CN100528184C - Chinese medicine for treating headache - Google Patents
Chinese medicine for treating headache Download PDFInfo
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- CN100528184C CN100528184C CNB2004100107791A CN200410010779A CN100528184C CN 100528184 C CN100528184 C CN 100528184C CN B2004100107791 A CNB2004100107791 A CN B2004100107791A CN 200410010779 A CN200410010779 A CN 200410010779A CN 100528184 C CN100528184 C CN 100528184C
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- dahurian angelica
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Abstract
The present invention relates to a Chinese drug for curing headache. Its raw material medicines include 6 Chinese medicinal materials of tribulus fruit, dahurian angelica root, ligusticum root, salvia root, asarum and scorpion. The above-mentioned raw material medicines are undergone the processes of soaking, distillation, extraction, reduced pressure concentration, pulverizing, drying and capsulizing so as to obtain the invented Chinese drug capsule preparation.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly be a kind of compound preparation for the treatment of headache.
Background technology
Headache is common clinical, frequently-occurring disease, and migraine accounts for the half of Headache Clinic, especially artificially sees with the youth more, and its outbreak is relevant with multiple factor, and migraine (wind blood stasis syndrome) is to serve as the commonly encountered diseases of main performance with the chronic paroxysmal outbreak.Its pathogenesis is also not clear fully so far.Chemistry medicine energy alleviating pain is can not control of seizures.According to tcm theory and at all times document opinion select for use the more chemical medicine of treatment by Chinese herbs migraine to have its points of course with clinical experience, the more chemical medicine advantage of late result is many.Research obtains certain progress about the headache tcm clinical over year surplus in the of nearly 10.Many scholars are guidance with the theory of Chinese medical science, inquire into Coryza Treated by Syndrome Differentiation headache rule, obtain certain achievement.Is rule of treatment as Chen Mingxin with the dispelling wind nourishing blood and promoting blood circulation, and wind-cold type is with the red SIWU TANG plus-minus of Mahuang Fuzi Xixin Tang walnut; Anemopyretic adds Radix Scutellariae, Gypsum Fibrosum, Radix Saposhnikoviae, the Radix Angelicae Dahuricae etc. with TAOHONG SIWU TANG; Phlegm-damp type is with the red SIWU TANG of ERCHEN TANG walnut; The liver-kidney yin deficiency red SIWU TANG of QIJU DIHUANG WAN walnut; Blood stasis type is with 'Xue Fu Zhu Yu ' Tonga Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae.But employed before this Chinese medicine, therapeutic effect is still not ideal enough.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of headache, overcome existing in, the above-mentioned deficiency of western medicine headache.
Medicine of the present invention is made by following bulk drugs:
Fructus Tribuli 2-4 part Radix Angelicae Dahuricae 2-4 part Rhizoma Chuanxiong 2-4 part
Radix Salviae Miltiorrhizae 2-4 part Herba Asari 0.8-1.2 part Scorpio 0.8-1.2 part
Raw material optimum amount parts by weight of the present invention are:
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 parts of Radixs Angelicae Dahuricae of Fructus Tribuli
1 part of 1 portion of Scorpio of 3 parts of Herba Asaris of Radix Salviae Miltiorrhizae
Medicine of the present invention can be made various dosage forms according to a conventional method.
The present invention is based on: sick position is liver, and is relevant with mechanism of qi operation, QI and blood, meridians.According to headache outbreak position, it is main that head removes inclined to one side side or frontal eminence, detours consistent with Liver Channel, if any overwork, disgruntled, cause that edema with the liver involved is become estranged, the endogenous wind turn, end when doing during pain, due to endogenous cause of ill, morbidity is anxious, and electric cloudization is rapid, and the feature that becomes for the wind having the nature of shifting number shows.Therefore be syndrome caused by endogenous wind.Except that headache, mood disorders is also for important behaviour, common fidgety, fear etc., how to bring out by emotional distress, illustrate that assertive evidence and liver vow catharsis, easily produce various mood disorderss, smooth or brain anger is not relaxed, insomnia and dreamful sleep etc. as mood, further influence the mechanism of qi operation.The ascending, descending, exiting and entering motion of mechanism of qi is the comprehensive function of each internal organs of body; Have only irritability rise to send out, cough gas and disappear and fall, temper the lucid yang sending up, gastric qi the turbid descending, heart-fire descends, and the vital organs of the human body such as kidney liter waterborne cooperatively interact, could safeguard that mechanism of qi normally moves, thus suffocating of liver and gall lose can, easily produce movement of QI being out of order, minimal irritation causes disorder of movement of QI, enters migraine.Migraine generation inducement is a lot, and as anxiety, anxiety, sleep, climate change, and Nervous and Mental Factors feelings will seven emotions are excessive etc., cause ascending or descending movement of vital Qi people regular incidence, above-mentioned various inducements; Act on body, all can produce the movement of QI being out of order morbidity, show as the migraine premonitory symptom and occur, because of the gas promoting the circulation of blood is also gone, disturbance of QI blood also disorderly causes QI and blood eventually against disorderly entering into the headache outbreak.
