CN106853207A - It is a kind of to treat Chinese medicine composition of adolescent myopia and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for treating adolescent myopia, it is obtained by the raw material of following weight portion：10 20 parts of the red sage root, 6 10 parts of riparian greenbrier root and rhizome, 6 14 parts of noodles dish, 11 15 parts of pyrola, 24 parts of Rhizoma Sparganii, 9 13 parts of Artemisia anomala, 59 parts of the Radix Astragali, 35 parts of catechu, 6 10 parts of Semen Cuscutae, 10 20 parts of Asiatic plantain, 24 parts of cuckooflower, 13 parts of passionflower, 48 parts of gynostemma pentaphylla, 5 10 parts of paris polyphylla.Chinese medicine composition of the present invention has inrigorating qi and promoting blood circulation, qi-restoratives kidney-nourishing, nourishes the liver to improve visual acuity and inducing diuresis and reducing edema effect, so that liver body the moon blood is filled, hepatic and renal function is normal, strengthens retinal photoreceptor cells function, solid eyeball tissue, increases neurotrophic factor in retina and cellular layer；Mesh system obtains the nutrition of abundance, and eye material and functional metabolism are normal, strengthen body self-healing ability and resistance, fundamentally treat adolescent myopia, treat both principal and secondary aspect of disease, have no toxic side effect.

Description

It is a kind of to treat Chinese medicine composition of adolescent myopia and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating adolescent myopia, the present invention is also related to And the preparation method of the Chinese medicine composition.

Background technology

Myopia refers to eye in the case where regulation is not used, and parallel rays (light that 5 meters of outer objects send) is through the in the wrong of eye After photosystem, before focusing on retina, the fuzzy image of only one of which on retina.Myopia is remote soon unclear, see it is near clear or Compare clear, show as vision disorder, visual fatigue etc..Adolescent myopia is one of current incidence of disease highest illness in eye, and China has A nearsighted person up to as many as 200,000,000 people, wherein：Pupil accounts for 30% or so, and middle school student account for 60% or so.With entering for the modern life The exacerbation of popularization and student's schoolwork burden of step, TV, computer etc., not only age of onset is carried current Children and teenager myopia Before, and the incidence of disease substantially increases, it has also become serious public health problem simultaneously causes the height of the Ministry of Education of the state and the Ministry of Public Health Pay attention to.Substantial amounts of medical research is confirmed, as myopia degree is deepened, myopia cause can blinding illness in eye also accordingly increase, such as ARM, detachment of retina, open-angle glaucoma etc..

Because the pathogenesis of myopia is not also fully aware of, so failing to obtain satisfied effect in terms of prevention and treatment Really, the method for various treatment myopia emerges in an endless stream.The method for the treatment of myopia is many at present, for example vision correction instrument, Micropole glasses, The therapies such as laser therapy, magnetic therapy, electrotherapy, acupuncture are generally.Although various therapies have certain curative effect, to a certain extent Do not consolidate to alleviation, but most of curative effects.The current treatment to myopia is still without a kind of preferable method.It is now socially universal What is used is still to wear spectacles.Although wearing spectacles can correct defects of vision, diopter is adjusted, to eyes in itself without treatment Effect, and the development of myopia can not be prevented.Currently in the urgent need to the medical personal of pharmaceutical technology field, vast green grass or young crops is solved as early as possible The prevention of juvenile myopia, treatment, consolidation, the problems such as thoroughly effect a radical cure.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine composition for treating adolescent myopia, the Chinese medicine composition can be from root Treat adolescent myopia on this, it is evident in efficacy, treat both principal and secondary aspect of disease, have no toxic side effect.

The technical solution adopted in the present invention is, a kind of Chinese medicine composition for treating adolescent myopia, by following weight portion Raw material be obtained：Red sage root 10-20 parts, riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 parts, Rhizoma Sparganii 2-4 parts, Liu posts Slave 9-13 parts, Radix Astragali 5-9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 parts, cuckooflower 2-4 parts, passionflower 1-3 Part, gynostemma pentaphylla 4-8 parts, paris polyphylla 5-10 parts.

Preferably, a kind of Chinese medicine composition for treating adolescent myopia, is obtained by the raw material of following weight portion：The red sage root 15 Part, 8 parts of riparian greenbrier root and rhizome, 10 parts of noodles dish, 13 parts of pyrola, 3 parts of Rhizoma Sparganii, 11 parts of Artemisia anomala, 7 parts of the Radix Astragali, 4 parts of catechu, Semen Cuscutae 8 Part, 15 parts of Asiatic plantain, 3 parts of cuckooflower, 2 parts of passionflower, 6 parts of gynostemma pentaphylla, 8 parts of paris polyphylla.

