CN106729556A - A kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and preparation method thereof - Google Patents
A kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and preparation method thereof Download PDFInfo
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- CN106729556A CN106729556A CN201611243482.9A CN201611243482A CN106729556A CN 106729556 A CN106729556 A CN 106729556A CN 201611243482 A CN201611243482 A CN 201611243482A CN 106729556 A CN106729556 A CN 106729556A
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8888—Pinellia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and preparation method thereof, the Chinese medicine composition is prepared from by windproof, schizonepeta, elscholtiza, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati, ginger.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition, the present invention relates to a kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and
Its preparation method
Technical background：
In the centralization-breeding factory in many areas of China, livestock and poultry stress environment (such as cold stress, heat stress) in certain
Under stimulation, the pathogenic microorganism, a series of syndromes shown in livestock and poultry respiratory system such as infection virus, bacterium, parasite
Group.During anti-system disease, chemicals can play certain therapeutic action, but the problems such as easily cause drug resistance；Weak poison
Seedling protective rate is high, but operating technology difficulty is big, should not promote；Inactivated vaccine is easy to operate, but its protective rate is far away from Attenuate vaccine.
Medicine of the present invention is based on China's traditional Chinese medicine to the pathogenetic understanding of cough and asthma and principle of reatment, with reference to existing
For pharmacological research achievement, Chinese medicine preparation is made by Chinese veterinarian's theory prescription.This medicine enhances the integrally-regulated work(of animal body
Can, can effectively alleviate cough symptom, the potential safety hazard that chemical drug is likely to result in is reduced, increased the security of medication.
The present invention provides a kind of Chinese medicine composition for treating cough.Specifically with windproof, schizonepeta, elscholtiza, perilla leaf,
The tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati, ginger are treated or alleviate cough due to wind-cold evil for herbal medicine patent medicine prepared by raw material.With clear
Gas, nourishing Yin and promoting production of body fluid, qi-regulating such as help digestion at the function under thermal detoxification, dissolving phlegm.For swine enzootic pneumonia etc. it is cough caused, expiratory dyspnea, appetite
Go down, the speed of growth is reduced, efficiency of feed utilization reduces the disease being characterized.The invention further relates to the preparation method of the medicine.
The content of the invention：
Present invention solves the technical problem that be to disclose a kind of Chinese medicine composition, its by following weight proportion Chinese medicine material medicine
It is prepared from：
Windproof 50-350g, schizonepeta 50-250g, elscholtiza 50-150g, perilla leaf 50-150g, tuber of pinellia 50-150g, mustard seed 50-
150g, Inula britannica chinensis 50-150g, radix ranunculi ternati 10-100g, ginger 10-100g.
Preferably, Chinese medicine composition of the invention, is prepared from by the Chinese medicine material medicine of following weight proportion：
Windproof 100-300g, schizonepeta 100-200g, elscholtiza 60-140g, perilla leaf 60-140g, tuber of pinellia 60-140g, mustard seed
60-140g, Inula britannica chinensis 60-140g, radix ranunculi ternati 20-90g, ginger 20-90g.
Most preferably, Chinese medicine composition of the invention, is prepared from by the Chinese medicine material medicine of following weight proportion：
Windproof 150-250g, schizonepeta 120-180g, elscholtiza 80-120g, perilla leaf 80-120g, tuber of pinellia 80-120g, mustard seed
80-120g, Inula britannica chinensis 80-120g, radix ranunculi ternati 30-80g, ginger 30-80g.
Chinese medicine composition of the invention, windproof is monarch drug in a prescription, and schizonepeta, elscholtiza are ministerial drug, perilla leaf, the tuber of pinellia, mustard seed, sheathed
Flower, radix ranunculi ternati are adjutant, and ginger is to make medicine, and effect of each component is as follows：
It is windproof：It is the windproof root of Umbelliferae herbaceos perennial.Taste is pungent, sweet, slightly warm in nature.Return bladder, liver, the spleen channel.Work(
Imitate to expel pathogenic wind from the body surface, win wet analgesic, only convulsion.Cure mainly diseases caused by external factors table card, rubella itch, arthralgia pain due to rheumatism, lockjaw.《This warp》：It is main big
The dizzy pain of public attention, foul wind, ailment said due to cold or exposure, mesh blindness is in fashion the whole body, joint pain numbness, dysphoria.《Bencao jizhu》：Kill monkshood poison.