Primary disease is prolonged does not heal, and pathogen usually intruding into collateral in protracted disease, channels are subjected to evil morbidity, and channels has the spill-over perfusion, oozes the function of cloth QI and blood in whole body.During normal condition, be evenly distributed, relax and contract freely, QI and blood is normally moved.After being subjected to certain cause of disease effect, change evenly state freely, or bend and roll up, or the channels of contracture traction becomes estranged, and influence the normal operation of QI and blood, make pathological changes channels position generation pain.
Arduous, the tepor of Fructus Tribuli is gone into liver, lung is a monarch drug, and tongue pond temperature is logical, and Xin Nengkai looses, the catharsis that lightly floats, and kind diffusing wind-heat of liver channel can not dispersing the stagnated live-QI to relieve the stagnation of QI, and promoting flow of QI and blood is used for wind-heat of liver channel, headache, disease such as dizzy.With the Fructus Tribuli bitter in the mouth, its yang-energy falls, and with spring meeting wood gas temperature rise the moon, cloudy yang invigorating falls to regulate the QI and blood balance, for curing mainly the monarch drug of headache.
Ministerial drug: the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, the hot temperature of the Radix Angelicae Dahuricae, fragrance can on reach sensiblely, be used for diseases such as migraine, toothache.The hot Wen Xiang of Rhizoma Chuanxiong scurries, walk and do not keep, can on reach a mountain peak, assign the sea of blood, the bypass extremity are gas medicine in the blood, and the merit of invigorating blood and dispelling wind pain relieving is arranged, wherein the Radix Angelicae Dahuricae relatively rises and looses, Rhizoma Chuanxiong is partial to blood-activating and qi-promoting, two medicines share, it is evident in efficacy that the principal drug assistance Fructus Tribuli is controlled migraine.
Adjuvant: Radix Salviae Miltiorrhizae, Herba Asari, Scorpio.The Radix Salviae Miltiorrhizae feeble QI is cold, goes into heart channel of Hand-Shaoyin, bitter in the mouth can fall and let out, and is slightly cold and relieves inflammation or internal heat, and blood circulation promoting and blood stasis dispelling is arranged, and effects such as relieving restlessness clear away heart-fire.Radix Salviae Miltiorrhizae, Fructus Tribuli are collaborative mutually, increase less important symptoms such as treatment headache, agitation.Herba Asari temperature, bitter in the mouth go into liver, intestinal, the wood gas of day spring liter is gone into Liver Channel, acrid in the mouth is nontoxic goes into lung, abnormal smells from the patient all rises.It is moving to cure mainly the brain of having a headache, the smooth liver of hot temperature, and liver opening at eye, hot eliminating cold for resuscitation is sent out, the sharp nine orifices of energy, collaborative monarch vegetables medicine is gone into liver, and edema with the liver involved is transferred and is reached, and strengthens analgesic effect.The sweet suffering of Scorpio is gone into liver, relieving spasm by subduing liver-wind, and activating collaterals to relieve pain, collaborative mutually with all medicines, cooperatively interact, reach soothing liver-QI for relieving depression, the effect of calming wind and dredging collateral.Has soothing liver-QI except that strongly fragrant, the calming wind and dredging collateral effect.
Good effect of the present invention is can soothing liver-QI to remove strongly fragrantly, and calming wind and dredging collateral effectively improves the acute brain microcirculation disturbance, and the blood vessel function that contracts that can the antagonism norepinephrine.Its indication: migraine (wind blood stasis syndrome) headache and dizzy or carefully pull and pain, headache outbreak, sore spot are fixed repeatedly,, vertigo and tinnitus vexed with flushing conjunctival congestion, xerostomia, purplish tongue is dark or ecchymosis, white and thin fur, stringy and thready pulse or stringy pulse are arranged.
