CN104740261A - Medicament for treating palpitation and insomnia and preparation method thereof - Google Patents
Medicament for treating palpitation and insomnia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating palpitation and insomnia. The medicament is prepared from the following main raw materials in parts by weight: 17-24 parts of lily, 12-18 parts of clematis filamentosa, 8-13 parts of mother-of-pearl, 7-12 parts of oyster, 11-16 parts of Salvia miltiorrhiza, 12-16 parts of Anisochilus, 10-13 parts of placenta hominis, 15-18 parts of rhizoma anemarrhenae, 13-17 parts of Ziziphora clinopodioides Lam, 15-20 parts of spina date seed, 9-14 parts of liquorice, 10-14 parts of kadsura pepper stem, 13-18 parts of Tuckahoe, 12-19 parts of Corylopsis sinensis, 9-13 parts of wild cherry, 12-16 parts of Euphorbia hirta and 9-17 parts of pittosporum root. The medicament has the functions of clearing heat from liver, tranquilizing by nourishing the heart, strengthening spleen and benefiting qi, nourishing yin and clearing heat, calming the mind and promoting sleep, and has a good effect for treating the palpitation and insomnia.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of medicament and preparation method for the treatment of palpitation and insomnia.
Background technology
Cardiopalmus comprises palpitation with fear and palpitation with a distress feeling, is names of disease of tcm.Refer to the conscious palpitation of patient, terrified uneasy a kind of symptom.Insomnia refers to and often can not obtain normal sleep, and situation has multiple, or not easily falls asleep, or sleep but easy to wake, can not fall asleep once again, even lie awake all night after waking up.In a word, cardiopalmus and insomnia often and see, also normal and dizzy, have a headache, tinnitus, the disease such as forgetful be mingled with mutually, often because of anxious state of mind or overwork and show effect.
The harm of palpitation and insomnia: 1. chronic insomnia can cause body immunity to decline, and weakens the resistance of various disease, can make people cross presenility, shortens the life-span; Easy trouble senile dementia, forgetful, diabetes, hypertension, obesity.2. the often insomnia normal work that can affect and life, frequent insomnia often causes lassitude on daytime, inefficiency, nervous irritability, get along inharmonious with people around, depressed, unhappy, serious also causing is pessimistic and worldweary, hypomnesis, headache, feel dizzy, tinnitus, neurasthenia etc.3. often there is disorderly phenomenon in the function of nervous system of insomniac, and chronic insomnia causes absent minded, and ability of thinking declines, produce the emotions such as depression, anxiety, psychentonia, cerebral cortex functional disorder, causes autonomic nervous dysfunction, and severe patient forms psychosis, neurosis etc.4. child is in the event of the phenomenon of not having enough sleep, and goes down for a long time and can affect the growth promoter of health, long not high, stupid, is also the risk factor causing suicidal tendency.
Insomnia affects one of maximum health problem of human lives, and the whole world about has the adult of 1/3rd by the torment suffering various sleep disorder, and can experience a series of miseries brought thus.External research data shows, about has the people of 40% to suffer from insomnia in various degree.The survey data display of domestic clinical principium, have at least the patient of 1/4th to there are various sleeping problems in general medicine outpatient service, what in the first visit patient of psychohygiene training and psychiatric outpatient department, have insomnia accounts for more than 90%.And the age, larger sickness rate was higher, and women is more than male.
At present, the medicine of Cure for insomnia is a lot, publication number CN 103830344 A(application number 201210475053.X) patent document discloses a kind of medicine for the treatment of palpitation and insomnia and preparation method thereof, described medicine calculates according to composition by weight, is prepared from by Cortex Albiziae 5-15 part, skin cedar seed 5-15 part, Radix Polygalae 5-15 part, Semen sojae atricolor 5-15 part and adjuvant.Publication number CN 103830545 A(application number 201210494964.7) the one that patent document discloses treat palpitation and insomnia medicated wine, it is prepared from by the following Chinese herbal medicine of every 3000ml soaking in Chinese liquor: Semen Platycladi 30-35 gram, Poria 30-35 gram, Radix Rehmanniae 40-45 gram, Semen Ziziphi Spinosae 60-65 gram, Radix Ophiopogonis 60-65 gram, imperial positive meat 60-65 gram.Publication number CN 104306755 A(application number 201410500805.2) the one that patent document discloses treat palpitation and insomnia medicine and preparation method thereof, in mass parts containing following composition: Ramulus et Folium Dichroae febrifugae 30-50 part, Concha Ostreae 20-40 part, Os Draconis 20-40 part, Radix Codonopsis 16-30 part, Fructus Lycii 15-30 part, Fructus Mori 10-20 part, Bulbus Lilii 20-35 part, Semen setariae 5-20 part, Radix Notoginseng 10-24 part, Rhizoma Polygonati 15-30 part, Sargassum 10-20 part, maltose 14-30 part, Radix Hemsleyae Macrospermae 1-7 part.
