CN104367957A - Marrow-tonifying and intelligence-improving preparation for treating cerebellar hypoplasia and preparation method thereof - Google Patents

Abstract

The invention discloses a marrow-tonifying and intelligence-improving preparation for treating cerebellar hypoplasia. The preparation is prepared from the following main raw materials in parts by weight: 10-16 parts of salvia miltiorrhiza, 3-6 parts of securinega suffruticosa, 5-10 parts of Corn Cervi Pantotrichum (processed with honey), 6-10 parts of the root of bidentate achyranthes, 4-8 parts of moutan bark, 6-9 parts of rhizoma acori graminei, 5-9 parts of pawpaw, 6-15 parts of Typhonium giganteum, 9-16 parts of radix curcumae, 8-15 parts of elecampane, 5-8 parts of glossy privet fruit and 4-8 parts of gastrodia elata. The drug effects of various raw material medicines supplement each other, the preparation has the effects of regulating blood and tonifying blood, tonifying marrow and improving intelligence and refreshing the brain and nourishing the heart and can activate dormant nerve cells of patients and accelerate blood circulation of the body. The components of the preparation are compatible with one another, the curative effect is obvious, and the gap of treatment of cerebellar hypoplasia in the field of traditional Chinese medicine is filled.

Description

Cerebellar hypoplasia mends marrow intelligence-raising formulation and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of cerebellar hypoplasia and mend marrow intelligence-raising formulation and method for making.

Background technology

Cerebellar hypoplasia is that cerebellum development is immature.Form in certain stage that it rests on embryo.Underdevelopment of cerebellum can be vermis cerebelli or hemisphaerium cerebelli does not reach full growth, and vermis cerebelli dysplasia can be independently deformity or the lopsided ingredient of Dandy-Walker.Several cases is often dead before 10 years old, and pathological changes is the lighter comparatively, and cerebella signs can be compensatory gradually and take a turn for the better.Cerebellar hypoplasia is the healthy disease of a kind of serious harm children's, infant is fullly tortured with a disease, can not grows up healthy and sound as normal child.If infant is treated not in time, severe patient can cause cerebral palsy of children, the physical and mental health of serious harm child and future development, brings certain burden also to family and society simultaneously.The motor capacity of cerebellar hypoplasia child is far below cotemporary normal child, and motion control is poor.Just hands, the foot-propelled of obstacle mild degree slightly seem dumb or clumsy, and serious then both hands can not grab thing, and both feet can not be walked, and what have even can not stand up, and can not sit up, and can not stand, and can not chew normally and swallow.Most of cerebral dysplasia child may with aphasis in various degree, dysnoesia and perceptual disturbance.

The clinical common factor of child's cerebral dysgenesis: 1. low birthweight infant: comprise premature labor premature infant, small for date infant.These babies intrauterine growth retardation all in various degree.Also affect development of central nervous system simultaneously, and Chang Bingfa SEH and intraventricular hemorrhage, the latter Yi Yinqi Little's disease.Easily cause cerebral dysplasia.2. birth defect: comprise the encephalodysplasia that a variety of causes causes, easily cause cerebral dysplasia.As araphia causes the flat agyria that full forebrain caused by congenital hydrocephalus, brain vesicles evolution dysplasia and nervous tissue divide a word with a hyphen at the end of a line caused by obstacle, pachygyria and little polygyria etc., the septum pellucidum comprised caused by associating obstacle lacks as or hypoplasia.3. neonatal hypoxia ischemia: therefore allly can cause blood circulation and gas interchange disturbance between parent and fetus, or cause neonate arterial hypotension, venous congestion person, all likely causes cerebral hypoxia ischemia, causes cerebral lesion and leaves over cerebral palsy.This this factor comprises mother's factor: as suffered from pregnancy induced hypertension syndrome, heart failure, massive hemorrhage, anemia, shock or drug abuse, overdose etc.; Placental abnormality: as placental abruption, placenta previa, placental infarction or placental function bad etc.; Adhesive tape bloodstream blocking; As adhesive tape prolapsus, compressing, knotting or around neck etc., circulatory failure, erythrocytosis etc.4. bilirubin encephalopathy: the Important cause of disease being also cerebral dysgenesis, but now due to perinatal medicine progress, the cerebral dysplasia ratio that bilirubin encephalopathy causes declines.