Processing technique of the present invention is:
1, get Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and put in the extraction pot, the water logging bubble that adds 5 times of amounts spends the night, distill 6 hours, and extraction volatile oil, medicinal residues, medicinal liquid are stand-by; Get beta-schardinger dextrin-and add after the qdx distilled water grinds well, put in 45 ℃ of water-baths, the alcoholic solution [volatile oil (ml) is 1: 8 with the ratio of beta-schardinger dextrin-(g)] that adds volatile oil grinds in mortar and became pastel, 40 ℃ of dryings in 3 hours; Get Radix Salviae Miltiorrhizae, add 7 times of amount 95% alcohol reflux 3 times, each 1 hour, merge extractive liquid, is evaporated to dry extract, is ground into fine powder, and was standby; Fructus Tribuli, Scorpio and propose oil back medicinal residues and alcohol extraction after medicinal residues with putting in the extraction pot, add 8 times of water gagings and soaked 1 hour, decoct 3 times, each 2 hours, collecting decoction and carry oil back medicinal residues, being concentrated into relative density is 1.10 ∽ 1.15 (25 ℃ of mensuration), add ethanol under stirring and reach 75% to containing the alcohol amount, placement is spent the night, and filters, decompression recycling ethanol, be concentrated into dry extract, be ground into fine powder, with above-mentioned fine powder, Benexate Hydrochloride mixing, dry (below 60 ℃) encapsulatedly promptly get medicine of the present invention.
Function of the present invention: soothing liver-QI removes strongly fragrant, calming wind and dredging collateral.
Indication: migraine (wind blood stasis syndrome) headache and dizzy or carefully pull and pain, headache outbreak, sore spot are fixed repeatedly,, vertigo and tinnitus vexed with flushing conjunctival congestion, xerostomia, purplish tongue is dark or ecchymosis, white and thin fur, stringy and thready pulse or stringy pulse are arranged.
The specific embodiment:
1, get Radix Angelicae Dahuricae 833g, Rhizoma Chuanxiong 833g, Herba Asari 278g puts in the extraction pot, the water logging bubble that adds 5 times of amounts spends the night, distill 6 hours, extraction volatile oil 15ml, medicinal residues, medicinal liquid are stand-by; Get beta-schardinger dextrin-and add after the qdx distilled water grinds well, put in 45 ℃ of water-baths, alcoholic solution concentration [volatile oil (ml) is 1: 8 with the ratio of beta-schardinger dextrin-(the g)] hand lapping in mortar that adds volatile oil became pastel in 3 hours, 40 ℃ of dryings; Get Radix Salviae Miltiorrhizae 833g and add 7 times of amount 95% alcohol reflux 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure get the 166g dry extract, are ground into fine powder, and be standby; Fructus Tribuli 833g, Scorpio 278g and propose oil back medicinal residues and alcohol extraction after medicinal residues with putting in the extraction pot, adding 8 times of water gagings soaked 1 hour, decoct 3 times, each 2 hours, collecting decoction and carry oil back medicinal residues, being concentrated into relative density is 1.10 ∽ 1.15 (25 ℃ of mensuration), add ethanol under stirring and reach 75% to containing the alcohol amount, placement is spent the night, and filters decompression recycling ethanol, concentrate the 427g dry extract, be ground into fine powder, with above-mentioned fine powder, the Benexate Hydrochloride mixing gets brown ceramic powder, add appropriate amount of starch, dry (below 60 ℃), encapsulated 1000, every capsules contains the about 0.6g of raw extract.Capsule formulation of the present invention can be named and be " puncture root of Dahurian angelica capsule ".Medicine of the present invention can also be made existing other form of Chinese drug with common process.
Consumption of the present invention: each 4, days three times, oral of being grown up; Half an hour ante cibum warm water delivery service.Children's old man is cut down according to the circumstance or is followed the doctor's advice.
The zoopery example
One, analgesic activity
(1), puncture root of Dahurian angelica capsule stimulates the influence of the writhing response that causes to mice acetic acid.
1. given the test agent: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.
2. laboratory animal: Kunming kind white mice, male and female half and half, body weight 18-22g, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument and reagent: 0.6% acetic acid, normal saline.Syringe, stopwatch.