《Do not record》：Hypochondriac pain, side of body public attention face is gone to come, four limbs contraction urgency, convulsion in word milk gold sore.《Japan hanako materia medica》：Control wind as 36, man
All labor are bad, bowl spares benefit god, blepharitis marginalis, and only tear and paralysis are slow, tonneau the five internal organs Guan pulse, general debility, thin damage night sweat, vexed body weight,
Can tranquilizing the mind, even gaseous pulse.《Pearl sac》：Body：Go windward, the tip：Go leeward.《Medicine class method as》：Control wind general.Purging the lung of pathogenic fire reality, dissipates
Stagnant gas in the head, except part of the body cavity above the diaphragm housing the heart and lungs ailment said due to cold or exposure.Wang Haogu：Search irritability.《Changsha medicine solution》：Pass through network, by wet excessive, get round by bribery, relieve the pain pain, relaxes
Tendon and vessel, stretches anxious contraction, podomere living, plays paralysis, holds back spontaneous perspiration, helmet sweat, breaks, metrorrhagia.《Book on Chinese herbal medicine asks former》：The solution rhizome of Chinese monkshood, lilac daphne, wild bacterium
All medicine of a warm nature poison.
Schizonepeta：The dry aerial parts of labiate schizonepeta (Nepeta cataria Linn Sp.).Taste is put down, warm in nature,
Nontoxic, faint scent is dense.Schizonepeta is sweating, and alexipyretic is one of conventional herbal medicine of China, can town phlegm, wind-dispelling, cool blood.Control popular sense
Emit, headache fever and chills sweating, vomit.《This warp》：Main fever and chills, mouse fistula, scrofula life sore breaks knot gather qi together, lower hemostasis, except arthritis with fixed pain caused by dampness.《The property of medicine
By》：Foul wind harmful wind is controlled, the askew heresy in mouth face, stupid numbness all over is had a guilty conscience and forgotten things, and beneficial power adds grain.The main poison gas that exorcises evil spirits, except labor, controls fourth and swells；Take
One holds and cuts, and with five liters of water, boils and takes two liters, cold point two clothes, and master is promoting blood circulation, transmission the five internal organs deficiency gas, can sweating, except cold wind；Again
Smash end and vinegar envelope poison is swollen.Meng's numerous：Affection by cold after delivery body is tetanic, grinds wine clothes.《Dietetic materia medica》：Help taste.《Feeding habits book on Chinese herbal medicine》：Main blood
Labor general mood stops up full, ridge pain, and abnormal sweating manages husband's tinea pedis, the tired pain of muscles and bones and YIN YANG toxin syndrome, and cold headache, head revolves dizzy, brothers' muscle
It is anxious.《Japan hanako materia medica》：Relieving the five internal organs, help digestion lower gas, sobers up.Heat of cooking is eaten and is simmered tea, and controls head wind and sweating；Fermented soya beans, salted or other wise juice is decocted and controls sudden and violent
Typhoid fever.《Bencao Tujing》：Control head wind, consumptive disease, sore scabies, married woman's blood wind.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：Traumatic injury is controlled, and applies carbuncle.Control and tell
Blood.Ching-chieh, the upper all wind of refresh oneself, only has a headache, improving eyesight, and solution lung, liver, throat heat pain, detumescence, except all poison, dissipate sore carbuncle.Control just
Blood, only woman's bleeding, disappear wind-heat, and logical lung qi nose key plug is closed.《Detailed outline》：Dissipate wind-heat, refresh oneself, throat, disappear sore swells.Control item
By force, black flower in mesh, and raw sore, it is cloudy ruined, spit blood, bleeding from five sense organs or subcutaneous tissue, lower blood, bloody flux, metrorrhagia, anal fistula.