But also do not occur at the medicament of field of Chinese medicines treatment cerebellar hypoplasia, just there is the medicament of many nourishing the brain and improving intelligence classes, picture publication number CN 101011549 A(application number 200710013432.6) patent document discloses a kind of liver and kidney tonifying, medicine of nourishing the brain and improving intelligence and preparation method thereof, its effective ingredient is made up of the raw material of following weight proportion, Fructus Mori 20-50g, Radix Polygoni Multiflori 20-50g, Fructus Lycii 8-16g, Fructus Schisandrae Chinensis 6-15g, Fructus Alpiniae Oxyphyllae 15-25g, Semen Ziziphi Spinosae 10-16g, Semen Platycladi 6-15g, Cortex Albiziae 10-16g, Radix Polygalae 10-16g, Radix Salviae Miltiorrhizae 10-20g, Radix Angelicae Sinensis 6-15g, Radix Puerariae 8-16g, Radix Codonopsis 10-20g, Rhizoma Acori Graminei 8-16g, Radix Achyranthis Bidentatae 2-5g.Publication number CN 102861290 A(application number 201210331789.X) patent document discloses a kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is: Fructus Alpiniae Oxyphyllae 1 weight portion, Rhizoma Curcumae Longae 0.2-3 weight portion.Publication number CN 101057948 A(application number 200610076789.4) patent document discloses a kind of there is nourishing the brain and improving intelligence, the Chinese medicine preparation of reposing of feeling at ease and preparation method thereof.It is prepared from primarily of active ingredient and/or adjuvant.Can be right doctor field treatment cerebellar hypoplasia in or blank out, the present invention also compensate for the vacancy of this art treatments cerebellar hypoplasia just.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of cerebellar hypoplasia to mend marrow intelligence-raising formulation, adopt Chinese crude drug comparatively common in the localities as raw material, the drug effect of each crude drug complements each other, for the pathomechanism of cerebellar hypoplasia, there is treating blood disorders QI invigorating, mend marrow Fructus Alpiniae Oxyphyllae, effect that brain-strengthening nourishes heart, the neuron of patient's dormancy can be activated, accelerate body blood circulation, its therapeutic effect is remarkable.Another object of the present invention is just to provide the preparation method that above-mentioned cerebellar hypoplasia mends marrow intelligence-raising formulation.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Cerebellar hypoplasia mends marrow intelligence-raising formulation, takes off the primary raw material stating weight proportion and is prepared from: Radix Salviae Miltiorrhizae 10-16 part; Cacumen Securinegae Suffruticosae 3-6 part; Cornu Cervi Pantotrichum (processed with honey) 5-10 part; Cattle rattan 6-10 part; Cortex Moutan 4-8 part; Rhizoma Acori Graminei 6-9 part; Fructus Chaenomelis 5-9 part; Herba Typhonii gigantei 6-15 part; Radix Curcumae 9-16 part; Radix Aucklandiae 8-15 part; Fructus Ligustri Lucidi 5-8 part; Rhizoma Gastrodiae 4-8 part.

Cerebellar hypoplasia mends marrow intelligence-raising formulation, and preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Salviae Miltiorrhizae 12-14 part; Cacumen Securinegae Suffruticosae 4-5 part; Cornu Cervi Pantotrichum (processed with honey) 6-9 part; Cattle rattan 7-9 part; Cortex Moutan 5-7 part; Rhizoma Acori Graminei 7-8 part; Fructus Chaenomelis 6-8 part; Herba Typhonii gigantei 9-12 part; Radix Curcumae 11-14 part; Radix Aucklandiae 10-13 part; Fructus Ligustri Lucidi 6-7 part; Rhizoma Gastrodiae 5-7 part.

Cerebellar hypoplasia mends marrow intelligence-raising formulation, and the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Salviae Miltiorrhizae 13 parts; Cacumen Securinegae Suffruticosae 4.5 parts; 8 parts, Cornu Cervi Pantotrichum (processed with honey); 8 parts, cattle rattan; Cortex Moutan 6 parts; Rhizoma Acori Graminei 7.5 parts; Fructus Chaenomelis 7 parts; Herba Typhonii gigantei 11 parts; Radix Curcumae 12 parts; The Radix Aucklandiae 12 parts; Fructus Ligustri Lucidi 6.5 parts; 6 parts, Rhizoma Gastrodiae.

Present invention also offers and above-mentioned cerebellar hypoplasia is mended the preparation method that marrow intelligence-raising formulation makes pharmaceutically acceptable syrup, granule, tablet and oral liquid.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation syrup, and step is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, alcohol content is made to be that 60%-80%(is preferred, alcohol content is 65%-75%, be more preferably, alcohol content is 70%), it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) by (preferred for the sucrose being equivalent to the 10%-20% of thick paste quality, be equivalent to the sucrose of the 13%-17% of thick paste quality, be more preferably, be equivalent to the sucrose of 15% of thick paste quality) make simple syrup, mix homogeneously with step (4) gained thick paste, add ethyl hydroxybenzoate, stir evenly, the purified water adding the 30%-40% quality of thick paste quality is (preferred, add the purified water of the 33%-37% quality of thick paste quality, be more preferably, add the purified water of 35% quality of thick paste quality), stir, sterile packaged.