At present, treatment palpitation and insomnia, mainly based on oral western medicine, is often taken and can be caused drug resistance, dependency, memory impairment etc., physical function even can be caused to degenerate.Although some medicines have appearred in traditional Chinese medical science aspect, curative effect is also indefinite.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of medicament for the treatment of palpitation and insomnia, has purging liver-fire, tranquilizing by nourishing the heart, invigorating the spleen and benefiting QI, nourishing YIN and clearing away heat, effect of calming soporific.Another object of the present invention is just to provide the preparation method of the medicament of above-mentioned treatment palpitation and insomnia.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a medicament for palpitation and insomnia, take off the primary raw material stating quality proportioning and be prepared from: Bulbus Lilii 17-24 part; Clematis filamentosa Dunn 12-18 part; Concha Margaritifera 8-13 part; Concha Ostreae 7-12 part; Radix Salviae Miltiorrhizae 11-16 part; Herba lysimachiae capillipedis 12-16 part; Placenta Hominis 10-13 part; Rhizoma Anemarrhenae 15-18 part; Lip Rhizoma et radix valerianae 13-17 part; Semen Ziziphi Spinosae 15-20 part; Radix Glycyrrhizae 9-14 part; Caulis Piperis Kadsurae 10-14 part; Poria 13-18 part; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 12-19 part; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 9-13 part; Herba Euphoubiae Hirtae 12-16 part; Radix Pittospori Glabrati 9-17 part.
Treat a medicament for palpitation and insomnia, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: Bulbus Lilii 19-22 part; Clematis filamentosa Dunn 14-16 part; Concha Margaritifera 9-12 part; Concha Ostreae 8-11 part; Radix Salviae Miltiorrhizae 12-15 part; Herba lysimachiae capillipedis 13-15 part; Placenta Hominis 11-12 part; Rhizoma Anemarrhenae 16-17 part; Lip Rhizoma et radix valerianae 14-16 part; Semen Ziziphi Spinosae 16-19 part; Radix Glycyrrhizae 10-13 part; Caulis Piperis Kadsurae 11-13 part; Poria 14-17 part; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 14-17 part; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 10-12 part; Herba Euphoubiae Hirtae 13-15 part; Radix Pittospori Glabrati 11-15 part.
Treat a medicament for palpitation and insomnia, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from
:bulbus Lilii 21 parts; Clematis filamentosa Dunn 15 parts; Concha Margaritifera 10 parts; Concha Ostreae 10 parts; Radix Salviae Miltiorrhizae 13 parts; Herba lysimachiae capillipedis 14 parts; Placenta Hominis 11.5 parts; The Rhizoma Anemarrhenae 16.5 parts; Lip Rhizoma et radix valerianae 15 parts; Semen Ziziphi Spinosae 18 parts; 12 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 12 parts; 15 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 15 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 11 parts; Herba Euphoubiae Hirtae 14 parts; Radix Pittospori Glabrati 13 parts.
Present invention also offers the preparation method medicament of above-mentioned treatment palpitation and insomnia being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the medicament powder of described treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools, and is ground into fine powder altogether, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) Concha Margaritifera and Concha Ostreae are smashed, water flies twice, merges suspension, and leave standstill 5-8 hour, the supernatant of inclining, will precipitate drying, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(3) Bulbus Lilii, Clematis filamentosa Dunn, Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, Placenta Hominis, the Rhizoma Anemarrhenae, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit, Herba Euphoubiae Hirtae and Radix Pittospori Glabrati are cleaned, dry, pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 4 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the medicament decoction of described treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), merging filtrate, be concentrated into 1/2 of original volume, obtain decoction.
