CN104383465A - Traditional Chinese medicine preparation for treating cataract and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating cataract and preparation method thereof Download PDF

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CN104383465A
CN104383465A CN201410759704.7A CN201410759704A CN104383465A CN 104383465 A CN104383465 A CN 104383465A CN 201410759704 A CN201410759704 A CN 201410759704A CN 104383465 A CN104383465 A CN 104383465A
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崔合芳
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine preparation for treating cataract. The traditional Chinese medicine preparation is prepared from the following medical materials: butterflybush flower, selfheal, black soybean flower, semen cassia, fructus lycii, scrophularia ningpoensis, radix curcumae, ternate grape fern herb, hollow azurite, marsh equisetum, crocus sativus, boa gall, littletooth hydrangeavine root and cardamine lyrata. The traditional Chinese medicine preparation takes the traditional Chinese medicines as raw materials, treats cataract by virtue of the synthetic effect of the medicines and has the advantages of high cure rate, low recurrence rate after recovery, high safety and no toxic and side effect.

Description

One treats cataractous Chinese medicine preparation and preparation method thereof
Technical field
The invention belongs to tcm field, relate to one particularly and treat cataractous Chinese medicine preparation and preparation method thereof.
Background technology
Cataract is a kind of common ocular disease, it is a kind of disease that can cause blindness, cause cataractous factor a lot, such as: the factor such as aging, hereditary, Developmental and Metabolic Disorder, wound, radiation, poisoning and local malnutrition can cause phacocyst membrane damage or cause crystalline lens metabolism disorder, crystallin generation degeneration and muddy is caused.Cataract have congenital and posteriority point.Senile cataract is modal acquired cataract, be mainly in more than 40 years old crowd, and increase with the age and increase, the reason of this phenomenon may that degeneration slowly occurs be relevant with old people's metabolism, also may be relevant with factors such as daylight long-term irradiation, endocrine regulation, dysbolismus.
At present, the method for the treatment of cataract the most frequently used is surgical therapy (ultrasonic emulsification for cataract, ECCE, intracapsular cataract extraction), but postcataract may cause a series of complication, and the patient suffering from hypertension, heart disease or Other diseases not easily performs the operation, be all old people mostly owing to suffering from cataractous patient, operation can bring very large psychological burden to them.Therefore, the cataractous medicine of a kind of safe and effective treatment is found very urgent.
Summary of the invention
Inventor, according to oneself experience of taking up a job as a doctor for many years, based on organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, provides one and treats cataractous Chinese medicine preparation.Inventor thinks that many weak, the Liver and kidney with age of primary disease are recklessly caused by void, asthenia of essence and blood, eyes losing nutrition; Or deficiency of spleen-YANG and kidneyYANG, insufficiency of the spleen mistake fortune, the five internal organs are not flourish in order; Or cloudy essence is weak, internal injury caused by excess of seven emotions, can not sun processed, asthenic fire superior caused by; Or stagnation of QI due to depression of the liver, strongly fragrant fire-transformation of a specified duration or work with one's mind exhaust in think of, heart-fire contain, conscience fire inflammation, brilliant pearl lose and support and become muddiness.Treatment primary disease, need from liver heat removing diuretic, liver and kidney tonifying, spleen invigorating adjust, yang invigorating profit key set about, the effect of removing nebula to improve visual acuity, treating both the principal and secondary aspects of a disease can be reached.
The present invention is achieved through the following technical solutions:
One treats cataractous Chinese medicine preparation, it is characterized in that: be made up of the medical material of following parts by weight: Flos Buddlejae 8-13 part, Spica Prunellae 8-13 part, Flos sojae atricolor 10-15 part, Semen Cassiae 8-13 part, Fructus Lycii 10-15 part, Radix Scrophulariae 8-13 part, Radix Curcumae 8-13 part, Herba Botrychii 10-15 part, Azuritum 10-15 part, Herba Equiseti Palustris 10-15 part, Stigma Croci 8-13 part, Fel python 5-10 part, Radix Schizophragmatis denticulati 10-15 part, Herba Cardamines Lyratae 10-15 part.
In side, Flos sojae atricolor, Azuritum, Fel python share, and have heat clearing away nourishing the liver, the effect of improving acuity of vision and removing nebula, Herba Botrychii, Spica Prunellae, Radix Scrophulariae can wind and heat dispersing, mass dissipating and swelling eliminatings, Semen Cassiae enters large intestine channel, clearing away heat to improve acuity of vision, and priming is descending, Radix Schizophragmatis denticulati, Herba Cardamines Lyratae can wind-damp dispelling, relieving heat toxins, Herba Equiseti Palustris coordinate with Stigma Croci invigorate blood circulation, pain relieving, Flos Buddlejae and Fructus Lycii share liver heat removing nourishing the liver, adopting both clearing heat method and tonification method, be aided with Radix Curcumae promoting QI circulation for relieving depression, full side plays the effect of heat-clearing and toxic substances removing, nourishing the liver nourishing kidney, improving acuity of vision and removing nebula altogether.
