CN101987157B - Medicine for treating nearsightedness and preparation method thereof - Google Patents
Medicine for treating nearsightedness and preparation method thereof Download PDFInfo
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- CN101987157B CN101987157B CN2010102649348A CN201010264934A CN101987157B CN 101987157 B CN101987157 B CN 101987157B CN 2010102649348 A CN2010102649348 A CN 2010102649348A CN 201010264934 A CN201010264934 A CN 201010264934A CN 101987157 B CN101987157 B CN 101987157B
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Abstract
The invention discloses a medicine for treating nearsightedness, which is characterized by being mainly prepared from the follow raw materials in parts by weight: 1 to 20 parts of rose, 1 to 20 parts of seville orange flower, 1 to 20 parts of mantis egg-case, 1 to 20 parts of raspberry, 1 to 20 parts of seed of Chinese dodder, 1 to 20 parts of pilose asiabell root, 1 to 20 parts of bighead atractylodes rhizome, 1 to 20 parts of common yam rhizome, 1 to 20 parts of coked medicated leaven and 1 to 20 parts of edible alcohol with the content higher 95 percent. The medicine can be absorbed by thespleen and the stomach through oral administration, can also be absorbed by the skin through external use, and can also be absorbed by compounding the two methods of the oral administration and the external use. The medicine of the invention has the advantages of reasonable formulation, simplified medicine compatibility and determined curative effect and can treat on both the symptoms and root causes. The invention also provides the preparation method of the medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, bathomorphic medicine of treatment of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Myopia is also claimed short-sighted eye, because this eye can only be seen closely can not see far.Bathomorphic hazardness mainly is complication, and except that the general low and distinctive sign of visual function such as distant vision, bathomorphic complication is varied.Usually increase gradually with dioptric intensification and age growth and increase the weight of, thereby cause the constantly impaired of more visual performances.And because the infringement of chorioretinal degeneration, maculopathy and detachment of retina etc., but the time blinding.The pathologic basis that leads to complications is mainly axis oculi prolongation, disturbance of blood circulation, malnutrition and specific tissue degeneratiaon etc.
Suffer from bathomorphic people except not seeing distant objects, majority also is easy to generate asthenopia.Because, often narrow eyes to see thing, can make extraocular muscles, ciliary muscle hypertonicity, cause eyestrain easily.Sometimes like putting books very closely in order to see font clearly, so more increased the weight of the adjusting of eye, impel the development of myopia.Read a book, write, see TV for a long time, will feel that eyes are dry and astringent, eyelid is heavy, and eye socket pain is expanded in eyeball acid.Then slur appears in blurred vision, the reading serial, serious giddy, headache can also appear, symptom such as feel sick.
The bathomorphic Chinese medicine product of treatment is too much paid attention to regulating at present, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to the decoction or the pill that are mostly to boil than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the bathomorphic medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
The bathomorphic medicine of a kind of treatment is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of Citrus aurantium L. var. amara Engl.; 1 ~ 20 part of Ootheca Mantidis, 1 ~ 20 part of Fructus Rubi, 1 ~ 20 part of Semen Cuscutae; 1 ~ 20 part of Radix Codonopsis, 1 ~ 20 part of the Rhizoma Atractylodis Macrocephalae, 1 ~ 20 part of RHIIZOMA DIOSCOREAE frOm Henan of China; Burnt six bent 1 ~ 20 part, content is 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of Citrus aurantium L. var. amara Engl.s; 15 ~ 20 parts of Ootheca Mantidiss, 15 ~ 20 parts of Fructus Rubies, 15 ~ 20 parts of Semen Cuscutae; 15 ~ 20 parts of Radix Codonopsis, 15 ~ 20 parts of the Rhizoma Atractylodis Macrocephalaes, 15 ~ 20 parts of RHIIZOMA DIOSCOREAE frOm Henan of China; Burnt six bent 15 ~ 20 parts, content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., Ootheca Mantidis, Fructus Rubi, Semen Cuscutae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, RHIIZOMA DIOSCOREAE frOm Henan of China and burnt six songs of said weight proportion, according to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds said weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity must be treated bathomorphic medicine.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to bathomorphic characteristics; Select Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., Ootheca Mantidis, Fructus Rubi, Semen Cuscutae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six songs for use; With being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, process to contain pure Chinese medicine extraction liquid.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the bathomorphic medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease.
The Ootheca Mantidis salty in the mouth is sweet, and property is flat, goes into liver, kidney channel, the kidney invigorating, controlling nocturnal emission with astringent drugs.The acid of Fructus Rubi sweet in the mouth, property is flat, goes into liver, kidney two warps; Invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs makes eye bright.The Semen Cuscutae suffering is sweet, and is flat, goes into liver, kidney channel; Invigorating the liver and kidney, beneficial marrow makes eye bright.Radix Codonopsis is sweet, and is flat, start with, meridian of Foot-TAI YIN, and invigorating middle warmer, QI invigorating promotes the production of body fluid.Rhizoma Atractylodis Macrocephalae hardship is sweet, and temperature is gone into spleen, stomach warp; Spleen reinforcing, stomach reinforcing, dampness and in.Burnt six is bent sweet, hot, temperature.Go into spleen, stomach warp and the food stomach that disappears.