Second technical scheme of the present invention be, a kind of preparation side of the Chinese medicine composition for treating adolescent myopia Method, specifically implements according to following steps：

Step 1, weighs respectively by weight：Red sage root 10-20 parts, riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 parts, Rhizoma Sparganii 2-4 parts, Artemisia anomala 9-13 parts, Radix Astragali 5-9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 Part, cuckooflower 2-4 parts, passionflower 1-3 parts, gynostemma pentaphylla 4-8 parts, paris polyphylla 5-10 parts；

Step 2, each raw material mixing that step 1 is weighed, adds the cold water of 8 times of medicinal material gross weight, soaks 1h, and intense fire is boiled Boiling, is cooked by slow fire 1h, filters to obtain 1 filtrate；

Step 3, adds the cold water of 4 times of medicinal material gross weight, boils by intense fire, is cooked by slow fire 30min, filters to obtain 2 filtrates；

Step 4,1 filtrate and 2 filtrates are merged, and heating concentration is obtained final product.

The beneficial effects of the invention are as follows, the Chinese medicine composition of present invention treatment adolescent myopia, compatibility of drugs is scientific and reasonable, Preparation process is simple, with good inrigorating qi and promoting blood circulation, qi-restoratives kidney-nourishing, nourishes the liver to improve visual acuity and inducing diuresis and reducing edema effect so that liver body is cloudy Blood is filled, and hepatic and renal function is normal, strengthens retinal photoreceptor cells function, and solid eyeball tissue increases in retina and cellular layer Neurotrophic factor；Mesh system obtains the nutrition of abundance, and eye material and functional metabolism are normal, strengthen body self-healing ability and resistance Power, fundamentally treats adolescent myopia, evident in efficacy, treat both principal and secondary aspect of disease, have no toxic side effect.

Specific embodiment

With reference to specific embodiment, the present invention is described in detail.

The Chinese medicine composition of present invention treatment adolescent myopia, is obtained by the raw material of following weight portion：Red sage root 10-20 parts, Riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 parts, Rhizoma Sparganii 2-4 parts, Artemisia anomala 9-13 parts, Radix Astragali 5-9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 parts, cuckooflower 2-4 parts, passionflower 1-3 parts, gynostemma pentaphylla 4-8 parts, one, seven leaf 5-10 parts of flower.

The preparation method of the Chinese medicine composition of above-mentioned treatment adolescent myopia, specifically implements according to following steps：

Step 1, weighs respectively by weight：Red sage root 10-20 parts, riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 parts, Rhizoma Sparganii 2-4 parts, Artemisia anomala 9-13 parts, Radix Astragali 5-9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 Part, cuckooflower 2-4 parts, passionflower 1-3 parts, gynostemma pentaphylla 4-8 parts, paris polyphylla 5-10 parts；

Step 2, each raw material mixing that step 1 is weighed, adds the cold water of 8 times of medicinal material gross weight, soaks 1h, and intense fire is boiled Boiling, is cooked by slow fire 1h, filters to obtain 1 filtrate；

Step 3, adds the cold water of 4 times of medicinal material gross weight, boils by intense fire, is cooked by slow fire 30min, filters to obtain 2 filtrates；

Step 4,1 filtrate and 2 filtrates are merged, and heating concentration is obtained final product.

The usage and consumption of the Chinese medicine composition of present invention treatment adolescent myopia：Decocting is oral, a side be it is one, one day It is one, twice a day, respectively take 200ml within 1 hour after meal sooner or later.It is within 10 days 1 course for the treatment of, the general 4-6 courses for the treatment of can cure.

The pharmacology of each raw material is as follows：

The red sage root：Bitter, cold nature.The thoughts of returning home, Liver Channel.Promoting blood circulation, nourishing blood and tranquilization, cool blood detumescence.Cure mainly hemostasis head, chest, The side of body, abdomen pain, accumulation, irregular menstruation, dysmenorrhoea Amenorrhea, postpartum stasis of blood, joint pain beat the stasis of blood swell, and warm disease is vexed, the deficiency of blood Palpitaition, sore swollen toxin, red rash mange.

Riparian greenbrier root and rhizome：Sweet, hardship, it is mild-natured.Return liver warp.Inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening, dispelling, collateral-activating, expelling phlegm and arresting coughing.For wind Wet arthritis, arthralgia and myalgia, traumatic injury, lumbar muscle strain, bronchitis, pulmonary tuberculosis cough spitting of blood.