Elscholtiza：It is the wounded in the battle herb of labiate elsholtzia splendens.Dry aerial parts are used as medicine, can sweating and inducing diaphoresis,
Again can dampness elimination and in and relieving summer-heat, moreover it is possible to open facilitaing lung gas and inducing diuresis for removing edema., like Chinese ephedra, the efficacy of a drug is also strong, controls cold sensation of the genitalia and closes heat and geomantic omen for work(
Oedema is most suitable, therefore have the title of summer month Chinese ephedra.Control acute gastroenteritis, stomachache vomiting and diarrhoea, summer and autumn yang summer-heat syndrome, have a headache and fever, aversion to cold is lossless,
The diseases such as cholera, oedema, nosebleed epistaxis, halitosis.《Mingyi Bielu》：Taste is pungent, tepor.Cholera is cured mainly, suffered from abdominal pain, told down, aproll swells.《Solar corona
Sub- book on Chinese herbal medicine》：Nontoxic, lower gas, relieving restlessness heat, treatment is vomitted against cold air.《Bencao Tujing》：Leaves of pulse plants unrest convulsion person, singly boils and takes it.《Book on Chinese herbal medicine spreads out
Justice》：Control cholera can not fault, imitated invariably with it.《The Decoction and Material Medica》：Taste is pungent, tepor.
Perilla leaf：Pungent, tepor is nontoxic, and returns spleen warp, lung channel two are passed through.Function is delivered, cold dispelling, qi-regulating, and battalion.Cure cold wind
Cold, fever with aversion to cold, cough is had a headache lossless, asthma, fullness and oppression of chest and abdomen, and evil of vomitting diarrhoea is blocked, pernicious vomiting, fetal irritability in pharynx.
And can solving toxin of fish and crab, ulcerative carbuncle snake venom is peppery.《Do not record》：Main lower gas, in cold.《Japan hanako materia medica》：Tonifying middle-Jiao and Qi.Control abdominal distnetion
Expire, only choleraic myospasm, whetting the appetite, and (controlling) all cold air, only tinea pedis.《Bencao Tujing》：Logical the heart channel of Hang-Shaoyin, Energy benefit taste.《Lv Cliff rocks
Book on Chinese herbal medicine》：Only metal-inflicted wound bleeding；Haemorrhoids is treated, decoct soup washes it.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：Sweating, solves anemogenous headache, and dissolving phlegm is shouted and breathed heavily surely.《Guiding principle
Mesh》：During promoting the circulation of qi is wide, dissolving phlegm profit lung, and blood, middle benefit gas, relieving pain, Dingchuan is antiabortive.《Book on Chinese herbal medicine meets original》：The heresy of blood vessels can be dissipated.
The tuber of pinellia：It is the stem tuber of the aroid tuber of pinellia.Function is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp phlegm
Cold drink, vomiting, gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless.Outer subduing inflammation.For abundant expectoration cough and asthma, phlegm and retained fluid
Feel dizzy and heart palpitations, interior phlegm dizziness, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus disease；Controlling outward carbuncle swells subcutaneous nodule is used in life.Pinellia is used for dropping check
Vomit.《This warp》：Main typhoid fever fever and chills, hardness in the epigastrium, lower gas, laryngopharynx swells and ache, and a dizzy chest is swollen, coughs inverse, borborygmus, hidroschesis.《Do not record》：Disappear the heart
The full knot of abdomen chest diaphragm phlegm heat, cough with dyspnea, acute pain in the epigastrium heavily fortified point ruffian, when gas vomit it is inverse；Impotence Huang is treated in subduing inflammation, induced abortion, pleases pool appearance.It is raw
Make us telling, it is ripe make us under.《Haigoushen》：Dissolving phlegm saliva, Appetizing spleen-tonifying, anti-nausea goes phlegm in the heart to expire, and lower lung qi, master coughs knot.It is newborn
Person rub painting carbuncle swells do not disappear, knurl goitre can be removed.The deficiency of vital energy and have mental disorder, plus and use it.《Japan hanako materia medica》：Control and tell food gastric disorder causing nausea, cholera turns
Muscle, intestines abdomen is cold, phlegm malaria.《Medicine origin》：Control cold phlegm and the cold cold injury lung by the emperor himself of shape and cough, big easing stomach-QI, except stomach cold, enter diet.Control
Sun phlegm and headache, non-this can not be removed.《Cure mainly secret wanting》Cloud, dry stomach is wet, resolving sputum, Energy benefit taste gas, dispersing swelling and dissipating binds, except phlegm in the heart
Saliva.