The preparation method of the medicament decoction of above-mentioned treatment palpitation and insomnia, the consumption of the preferred rice vinegar of step (1) is the 15%-20% of Poria quality, and the consumption being more preferably rice vinegar is 18% of Poria quality.
Instructions of taking: each 50-80ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 4 days courses for the treatment of.
The preparation method of the medicament pill of described treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), merging filtrate, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill and (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 4 days courses for the treatment of.
The preparation method of the medicament tablet of described treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), merging filtrate, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 4 days courses for the treatment of.
The preparation method of the pharmacy particle agent of described treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), merging filtrate, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the medicament agent granule of above-mentioned treatment palpitation and insomnia, the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 4 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, each raw material effect of the present invention is worked in coordination with, and has purging liver-fire, tranquilizing by nourishing the heart, invigorating the spleen and benefiting QI, nourishing YIN and clearing away heat, effect of calming soporific, has obvious curative effect to palpitation and insomnia.
2, the present invention effectively can regulate central nervous system, fundamentally eliminates nervous dysfunction, alleviates brain tired, and repair brains balance physiological function, improve immunity of organisms, real has accomplished treating both the principal and secondary aspects of a disease comprehensively.
3, selected materials great majority of the present invention are Chinese medicine material, and not containing any hormone, no dependence, has no side effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a medicament for palpitation and insomnia, take off the primary raw material stating weight proportion and be prepared from (every part of 50g): Bulbus Lilii 17 parts; Clematis filamentosa Dunn 12 parts; Concha Margaritifera 8 parts; Concha Ostreae 7 parts; Radix Salviae Miltiorrhizae 11 parts; Herba lysimachiae capillipedis 12 parts; Placenta Hominis 10 parts; The Rhizoma Anemarrhenae 15 parts; Lip Rhizoma et radix valerianae 13 parts; Semen Ziziphi Spinosae 15 parts; 9 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 10 parts; 13 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 12 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 9 parts; Herba Euphoubiae Hirtae 12 parts; Radix Pittospori Glabrati 9 parts.
The preparation method of the medicament powder of above-mentioned treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 35 minutes, put in parch container, slow fire heats, and fried dry, cools, and is ground into fine powder altogether, crosses 140 mesh sieves;
(2) Concha Margaritifera and Concha Ostreae are smashed, water flies twice, merges suspension, and leave standstill 6 hours, the supernatant of inclining, will precipitate drying, porphyrize, crosses 140 mesh sieves;
(3) Bulbus Lilii, Clematis filamentosa Dunn, Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, Placenta Hominis, the Rhizoma Anemarrhenae, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit, Herba Euphoubiae Hirtae and Radix Pittospori Glabrati are cleaned, dry, pulverize, cross 140 mesh sieves;
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 4 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2treat a medicament for palpitation and insomnia, take off the primary raw material stating weight proportion and be prepared from (every part of 20g): Bulbus Lilii 24 parts; Clematis filamentosa Dunn 18 parts; Concha Margaritifera 13 parts; Concha Ostreae 12 parts; Radix Salviae Miltiorrhizae 16 parts; Herba lysimachiae capillipedis 16 parts; Placenta Hominis 13 parts; The Rhizoma Anemarrhenae 18 parts; Lip Rhizoma et radix valerianae 17 parts; Semen Ziziphi Spinosae 20 parts; 14 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 14 parts; 18 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 19 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 13 parts; Herba Euphoubiae Hirtae 16 parts; Radix Pittospori Glabrati 17 parts.
The preparation method of the medicament decoction of above-mentioned treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 35 minutes, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 50 minutes, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 35 minutes, merging filtrate, is concentrated into 1/2 of original volume, obtains decoction.
Instructions of taking: each 70ml, every day 3 times, 4 days courses for the treatment of.
model case onegrandson XX, female, 19 years old, people from Nanjing.From having risen up into since high three, often feeling to feel exhausted, often feeling to have a heart but no strength, worse and worse, hypomnesis, shows more obvious the reaction of sensation brain before examination.Can have a sleepless night before taking an examination when just starting at every turn, gently then could fall asleep after several hours, heavy then lie awake all night, serious all the more afterwards, usually also regular insomnia, has a rest and just easily feel sleepy evening bad daytime.Learning time is slightly grown and just yawns incessantly, and feels dizzy.Sometimes, not at all easyly to fall asleep, but wake up with a start because of sound.Usually need could fall asleep by sleeping pill, the dose of sleeping pill is also increasing, takes a slice at first and just can work, and it is also not so good to eat two or three effect afterwards.
