 34 women are aged 8-18 years, the average age is 10.6 years, and the course of disease is 2 months-6 years; the control group had 70 137 eyes, 35 male and 35 female, ages 8-18 years, mean 10.9 years, and course 2 months-6 years. The comparison difference between two groups of general data is not statistically significant (P >0.05) and is comparable.
Diagnostic criteria: the naked eye vision of the patient is lower than 4.8 (standard logarithmic visual acuity chart lamp SLD-II-type); organic pathological changes are eliminated through slit lamp and ophthalmoscope examination, and the diagnosis is confirmed to be myopia; and meets the definition and classification standard of true and false myopia prepared by eye refractive optical group of the society of ophthalmology of China medical society in 1985 (refer to modern ophthalmology handbook, Beijing, national public health Press, 1993, page 563-564).
Exclusion criteria: 1) severe systemic diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system are complicated; psychotic patients; 2) patients who take other related medicines for a long time or apply other treatment methods cannot complete the treatment; 3) patients with pathological myopic fundus changes and obviously impaired visual function; 4) patients with eye diseases complicated with other eye diseases and affecting the judgment of curative effect; 5) if the treatment is not in accordance with the inclusion criteria, the treatment is not performed on time according to the regulations, and the judgment of the curative effect is not affected by the incompleteness of the treatment effect or the data.
The treatment method comprises the following steps: the traditional Chinese medicine composition is taken by treatment groups, one dose is taken once a day, twice a day, and 200ml of the traditional Chinese medicine composition is taken 1 hour after breakfast and supper; 10 days is 1 course of treatment, and 5 courses of treatment are given in total. Oral administration of the control group for increasing luster tablet (Chinese medicine standard Z10983126), 4-6 tablets each time, 3 times daily; 10 days is 1 course of treatment, and 5 courses of treatment are given in total.
Treatment judgment criteria: refer to "diagnosis and treatment efficacy determination (criteria) for common diseases" [ M ]. beijing: chinese traditional medicine press, 2001: 06) formulating:
and (3) curing: vision improvement of 1.0 or more;
the effect is shown: the vision is improved by more than 2 grades but not 1.0;
the method has the following advantages: vision improvement of grade 1-2;
and (4) invalidation: those with less than grade 1 or no increase in vision.
Note: the international standard logarithmic visual acuity chart is standard, and level 1 is row 1.
The cure rate is (cure/total number of eyes) × 100%.
Total effective rate [ (cured + significant + effective)/total eye number ] × 100%.
The statistical method comprises the following steps: statistical analysis was performed using SPSS17.0 statistical software, with data measured as mean + -SD
Figure BDA0001232149970000082
Representing, using t-test, comparison of the count data rates using χ2And (6) checking.
The treatment results are as follows: the treatment results of the treatment group and the control group are shown in table 1.
TABLE 1 treatment results after application of the Chinese medicinal composition of the present invention
Figure BDA0001232149970000081
P is less than 0.05 compared with the control group.
As can be seen from table 1, the treatment group cured 42 eyes, showed 48 eyes, showed 39 eyes and failed 7 eyes, the cure rate was 30.9%, and the total effective rate was 94.9%; the control group has 15 eyes cured, 29 eyes with obvious effect, 39 eyes with effect and 54 eyes with no effect, the cure rate is 10.9 percent, and the total effective rate is 60.6 percent. The comparative difference between the cure rate and the total effective rate of the group 2 had statistical significance (P < 0.05), and the treatment effect of the treatment group was significantly better than that of the control group.
The vital signs of the patients in the treatment group are stable and have no serious adverse reactions such as allergy, and the like, and the laboratory indexes of the patients in the treatment group, such as blood routine, stool routine, urine routine, electrocardiogram and the like, are statistically processed after the treatment is finished, so that no obvious abnormality is seen. The results show that the clinical application of the invention is safe and effective, and is worth further research, popularization and application.

Claims (2)

1. A traditional Chinese medicine composition for treating juvenile myopia is characterized by being prepared from the following raw materials in parts by weight: 15 parts of salvia miltiorrhiza, 8 parts of sargassum thunbergii, 10 parts of Chinese honeylocust herb, 13 parts of pyrola, 3 parts of rhizoma sparganii, 11 parts of artemisia anomala, 7 parts of astragalus membranaceus, 4 parts of catechu, 8 parts of semen cuscutae, 15 parts of plantain herb, 3 parts of creeping oxalis, 2 parts of passionflower herb, 6 parts of gynostemma pentaphylla and 8 parts of paris polyphylla.
2. A traditional Chinese medicine composition for treating juvenile myopia is characterized by being prepared by the following steps:
step 1, weighing the following components in parts by weight: 15 parts of salvia miltiorrhiza, 8 parts of sargassum thunbergii, 10 parts of Chinese honeylocust herb, 13 parts of pyrola, 3 parts of rhizoma sparganii, 11 parts of artemisia anomala, 7 parts of astragalus membranaceus, 4 parts of catechu, 8 parts of semen cuscutae, 15 parts of plantain herb, 3 parts of creeping oxalis, 2 parts of passionflower herb, 6 parts of gynostemma pentaphylla and 8 parts of paris polyphylla;
step 2, mixing the raw materials weighed in the step 1, adding cold water which is 8 times of the total weight of the decocted medicinal materials, soaking for 1 hour, boiling with strong fire, decocting with slow fire for 1 hour, and filtering to obtain filtrate for 1 time;
step 3, adding cold water which is 4 times of the total weight of the decocted medicinal materials into the casserole, boiling with strong fire, decocting with slow fire for 30min, and filtering to obtain filtrate for 2 times;
and 4, combining the filtrate obtained in the step 1 and the filtrate obtained in the step 2, and heating and concentrating the mixture to 400 ml.
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098001A (en) * 1993-07-24 1995-02-01 王凯 Vision is bright
CN1246355A (en) * 1999-08-20 2000-03-08 张四岩 Medicinal composition for treating juvenile myopia
CN104666613A (en) * 2013-12-03 2015-06-03 赵刚 Traditional Chinese medicine for treating myopic eyes
CN106214992A (en) * 2016-07-08 2016-12-14 贵州宗智医药科技有限公司 A kind of Chinese medicine formula for treating myopia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098001A (en) * 1993-07-24 1995-02-01 王凯 Vision is bright
CN1246355A (en) * 1999-08-20 2000-03-08 张四岩 Medicinal composition for treating juvenile myopia
CN104666613A (en) * 2013-12-03 2015-06-03 赵刚 Traditional Chinese medicine for treating myopic eyes
CN106214992A (en) * 2016-07-08 2016-12-14 贵州宗智医药科技有限公司 A kind of Chinese medicine formula for treating myopia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
中西医结合疗法治疗高度近视临床观察;雍林晓;《辽宁中医杂志》;20090430;第36卷(第4期);第599页左栏第3段 *

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