CN106729109A - A kind of plants essential oil and preparation method - Google Patents

A kind of plants essential oil and preparation method Download PDF

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Publication number
CN106729109A
CN106729109A CN201710088086.1A CN201710088086A CN106729109A CN 106729109 A CN106729109 A CN 106729109A CN 201710088086 A CN201710088086 A CN 201710088086A CN 106729109 A CN106729109 A CN 106729109A
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essential oil
grades
parts
essential
plants
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刘世胜
刘峰
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YUNNAN TONGFANG TECHNOLOGY Co Ltd
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YUNNAN TONGFANG TECHNOLOGY Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of plants essential oil for calming the nerves and preparation method.Its technical field belongs to the applied technical field of plant extracts.The plants essential oil calmed the nerves of the present invention, is made up of the component of following masses part：Chinese juniper essential oil, Salvia japonica essential oil, thyme essential oil, geranium wilfordii essential oil, cypress essential oil, Bergamot, vetiver essential oil is fully mixed, obtain mixed liquor A mutually standby, configuration Chinese medicine compound prescription ethanol solution is B phases, and A is added in B phases, and 100 parts of finished product is obtained after fully mixing；Described Chinese medicine compound prescription ethanol solution is made up of spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and honeysuckle.The plants essential oil purity prepared the beneficial effects of the present invention are the present invention reaches 99.99%.Meanwhile, the present invention reaches the purpose calmed the nerves using the high volatile and high osmosis of essential oil and the synergy of various essential oils.

Description

A kind of plants essential oil and preparation method
Technical field
The present invention relates to a kind of plants essential oil for calming the nerves, belong to the applied technical field of plant extracts.
Background technology
Insomnia is sleep disorder.Difficulty falling asleep is shown as, it is intermittently discontinuous, and prematurely wake up, can not be again after waking up Continue to sleep, there is sleep insufficiency, malaise, burnout feels that more because health condition is not good, pain does not feel like oneself, circadian rhythm quilt Upset, sleep environment influence etc. also has fearness to sleep and has a sleepless night.Can be taken appropriate measures according to the reason for different.
The method that current routine is calmed the nerves is hypnotic.Hypnotic sedative agent has experienced the development of front and rear three generations so far.First Include barbiturates, chloraldurate, mixture tribromide and hydroxyzine (atarax) etc. for sedative hypnotic drug；Their therapeutic index compared with It is low, need median dose just to improve the health care of sleep, to be influenced each other between medicine and influence breathing than larger, heavy dose of.Second generation calmness is urged Dormancy medicine is primarily referred to as Benzodiazepines hypnotic sedative agent.Benzodiazepine respectively has feature.Such as triazolam：Absorb fast, rise Effect is fast, is comparatively ideal hypnotic drug without aftereffect without accumulation；But have the disadvantage half-life short, early morning mistake is also easy to produce after medication Sleep and daytime anxiety.Flurazepam：Half-life period is more long, and early morning insomnia and daytime anxiety seldom occur, but because its main metabolic is produced Thing is active, and active metabolite long half time is up to 47~100h, therefore easily accumulation.Third generation sedative hypnotic drug mainly includes Zolpidem, Zaleplon, zopiclone.Compared with the first generation and second generation sedative hypnotic drug, third generation sedative hypnotic drug pole It is few to produce " sleeping place " phenomenon, the cerebration in time morning and the dexterity of action are nor affected on, tolerance, dependence are not produced, but It is also have drowsy, dizzy, bitter taste, nauseous and forgetful etc. occasionally.Above-mentioned these treatment methods use Oral Chemical preparation for treating Method.Inventor is wished by Chinese medicine or pure natural preparation, on the premise of normal physiologic sleep structure is not changed, is used External preparation, plays a part of calmness, calms the nerves.
Essential oil can say be plant hormone, it possess and mankind's identical constitute material and life energy.Different essences Oil can be combined with each other, and mix the fragrance oneself liked, and will not destroy the speciality of essential oil, and the with better function of essential oil is made on the contrary. Selected essential oil of the invention has anti-inflammation, anti-oxidant, anti-aging, antiviral, yu anti-communicable diseases, anti-inflammation, anti-spasm, tune Section endocrine organ, promotes hormone secretion, promotes the functions such as cell metabolism and cytothesis.And some essential oil energy, allow The physiology and psychological activity of human body, obtain good development.