After taking 2 courses for the treatment of of medicament decoction (embodiment 2) of gained of the present invention treatment palpitation and insomnia, the symptom of insomnia is imprinted on one's mind and is alleviated, and can sleep substantially every night five or six hours, and daytime, conscious spirit obviously took a turn for the better, just before examination or insomnia appears in occasional.Seldom occur insomnia again after continuing to take 1 course for the treatment of, temper also becomes gentle a lot.Later stage visits and learns and no longer have a sleepless night, and daytime, the mental status was good, and school grade also obviously promotes.
embodiment 3treat a medicament for palpitation and insomnia, take off the primary raw material stating weight proportion and be prepared from (getting 35g for every part): Bulbus Lilii 19 parts; Clematis filamentosa Dunn 14 parts; Concha Margaritifera 9 parts; Concha Ostreae 8 parts; Radix Salviae Miltiorrhizae 12 parts; Herba lysimachiae capillipedis 13 parts; Placenta Hominis 11 parts; The Rhizoma Anemarrhenae 16 parts; Lip Rhizoma et radix valerianae 14 parts; Semen Ziziphi Spinosae 16 parts; 10 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 11 parts; 14 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 14 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 10 parts; Herba Euphoubiae Hirtae 13 parts; Radix Pittospori Glabrati 11 parts.
The preparation method of the medicament pill of above-mentioned treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 35 minutes, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 50 minutes, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 35 minutes, merging filtrate, being condensed into relative density is 1.20(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 4 days courses for the treatment of.
embodiment 4treat a medicament for palpitation and insomnia, take off the primary raw material stating weight proportion and be prepared from (getting 20g for every part): Bulbus Lilii 22 parts; Clematis filamentosa Dunn 16 parts; Concha Margaritifera 12 parts; Concha Ostreae 11 parts; Radix Salviae Miltiorrhizae 15 parts; Herba lysimachiae capillipedis 15 parts; Placenta Hominis 12 parts; The Rhizoma Anemarrhenae 17 parts; Lip Rhizoma et radix valerianae 16 parts; Semen Ziziphi Spinosae 19 parts; 13 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 13 parts; 17 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 17 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 12 parts; Herba Euphoubiae Hirtae 15 parts; Radix Pittospori Glabrati 15 parts.
The preparation method of the medicament tablet of above-mentioned treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 35 minutes, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 50 minutes, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 35 minutes, merging filtrate, being condensed into relative density is 1.20(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 4 days courses for the treatment of.
model case twosoviet Union XX, man, 31 years old, Shandong Province Laiwu City people.Worked 5 or six years, work and life are tending towards tranquil, and Mr. Su should live a happy life originally, but but health is day by day fat, uneasy sleeping at night then, and once went to a doctor in many places, has no and be clearly better.Often through insomnia, even if sleep also especially easily pleasantly surprised, be difficult to after waking up again fall asleep, can sleep for three or four hour reluctantly, but all not enter the state of deep sleep, time ill-conditioned, can't fall asleep whole night time situation is good in the evening, and the daybreak such as lie on a bed.Lethargy all day, murky dizzy.
After taking 2 courses for the treatment of of medicament tablet (embodiment 4) of gained of the present invention treatment palpitation and insomnia, symptom obviously alleviates, and insomnia number of times obviously reduces, and sleep quality improves a lot, and every day on average sleeps five hours, but still dreaminess, easily wake up with a start.After continuing to take 2 courses for the treatment of, the length of one's sleep, quality are all greatly improved, and spirit is comparatively front to take a turn for the better, and symptom is almost recovered.
embodiment 5treat a medicament for palpitation and insomnia, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Bulbus Lilii 21 parts; Clematis filamentosa Dunn 15 parts; Concha Margaritifera 10 parts; Concha Ostreae 10 parts; Radix Salviae Miltiorrhizae 13 parts; Herba lysimachiae capillipedis 14 parts; Placenta Hominis 11.5 parts; The Rhizoma Anemarrhenae 16.5 parts; Lip Rhizoma et radix valerianae 15 parts; Semen Ziziphi Spinosae 18 parts; 12 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 12 parts; 15 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 15 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 11 parts; Herba Euphoubiae Hirtae 14 parts; Radix Pittospori Glabrati 13 parts.