Noodles dish：It is sweet, it is cool in nature.The thoughts of returning home, Liver Channel.Yin-nourishing, heat-clearing, blood-arresting catamenia-regulating.For spitting blood, bleeding from five sense organs or subcutaneous tissue, tuberculosis cough, Spitting of blood, hematuria, irregular menstruation.

Pyrola：Sweet, hardship, it is warm in nature.Return lung, stomach, liver and kidney channel.Can qi-restoratives, kidney-nourishing, dispelling wind and eliminating dampness, promoting blood circulation for regulating menstruation, benefit The strong bone of kidney, cough-relieving, hemostasis.

Rhizoma Sparganii：Taste is pungent, hardship, it is mild-natured.Return liver, the spleen channel.Blood-breaking, Xiao Ji Zhi Tong.With blood-breaking, Xiao Ji Zhi Tong Effect.For abdominal mass lump in the abdomen, dysmenorrhoea, blood stasis closed, chest impediment and cardialgia, dyspepsia distending pain.

Artemisia anomala：Taste is pungent, slight bitter, it is warm in nature.The thoughts of returning home, liver and the spleen channel.Broken stasis of blood is stimulated the menstrual flow, hemostasia and detumescence, promoting digestion and removing indigestion.

The Radix Astragali：It is sweet, slightly warm in nature.Return lung, spleen, liver and kidney channel.Invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema. For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood is withered Huang, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..

Catechu：Bitter, puckery, cold nature.Clearing heat and eliminating phlegm, promotes the production of body fluid to quench thirst, stop blooding analgesic therapy, hygroscopic sore.Cure mainly phlegm-heat cough, Dysphoria with smothery sensation is quenched one's thirst, larynx numbness, aphtha, noma, spitting of blood, is spitted blood, and bleeding from five sense organs or subcutaneous tissue, hematuria is had blood in stool, bloody flux, metrorrhagia, traumatism and bleeding, hemorrhoid gall, Sore is not held back, eczema flowing water, leukorrhea.

Semen Cuscutae：It is sweet, pungent, slightly warm in nature.Return liver, kidney, the spleen channel.Tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity, antiabortive, improving eyesight and antidiarrheal, Astringent sperm contracting urine.

Car fare grass：It is sweet, light, cold nature.Return lung, liver, kidney, bladder warp.Reducing fever and causing diuresis, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm. Hidden from view for difficult urination, stranguria with turbid discharge under band, oedema turgor, summer-heat and damp rush down dysentery, hot eyes, the hot cough and asthma of phlegm.

Cuckooflower：It is sour, it is cold in nature.Return liver, lung, bladder warp.Clearing heat and promoting diuresis, cool blood dissipates the stasis of blood, subdhing swelling and detoxicating.Control diarrhea, dysentery Disease, jaundice, gonorrhoea, leukorrhea with reddish discharge, measles is spitted blood, and bleeding from five sense organs or subcutaneous tissue, abscess of throat, furunculosis, carbuncle swells, mange, haemorrhoids, prolapse of the anus, bruise is damaged Wound, burn.

Passionflower：Bitter, it is warm in nature.It is relieving cough and reducing sputum except wind heat-clearing.Control wind-heat dizzy, runny nose of having a stuffy nose.

Gynostemma pentaphylla：Sweet, hardship, cold nature.Return lung, spleen, kidney channel.QI invigorating, calms the nerves, and hypotensive is clearing heat and detoxicating, and cough-relieving is dispelled Phlegm.

Paris polyphylla：Bitter, it is cool in nature.The thoughts of returning home, liver, lung, stomach, large intestine channel.Internal heat anticance, swelling and pain relieving, heat-clearing arresting convulsion, Antitussive and antiasthmatic.For clearing heat and detoxicating, swelling and pain relieving, Japanese Type-B encephalitis, stomachache, appendicitis, scrofula, tonsillotome Inflammation, parotitis, mastitis, poisonous snake, insect-bite, sore swollen toxin.

In the present invention, the red sage root and riparian greenbrier root and rhizome are monarch, and the effect of play inrigorating qi and promoting blood circulation, dispelling, collateral-activating, enhancing body blood is followed Ring, promotes organism metabolism function, increases retinal photoreceptor cells function；Noodles dish, pyrola, Rhizoma Sparganii and Artemisia anomala are minister, are risen To qi-restoratives kidney-nourishing, the effect of promoting qi circulation and relieving pain, monarch drug in a prescription enhancing organism metabolism function is assisted, strengthen retinal photoreceptor cells function, adjusted Solution function of immune system, strengthens the toughness of scleral tissue；The Radix Astragali, catechu, Semen Cuscutae and Asiatic plantain are assistant, play nourishing the liver bright The effect of mesh, invigorating qi for consolidating superficies and reducing fever and causing diuresis, the abnormal heat of retinal pigment cell's layer is removed, solid eyeball tissue increases view Neurotrophic factor in film and cellular layer；Cuckooflower, passionflower, gynostemma pentaphylla and paris polyphylla play clearing heat and detoxicating to make, benefit Gas is calmed the nerves, and the effect of inducing diuresis and reducing edema, removes internal abnormal heat, suppresses sclera deformation, strengthens body self-healing ability and resistance.