Be the function and effect of each medical material in the present invention below:
Flos Buddlejae: sweet, is slightly cold.Return Liver Channel.Function cures mainly: heat clearing away nourishing the liver, improving acuity of vision and removing nebula.For conjunctival congestion and swelling pain, many tear photophobia, nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.
Spica Prunellae: cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.Select Lamiales labiate Spica Prunellae partial desiccation fruit ear.
Flos sojae atricolor: improving eyesight removing nebula.Main pterygium.Elect the flower of legume soybean as.
Semen Cassiae: sweet, bitter, salty, is slightly cold.Return liver, large intestine channel.Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Select the dry mature fruit of plant of Solanaceae lycium barbarum.
Radix Scrophulariae: removing heat from blood YIN nourishing, eliminating fire and detoxication.Cure mainly: warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin hinder constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore.Select the dry root of goatweed Radix Scrophulariae.
Radix Curcumae: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Cure mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Herba Botrychii: suppressing the hyperactive liver, heat clearing away, antitussive.Control dizziness headache, hemoptysis, infantile convulsion, acute catarrhal conjunctivitis, corneal nebula, sore swollen toxin.Select the whole herb with root of Botrychiaceae plant Herba Botrychii.
Azuritum: improving eyesight, removing nebula, sharp key.Control optic atrohic blindness, nyctalopia, nebula film cataract, acute conjunctivitis swells and ache, and middle air port is askew, and arm is meciless, wind syndrome of head, deaf.Select the Ore of carbonate mineral chessy copper, globulate or hollow person.
Herba Equiseti Palustris: dispelling wind; Improving eyesight; Invigorate blood circulation; Pain relieving.Main epiphora induced by wind; Pterygium; Traumatic injury; Rheumatalgia.Select the herb of pteridophyta medicine Equisetaceae plant dog Herba Equiseti Arvinsis.
Stigma Croci: blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.Select top and the stigma of irides Stigma Croci style.
Fel python: the attached infantile malnutrition of parasite killing; Improving eyesight removing nebula; Reducing swelling and alleviating pain.Main infantile malnutrition; Chronic dysentery; Gastral cavity abdomen worm pain; Infantile convulsion; Corneal nebula swells and ache; Man's primary sore; Hemorrhoid; Leprosy.Select the gallbladder of Boidae animal Boa Serpentis.
Radix Schizophragmatis denticulati: wind-damp dispelling, relieving heat toxin.Control blood stasis to stagnate, the diseases such as muscles and bones gout and sore redness.Select the root of saxifragaceae plant Radix Schizophragmatis denticulati.
Herba Cardamines Lyratae: clearing away heat and cooling blood, improving eyesight, regulating menstruation.Control dysentery, spit blood, conjunctival congestion with ophthalmalgia, menoxenia.Select the herb of crucifer Herba Cardamines Lyratae.
Inventor is preferred to invention has been to the curative effect of cataract patient according to Chinese medicine preparation of the present invention, preferably, the cataractous Chinese medicine preparation of described treatment, is made up of the medical material of following parts by weight: Flos Buddlejae 10 parts, Spica Prunellae 10 parts, Flos sojae atricolor 13 parts, Semen Cassiae 10 parts, Fructus Lycii 13 parts, Radix Scrophulariae 10 parts, Radix Curcumae 10 parts, Herba Botrychii 12 parts, Azuritum 12 parts, Herba Equiseti Palustris 13 parts, Stigma Croci 10 parts, Fel python 8 parts, Radix Schizophragmatis denticulati 12 parts, Herba Cardamines Lyratae 13 parts.
The preparation method of the cataractous Chinese medicine preparation for the treatment of of the present invention comprises the steps: to take described medicinal raw material by weight, add described medical material gross weight 6-10 purified water doubly, decoct 2-4 hour, pour out decocting liquid, add described medical material gross weight 5-8 purified water doubly again and continue decoction 1 hour, merge twice decocting liquid, filter, being evaporated to relative density is 1.10-1.30(65 DEG C) clear paste, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, conventional Chinese medicine peroral dosage form is clinically prepared by Chinese medicine preparation common process.
Preferred described extract oral dosage form is any one in the middle of pill, tablet, granule, capsule.
Preferably, Chinese medicine composition of the present invention is prepared into granule according to Chinese medicine preparation conventional fabrication process.In addition, the present invention's also application of this Chinese medicine preparation claimed in preparation treatment cataract medicine.
The invention has the beneficial effects as follows: the present invention for raw material, utilizes the comprehensive function treatment cataract of each taste medicine with natural Chinese medicine, have cure rate high, more after not easily recur, the advantage of safe without toxic side effect.
Detailed description of the invention
Embodiment 1
Get Flos Buddlejae 10 parts by weight, Spica Prunellae 10 parts, Flos sojae atricolor 13 parts, Semen Cassiae 10 parts, Fructus Lycii 13 parts, Radix Scrophulariae 10 parts, Radix Curcumae 10 parts, Herba Botrychii 12 parts, Azuritum 12 parts, Herba Equiseti Palustris 13 parts, Stigma Croci 10 parts, Fel python 8 parts, Radix Schizophragmatis denticulati 12 parts, Herba Cardamines Lyratae 13 parts, add the purified water of described medical material gross weight 8 times, decoct 3 hours, pour out decocting liquid, the purified water adding described medical material gross weight 6 times again continues decoction 1 hour, merge twice decocting liquid, filter, being evaporated to relative density is 1.10-1.30(65 DEG C) clear paste, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, granule 10 bags (amounting to crude drug 3.6g/ bag) is prepared by Chinese medicine preparation common process.