The preparation method of the pharmacy particle agent of above-mentioned treatment palpitation and insomnia, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 35 minutes, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 50 minutes, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 35 minutes, merging filtrate, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 4 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Bulbus Lilii: sweet in the mouth, cold in nature.GUIXIN, lung meridian.For the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.There is nourishing YIN and moistening the lung, effect of clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Clematis filamentosa Dunn: bitter in the mouth, cool in nature.GUIXIN, Liver Channel.For the leaf of Ranunculaceae Clematis filamentosa Dunn.Containing flavonoid, reducing sugar, polysaccharide, steroidal, phenolic substance, tannin, aminoacid etc.There is clearing away liver-fire, mind calming god, blood pressure lowering, effect of removing obstruction in the collateral to relieve pain.For hypertension, insomnia, headache, numb limbs and tense tendons, wind-heat of liver channel, conjunctival congestion and swelling pain, acute toothache, rheumatic arthralgia.
Concha Margaritifera: salty in the mouth, cold in nature.Return liver, heart channel.For the shell of Unionidae animal hydriopsis cumingii, cristaria plicata or Pteriidae animal Pteria martensii Dunker.There is suppressing the hyperactive liver and subsiding YANG, effect of arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Concha Ostreae: salty in the mouth, cold nature.Return liver, gallbladder, kidney channel.For the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, nontoxic.GUIXIN, Liver Channel.For the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.
Herba lysimachiae capillipedis: acrid in the mouth, warm in nature.For the root and rhizome of labiate Herba lysimachiae capillipedis.Containing a small amount of apigenin and luteolin.Having removing dampness keeps away turbid, effect of inducing diuresis to remove edema.Vomit and diarrhoea for summer-heat is aobvious, edema, dysuria.
Placenta Hominis: sweet in the mouth, salty, warm in nature.GUIXIN, lung, kidney channel.For the dry Placenta Hominis of Healthy People.Fresh human placenta being removed amniotic membrane and umbilical cord, repeatedly rinsing to removing blood, after steaming or putting and slightly boil in boiling water, dry.There is the kidney warming and mend essence, effect of benefiting QI and nourishing blood.Win thin for asthenia, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature.Return lung, stomach, kidney channel.For the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae.There is clearing away heat-fire, effect of moisturizing of promoting the production of body fluid.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Lip Rhizoma et radix valerianae: acrid in the mouth, cool in nature.For the Herb of labiate lip Rhizoma et radix valerianae.Containing flavone: gloomy rhinoceros grass element, obscure flower glycoside, 7-methyl 5,7,4'-trihydroxy-6,8,3'-trimethoxyflavone, chrysin-7-O-rutinoside and caffeic acid, 4-hydroxyl-3,5-dimethoxy p-methyl, oleanolic acid, daflon.There is mind tranquilizing and the heart calming, effect of diuretic heat clearing away.For cardiopalmus, insomnia, edema, cold, fever, conjunctival congestion and swelling pain, sore swollen toxin.
Semen Ziziphi Spinosae: sweet in the mouth, acid, property is put down.Return liver, gallbladder, heart channel.For the dry mature seed of Rhamnaceae plant Ziziphi Spinosae.There is tonifying liver, mind calming, arresting sweating, the effect of promoting the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Radix Glycyrrhizae: sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.For the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, effect of relieving spasm to stop pain.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity.
Caulis Piperis Kadsurae: acrid in the mouth, slightly warm in nature.For root and the old rattan of Magnoliaceae Kadsura abnormity Fructus Schisandrae Sphenantherae.There is expelling wind and removing dampness, regulating QI to relieve pain, effect of promoting blood circulation to remove blood stasis.For rheumatism bones and muscles pain, lumbar muscle strain, sciatica, acute gastroenteritis, chronic gastritis, taste-blindness rate, dysmenorrhea, puerperal abdonimal pain, traumatic injury.