Essential oil is to nervous system, and essential oil is directly entered subcutaneous, one side stimulation nerve by affinity interaction, final to adjust refreshing Through activity and interior circulation；On the other hand the stable states such as interior environment are directly acted on, accelerates body fluid activity, so as to improve inner ring Border, further up to the effect for adjusting whole body and mind.Stimulate sympathetic nerve and parasympathetic nerve, calm and hypnosis, excitement to refresh oneself, Adjustment mental status, anti-melancholy, relieving psychological pressure, reparation nervous system.
The combination of various essential oils is prepared into the plants essential oil for calming the nerves by the present invention.So as to overcome existing mind-tranquilizing formulation Defect.
However, prepared by existing essential oil there are problems that：①
The present invention prepares purity plants essential oil preparation high, for calming the nerves.
The content of the invention
To solve the problems of the prior art, the present invention provides a kind of purity plants essential oil preparation high, plays what is calmed the nerves The external preparation of effect, and security is good.
The present invention is realized by following technical proposal：A kind of plants essential oil for calming the nerves, by the component of following masses part Composition：Chinese juniper essential oil, Salvia japonica essential oil, thyme essential oil, geranium wilfordii essential oil, cypress essential oil, Bergamot, vetiver essence Oil, fully mixes, and it is mutually standby to obtain mixed liquor A, and configuration Chinese medicine compound prescription ethanol solution is B phases, and A is added in B phases, is fully mixed 100 parts of finished product is obtained after even；Described Chinese medicine compound prescription ethanol solution is by spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and honeysuckle group Into.
The preparation method of plants essential oil of the present invention is carried out according to the following steps：
1) way of distillation is used, respectively by Chinese juniper leaf, Salvia japonica herb, thyme, geranium wilfordii herb, cypress fruit, Buddha's hand Mandarin orange pericarp, vetiver herb is distilled, and prepares corresponding rough essential oil；
2) by described Chinese juniper, green tea, Salvia japonica, thyme, geranium wilfordii, cypress, bergamot, the rough essential oil of vetiver Carbon dioxide supercritical extraction is carried out respectively, obtains corresponding two grades of essential oils；
3) two grades of described essential oils are carried out respectively drawing section fractionation, wherein, two grades of essential oils of the Chinese juniper collect Chinese juniper essential oil； Two grades of essential oils of the Salvia japonica collect Salvia japonica essential oil；Two grades of essential oils of the thyme collect thyme essential oil；The geranium wilfordii Two grades of essential oils collect geranium wilfordii essential oil；Two grades of essential oils of the cypress collect cypress essential oil；Two grades of essential oils of the bergamot collect Buddhist Hand mandarin orange essential oil；Two grades of essential oils of the vetiver collect vetiver essential oil；Essential oil purity >=99.99% of collection；
4) 6~8 parts of Chinese juniper essential oil, 3~5 parts of Salvia japonica essential oil, 5~7 parts of thyme essential oil, old stork are weighed by mass fraction 6~8 parts of careless essential oil, 8~10 parts of cypress essential oil, 3~5 parts of Bergamot, in 5~7 parts of vetiver essential oil, and certain number Medicine compound ethanol solution is added separately in sealing mixing tank, is added while stirring under normal temperature, and 3 points of stirring is further continued for after adding Clock；Described Chinese medicine compound prescription ethanol solution is spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and each 10 grams of honeysuckle, is soaked with 65% ethanol The filtrate steep, being filtrated to get；
5) the essential oil mixed liquor in mixing tank will be sealed and will add high-speed stirred 5 minutes after big mixing tank, be well mixed laggard Row is filling, filling while stirring when filling, packaged to can obtain product afterwards.
The application of plants essential oil of the present invention：For calming the nerves, the present invention can be prepared into spray, lotion.
Beneficial effect：
Plants essential oil purity prepared by the present invention reaches 99.99%.Meanwhile, the present invention utilizes the high volatile and height of essential oil The synergy of permeability and various essential oils reaches the purpose calmed the nerves.Effect of the invention is that (1) shortens time for falling asleep； (2) quality is improved the health care of sleep；(3) long-term use does not produce " sleeping place " phenomenon, and normal physiologic sleep structure is not changed；(4) safety, It is non-stimulated.