4. experimental technique: 60 of mices, male and female half and half, be divided into 5 groups at random by body weight, matched group gavages the isometric(al) normal saline, positive controls gavages ZHENGTIAN WAN suspension 6g/kg, and high, medium and low three the dosage groups of compound recipe puncture root of Dahurian angelica capsule contents are respectively 14g crude drug/kg, 7g crude drug/kg and 3.5g crude drug/kg.Gastric infusion is 3 days continuously, behind the last administration 40min, every Mus lumbar injection 0.6% acetum 0.2mL/ only turns round body time of occurrence (incubation period) and turns round the body number of times in the observed and recorded 20min, the result handles through the t check, the results are shown in Table 1 mice and the time of writhing response occurs and turn round the body number of times.
5. experimental result: puncture root of Dahurian angelica capsule stimulates the experimental result that influences of the writhing response that causes to see Table 1. to mice acetic acid
Table 1, puncture root of Dahurian angelica capsule stimulate the influence of the writhing response that causes to mice acetic acid.
Each dosing group and matched group compare: * P＜0.05, * * P＜001
(2), puncture root of Dahurian angelica capsule is to the influence of the pain caused effect of mice hot plate method
1. given the test agent: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404
2. laboratory animal: 60 of the female white mice of Kunming kind, body weight 20-22g, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: the quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument: the electric heating constant temperature bain-marie, Shantou, Guangdong Province medical equipment factory produces.Stopwatch.
4. experimental technique: select several 60 of the female Kunming mouse of 18～22g for use, experiment divides five groups of normal saline groups, ZHENGTIAN WAN group, high, normal, basic three the dosage groups of puncture root of Dahurian angelica capsule (dosage is the same).Under 20 ℃ of room temperature environments, put into the 500ml beaker that thermostat water bath is preheating to 55 ± 0.5 ℃, each 1 with stopwatch record mice from dropping into beaker to the time that metapedes occurs licking.At interval behind the 30min, replication once, the average that every animal is got twice time as administration before pain threshold (meansigma methods surpasses 30s person for defective), choosing 60 of qualified mices like this is divided into matched group by the pain threshold values and gavages equal-volume normal saline, ZHENGTIAN WAN group, high, normal, basic 3 the dosage groups of puncture root of Dahurian angelica capsule, every group 12, more than each treated animal before medicine and successive administration 3 days, after the last administration, respectively at 0.5,1.0,1.5,2h measures 1 time by preceding method, surpass 60s as pain threshold, promptly stop test, and press 60s and calculate, add up pain threshold then.
5. experimental result: puncture root of Dahurian angelica capsule sees Table 2 to the influence of mice analgesia (hot plate method) effect.
The influence that table 2, puncture root of Dahurian angelica capsule act on mice analgesia (hot plate method).
Each dosing group and matched group compare:
*P＜0.05,
*P＜0.01.
(3), puncture root of Dahurian angelica capsule is to mice Mus tail stimulus method:
1. given the test agent: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.
2. laboratory animal: Kunming kind white mice, male and female half and half, body weight 18-22g, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument: YSD-4 pharmacology physiology is used instrument more, and radio two factories in Bengbu produce.Time register, stopwatch.
4. white mice tail electrostimulation: male mice, be contained in respectively in the mice stationary magazine creel, making it can not autonomic activities and tail is exposed.Wipe sebum on the tail with 75% ethanol then, treat ethanol volatilization after, be coated with the skim normal saline in root of the tail portion, use instrument with pharmacology physiology, voltage 45V, the wide 2ms of ripple more, the square wave of frequency 1Hz stimulates the mouse tail root, and in the continued stimulus three times 3 responders of shouting being arranged is qualified mice.50 qualified mices are divided into 5 groups at random, and matched group gavages the isometric(al) normal saline, and positive controls gavages ZHENGTIAN WAN suspension 6g/kg, and high, medium and low three the dosage groups of puncture root of Dahurian angelica capsule contents are respectively 14g crude drug/kg, 7g crude drug/kg and 3.5g crude drug/kg.Successive administration 3 days, last administration 30min and 60min similarity condition repetitive stimulation, continued stimulus does not cause the person of shouting 2 times, is the analgesia Mus.
5. experimental result: puncture root of Dahurian angelica capsule sees Table 3 to the experimental result that influences of the pain reaction that the mice electricity irritation causes.
The influence that table 3, puncture root of Dahurian angelica capsule react the pain that the mice electricity irritation causes.
Two, calm, sleep effect:
(1), puncture root of Dahurian angelica capsule is to the influence of spontaneous activity in mice
1. given the test agent: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
2. laboratory animal: Kunming kind white mice, male and female half and half, body weight 18-22g, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument and reagent: the animal inspection box: making colourless lucite case specification by oneself is 15cm * 25cm * 20cm, and the wood flour bedding and padding are put in the bottom.