According to preparation method recited above, preferred scheme is: the consumption of step (5) ethyl hydroxybenzoate is the 0.1%-0.2% of thick paste quality, is more preferably, and the consumption of ethyl hydroxybenzoate is 0.15% of thick paste quality.

Instructions of taking: each 4-6ml, takes with after warm water dilution, every day 3 times, 10 days courses for the treatment of.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation granule, and step is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) by (preferred for the sucrose being equivalent to the 10%-20% of thick paste quality, be equivalent to the sucrose of the 13%-17% of thick paste quality, be more preferably, be equivalent to the sucrose of 15% of thick paste quality) make simple syrup, mix homogeneously with step (4) gained thick paste, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

According to preparation method recited above, preferred scheme is: step (2) adds ethanol, makes alcohol content be that 60%-80%(is preferred, makes alcohol content be 65%-75%, be more preferably, make alcohol content be 70%).

Instructions of taking: each 1 parcel, takes after dissolving by the warm water of 35-45 DEG C, every day 3 times, 10 days courses for the treatment of.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation tablet, and step is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) mixed by the thick paste of step (2)-(3) gained, add step (1) gained powder, mix homogeneously, add the starch taking out high-quality 10%, mixing, sieves, makes granule, dry, is pressed into tablet, sugar coating.

Instructions of taking: each 2-4 sheet, every day 3 times, 10 days courses for the treatment of.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation oral liquid, and step is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, alcohol content is made to be that 60%-80%(is preferred, alcohol content is 65%-75%, be more preferably, alcohol content is 70%), it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), get supernatant,

(4) supernatant of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute, be more preferably 15 minutes), carry out sterile packaged with the dosage often propping up 6ml.

According to preparation method recited above, preferred scheme is: the consumption of step (4) sodium benzoate is the 0.1%-0.3%(preferably 0.2% of concentrated solution quality), correctives uses sucrose, and consumption is the 6%-8%(preferably 7% of concentrated solution quality).

Instructions of taking: each 1, every day 3 times, 10 days courses for the treatment of.

The pharmacological effect of each crude drug is respectively:

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.GUIXIN, Liver Channel.For the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Cacumen Securinegae Suffruticosae: sweet in the mouth, micro-pungent, warm in nature.Return liver,kidney,spleen three warp.For browse and the root of dicotyledon medicine euphorbia plant Cacumen Securinegae Suffruticosae, leaf is containing Securinine, and duration of flowering content is the highest, minimum during result, and in cured leaf, content is generally 0.2-0.3%.Tender stem and mature fruit are also containing Securan-11-one., and content is high not as good as leaf.Ye Zhongshang is containing globulariacitrin, tannin, a small amount of other Securinine, dihydrosecurinine and three kinds of securinols: securinol A, securinol B, securinol C etc.Root containing volume Bie Securinine (0.42%), a small amount of Securinine and Bie Securinine methoxy compound.There is relaxing muscles and tendons to promote blood circulation, effect of tonifying speen and tonifying kidney.For lumbago due to pathogenic wind-dampness, numb limbs and tense tendons, hemiplegia, sexual impotence, facial paralysis, poliomyelitis sequela.

Cornu Cervi Pantotrichum: sweet in the mouth, salty, warm in nature.Return kidney, Liver Channel.For the young horn of the unossified close raw fine hair of stag of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus.There is invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjust punching to appoint, effect of holder sore.For sexual impotence spermatorrhea, cold womb is infertile, wins thin, Mental fatigue, fear of cold, and dizzy Hiccough and deaf, spinal column cold type of pain, muscles and bones flaccidity is soft, bleeding not during menses, and carbuncle of yin nature is not held back.Cornu Cervi Pantotrichum (processed with honey): diluted by refined honey with warm water, is placed in pot, and moderate heat heats, and drops into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, sieve after sweet liquid boiling.

Niu Teng: bitter in the mouth, cool in nature.Return liver, urinary bladder channel.For stem and the root of that rattan of plants of Lardizabalaceae or that rattan of caudal lobe.There is the dissipating blood stasis that dispels the wind, pain relieving, effect of inducing diuresis to remove edema.For rheumatic arthralgia, traumatic pain, various neuropathic pain, dysuria, edema.

Cortex Moutan: bitter in the mouth, pungent, cold nature.GUIXIN, liver, kidney channel.For the dry root bark of ranunculaceae peony.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Rhizoma Acori Graminei: another name have Rhizoma Acori Graminei, prosperous grass, spring snow, water Rhizoma Acori Graminei etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.For the dry rhizome of acorus gramineus araceae plant.There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.