Poria: sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.For the dry sclerotia of On Polyporaceae Poria.Have promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieve internal heat anticancer effect.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia, dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, and malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root: sweet in the mouth, property is put down.Return stomach, heart channel.For root or the root bark of Hamamelidaceae Plants China Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．).Containing Bergeninum, quercitrin.There is dispelling wind stomach function regulating, effect of mind tranquilizing and the heart calming.For diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, headache, nausea and vomiting, cardiopalmus, dysphoria.
Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit: sweet in the mouth, micro-acid, property is put down.For the fruit of Buxaceae Sarcococca plant open country fan flower.There is effect that nourishing the liver is calmed the nerves.For dizziness, order flower, cardiopalmus, night sleeps uneasy.
Herba Euphoubiae Hirtae: acrid in the mouth, acid, cool in nature, mild toxicity.Return lung, Liver Channel.For the whole herb with root of Euphorbiaceae euphorbia Ramulus et Folium Bauhiniae Faberi.Containing freidelin, β-Amyrin, hentriacontane, cupreol, again containing taraxerol, taraxerone, chondrillasterol, stigmasterol, Jambul alcohol, bark element, rhamnetin-3-rhamnoside.Have heat-clearing and toxic substances removing, dampness removing is antipruritic, effect of lactogenesis.For lung abscess, acute mastitis, dysentery, has loose bowels, pyretic stranguria, hematuria, eczema, tinea pedis, skin pruritus, furuncle swelling toxin, ulcerative gingivitis, puerperal lactation deficiency.
Radix Pittospori Glabrati: sweet in the mouth, hardship, pungent, cool in nature.For root or the root bark of Pittosporaceae plant Pittosporum glabratum Lindl..There is tonifying the lung kidney, wind-damp dispelling, effect of promoting blood circulation to remove obstruction in the collateral.Breath with cough for asthenia, seminal emission premature ejaculation, insomnia, dizzy, hypertension, rheumatic arthralgia, infantile paralysis.
test examplein order to verify the curative effect of medicament (embodiment 5) of gained of the present invention treatment palpitation and insomnia, in February, 2009 in JIUYUE ,-2010 done contrast test:
General data: the patient of screening 200 example insomnia, wherein minimal ages 18 years old, max age 62 years old, 38.1 years old mean age; 18-30 year 52 people, 31-40 year 57 people, 41-50 year 44 people, 51-65 year 47 people.Be divided into experimental group and matched group two groups (wherein experimental group 150 people, matched group 50 people) at random, two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: 1. main suit or difficulty falling asleep, or be difficult to maintain sleep, or poor sleeping quality.2. this sleep disordered at least generation weekly also continues more than 1 month 3 times.3. day and night insomnia is absorbed in, the consequence of excessive worry insomnia.4. amount of sleep and/or the dissatisfied of matter cause obvious worries or have impact on society and occupational function.
Usage and dosage: experimental group takes the pharmacy particle agent of gained of the present invention treatment palpitation and insomnia, each 1 bag, every day 3 times, 4 days courses for the treatment of; Matched group takes other medicine (as Yang Yin Zhen Jing Tablet, beneficial peace pill etc.), wherein, and Yang Yin Zhen Jing Tablet: oral, a 4-6 sheet, 3 times on the one.Benefit peace pill: oral, every day 1 to 2 time, each 12 to 18 balls.
Criterion of therapeutical effect: recovery from illness: sleep is normal, more than the 6 hours length of one's sleep, simultaneous phenomenon disappears.Effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improved.Invalid: before sleeping as taking medicine, or extend the length of one's sleep less than 2 hours, symptom is without improvement.
4 courses for the treatment of of medication treatment, observe latter 1 year for the treatment of.The Comparison of therapeutic of the experimental group of the matched group taking other drug and the medicament taking gained of the present invention treatment palpitation and insomnia, result is as shown in table 1:
Table 1
As can be seen from Table 1, take the cure rate of the medicament of gained of the present invention treatment palpitation and insomnia up to 75.34%, effective percentage is up to 96.67%; And the cure rate taking other drug only 44%, effective percentage also only has 80%, so can find out that the successful of the medicament of gained of the present invention treatment palpitation and insomnia is better than the effect of other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a medicament for palpitation and insomnia, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Bulbus Lilii 17-24 part; Clematis filamentosa Dunn 12-18 part; Concha Margaritifera 8-13 part; Concha Ostreae 7-12 part; Radix Salviae Miltiorrhizae 11-16 part; Herba lysimachiae capillipedis 12-16 part; Placenta Hominis 10-13 part; Rhizoma Anemarrhenae 15-18 part; Lip Rhizoma et radix valerianae 13-17 part; Semen Ziziphi Spinosae 15-20 part; Radix Glycyrrhizae 9-14 part; Caulis Piperis Kadsurae 10-14 part; Poria 13-18 part; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 12-19 part; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 9-13 part; Herba Euphoubiae Hirtae 12-16 part; Radix Pittospori Glabrati 9-17 part.