4. puncture root of Dahurian angelica capsule is to the influence of spontaneous activity in mice (walk about time and lift two forelimb methods): 60 of mices, by sex, body weight is divided into 5 groups at random, gavages puncture root of Dahurian angelica capsule, the ZHENGTIAN WAN suspension of various dose respectively, and matched group gavages isometric(al) normal saline (administration is the same).Mice is dropped in the self-control case before the administration, the movable number that adapts to record 2min behind the 2min is as normal value, and 60min behind the gastric infusion measures walk about time and two forelimbs of mice by the same method and upwards praises number of times.
5. experimental result: puncture root of Dahurian angelica capsule sees Table 4 to the influence of mice autonomic activities.
Table 4, puncture root of Dahurian angelica capsule are to the influence of mice autonomic activities.
Each dosing group and matched group compare: * P＜0.05, * * P＜0.01
(2), to the influence of pentobarbital sodium mouse sleep time:
1. be subjected to sample: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.
2. laboratory animal: 60 of the female white mice of Kunming kind, body weight 18-22g, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. reagent: normal saline.Pentobarbital sodium, the chemical experimental factory, Foshan City.
Puncture root of Dahurian angelica capsule to the pentobarbital sodium mouse sleep time influence 60 of mices, be divided into 5 groups at random by sex, body weight, gavage the ZHENGTIAN WAN suspension of various dose respectively, matched group gavages the isometric(al) normal saline.60min behind the gastric infusion, lumbar injection pentobarbital sodium 40mg/kg is a time for falling asleep with the righting reflex loss, is the sleeping eyes persistent period from righting reflex loss to recovery time.
5. experimental result: puncture root of Dahurian angelica capsule sees Table 5 to the influence of mice pentobarbital sodium mouse sleep time.
Table 5, puncture root of Dahurian angelica capsule are to the influence of mice pentobarbital sodium mouse sleep time.
Each dosing group and matched group compare: * P＜0.05, * * P＜0.01, * * * P＜0.01.
Three, function of promoting blood circulation to disperse blood clots
1. be subjected to sample: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.
2. laboratory animal: 60 of SD rat, body weight 220-240g, male and female half and half, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument and reagent: normal saline, epinephrine (Shanghai Hefeng Pharmaceutical Co., Ltd.'s production), stopwatch, syringe.MVIS-2020 full-automatic computer multichannel hemorheology system instrument (Chinese Chongqing Tianhai Medical Equipment Co., Ltd. produces).
4. to the influence of stasis syndrome rat model hemorheological property: 60 of rats, be divided into 6 groups at random by sex, body weight, normal control group and model group gavage the isometric(al) normal saline, positive control gavages ZHENGTIAN WAN suspension group 6g/kg, and three dosage groups of puncture root of Dahurian angelica capsule are respectively 10,5,2.5g crude drug/kg.Successive administration 10 days, after the administration in the 9th day, every rat skin lower injection 0.1% epinephrine 0.2mL injects once with method behind the 6h again.Between the double injection rat immersed (8 ℃) 5min in the cold water, dispose the back fasting, 1h after (being administration the 10th day) administration in second day, all the rat aorta blood-letting is measured every blood denaturation index in there being heparin sodium in vitro with full-automatic computer multichannel hemorheology system instrument.
5, experimental result: puncture root of Dahurian angelica capsule sees Table 6 to the influence of stasis syndrome rat model hemorheological property.
Four, puncture root of Dahurian angelica capsule is to the influence of rat acute cerebral microcirculation disturbance
1. be subjected to sample: medicine is brown ceramic powder in the puncture root of Dahurian angelica capsule, and Drug Manufacturing Room provide by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, lot number: 20030615.ZHENGTIAN WAN is provided by Sanjiu Pharmaceutical Co., Ltd, lot number: 20030404.
2. laboratory animal: 50 of SD rat, body weight 220-240g, male and female half and half, laboratory animal is bought by Dalian Medical Univ's Experimental Animal Center, and experiment is raised in the Dalian Medical Univ's Experimental Animal Center that is possessing the animal feeding environment quality certification.The quality certification: SCXK[the Liao Dynasty] 2002-0002.SYXK[the Liao Dynasty] 2002-0005.