Mustard seed：It is crucifer sinapsis alba Sinapis alba L. or mustard Brassica juncea (L.) Czern.et
Coss. dry mature seed.There are warm lung slit phlegm profit gas, effect that dissipating bind is removed obstruction in channels to relieve pain.Coughed with the cold productive cough of son, distending pain in the chest and hypochondrium,
The stagnant channels and collaterals of phlegm, joint numbness, pain, phlegm-damp oozing in the body, cloudy subcutaneous ulcer pyogenic infections.《Compendium of Materia Medica》：Sole center is applied, is drawn under heat returns, acne rash does not enter
Mesh.《Do not record》：Master is penetrated at work and the hair impermanence of Zhu gas, and ball takes it；Or it is end, jealous woman and painting to smash.《Solar corona》：Control wind toxin swollen and numb
Numbness, vinegar grind it is deposited it；Damage hemostasis is flutterred, pain in the back kidney is cold, and ginger grinds micro- warm painting and pastes；Pained, wine vinegar takes it.
Inula britannica chinensis：Belong to composite family, Inula perennial herb, be distributed mainly on northeast, North China, East China, Central China and wide
The ground such as west.Harvested when summer, season in autumn two, the flowers are in blossom, remove impurity, dried in the shade or dry.Raw use or honey process use.《Sheng Nong's herbal classic》：Main knot
Gas hypochondrium fullness, palpitation with fear.Water removal, removes fever and chills between the five internal organs, bowl spares, lower gas.Modern study, Inula britannica chinensis has protection to immunological liver injury
Effect, its chemical composition gaillardin has antitumaous effect.Its root and cauline leaf or aerial part can also be used as medicine, and control knife wound, serious case of furuncle,
Decoction can antiasthmatic effect.
Radix ranunculi ternati：Radix ranunculi ternati is the root tuber of Ranunculaceae ranunculus Seynuns Kugelann, and radix ranunculi ternati has a dissipating bind, effect of detumescence,
Radix ranunculi ternati cures mainly scrofula, scrofula not routed, pulmonary tuberculosis, scrofula, lymphnoditis, sphagitis.《Chinese medicine handbook》：
Control scrofula tuberculosis on neck.《Henan Chinese herbal medicine handbook》：Detumescence, preventing malaria.Control scrofula, pulmonary tuberculosis.