2. medicament according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Bulbus Lilii 19-22 part; Clematis filamentosa Dunn 14-16 part; Concha Margaritifera 9-12 part; Concha Ostreae 8-11 part; Radix Salviae Miltiorrhizae 12-15 part; Herba lysimachiae capillipedis 13-15 part; Placenta Hominis 11-12 part; Rhizoma Anemarrhenae 16-17 part; Lip Rhizoma et radix valerianae 14-16 part; Semen Ziziphi Spinosae 16-19 part; Radix Glycyrrhizae 10-13 part; Caulis Piperis Kadsurae 11-13 part; Poria 14-17 part; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 14-17 part; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 10-12 part; Herba Euphoubiae Hirtae 13-15 part; Radix Pittospori Glabrati 11-15 part.
3. medicament according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Bulbus Lilii 21 parts; Clematis filamentosa Dunn 15 parts; Concha Margaritifera 10 parts; Concha Ostreae 10 parts; Radix Salviae Miltiorrhizae 13 parts; Herba lysimachiae capillipedis 14 parts; Placenta Hominis 11.5 parts; The Rhizoma Anemarrhenae 16.5 parts; Lip Rhizoma et radix valerianae 15 parts; Semen Ziziphi Spinosae 18 parts; 12 parts, Radix Glycyrrhizae; Caulis Piperis Kadsurae 12 parts; 15 parts, Poria; Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root 15 parts; Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit 11 parts; Herba Euphoubiae Hirtae 14 parts; Radix Pittospori Glabrati 13 parts.
4., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools, and is ground into fine powder altogether, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) Concha Margaritifera and Concha Ostreae are smashed, water flies twice, merges suspension, and leave standstill 5-8 hour, the supernatant of inclining, will precipitate drying, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(3) Bulbus Lilii, Clematis filamentosa Dunn, Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, Placenta Hominis, the Rhizoma Anemarrhenae, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit, Herba Euphoubiae Hirtae and Radix Pittospori Glabrati are cleaned, dry, pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
5., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), merging filtrate, be concentrated into 1/2 of original volume, obtain decoction.
6. the preparation method of medicament decoction according to claim 5, is characterized in that: the consumption of the preferred rice vinegar of step (1) is the 15%-20% of Poria quality, and the consumption being more preferably rice vinegar is 18% of Poria quality.
7., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), merging filtrate, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill and (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), merging filtrate, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
9., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:
(1) be placed in container by Poria, add rice vinegar and mix thoroughly, moistening 30-40 minute, put in parch container, slow fire heats, and fried dry, cools;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) Radix Salviae Miltiorrhizae, Herba lysimachiae capillipedis, the Rhizoma Anemarrhenae, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl．) root and Radix Pittospori Glabrati are cut into slices, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) Concha Margaritifera and Concha Ostreae are placed in marmite, decoct with water 40-60 minute, add step (1) gains, step (3) gains, Bulbus Lilii, Clematis filamentosa Dunn, Placenta Hominis, lip Rhizoma et radix valerianae, Semen Ziziphi Spinosae, Caulis Piperis Kadsurae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) fruit and Herba Euphoubiae Hirtae, decoct twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), merging filtrate, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. the preparation method of pharmacy particle agent according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
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| CN100998748A (en) * | 2006-12-31 | 2007-07-18 | 柴增胜 | Oral traditional Chinese medicine for treating serious hyposomnia of deficiency of gallbladder-qi |
| KR101242596B1 (en) * | 2010-11-30 | 2013-03-19 | 건국대학교 산학협력단 | Composition comprising an extact of cordyceps militaris and cordycepin isolated thereform for the improvement and remedial of insomnia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106075339A (en) * | 2016-07-09 | 2016-11-09 | 信阳农林学院 | A kind of sleep promoting tea |
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Application publication date: 20150701 |