CN106831974B - 一种胜肽及其应用 - Google Patents
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Abstract
本发明提出一种胜肽，由SEQ ID NO：1所示的胺基酸序列所组成。此外，本发明还提出所提的胜肽用于制备真皮乳突细胞增生的促进剂、用于制备毛囊生长促进剂与用于制备毛发生长剂等用途。
Description
技术领域
本发明关于一种胜肽，且特别关于一种用于促进毛发生长的胜肽。
背景技术
敏洛西迪(minoxidil)、螺内酯(spironolactone)及非那雄安(finasteride)是目前常见的毛发生长成分。敏洛西迪与螺内酯可制作成外用涂剂来改善秃头，非那雄安则可制作成口服用药来改善秃头。然而，这些化合物非来自天然，须通过化学合成始能取得，因此施用于生物体时，可能会对其造成副作用。举例而言，敏洛西迪常见的副作用如对眼睛产生灼热或刺痛感、对施予部位造成红肿、搔痒或刺激，螺内酯常见的副作用如电解质失衡(以高血钠症为常见)、恶心、呕吐、头痛、疹子或性欲降低，而非那雄安常见的副作用如性能力降低。
发明内容
本发明的目的在于提供一种胜肽及其应用。
为实现上述目的，本发明提供一种胜肽，其由SEQ ID NO：1所示的胺基酸序列所组成。
在一实施方式中，该胜肽可通过从生物体萃取并经消化处理取得、化学合成取得或基因工程取得。
为实现上述目的，本发明还提供一种前述胜肽在制备真皮乳突细胞增生促进剂中的应用。
在一实施方式中，真皮乳突细胞增生促进剂可制备成液体(如细胞培养液)、块体或粉体形式。
为实现上述目的，本发明还提供一种前述胜肽在制备毛囊生长促进剂中的应用。
在一实施方式中，毛囊生长促进剂可制备成液体(如毛囊组织培养液)、块体或粉体形式。
本发明还提供一种前述胜肽在制备毛发生长剂中的应用。
在一实施方式中，毛发生长剂可制备成化妆料、外用制剂、内服制剂、食品或饮品形式。
在另一实施方式中，化妆料可为洗发精、润发精、发型造型品、睫毛膏或宠物用沐浴乳。
在又一实施方式中，外用制剂可呈洗剂、乳膏剂、凝胶、油剂、软膏剂、油膏剂、乳液、溶液或悬浮液形式。
在再一实施方式中，内服制剂可呈硬胶囊、软胶囊、锭剂、糖浆、悬浮液、乳液、溶液、固态分散体、粉片或酏剂形式。
本发明是基于一项不可预料的发现所完成的。在此，找到人类黏蛋白-15(Mucin-15)中的一特定胺基酸片段会促进大鼠真皮乳突细胞(dermal papilla cell)增生。此外，依文献Cold Spring Harb Perspect Med.2014 Jul 1；4(7)所述，真皮乳突细胞的增生可促进毛囊生长，进而导致毛发生长。故，可合理地理解到所找到的氨基酸片段也可促进毛囊与毛发的生长。
本发明的有益效果是：本发明所提供的胜肽可促进真皮乳突细胞增生并可进一步地应用于促进毛囊生长与毛发生长等相关用途。此外，本发明所提供的胜肽来自于天然，因而具有高生物兼容性，以降低施用于生物体时所产生的副作用。
附图说明
图1为本发明不同物质处理真皮乳突细胞48及96小时后的细胞增生情况的直方图。
具体实施方式
为让本发明上述及/或其他目的、功效、特征更明显易懂，下文特举具体实施例，作详细说明于下：
《实例1：胜肽的制备》
Mucinhair胜肽(序列为：NTSDPQKENRNTG)委托生工有限公司(MDBio,Inc)合成，且通过型号为Applied Biosystems 433A Peptide Synthesis System的合成仪来合成。此外，合成原理为本发明所属技术领域人士所熟悉的，可参考Albericio,F.Solid-PhaseSynthesis:A Practical Guide 1.Boca Raton:CRC Press.2000:848.ISBN 0-8247-0359-6。Mucinhair胜肽合成后通过高效液相层析仪(high performance liquidchromatography，HPLC)与质谱仪(mass spectrometer，MS)分析确认序列与纯度。接着，将Mucinhair胜肽溶解于去离子蒸馏水中，以取得浓度为12.84μM的Mucinhair胜肽溶液。