Specific embodiment：
Embodiment 1
Preparation method of the present invention：Respectively by Chinese juniper leaf, Salvia japonica herb, thyme, geranium wilfordii herb, cypress fruit, Buddhist Hand mandarin orange pericarp, vetiver herb is distilled, and prepares corresponding rough essential oil；By described Chinese juniper, Salvia japonica, thyme, Geranium wilfordii, cypress, bergamot, the rough essential oil of vetiver carries out carbon dioxide supercritical extraction respectively, obtains corresponding two grades Essential oil；Wherein, the operation of carbon dioxide supercritical extraction is：Rough essential oil is fitted into extractor, 40 DEG C, extraction pressure are heated to Power is 20MPa, and extraction flow velocity is 25Lh-1, continuous extraction 8h, the mixture input separation of carbon dioxide and the essential oil for extracting In device, reduce to normal pressure and be down to room temperature, carbon dioxide therein is separated with essential oil, obtain two grades of essential oils；By two grades of described essences Oil does not carry out drawing section fractionation, wherein, two grades of essential oils of Chinese juniper collect 260-310 DEG C of cut in fractionation, obtain Chinese juniper essential oil； Two grades of essential oils of Salvia japonica collect 170-200 DEG C of cut in fractionation, obtain Salvia japonica essential oil；Two grades of essential oils of thyme are in fractionation When collect 210-260 DEG C of cut, obtain thyme essential oil；Geranium wilfordii two grades of essential oils are collected 230-270 DEG C and are evaporated in fractionation Point, obtain geranium wilfordii essential oil；Two grades of essential oils of cypress collect 200-270 DEG C of cut in fractionation, obtain cypress essential oil；Bergamot Two grades of essential oils collect 140-200 DEG C of cut in fractionation, obtain Bergamot；Two grades of essential oils of vetiver are collected in fractionation 250 DEG C of cut, obtains vetiver essential oil；Essential oil purity >=99.99% of collection；Each essential oil is weighed into Chinese juniper by mass fraction 6 parts of essential oil, 3 parts of Salvia japonica essential oil, 5 parts of thyme essential oil, 6 parts of geranium wilfordii essential oil, 8 parts of cypress essential oil, 3 parts of Bergamot, 5 parts of vetiver essential oil, 64 parts of Chinese medicine compound prescription ethanol solution is respectively put into sealing mixing tank, is added while stirring under normal temperature, plus Stirring 3 minutes is further continued for after complete；The essential oil mixed liquor in mixing tank will be sealed and add high-speed stirred 5 minutes after big mixing tank, mixed Close it is uniform after carry out it is filling, it is filling while stirring when filling, it is packaged after can obtain product.Described Chinese medicine compound prescription ethanol is molten Liquid is spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and each 10 grams of honeysuckle, the filtrate soaked, be filtrated to get with 65% ethanol.
Embodiment 2
The present embodiment is used for the natural plant essential oils calmed the nerves by mass fraction by Chinese juniper essential oil 8 as different from Example 1 Part, 5 parts of Salvia japonica essential oil, 7 parts of thyme essential oil, 8 parts of geranium wilfordii essential oil, 10 parts of cypress essential oil, 5 parts of Bergamot, cus-cus 7 parts of careless essential oil, and 50 parts of Chinese medicine compound prescription ethanol solution compositions, its preparation method are same as Example 1.
Embodiment 3
The present embodiment is used for the natural plant essential oils calmed the nerves by mass fraction by Chinese juniper essential oil 7 as different from Example 1 Part, 4 parts of Salvia japonica essential oil, 6 parts of thyme essential oil, 7 parts of geranium wilfordii essential oil, 9 parts of cypress essential oil, 4 parts of Bergamot, vetiver 6 parts of essential oil, and 57 parts of Chinese medicine compound prescription ethanol solution compositions, its preparation method are same as Example 1.
Embodiment 4
Plants essential oil application test prepared by the present invention：
Begin from November, 2013, stop in by the end of December, 2014 to, public affairs department point Do in Guangdong, the area such as Sichuan, point Do to by The disconnected patient for determining to suffer from insomnia of treasure is tested with the present invention to clinical effectiveness, and it is 156, age to participate in total number of persons on probation 45-65 Sui.Application method is：The application method of spray：It is within 6 days a course for the treatment of under alignment patient temple spray 5-8 before sleep. The method of lotion is：In putting 300ml warm water into this product 2ml, sleep front foot portion and soak 20 minutes, be within 6 days a course for the treatment of.