Embodiment 1

A kind of Chinese medicine composition for treating adolescent myopia, is as obtained in the raw material of following weight portion：20 parts of the red sage root, ox 6 parts of waste dish, 6 parts of noodles dish, 11 parts of pyrola, 4 parts of Rhizoma Sparganii, 13 parts of Artemisia anomala, 9 parts of the Radix Astragali, 3 parts of catechu, 10 parts of Semen Cuscutae, car First careless 20 parts, 2 parts of cuckooflower, 1 part of passionflower, 4 parts of gynostemma pentaphylla, 5 parts of paris polyphylla.

The Chinese medicine composition of present invention treatment adolescent myopia is as obtained in following steps：

(1) weigh by weight during each bulk drug adds to marmite, add the cold water of 8 times of decocting herbs gross weight, soak 1h, Boil by intense fire, be cooked by slow fire 1h, filter to obtain 1 filtrate；

(2) boiled by intense fire to the cold water that 4 times of decocting herbs gross weight is added in marmite again, be cooked by slow fire 30min, filter 2 Secondary filtrate；

(3) 1 filtrate and 2 filtrates are merged, heating is concentrated into 400ml.

Embodiment 2

A kind of Chinese medicine composition for treating adolescent myopia, is as obtained in the raw material of following weight portion：15 parts of the red sage root, ox 8 parts of waste dish, 10 parts of noodles dish, 13 parts of pyrola, 3 parts of Rhizoma Sparganii, 11 parts of Artemisia anomala, 7 parts of the Radix Astragali, 4 parts of catechu, 8 parts of Semen Cuscutae, car First careless 15 parts, 3 parts of cuckooflower, 2 parts of passionflower, 6 parts of gynostemma pentaphylla, 8 parts of paris polyphylla.

Remaining is with embodiment 1.

Embodiment 3

A kind of Chinese medicine composition for treating adolescent myopia, is as obtained in the raw material of following weight portion：10 parts of the red sage root, ox 10 parts of waste dish, 14 parts of noodles dish, 15 parts of pyrola, 2 parts of Rhizoma Sparganii, 9 parts of Artemisia anomala, 5 parts of the Radix Astragali, 5 parts of catechu, 6 parts of Semen Cuscutae, car First careless 10 parts, 4 parts of cuckooflower, 3 parts of passionflower, 8 parts of gynostemma pentaphylla, 10 parts of paris polyphylla.

Remaining is with embodiment 1.

Clinical data

Physical data：Selection hospital outpatient adolescent myopia patient 140, is randomly divided into two groups；Treatment group 70 136 Eye, wherein man 36, female 34, age 8-18 Sui, average 10.6 years old, the course of disease -6 years 2 months；Control group 70 137, wherein man 35, female 35, age 8-18 Sui, average 10.9 years old, the course of disease -6 years 2 months.Two groups of physical data comparing differences are anticipated without statistics Justice (P>0.05), with comparativity.

Diagnostic criteria：The UCVA of patient is less than 4.8 (standard logarithmic visual acuity chart lamp SLD-II- types)；Through slit-lamp, eye Bottom spectroscopy excludes organic disease, is diagnosed as myopia；And meet Society of Ophthalmology of Chinese Medical Association ophthalmic dioptrics group system in 1985 True, pseudo-myopia the definition ordered and criteria for classification (referring to《Modern ophthalmology handbook》, Beijing, People's Health Publisher, 1993 Year, the 563-564 pages).

Exclusion standard：1) severe systemic diseases such as angiocarpy, the cerebrovascular, liver, kidney and hemopoietic system are associated with；Mental disease Patient；2) long-term taking other about drug therapy or apply other treatment methods, fail the completion person of controlling；3) there is pathologic near Depending on the obvious sufferer of Fundus oculi changes and visual function；4) suffer from eye and merge other illness in eye, affect the treatment judgement person；5) do not meet and include Standard, is not treated, it is impossible to judge the not congruent judgement person that affects the treatment of curative effect or data on time by regulation.