Embodiment 2
Get Flos Buddlejae 8 parts by weight, Spica Prunellae 8 parts, Flos sojae atricolor 10 parts, Semen Cassiae 8 parts, Fructus Lycii 10 parts, Radix Scrophulariae 8 parts, Radix Curcumae 8 parts, Herba Botrychii 10 parts, Azuritum 10 parts, Herba Equiseti Palustris 10 parts, Stigma Croci 8 parts, Fel python 5 parts, Radix Schizophragmatis denticulati 10 parts, Herba Cardamines Lyratae 10 parts, add the purified water of described medical material gross weight 6 times, decoct 2 hours, pour out decocting liquid, the purified water adding described medical material gross weight 5 times again continues decoction 1 hour, merge twice decocting liquid, filter, being evaporated to relative density is 1.10-1.30(65 DEG C) clear paste, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, granule is prepared by Chinese medicine preparation common process.
Embodiment 3
Get Flos Buddlejae 13 parts by weight, Spica Prunellae 13 parts, Flos sojae atricolor 15 parts, Semen Cassiae 13 parts, Fructus Lycii 15 parts, Radix Scrophulariae 13 parts, Radix Curcumae 13 parts, Herba Botrychii 15 parts, Azuritum 15 parts, Herba Equiseti Palustris 15 parts, Stigma Croci 13 parts, Fel python 10 parts, Radix Schizophragmatis denticulati 15 parts, Herba Cardamines Lyratae 15 parts, add the purified water of described medical material gross weight 0 times, decoct 4 hours, pour out decocting liquid, the purified water adding described medical material gross weight 8 times again continues decoction 1 hour, merge twice decocting liquid, filter, being evaporated to relative density is 1.10-1.30(65 DEG C) clear paste, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, granule is prepared by Chinese medicine preparation common process.
Embodiment 4
Get Flos Buddlejae 9 parts by weight, Spica Prunellae 9 parts, Flos sojae atricolor 12 parts, Semen Cassiae 12 parts, Fructus Lycii 12 parts, Radix Scrophulariae 8 parts, Radix Curcumae 10 parts, Herba Botrychii 12 parts, Azuritum 14 parts, Herba Equiseti Palustris 14 parts, Stigma Croci 10 parts, Fel python 10 parts, Radix Schizophragmatis denticulati 12 parts, Herba Cardamines Lyratae 14 parts, add the purified water of described medical material gross weight 8 times, decoct 3 hours, pour out decocting liquid, the purified water adding described medical material gross weight 6 times again continues decoction 1 hour, merge twice decocting liquid, filter, being evaporated to relative density is 1.10-1.30(65 DEG C) clear paste, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, granule is prepared by Chinese medicine preparation common process.
Embodiment 5
The pharmacodynamic study of Chinese medicine preparation of the present invention
Clinical observation material is as follows:
1. physical data: the case of collection is from the cataract patient of in March, 2012 ~ 2014 year March at my institute's ophthalmology outpatient clinic.Patient is totally 224 examples, 355 sick eyes, wherein female 135 example, man 89 example, eyes 132 example, left eye 56 example, right eye 36 example.Age 30-40 year, 4 example; 41-50 year, 27 example; 51-61 year, 54 example; 61-70 year, 125 example; More than 71 years old 14 examples; The course of disease is the shortest 2 months, the longest 8 years.
Classification: senile cataract 201 example; Initial phase 135 example; Immature phase 66 example; Complicated cataract 23 example.
2. treatment and care method: patient takes granule prepared by the embodiment of the present invention 1, and a day twice, each a bag (amounting to crude drug 3.6g/ bag) 30 days was a course for the treatment of.Period in a medicine must guard against the irritable foods such as raw, cold, pungent, peppery, and medicinal liquid decoction being taken warmly, takes a good rest.
3 efficacy assessment standards:
(1) fully recover: disappear completely by treating the symptoms such as rear blurred vision, indices recovers normal on inspection;
(2) effective: disappear by treating the basic or major part of the symptoms such as rear blurred vision, indices recovers normal substantially on inspection;
(3) invalid: by treating rear symptom without being clearly better.
4. therapeutic outcome
Patient is many reached recovery from illness or effective standard after 1 month, and cataract in initial stage patient effective percentage is higher than the period of maturation, and secondary is complicated cataract patient.
5 experiment conclusion
Known by therapeutic outcome, technical advantage of the present invention shows: total effective rate high and more after not easily recur.The present invention is according to organic conception, the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is made has nourishing the liver and kidney, replenishing vital essence to improve eyesight, clearing away heat-damp and promoting diuresis, the cataractous Chinese medicine preparation for the treatment of of expelling wind and removing nebula effect, particularly the medicament of embodiment 1 preparation is for both liver and kidney deficiency, and the nascent phase that asthenia of essence and blood or insufficiency of the spleen mistake fortune and stagnated heat of liver channel etc. cause, immature phase, complicated cataract all have good clinical efficacy, and after patient medication, curative effect is all good.