Result shows：Investigation is on probation and statistics see the table below 1：
The clinical effectiveness test result of the invention of table 1
Investigation result shows product of the invention to calming the nerves with preferable curative effect, and average effectiveness level is 86.2%.It is one Plant potential sedative health-care product.
Embodiment 5
Skin irritation test includes acute skin irritation experiment and multiple skin irritation test.
Foundation《Cosmetics health specification (2007 editions)》, acute skin irritation is carried out to plants essential oil prepared by embodiment 1 Property experiment and multiple skin irritation test.
(1) acute skin irritation test method：Take SD rats 10, about 24h before experiment, by rat back backbone both sides Hair is cut, and can not damage epidermis, the left and right each about 3cm × 3cm of unhairing scope.Plants essential oil about 0.5mL prepared by Example 1 It is coated directly on the skin of side, then with two layers of gauze (2.5cm × 2.5cm) and one layer of glassine paper or the like covering, then uses Nonirritant adhesive plaster and bandage are fixed.Opposite side skin is used as control.Using blocking test, the application time is 4h.Experiment After end plants essential oil prepared by residual embodiment 1 is removed with warm water.Respectively after plants essential oil prepared by embodiment 1 is removed 1st, 24,48 and 72h observations rat smears the erythema and oedema response situation of area skin.
Result shows, remove after plants essential oil prepared by embodiment 11,24,48 and 72h rat skins do not occur erythema With oedema phenomenon.As can be seen here, the plants essential oil that prepared by embodiment 1 is to no skin irritation.
(2) multiple skin irritation test method：Take SD rats 10, about 24h before experiment, by rat back backbone both sides Cut by hair, unhairing scope is respectively 3cm × 3cm, application area 2.5cm × 2.5cm.Plants essential oil prepared by Example 1 is about 0.5mL is coated directly on the skin of side, and opposite side applies solvent as control, smears 1 time daily, continuously smears 14d.From second day Start, cropping is answered before smearing every time, plants essential oil prepared by residual embodiment 1 is removed with water.Rat is observed after one hour to smear The erythema and oedema response situation of area skin.
Result shows after the plants essential oil for preparing embodiment 1 coats rat side skin in continuous 14 days, do not occur Erythema and oedema phenomenon.As can be seen here, the plants essential oil that prepared by embodiment 1 is to no skin irritation.
Embodiment 6
The effect of the plants essential oil prepared with spontaneous activity experimental evaluation embodiment 1.Using mouse as animal subject, take 100 mouse are randomly divided into 10 groups：Embodiment 1 prepare plants essential oil group, Chinese juniper essential oil, Salvia japonica essential oil, thyme essential oil, Geranium wilfordii essential oil, cypress essential oil, Bergamot, vetiver essential oil group, positive controls, normal group, every group of l0 is only.Normal group The ethanol of dosage 65% according to 0.2ml/10g embrocates exposed position；Positive controls gavage 1mg/kg diazepam tablets；Other experimental groups Exposed position is embrocated using 20 μ l/10g.Successive administration 20 days.After last dose 50min, mouse is sequentially placed into SD-5G types In the multiplex instrument of pharmacology Physiological Experiment, after adapting to environment, the autonomic activities number of times of mouse in record 5min.
As a result：It is shown in Table 2.Plants essential oil energy conspicuousness prepared by embodiment 1 reduces the autonomic activities number of times of mouse, and normal Group compares significant difference (P<0.05).
The influence (means ± s) of plants essential oil prepared by 2 embodiment of table 1 to spontaneous activity in mice number of times
*p<0.05, * * p<0.01 compared with normal group
Embodiment 7
The influence of plants essential oil prepared by embodiment 1 to the yellow Jackets incubation period length of one's sleep and duration.Take 100 Mouse is randomly divided into 10 groups：Plants essential oil group, Chinese juniper essential oil, Salvia japonica essential oil, thyme essential oil, old stork prepared by embodiment 1 Careless essential oil, cypress essential oil, Bergamot, vetiver essential oil group, positive controls, normal group, every group of l0 is only.Each group mouse elder generation Fasting 12h, normal group embrocates exposed position according to the ethanol of dosage 65% of 0.2ml/10g；Positive controls gavage 1mg/kg pacifies Stator；Other experimental groups embrocate exposed position using 20 μ l/10g.The equal intraperitoneal injection yellow Jackets of each group mouse after 30min 35mg/Kg, records incubation period, the duration of mice sleep.