Treatment method：Chinese medicine composition of the invention is taken by treatment group, and one is one, twice a day, 1 hour after meal sooner or later Respectively take 200ml；It is within 10 days 1 course for the treatment of, shares 5 courses for the treatment of of medicine.The oral brightening piece (Chinese medicines quasi-word Z10983126) of control group, often Secondary 4-6 pieces, 3 times a day；It is within 10 days 1 course for the treatment of, shares 5 courses for the treatment of of medicine.

Treatment criterion：Reference《The diagnosis of common disease and efficacy determination (standard)》[M] Beijing：Chinese traditional Chinese medicine Publishing house, 2001：06) formulate：

Cure：Eyesight is improved and reaches 1.0 or more persons；

It is effective：Eyesight improves more than 2 grades but not up to 1.0；

Effectively：Eyesight improves 1-2 level persons；

It is invalid：Eyesight is increased less than 1 grade or without increased perosn.

Note：International standard logarithmic visual acuity chart is defined, and 1 grade is 1 row.

Cure rate=(curing/total eye number) × 100%.

Total effective rate=[﹙ healing+effective+You Xiao ﹚/total eye number] × 100%.

Statistical method：Statistical analysis are carried out using SPSS17.0 statistical softwares, measurement data is with mean ± standard deviationRepresent, checked using t, enumeration data rate relatively uses χ²Inspection.

Treatment results：The treatment results for the treatment of group and control group are shown in Table 1.

Treatment results after the application Chinese medicine composition of the invention of table 1

Compare with control group, P ＜ 0.05.

As shown in Table 1, treatment group cures 42, and effective 48, effective 39, invalid 7, cure rate is 30.9%, always Effective percentage is 94.9%；Control group cures 15, and effective 29, effective 39, invalid 54, cure rate is 10.9%, is always had Efficiency is 60.6%.2 groups of cure rates and total effective rate comparing difference You Tong meters learn Yi Yi ﹙ P<0.05 ﹚, treatment group's curative effect is substantially excellent In control group.

Vital sign is steady and without serious adverse reactions such as allergy in treatment group's therapeutic process, to treatment group after treatment end Lab index blood routine, stool routine examination, urine routine, electrocardiogram of patient etc. carry out statistical procedures, show no obvious abnormalities. Result shows that clinical application of the invention is safely and effectively, to be worth further research and popularization and application.

Claims (3)

1. a kind of Chinese medicine composition for treating adolescent myopia, it is characterised in that be obtained by the raw material of following weight portion：The red sage root 10-20 parts, riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 parts, Rhizoma Sparganii 2-4 parts, Artemisia anomala 9-13 parts, Radix Astragali 5- 9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 parts, cuckooflower 2-4 parts, passionflower 1-3 parts, gynostemma pentaphylla 4-8 parts, Paris polyphylla 5-10 parts.

2. it is according to claim 1 treatment adolescent myopia Chinese medicine composition, it is characterised in that be by following weight portion Raw material be obtained：15 parts of the red sage root, 8 parts of riparian greenbrier root and rhizome, 10 parts of noodles dish, 13 parts of pyrola, 3 parts of Rhizoma Sparganii, 11 parts of Artemisia anomala, the Radix Astragali 7 Part, 4 parts of catechu, 8 parts of Semen Cuscutae, 15 parts of Asiatic plantain, 3 parts of cuckooflower, 2 parts of passionflower, 6 parts of gynostemma pentaphylla, 8 parts of paris polyphylla.

3. a kind of preparation method of the Chinese medicine composition for treating adolescent myopia, it is characterised in that specifically according to following steps reality Apply：

Step 1, weighs respectively by weight：Red sage root 10-20 parts, riparian greenbrier root and rhizome 6-10 parts, 6-14 parts of noodles dish, pyrola 11-15 Part, Rhizoma Sparganii 2-4 parts, Artemisia anomala 9-13 parts, Radix Astragali 5-9 parts, catechu 3-5 parts, Semen Cuscutae 6-10 parts, Asiatic plantain 10-20 parts, jealous woman sauce It is careless 2-4 parts, passionflower 1-3 parts, gynostemma pentaphylla 4-8 parts, paris polyphylla 5-10 parts；

Step 2, each raw material mixing that step 1 is weighed, adds the cold water of 8 times of medicinal material gross weight, soaks 1h, boils by intense fire, text The pan-fried 1h of fire, filters to obtain 1 filtrate；

Step 3, adds the cold water of 4 times of medicinal material gross weight, boils by intense fire, is cooked by slow fire 30min, filters to obtain 2 filtrates；

Step 4,1 filtrate and 2 filtrates are merged, and heating concentration is obtained final product.