Claims (6)

1. treat a cataractous Chinese medicine preparation, it is characterized in that being made up of the raw material of following weight portion: Flos Buddlejae 8-13 part, Spica Prunellae 8-13 part, Flos sojae atricolor 10-15 part, Semen Cassiae 8-13 part, Fructus Lycii 10-15 part, Radix Scrophulariae 8-13 part, Radix Curcumae 8-13 part, Herba Botrychii 10-15 part, Azuritum 10-15 part, Herba Equiseti Palustris 10-15 part, Stigma Croci 8-13 part, Fel python 5-10 part, Radix Schizophragmatis denticulati 10-15 part, Herba Cardamines Lyratae 10-15 part.
2. the cataractous Chinese medicine preparation for the treatment of as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Flos Buddlejae 10 parts, Spica Prunellae 10 parts, Flos sojae atricolor 13 parts, Semen Cassiae 10 parts, Fructus Lycii 13 parts, Radix Scrophulariae 10 parts, Radix Curcumae 10 parts, Herba Botrychii 12 parts, Azuritum 12 parts, Herba Equiseti Palustris 13 parts, Stigma Croci 10 parts, Fel python 8 parts, Radix Schizophragmatis denticulati 12 parts, Herba Cardamines Lyratae 13 parts.
3. treat the preparation method of cataractous Chinese medicine preparation as claimed in claim 1 or 2 for one kind, it is characterized in that comprising the steps: to take Chinese medicine preparation raw material, add Chinese medicine preparation raw material gross weight 6-10 purified water doubly, decoct 2-4 hour, pour out decocting liquid, add Chinese medicine preparation raw material gross weight 5-8 purified water doubly again and continue decoction 1 hour, merge twice decocting liquid, filter, when being evaporated to 65 DEG C, relative density is the clear paste of 1.10-1.30, soft material made by the ethanol adding 95% concentration add dextrin mixing in clear paste after again, sieve series becomes granule, dry, conventional Chinese medicine peroral dosage form is clinically prepared by Chinese medicine preparation common process.
4. the cataractous Chinese medicine preparation for the treatment of as claimed in claim 1 or 2, is characterized in that: described Chinese medicine preparation is the one in pill, tablet, granule, capsule.
5. the cataractous Chinese medicine preparation for the treatment of as claimed in claim 4, is characterized in that: described Chinese medicine preparation is granule.
6. the application of the cataractous Chinese medicine preparation of the treatment described in claim 1 or 2 in the cataractous medicine of preparation treatment.
CN201410759704.7A 2014-12-12 2014-12-12 Traditional Chinese medicine preparation for treating cataract and preparation method thereof Withdrawn CN104383465A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105079320A (en) * 2015-09-09 2015-11-25 白玛仁增 Tibetan medicine compound preparation for treating eye diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104056000A (en) * 2014-06-28 2014-09-24 姜晓红 Traditional Chinese medicine for treating cataract

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104056000A (en) * 2014-06-28 2014-09-24 姜晓红 Traditional Chinese medicine for treating cataract

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105079320A (en) * 2015-09-09 2015-11-25 白玛仁增 Tibetan medicine compound preparation for treating eye diseases

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Application publication date: 20150304