Ginger：Ginger contains pungent and fragrance ingredient.Piquancy component is the zingerone in a kind of armaticity stearopten.Its
In predominantly ginger oil terpene, phellandium, CAM, gingerol, folium eucalypti olein, starch, mucus etc..CORTEX ZINGIBERIS RHIZOMAE is pungent cool, controls skin and floats
It is swollen, the row severe edema due to hypofunction of the spleen；Ginger juice pungent-warm, pungent scattered stomach cold strength is strong, is used for vomiting；Rhizoma zingiberis pungent-warm, middle benefit gas instigate cold, Back to Yang Tongmai,
Warm malaria strength is big, and baked ginger taste is pungent hardship does not walk table in walking, and temperature is lower burnt cold；Baked ginger charcoal is warm in nature, and relatively homoiothermy point is cold；Simmer ginger bitter
Temperature, relatively warming intestines and stomach is cold.The pungent and scattered temperature of ginger, Energy benefit taste is apt to middle benefit gas stopping nausea and vomiting by lowering the adverse flow of QI, and dehumidify the ruffian that disappears, and cough-relieving apophlegmatic is inverse to drop
Preventing or arresting vomiting is length.《Mingyi Bielu》：Taste is pungent, tepor.Cure mainly cold headache, nasal obstruction, cough with dyspnea, anti-nausea.Also, ginger, tepor,
It is pungent, Gui Wuzang.Go phlegm, lower gas, anti-nausea, exorcising fever and chills.The few intelligence of the small will of long term usage, sad gas.《Bencao Shiyi》：Outside this work(,
Juice antidote, from remaining blood-breaking, in tune, goes cold, eliminating phlegm, whets the appetite.Hot must remove the peel, cold and stay skin.《Haigoushen》：Make.Main phlegm
Aqueous vapor expires, lower gas.Life is controlled with dry doubling and coughed, disease during treatment, the inverse not lower food of preventing or arresting vomiting.Raw and the tuber of pinellia, main acute pain in the epigastrium, if middle heat can not
Food, smashes juice conjunction honey and takes it.Juice and almond are decocted again, and lower all knot gas, solid chest gathers around thermal insulating gas, the magical effect.
Composition described above of the invention is, by weight as proportioning, can to increase or reduce according to corresponding proportion in production,
Such as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also be in units of milligram, and weight can
To increase or reduce, but the respectively constant rate of the raw medicinal herbs weight proportion between composition.
The ratio of above weight proportion is obtained by science screening, fat for special circumstances, such as severe or mild
Or slight of stature, the proportioning of the amount of composition can be accordingly adjusted, increase or decrease no more than 100%, drug effect is constant.
Single medicinal material in composition described above, especially ministerial drug and adjutant, it is also possible to by appropriate with the identical property of medicine
Medicine is replaced, and Chinese medicine preparation its medicine effect after replacement is constant.
Chinese medicine composition of the invention, be by by the pharmaceutically active substance of above-mentioned formula according to galenic pharmacy routine techniques system
It is standby into pharmaceutical dosage forms.When pharmaceutical preparation is prepared into, pharmaceutically acceptable carrier can be added if necessary, according to galenic pharmacy
It is prepared by routine techniques.Pharmaceutical dosage forms of the invention, exist in a unit, and the unit dosage form refers to preparation
Unit, such as every of tablet, every capsule of capsule, every bag of granule etc..
Chinese medicine preparation of the invention can be any pharmaceutically useful formulation, and these formulations include：Tablet, capsule, particle
Agent, pill, powder, paste, sublimed preparation, pulvis, solution, injection, suppository, spray, drops, patch.Preparation of the invention,
Preferably peroral dosage form, such as：Capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, paste etc..
Chinese medicine preparation of the invention, the preparation that it is administered orally can contain conventional excipient, such as adhesive, filling
Agent, diluent, tablet agent, lubricant, disintegrant, colouring agent, flavor enhancement and wetting agent.Applicable filler includes starch, sugarcane
Sugar, cellulose, mannitol, the lactose filler similar with other.Suitable disintegrant includes starch, polyvinylpyrrolidone
And starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as magnesium stearate.Can be filled out by mixing
Fill, the conventional method such as compressing tablet prepares solid oral composition.Being mixed repeatedly can be distributed in active material entirely to use
In those compositions of a large amount of fillers；Conventional adjunct ingredient includes：Mannitol, sorbierite, sodium pyrosulfite, bisulfite
Sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, monoacidic base gold
The carbonate of category, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride,
Sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon spread out
Biology, cellulose and its derivates, alginates, gelatin, polyvinylpyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate, carbonic acid
Hydrogen calcium, surfactant, polyethylene glycol, cyclodextrin, beta-schardinger dextrin, phospholipid material, kaolin, talcum powder, calcium stearate,
Magnesium stearate etc..
Preparation of the invention is determining usage and dosage according to condition when using, and can take 1-2 times daily, presses per kilogram body every time
Weight 0.5-3g dosage.