Fructus Chaenomelis: sour in the mouth, warm in nature.Return liver, spleen channel.For the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.There is suppressing the hyperactive liver relaxing muscles and tendons, effect of stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.

Herba Typhonii gigantei: acrid in the mouth, sweet, warm in nature.Return stomach, Liver Channel.For the herb of aroid Herba Typhonii gigantei.There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of detoxicating and resolving stagnation of pathogens pain relieving.Oblique for air port eye in caused by wind-phlegm, infantile convulsion epilepsy, tetanus, migraine etc.; Tuberculous lymphadenitis, swollen ulcer drug and venom.

Radix Curcumae: acrid in the mouth, hardship, cold in nature.Return liver, the heart, lung meridian.For the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.For the dry root of the feverfew Radix Aucklandiae.There are promoting the circulation of QI to relieve pain, effect of strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, cool in nature.Return liver, kidney channel.For the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.There is nourishing the liver and kidney, effect of improving eyesight black hair.For Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.

Rhizoma Gastrodiae: sweet in the mouth, property is put down.Return Liver Channel.For the dry tuber of orchid Rhizoma Gastrodiae.There is effect of suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.

Cerebellar hypoplasia of the present invention mends marrow intelligence-raising formulation, for the pathomechanism of cerebellar hypoplasia, meet the theory of the traditional Chinese medical science about treatment cerebellar hypoplasia, the present invention adopts pure natural draft Chinese medicine unique formula and technique to refine and forms, the drug effect of each crude drug complements each other, there is treating blood disorders QI invigorating, mend marrow Fructus Alpiniae Oxyphyllae, effect that brain-strengthening nourishes heart, the neuron of patient's dormancy can be activated, accelerate body blood circulation.The mutual compatibility of this product component, evident in efficacy, compensate for the vacancy of tcm field treatment cerebellar hypoplasia.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1cerebellar hypoplasia mends marrow intelligence-raising formulation, takes off to state primary raw material and be prepared from (getting 30g for every part): Radix Salviae Miltiorrhizae 10 parts; Cacumen Securinegae Suffruticosae 3 parts; 5 parts, Cornu Cervi Pantotrichum (processed with honey); 6 parts, cattle rattan; Cortex Moutan 4 parts; Rhizoma Acori Graminei 6 parts; Fructus Chaenomelis 5 parts; Herba Typhonii gigantei 6 parts; Radix Curcumae 9 parts; The Radix Aucklandiae 8 parts; Fructus Ligustri Lucidi 5 parts; Rhizoma Gastrodiae 4-8 part.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation syrup, and step is as follows:

(1) diluted by refined honey with the warm water of 50 DEG C, be placed in pot, moderate heat heats, and drops into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 350 mesh sieves after sweet liquid boiling;

(2) Radix Salviae Miltiorrhizae is cut into segment, adds the hot water of 80 DEG C, extract twice, merge extractive liquid, filter, filtrate is evaporated to the clear paste that relative density is 1.20 at 60 DEG C, and cooling, adds ethanol, make alcohol content be 70%, leave standstill 10 hours, get supernatant, decompression recycling ethanol, and be concentrated into thick paste;

(3) Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, decoct with water 40 minutes, Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 30 minutes, twice filtrate merges, leave standstill 5 hours, get supernatant concentration and become (at 60 DEG C) relative density to be the thick paste of 1.20;

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) sucrose of be equivalent to thick paste quality 15% is made simple syrup, mix homogeneously with step (4) gained thick paste, add the ethyl hydroxybenzoate of 0.15% of thick paste quality, stir evenly, add the purified water of 35% of thick paste quality, stir, sterile packaged.

Instructions of taking: each 4-6ml, takes with after warm water dilution, every day 3 times, 10 days courses for the treatment of.

model case oneold XX, female, 2 years old, Accessories during Binzhou, Shandong Province from Huimin County.Lost 2 years old at present, still can not walk, knee turns over slightly afterwards, and health is partially thin.Congenital maldevelopment of brain is diagnosed as in hospital when child is one-year-old.Some medicines of doctor prescribed are used by baby clothes.Beaten nerve growth factor to treat cerebral dysgenesis to child's low dose, but effect is bad simultaneously.Afterwards, promote cerebellum development, spray closed liquid medicine every day, acupuncture adds massage.Treat half wheat harvesting period, child is not said by many crime, does not but obtain positive effect.