《实例2：真皮乳突细胞的分离》
取下六周大的大鼠(购自乐斯科生物科技股份有限公司)两颊胡须的毛囊。将所取的毛囊的根部剪下并置于第1型胶原蛋白酶溶液(浓度为2mg/mL，含1％胎牛血清(fetalbovine serum，FBS)的杜氏改良式伊格培养液(Dulbecco's Modified Eagle Medium，DMEM))中。接着，将此溶液置于温度37℃且二氧化碳浓度5％的培养箱中约2小时。在外根鞘松动后，加入含10％FBS的DMEM培养液至上述溶液中，并在所得的混合液轻微搅拌后，离心以分离出真皮乳突细胞。然后，在保留真皮乳突细胞后，重新添加含20％FBS的DMEM培养液至细胞进行培养。在观察到细胞贴附于培养皿底部并有向外延伸状态后，每隔3天替换一次培养液，并于培养后第7天进行后续实验。
《实例3：细胞增生的分析》
本实例采用MTT(3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四唑，3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)方法。MTT方法的原理与详细操作为本发明所属技术领域的普通技术人员所熟悉的，于此不再赘述。须提出的是：分析前，以每孔1,000个细胞密度将真皮乳突细胞种在含有20％FBS的DMEM培养液的96孔盘内。另须提出的是：细胞贴附后，添加等体积的去离子蒸馏水(在后文，称作“控制组”)或12.84μM的Mucinhair胜肽溶液至细胞，并再次培养细胞。又须提出的是：下文所述的“细胞增生相对比值”指某一物质处理细胞特定时间后利用MTT方法测得的数值除以同一物质处理细胞0小时后利用MTT方法测得的数值所得到的商。
细胞增生分析结果请参照图1。由此可知，处理48小时后，控制组处理后的真皮乳突细胞的增生相对比值为1.77±0.12，Mucinhair胜肽溶液处理后的真皮乳突细胞的增生相对比值为2.26±0.23；而处理96小时后，控制组处理后的真皮乳突细胞的增生相对比值为2.68±0.20，Mucinhair胜肽溶液处理后的真皮乳突细胞的增生相对比值为3.31±0.21。上述结果说明着：相对于控制组，Mucinhair胜肽确实可促进真皮乳突细胞生长。
综上，证实着本发明所提的胜肽可促进真皮乳突细胞增生。如此一来，此胜肽可进一步地应用于促进毛囊生长与毛发生长等相关用途。此外，本发明所提的胜肽来自于天然，因而具有高生物兼容性，以降低施用于生物体时所产生的副作用。
当然，本发明还可有其它多种实施例，在不背离本发明精神及其实质的情况下，熟悉本领域的技术人员可根据本发明作出各种相应的改变和变形，但这些相应的改变和变形都应属于本发明权利要求的保护范围。
Claims (9)
1.一种胜肽，其特征在于，由SEQ ID NO：1所示的氨基酸序列所组成。
2.权利要求1所述的胜肽在制备真皮乳突细胞增生促进剂中的应用。
3.根据权利要求2所述的胜肽在制备真皮乳突细胞增生促进剂中的应用，其特征在于，该真皮乳突细胞增生促进剂制备成液体、块体或粉体形式。
4.权利要求1所述的胜肽在制备毛囊生长促进剂中的应用。
5.根据权利要求4所述的胜肽在制备毛囊生长促进剂中的应用，其特征在于，该毛囊生长促进剂制备成液体、块体或粉体形式。
6.权利要求1所述的胜肽在制备毛发生长剂中的应用。
7.根据权利要求6所述的胜肽在制备毛发生长剂中的应用，其特征在于，该毛发生长剂制备成化妆料或外用制剂形式。
8.根据权利要求7所述的胜肽在制备毛发生长剂中的应用，其特征在于，该化妆料是洗发精、润发精、发型造型品、睫毛膏或宠物用沐浴乳。
9.根据权利要求7所述的胜肽在制备毛发生长剂中的应用，其特征在于，该外用制剂呈洗剂、乳膏剂、凝胶、油剂、软膏剂、油膏剂、乳液、溶液或悬浮液形式。
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