The present invention further provides the preparation method of Chinese medicine composition of the invention, the preparation method is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm under the conditions of 50 DEG C3, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, that is, Chinese medicine composition is obtained.
Confirm that this preparation process stabilization is adapted to big production by study of pharmacy.
Beneficial effects of the present invention are illustrated below by way of experimental data：
Pharmacodynamics are tested
This Chinese medicine compound prescription causes to cough the influence of mouse to concentrated ammonia liquor
Experimental animal：Mouse, body weight 18-22g, male and female dual-purpose,
Chinese medicinal preparation method is prepared by the method for embodiment 1
50 mouse are taken, male and female half and half are randomly divided into 5 groups, respectively every group 10, the isometric physiology salt of blank control group
Water, Chinese medicine control group GUILONG KECHUANNING JIAONANG (0.59g/Kg), Chinese medicine group, scarce ministerial drug group, scarce monarch drug in a prescription group are administered 2g/Kg respectively,
Gastric infusion, is administered once daily, continuous 5 days, and each group mouse fasting 16h, 30min after last dose, mouse is put into before experiment
In lured to cough to draw and breathes heavily instrument added with concentrated ammonia liquor, 15s is atomized, the cough latent period of observed and recorded mouse (goes out since spraying to animal
The time now coughed) and the interior cough number of times of 2min.
The antitussive effect of table 1
Remarks：Different lowercase letter indication differences significantly (P<0.05), different capitalizations represent difference extremely significantly (P<
0.01), same letter represents difference not significantly (P>0.05)
This product Chinese medicine group, lack ministerial drug group, lack the extension concentrated ammonia liquor that monarch drug in a prescription group can be different degrees of and cause mouse cough incubation period,
Reduce cough number of times in 2min, Chinese medicine group, the incubation period for lacking ministerial drug group and cough number of times inequality heteropole compared with blank control group
Significantly (P<0.01), the not notable (P of the incubation period of scarce monarch drug in a prescription group difference compared with blank control group>0.05), but cough number of times with
Blank control group is compared to inequality heteropole significantly (P<0.01).Show that the medical instrument has good antitussive action.
The present invention is found surprisingly that the collocation of each component of the present invention has synergistic function,
Specific embodiment：
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment 1
Windproof 200g, schizonepeta 150g, elscholtiza 100g, perilla leaf 100g, tuber of pinellia 100g, mustard seed 100g, Inula britannica chinensis 100g, cat
Pawl grass 50g, ginger 50g
Preparation method is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm under the conditions of 50 DEG C3, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, 1000g is made, packing is obtained final product.
Embodiment 2
Windproof 300g, schizonepeta 250g, elscholtiza 120g, perilla leaf 120g, tuber of pinellia 120g, mustard seed 100g, Inula britannica chinensis 100g, cat
Pawl grass 30g, ginger 30g
The preparation method of tablet is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm under the conditions of 50 DEG C3, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, 1000 are made, packing is obtained final product.
Embodiment 3
Windproof 300g, schizonepeta 150g, elscholtiza 80g, perilla leaf 80g, tuber of pinellia 120g, mustard seed 120g, Inula britannica chinensis 80g, ram's horn
Careless 50g, ginger 50g
The preparation method of capsule is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm under the conditions of 50 DEG C3, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, encapsulated 1000, obtain final product.
Embodiment 4
Windproof 300g, schizonepeta 200g, elscholtiza 120g, perilla leaf 120g, tuber of pinellia 120g, mustard seed 120g, Inula britannica chinensis 120g, cat
Pawl grass 90g, ginger 90g
The preparation method of oral liquid is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.15-1.20g/cm under the conditions of 50 DEG C3, obtain concentrate；
Step 3, the concentrate for obtaining step 2 add 95% ethanol to reach determining alcohol 60-80%, alcohol precipitation 48h, take supernatant
Liquid reclaims ethanol to without alcohol taste
Step 4, by volatile oil and Tween-80 (1:3) it is well mixed, then the liquid blending obtained with step 3, add 2g
Potassium sorbate, adds water to 1000ml, mixes, and sterilizing, packing is obtained final product.