As a result：Such as table 3.Compared with normal group mouse, plants essential oil group energy conspicuousness prepared by embodiment 1 shortens mouse and sleeps Sleep incubation period (P<0.05), the duration (P is extended<0.05).
The influence of plants essential oil prepared by 3 embodiment of table 1 to the yellow Jackets incubation period length of one's sleep and duration (means±s)
*p<0.05, * * p<0.01 compared with normal group
Conclusion：Plants essential oil prepared by embodiment 1 can shorten mice sleep incubation period, extend the duration, with what is calmed the nerves Effect.

Claims (4)

1. a kind of plants essential oil for calming the nerves, it is characterised in that：Described plants essential oil is made up of the component of following masses part： Chinese juniper essential oil, Salvia japonica essential oil, thyme essential oil, geranium wilfordii essential oil, cypress essential oil, Bergamot, vetiver essential oil, fully Mix, it is mutually standby to obtain mixed liquor A, configuration Chinese medicine compound prescription ethanol solution is B phases, and A is added in B phases, obtained after fully mixing To 100 parts of finished product；Described Chinese medicine compound prescription ethanol solution is made up of spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and honeysuckle.
2. according to claims 1 plants essential oil preparation method, it is characterised in that：Step includes：
1) way of distillation is used, respectively by Chinese juniper leaf, Salvia japonica herb, thyme, geranium wilfordii herb, cypress fruit, bergamot is really Skin, vetiver herb is distilled, and prepares corresponding rough essential oil；
2) by described Chinese juniper, Salvia japonica, thyme, geranium wilfordii, cypress, bergamot, the rough essential oil of vetiver is carried out respectively Carbon dioxide supercritical extraction, obtains corresponding two grades of essential oils；
3) two grades of described essential oils are carried out respectively drawing section fractionation, wherein, two grades of essential oils of the Chinese juniper collect Chinese juniper essential oil；It is described Two grades of essential oils of Salvia japonica collect Salvia japonica essential oil；Two grades of essential oils of the thyme collect thyme essential oil；Two grades of the geranium wilfordii Essential oil collects geranium wilfordii essential oil；Two grades of essential oils of the cypress collect cypress essential oil；Two grades of essential oils of the bergamot collect bergamot Essential oil；Two grades of essential oils of the vetiver collect vetiver essential oil；
4) 6 ~ 8 parts of Chinese juniper essential oil, 3 ~ 5 parts of Salvia japonica essential oil, 5 ~ 7 parts of thyme essential oil, geranium wilfordii essential oil 6 are weighed by mass fraction ~ 8 parts, 8 ~ 10 parts of cypress essential oil, 3 ~ 5 parts of Bergamot, 5 ~ 7 parts of vetiver essential oil, and the necessarily Chinese medicine compound prescription ethanol of number Solution is added separately in sealing mixing tank, is added while stirring under normal temperature, and stirring 3 minutes is further continued for after adding；In described Medicine compound ethanol solution is after crushing spina date seed, the seed of Oriental arborvitae, polygala, cortex albiziae and each 10 grams of honeysuckle, with the immersion of 65% ethanol, mistake The filtrate that filter is obtained；
5) the essential oil mixed liquor in mixing tank will be sealed and add high-speed stirred 5 minutes after big mixing tank, it is well mixed after filled Dress, it is filling while stirring when filling, it is packaged to can obtain product afterwards.
3. the plants essential oil according to claims 1, it is characterised in that：Can be used to calm the nerves.
4. according to any plants essential oils of claims 1-3, it is characterised in that：Spray, lotion can be prepared into.
CN201710088086.1A 2017-02-19 2017-02-19 A kind of plants essential oil and preparation method Withdrawn CN106729109A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104117031A (en) * 2014-06-26 2014-10-29 张少维 Sleeping promoting essential oil
CN104983927A (en) * 2015-06-15 2015-10-21 中国人民解放军第一八七中心医院 Compound essential oil applied to meditation and calming in rehabilitation therapy of anxiety disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104117031A (en) * 2014-06-26 2014-10-29 张少维 Sleeping promoting essential oil
CN104983927A (en) * 2015-06-15 2015-10-21 中国人民解放军第一八七中心医院 Compound essential oil applied to meditation and calming in rehabilitation therapy of anxiety disorder

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Application publication date: 20170531