Cerebellar hypoplasia of the present invention mends the curative effect of marrow intelligence-raising formulation pretty good to listen the father and mother of an infant to say afterwards, can take care of oneself after his family child takes this exactly.Perceptual image has caught like a straw to clutch at that time, so buy embodiment 1 gained cerebellar hypoplasia to mend 2 courses for the treatment of of marrow intelligence-raising formulation syrup, after having taken, the mental status of child makes moderate progress, tease time her and can rush your smile, people can be allowed to hold up and walk ten multisteps.Take again 2 courses for the treatment of, oneself can attempt and walk, just more easily fall down relative to child of the same age, the diet of child also improves than in the past a lot.Visit after half a year, learn that child can take care of oneself.

embodiment 2cerebellar hypoplasia mends marrow intelligence-raising formulation, takes off to state primary raw material and be prepared from (getting 25g for every part): Radix Salviae Miltiorrhizae 12 parts; Cacumen Securinegae Suffruticosae 4 parts; 6 parts, Cornu Cervi Pantotrichum (processed with honey); 7 parts, cattle rattan; Cortex Moutan 5 parts; Rhizoma Acori Graminei 7 parts; Fructus Chaenomelis 6 parts; Herba Typhonii gigantei 9 parts; Radix Curcumae 11 parts; The Radix Aucklandiae 10 parts; Fructus Ligustri Lucidi 6 parts; 5 parts, Rhizoma Gastrodiae.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation granule, and step is as follows:

(1) diluted by refined honey with the warm water of 50 DEG C, be placed in pot, moderate heat heats, and drops into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 350 mesh sieves after sweet liquid boiling;

(2) Radix Salviae Miltiorrhizae is cut into segment, adds the hot water of 80 DEG C, extract twice, merge extractive liquid, filter, filtrate is evaporated to the clear paste that relative density is 1.20 at 60 DEG C, and cooling, adds ethanol, make alcohol content be 70%, leave standstill 10 hours, get supernatant, decompression recycling ethanol, and be concentrated into thick paste;

(3) Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, decoct with water 40 minutes, Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 30 minutes, twice filtrate merges, leave standstill 5 hours, get supernatant concentration and become (at 60 DEG C) relative density to be the thick paste of 1.20;

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) sucrose of be equivalent to thick paste quality 15% is made simple syrup, mix homogeneously, make uniform granule, be aided with pharmaceutically acceptable carrier package with step (4) gained thick paste, the quality of every parcel is 6g.

Instructions of taking: each 1 parcel, takes after dissolving by the warm water of 35-45 DEG C, every day 3 times, 10 days courses for the treatment of.

model case twoglad XX, man, 4 years old, Jinan City, Shandong Province people from Zhangqiu City.Infant full-term normal delivery is raw, without anoxia, suffocates, without jaundice etc.When infant six months, head can't well be erect, the mobility also non-constant of extremity, and very little thing is also taken incessantly.Thought that child was more lazy at that time, and do not like grabbing by thing.Until find when within 1 years old, staying wheat harvesting period to occur two lower limb astasia, can not walk, when holding up walking, left foot point lands, and left knee joint hyperextension is easily fallen.In hospitalize, be diagnosed as cerebellar hypoplasia, treat a wheat harvesting period and have no result.

Through making some inquiries about, recognize that the curative effect of cerebellar hypoplasia of the present invention benefit marrow intelligence-raising formulation is pretty good, so buy embodiment 2 gained cerebellar hypoplasia to mend 2 courses for the treatment of of marrow intelligence-raising formulation granule, after having taken, the walk of child makes moderate progress, still can fall, just number of times obviously reduces a lot than in the past, and hands also can take lighter thing to continue a few minutes.See this curative effect, its father and mother are very delight, bought again 2 courses for the treatment of, taken the rear discovery state of an illness and have been clearly better, both hands stretch freely, and grab thing comparatively flexibly, can walk slowly alone, no longer need others to assist in, can control oneself and have a meal, defecation also almost can take care of oneself.Visit after half a year and learn, can take care of oneself, its father and mother very gratitude.

embodiment 3cerebellar hypoplasia mends marrow intelligence-raising formulation, takes off to state primary raw material and be prepared from (getting 20g for every part): Radix Salviae Miltiorrhizae 14 parts; Cacumen Securinegae Suffruticosae 5 parts; 9 parts, Cornu Cervi Pantotrichum (processed with honey); 9 parts, cattle rattan; Cortex Moutan 7 parts; Rhizoma Acori Graminei 8 parts; Fructus Chaenomelis 8 parts; Herba Typhonii gigantei 12 parts; Radix Curcumae 14 parts; The Radix Aucklandiae 13 parts; Fructus Ligustri Lucidi 7 parts; 7 parts, Rhizoma Gastrodiae.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation tablet, and step is as follows:

(1) diluted by refined honey with the warm water of 50 DEG C, be placed in pot, moderate heat heats, and drops into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 350 mesh sieves after sweet liquid boiling;

(2) Radix Salviae Miltiorrhizae is cut into segment, adds the hot water of 80 DEG C, extract twice, merge extractive liquid, filter, filtrate is evaporated to the clear paste that relative density is 1.20 at 60 DEG C, and cooling, adds ethanol, leave standstill 10 hours, get supernatant, decompression recycling ethanol, and be concentrated into thick paste;

(3) Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, decoct with water 40 minutes, Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 30 minutes, twice filtrate merges, leave standstill 5 hours, get supernatant concentration and become (at 60 DEG C) relative density to be the thick paste of 1.20;

(4) mixed by the thick paste of step (2)-(3) gained, add step (1) gained powder, mix homogeneously, add the starch taking out high-quality 10%, mixing, sieves, makes granule, dry, is pressed into tablet, sugar coating.