Ootheca Mantidis is gone into Liver and kidney warp, tonifying YIN spermatogenesis, the special astringent therapy of merit in the medicine of the present invention; Fructus Rubi people Liver and kidney warp, supplementing the kidney to control the nocturnal, tonifying liver make eye bright; Semen Cuscutae is not warm not dry, puts down the nourishing YIN sun and the kidney invigorating nourishing the liver; Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating help fortune; Rhizoma Atractylodis Macrocephalae spleen reinforcing dampness; The burnt six songs stomach function regulating that helps digestion; First the foundation of acquired constitution is mended in RHIIZOMA DIOSCOREAE frOm Henan of China strengthening the spleen kidney, training.All medicines share, and the spleen benefiting and strengthen kidney arresting seminal emission is mended congenital defect, and essence and blood is abundant, and refreshing light is sent out more and looked far, can strengthen visual function, improves vision.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The Citrus aurantium L. var. amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can be smeared portion near the eyes with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the myopia curative effect, and clinical usefulness repeatly, effect are very prompt.Be applicable to teenage pseudomyopia, evident in efficacy.Then can control stablely to true myopia, vision is improved.Medicine of the present invention is through clinical 80 routine patients' clinical verification, and curing number is 56 examples, and significant figure is 16 examples, and invalid number is 8 examples, and total effective rate reaches 90%.Do not see toxic side effect in the therapeutic process.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain man 20 years old, suffer from pseudomyopia, eyes correct defects of vision < 0.7.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 10 days, and correcting defects of vision after 60 days is eyes 1.1.Paying a return visit after 12 months does not have recurrence.
Case 2: certain woman 18 years old, suffer from pseudomyopia, the naked vision left eye 0.8, right eye < 0.9.External medicine of the present invention is smeared portion and whole body near the eyes, every day 2 times, each 10 milliliters, locates near the eyes repeatedly to smear.Correct defects of vision after 50 days and be left eye 1.1, right eye 1.3.Paying a return visit after 12 months does not have recurrence.
Case 3: certain man 23 years old, naked vision before the medication not, left eye 0.8, right eye < 0.7.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared portion and whole body near the eyes, every day 2 times, each 10 milliliters, locates near the eyes repeatedly to smear.Above symptom is oral to be alleviated after 20 days with external, and correcting defects of vision after 30 days is left eye 1.3, right eye 1.2.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 18 parts of Ootheca Mantidiss, 16 parts of Fructus Rubies, 15 parts of Semen Cuscutae, 15 parts of Radix Codonopsis, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 17 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 18 parts of burnt six songs adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the bathomorphic medicine of treatment that gained filtrating is oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of Citrus aurantium L. var. amara Engl.s, 19 parts of Ootheca Mantidiss, 19 parts of Fructus Rubies, 18 parts of Semen Cuscutae, 18 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 19 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six bent 20 parts, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of Citrus aurantium L. var. amara Engl.s, 20 parts of Ootheca Mantidiss, 20 parts of Fructus Rubies, 20 parts of Semen Cuscutae, 19 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 19 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six bent 19 parts, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 17 parts of Citrus aurantium L. var. amara Engl.s, 15 parts of Ootheca Mantidiss, 16 parts of Fructus Rubies, 17 parts of Semen Cuscutae, 18 parts of Radix Codonopsis, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six bent 17 parts, content is 15 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, and 18 parts of Citrus aurantium L. var. amara Engl.s, 17 parts of Ootheca Mantidiss, 19 parts of Fructus Rubies, 20 parts of Semen Cuscutae, 18 parts of Radix Codonopsis, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 19 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six bent 19 parts, content is 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of Citrus aurantium L. var. amara Engl.s, 19 parts of Ootheca Mantidiss, 20 parts of Fructus Rubies, 20 parts of Semen Cuscutae, 19 parts of Radix Codonopsis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 19 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, burnt six bent 20 parts, content is 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. treat bathomorphic medicine for one kind, it is characterized in that processing by following method:
(1) take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 18 parts of Ootheca Mantidiss, 16 parts of Fructus Rubies, 15 parts of Semen Cuscutae, 15 parts of Radix Codonopsis, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 17 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 18 parts of burnt six songs adopt the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and are subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the bathomorphic medicine of treatment that gained filtrating is for oral administration or external carries out fill under aseptic condition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102649348A CN101987157B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating nearsightedness and preparation method thereof |
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| CN2010102649348A CN101987157B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating nearsightedness and preparation method thereof |
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| CN101987157A CN101987157A (en) | 2011-03-23 |
| CN101987157B true CN101987157B (en) | 2012-11-21 |
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| CN106668429A (en) * | 2016-11-21 | 2017-05-17 | 湖北东信药业有限公司 | Traditional Chinese medicine preparation for treating pseudomyopia of adolescents |
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Non-Patent Citations (7)
| Title |
|---|
| 南京中医药大学.玫瑰花 |
| 南京中医药大学.玫瑰花;玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748,2098. * |
| 卢祥之.桑螵蛸方.《中国名医名方》.中国医药科技出版社,1991,599. * |
| 张兆旺，等.中药合剂（含口服液） |
| 张兆旺,等.中药合剂(含口服液)渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105,185-187. * |
| 渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105，185-187. |
| 玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748，2098. |
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Granted publication date: 20121121 Termination date: 20180827 |