Embodiment 5
Windproof 150g, schizonepeta 120g, elscholtiza 90g, perilla leaf 90g, tuber of pinellia 90g, mustard seed 90g, Inula britannica chinensis 90g, radix ranunculi ternati
50g, ginger 50g
Preparation method is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, 1000g is made, packing is obtained final product.
Embodiment 6
Windproof 250g, schizonepeta 180g, elscholtiza 110g, perilla leaf 110g, tuber of pinellia 110g, mustard seed 110g, Inula britannica chinensis 110g, cat
Pawl grass 70g, ginger 70g
Preparation method is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, 1000g is made, packing is obtained final product.
Embodiment 7
Windproof 200g, schizonepeta 150g, elscholtiza 110g, perilla leaf 110g, tuber of pinellia 110g, mustard seed 100g, Inula britannica chinensis 100g, cat
Pawl grass 60g, ginger 60g
Preparation method is as follows：
Step one, take elscholtiza, 6-10 times of ginger dosing material weight measure water and soak 0.5-3 hour, extraction volatile oil 6-10
Hour, volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-ring paste
Inclusion compounds, the liquid storage after extraction；
Step 2, the dregs of a decoction for obtaining step one add with windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati
8-12 times of medicinal material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering, the liquid obtained with step one is closed
And, standing overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, 1000g is made, packing is obtained final product.
Claims (6)
1. a kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil, is prepared from by the Chinese medicine material medicine of following weight proportion：It is anti-
It is wind 50-350g, schizonepeta 50-250g, elscholtiza 50-150g, perilla leaf 50-150g, tuber of pinellia 50-150g, mustard seed 50-150g, sheathed
Flower 50-150g, radix ranunculi ternati 10-100g, ginger 10-100g.
2. composition according to claim 1, is prepared from by the Chinese medicine material medicine of following weight proportion：Windproof 100-
300g, schizonepeta 100-200g, elscholtiza 60-140g, perilla leaf 60-140g, tuber of pinellia 60-140g, mustard seed 60-140g, Inula britannica chinensis 60-
140g, radix ranunculi ternati 20-90g, ginger 20-90g.
3. composition according to claim 1, is prepared from by the Chinese medicine material medicine of following weight proportion：Windproof 200g,
Schizonepeta 150g, elscholtiza 100g, perilla leaf 100g, tuber of pinellia 100g, mustard seed 100g, Inula britannica chinensis 100g, radix ranunculi ternati 50g, ginger 50g.
4. composition according to claim 1, is any pharmaceutically useful formulation.
5. composition according to claim 4, the formulation is selected from：Tablet, capsule, granule, pill, powder, cream
Agent, sublimed preparation, pulvis, solution, injection, suppository, spray, drops, patch.
6. the preparation method of the composition described in claim 1, step is as follows：Step one, take elscholtiza, ginger dosing material weight
Measure water for 6-10 times to soak 0.5-3 hours, extract volatile oil 6-10 hours, collect volatile oil, volatile oil is with beta-schardinger dextrin by weight
Than 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta cyclodextrin inclusion complex, the liquid storage after extraction；
Step 2, the dregs of a decoction that step one is obtained and windproof, schizonepeta, perilla leaf, the tuber of pinellia, mustard seed, Inula britannica chinensis, radix ranunculi ternati dosing material
8-12 times of gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained, quiet
Put overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed,
Chinese medicine composition is obtained.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611243482.9A CN106729556A (en) | 2016-12-29 | 2016-12-29 | A kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and preparation method thereof |
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|---|---|---|---|
| CN201611243482.9A CN106729556A (en) | 2016-12-29 | 2016-12-29 | A kind of Chinese medicine composition for livestock and poultry cough due to wind-cold evil and preparation method thereof |
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| CN106729556A true CN106729556A (en) | 2017-05-31 |
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Non-Patent Citations (1)
| Title |
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| 汤德元等: "《实用中兽医学》", 31 March 2005, 中国农业出版社 * |
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