Instructions of taking: each 2-4 sheet, every day 3 times, 10 days courses for the treatment of.

model case threeguo XX, man, 9 years old, people from Luozhuang District, Linyi .not mature premature labor, has stayed one week in couveuse.Found that child grew compared with normal child afterwards all more late, during six months sizes, hands can't grab object, can't sit during 9 months sizes, can only climb a few step, also easily will toward askew.Also can not walk when 1 year old 7 months, not sociable yet.Until 9 years old soon, speech stutter is unclear, always bumpy, and always speaking, the language fails to express the meaning, and equilibrium sense is very poor, and easily fall down on foot, understandability is very poor, always do not understand others and what is being said.Put his forehead gently with finger, be originally seated he whole people can take advantage of a situation and lie down, collapsing in the ground, similarly is do not have like long bone with it.Remove examination in hospital, be diagnosed as cerebellar hypoplasia, but owing to missing golden hour, doctor says and dare not ensure therapeutic effect.

Sick in order to cure this, his father's master tape son and is gone to hospital of too much family, but effect is not fine.Mother listened friend to be right to cure therapeutic effect pretty good afterwards, so take after embodiment 3 gained cerebellar hypoplasia mends 2 courses for the treatment of of marrow intelligence-raising formulation tablet, the situation of always falling down on foot reduces to some extent.After continuing to take 2 courses for the treatment of, language competence also takes a turn for the better to some extent, can be good at the meaning understanding others, realizes that it gradually likes oneself walking, has many times fallen down and also can oneself.When removing examination in hospital, recovery so fast, doctor also feels very surprised.Visit after 1 year, learn and substantially can take care of oneself.

embodiment 4cerebellar hypoplasia mends marrow intelligence-raising formulation, takes off to state primary raw material and be prepared from (getting 10g for every part): Radix Salviae Miltiorrhizae 13 parts; Cacumen Securinegae Suffruticosae 4.5 parts; 8 parts, Cornu Cervi Pantotrichum (processed with honey); 8 parts, cattle rattan; Cortex Moutan 6 parts; Rhizoma Acori Graminei 7.5 parts; Fructus Chaenomelis 7 parts; Herba Typhonii gigantei 11 parts; Radix Curcumae 12 parts; The Radix Aucklandiae 12 parts; Fructus Ligustri Lucidi 6.5 parts; 6 parts, Rhizoma Gastrodiae.

Described cerebellar hypoplasia mends the preparation method of marrow intelligence-raising formulation oral liquid, and step is as follows:

(1) diluted by refined honey with the warm water of 50 DEG C, be placed in pot, moderate heat heats, and drops into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 350 mesh sieves after sweet liquid boiling;

(2) Radix Salviae Miltiorrhizae is cut into segment, adds the hot water of 80 DEG C, extract twice, merge extractive liquid, filter, filtrate is evaporated to the clear paste that relative density is 1.20 at 60 DEG C, and cooling, adds ethanol, make alcohol content be 70%, leaves standstill 10 hours, gets supernatant;

(3) Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, decoct with water 40 minutes, Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 30 minutes, twice filtrate merges, leave standstill 5 hours, get supernatant;

(4) supernatant of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously, be concentrated into 1/2 of original volume, add the correctives of the sodium benzoate of 0.2% of concentrated solution quality and 7% of concentrated solution quality, mixing, sterilizes 15 minutes, carries out sterile packaged with the dosage often propping up 6ml.

Instructions of taking: each 1, every day 3 times, 10 days courses for the treatment of.

test example:in order to verify that the cerebellar hypoplasia of embodiment 4 gained mends the curative effect of marrow intelligence-raising formulation oral liquid, We conducted contrast test.Patient 250 people is selected in experiment, and be divided into matched group and experimental group randomly, wherein experimental group has 150 people, and matched group has 100 people.Before test 1 week, Continuous Observation is carried out to this crowd, record symptom and change.Experimental group: take embodiment 4 gained cerebellar hypoplasia and mend marrow intelligence-raising formulation oral liquid, each 1, every day 3 times, 10 days courses for the treatment of.Matched group: adopt other treatment scheme, such as take Western medicine, acupuncture etc.Our every days same equal time, medication under square one, and the health of observing simultaneously, recording every group patient.Curative effect situation criterion: cure: after 4 courses for the treatment of, more than 2 years old can take care of oneself completely, substantially return to child's level of the same age within 2 years old.Effective: after 4 courses for the treatment of, all symptoms are alleviated to some extent, more than 2 years old can oneself walk, also someone can hold up ten multisteps of walking within 2 years old.Invalid: after 4 courses for the treatment of, all symptoms are without any improvement.Wherein effectively comprise recovery from illness and effective.Adopt the matched group of other treatment scheme and use embodiment 4 gained cerebellar hypoplasia to mend the Comparison of therapeutic of the experimental group of marrow intelligence-raising formulation oral liquid, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, the inefficiency taking the embodiment of the present invention 4 gained cerebellar hypoplasia benefit marrow intelligence-raising formulation oral liquid is only 6%, and cure rate is up to 66%, effective percentage is up to 94%, and adopt other treatment scheme have 22% inefficiency, cure rate only reaches 32%, and effective percentage is also only 78%.Experiment shows that taking embodiment 4 gained cerebellar hypoplasia mends marrow intelligence-raising formulation oral liquid compared with employing other treatment scheme (such as taking Western medicine, acupuncture etc.), and it is evident in efficacy, and cure rate is high, and inefficiency is low.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. cerebellar hypoplasia mends marrow intelligence-raising formulation, it is characterized in that, takes off the primary raw material stating weight proportion and be prepared from: Radix Salviae Miltiorrhizae 10-16 part; Cacumen Securinegae Suffruticosae 3-6 part; Cornu Cervi Pantotrichum (processed with honey) 5-10 part; Cattle rattan 6-10 part; Cortex Moutan 4-8 part; Rhizoma Acori Graminei 6-9 part; Fructus Chaenomelis 5-9 part; Herba Typhonii gigantei 6-15 part; Radix Curcumae 9-16 part; Radix Aucklandiae 8-15 part; Fructus Ligustri Lucidi 5-8 part; Rhizoma Gastrodiae 4-8 part.

2. cerebellar hypoplasia according to claim 1 mends marrow intelligence-raising formulation, it is characterized in that, takes off the primary raw material stating weight proportion and be prepared from: Radix Salviae Miltiorrhizae 12-14 part; Cacumen Securinegae Suffruticosae 4-5 part; Cornu Cervi Pantotrichum (processed with honey) 6-9 part; Cattle rattan 7-9 part; Cortex Moutan 5-7 part; Rhizoma Acori Graminei 7-8 part; Fructus Chaenomelis 6-8 part; Herba Typhonii gigantei 9-12 part; Radix Curcumae 11-14 part; Radix Aucklandiae 10-13 part; Fructus Ligustri Lucidi 6-7 part; Rhizoma Gastrodiae 5-7 part.

3. cerebellar hypoplasia according to claim 1 mends marrow intelligence-raising formulation, it is characterized in that, takes off the primary raw material stating weight proportion and be prepared from: Radix Salviae Miltiorrhizae 13 parts; Cacumen Securinegae Suffruticosae 4.5 parts; 8 parts, Cornu Cervi Pantotrichum (processed with honey); 8 parts, cattle rattan; Cortex Moutan 6 parts; Rhizoma Acori Graminei 7.5 parts; Fructus Chaenomelis 7 parts; Herba Typhonii gigantei 11 parts; Radix Curcumae 12 parts; The Radix Aucklandiae 12 parts; Fructus Ligustri Lucidi 6.5 parts; 6 parts, Rhizoma Gastrodiae.

4. mend marrow intelligence-raising formulation according to the arbitrary described cerebellar hypoplasia of claim 1-3, it is characterized in that, this cerebellar hypoplasia can be mended marrow intelligence-raising formulation and make pharmaceutically acceptable syrup, preparation method is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, alcohol content is made to be that 60%-80%(is preferred, alcohol content is 65%-75%, be more preferably, alcohol content is 70%), it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) by (preferred for the sucrose being equivalent to the 10%-20% of thick paste quality, be equivalent to the sucrose of the 13%-17% of thick paste quality, be more preferably, be equivalent to the sucrose of 15% of thick paste quality) make simple syrup, mix homogeneously with step (4) gained thick paste, add ethyl hydroxybenzoate, stir evenly, the purified water adding the 30%-40% quality of thick paste quality is (preferred, add the purified water of the 33%-37% quality of thick paste quality, be more preferably, add the purified water of 35% quality of thick paste quality), stir, sterile packaged.

5. preparation method according to claim 4, is characterized in that: the consumption of step (5) ethyl hydroxybenzoate is the 0.1%-0.2% of thick paste quality, is more preferably, and the consumption of ethyl hydroxybenzoate is 0.15% of thick paste quality.

6. mend marrow intelligence-raising formulation according to the arbitrary described cerebellar hypoplasia of claim 1-3, it is characterized in that, this cerebellar hypoplasia can be mended marrow intelligence-raising formulation and make pharmaceutically acceptable granule, preparation method is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) thick paste of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously;

(5) by (preferred for the sucrose being equivalent to the 10%-20% of thick paste quality, be equivalent to the sucrose of the 13%-17% of thick paste quality, be more preferably, be equivalent to the sucrose of 15% of thick paste quality) make simple syrup, mix homogeneously with step (4) gained thick paste, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

7. preparation method according to claim 6, is characterized in that: step (2) adds ethanol, makes alcohol content be that 60%-80%(is preferred, makes alcohol content be 65%-75%, be more preferably, make alcohol content be 70%).

8. mend marrow intelligence-raising formulation according to the arbitrary described cerebellar hypoplasia of claim 1-3, it is characterized in that, this cerebellar hypoplasia can be mended marrow intelligence-raising formulation and make pharmaceutically acceptable tablet, preparation method is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant, decompression recycling ethanol, and be concentrated into thick paste,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), getting supernatant concentration becomes (at 60 DEG C) relative density to be that the thick paste of 1.10-1.30 is (preferred, be condensed into the thick paste that relative density is 1.15-1.25, be more preferably, be condensed into the thick paste that relative density is 1.20),

(4) mixed by the thick paste of step (2)-(3) gained, add step (1) gained powder, mix homogeneously, add the starch taking out high-quality 10%, mixing, sieves, makes granule, dry, is pressed into tablet, sugar coating.

9. mend marrow intelligence-raising formulation according to the arbitrary described cerebellar hypoplasia of claim 1-3, it is characterized in that, this cerebellar hypoplasia can be mended marrow intelligence-raising formulation and make pharmaceutically acceptable oral liquid, preparation method is as follows:

(1) (preferably, with the warm water of 45 DEG C-55 DEG C, be more preferably with the warm water of 40 DEG C-60 DEG C, warm water with 50 DEG C) refined honey is diluted (1/3-2/3 that water consumption is the quality of honey), be placed in pot, moderate heat heats, after sweet liquid boiling, drop into Cornu Cervi Pantotrichum, constantly stir-fry, when sweet liquid is inhaled saturating, stop heating, take out airing, dry, pulverize, cross 300-400 mesh sieve (preferred, cross 330-370 mesh sieve, be more preferably, cross 350 mesh sieves);

(2) Radix Salviae Miltiorrhizae is cut into segment, the hot water adding 70 DEG C-90 DEG C is (preferred, add the hot water of 75 DEG C-85 DEG C, be more preferably, add the hot water of 80 DEG C), extract twice, merge extractive liquid, filter, it is (preferred that filtrate is evaporated to the clear paste that relative density is 1.10-1.30 at 60 DEG C, be concentrated into the clear paste that relative density is 1.10-1.30, be more preferably, be concentrated into the clear paste that relative density is 1.20), cooling, add ethanol, alcohol content is made to be that 60%-80%(is preferred, alcohol content is 65%-75%, be more preferably, alcohol content is 70%), it is (preferred to leave standstill 8-12 hour, leave standstill 9-11 hour, be more preferably, leave standstill 10 hours), get supernatant,

(3) by Cacumen Securinegae Suffruticosae, Niu Teng, Cortex Moutan, Rhizoma Acori Graminei, Radix Curcumae and the Radix Aucklandiae are cut into chunks, be placed in marmite, it is (preferred to decoct with water 30-50 minute, decoct 35-45 minute, be more preferably, decoct 40 minutes), by Fructus Chaenomelis, Fructus Ligustri Lucidi, Rhizoma Gastrodiae and Herba Typhonii gigantei are ground into coarse powder, load in medicated bag, put into marmite, continue decoction twice, each decoction 20-40 minute is (preferred, decoct 25-35 minute, be more preferably, decoct 30 minutes), twice filtrate merges, it is (preferred to leave standstill 3-7 hour, leave standstill 4-6 hour, be more preferably, leave standstill 5 hours), get supernatant,

(4) supernatant of step (2)-(3) gained is mixed, add step (1) gained powder, mix homogeneously, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute, be more preferably 15 minutes), carry out sterile packaged with the dosage often propping up 6ml.

10. preparation method according to claim 9, is characterized in that: the consumption of step (4) sodium benzoate is the 0.1%-0.3%(preferably 0.2% of concentrated solution quality), correctives uses sucrose, and consumption is the 6%-8%(preferably 7% of concentrated solution quality).