3. instrument and reagent: normal saline; Norepinephrine Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number: 000502.Stereomicroscope (OLYMPUS, Japan).Pentobarbital sodium, the chemical experimental factory, Foshan City
4. experimental technique: rats by intraperitoneal injection pentobarbital sodium (40mg/kg) anesthesia, separate esophagus, insert stomach tube, sew up wound.The ventricumbent position is rat fixedly, remove the hair of head, wipe out cranium portion skin, at the eye socket trailing edge to the about 1mm of the other sagittal suture of occipital bone tuberosity line mid point place, remove osteocomma with dental burr boring (diameter 2.5-3.0mm), separate cerebral dura mater and arachnoidea, fully expose pia mater encephali and blood vessel thereof, drip 36-37 ℃ of normal saline to pia mater encephali, and do the cerebellomedullary cistern drain.Ambient-temp-stable is in 18-22 ℃, 36.8-37.5 ℃ of animal anus temperature.
50 of rats, male and female half and half are divided into 5 groups at random by body weight, gavage puncture root of Dahurian angelica capsule medicinal liquid, the ZHENGTIAN WAN suspension of various dose respectively, and matched group gavages the isometric(al) normal saline.Each organizes after the administration after 30 minutes local instillation norepinephrine 20 μ l on pia mater encephali.
5. observation index: the arteriole bore: in field of excursion, every animal is all measured 3 arteriole bores, gets its meansigma methods.The open number of blood capillary is counted blood capillaries all under the mirror 3 times, gets its meansigma methods.The open number of arteriole bore, blood capillary before administration and after the administration 30 minutes drips 15 minutes observed and recordeds behind the norepinephrine.
6. experimental result: puncture root of Dahurian angelica capsule sees Table 7-1,7-2 to the influence of rat acute cerebral microcirculation disturbance.
Table 7-1, puncture root of Dahurian angelica capsule to the influence of rat acute cerebral microcirculation disturbance (x ± s).
Each dosing group and matched group compare: * P＜0.05, * * P＜0.01
Table 7-2, puncture root of Dahurian angelica capsule to the influence of rat acute cerebral microcirculation disturbance (x ± s).
Each dosing group and matched group compare: * P＜0.05, * * P＜0.01
Five, puncture root of Dahurian angelica capsule is to the influence of domesticated dog cerebral blood flow and cerebral vascular resistance
Puncture root of Dahurian angelica capsule does not have the effect that increases the domesticated dog cerebral blood flow and reduce cerebral vascular resistance.Puncture root of Dahurian angelica capsule analgesic activity may be by blood circulation promoting and blood stasis dispelling and microcirculation improvement.
Experiment conclusion: puncture root of Dahurian angelica capsule can significantly suppress the caused pain reaction of chemical stimulation, thermostimulation and electricity irritation; The autonomic activities that can obviously suppress mice; Hypnosis to nembutal has synergism; Every hemorheology index of cold-condensing type rat can be improved, the acute brain microcirculation disturbance can be effectively improved, and the blood vessel function that contracts of energy antagonism norepinephrine.
Claims (3)
1, a kind of Chinese medicine for the treatment of headache, it is characterized in that: it is made by following bulk drugs:
Fructus Tribuli 2-4 part Radix Angelicae Dahuricae 2-4 part Rhizoma Chuanxiong 2-4 part
Radix Salviae Miltiorrhizae 2-4 part Herba Asari 0.8-1.2 part Scorpio 0.8-1.2 part.
2, medicine according to claim 1, wherein the consumption weight portion of each crude drug is:
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 parts of Radixs Angelicae Dahuricae of Fructus Tribuli
1 part of 1 portion of Scorpio of 3 parts of Herba Asaris of Radix Salviae Miltiorrhizae.
3, a kind of preparation method of Chinese medicine for the treatment of headache, it comprises the following steps:
Get Fructus Tribuli 2-4 part, Radix Angelicae Dahuricae 2-4 part, Rhizoma Chuanxiong 2-4 part, Radix Salviae Miltiorrhizae 2-4 part, Herba Asari 0.8-1.2 part, Scorpio 0.8-1.2 part by weight, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari are put in the extraction pot, and the water logging bubble that adds 5 times of amounts spends the night, and distills 6 hours, extract volatile oil, medicinal residues, medicinal liquid are stand-by; Getting beta-schardinger dextrin-adds after the qdx distilled water grinds well, put in 45 ℃ of water-baths, add the alcoholic solution of volatile oil, addition is that 1ml compares 8g by volatile oil than beta-schardinger dextrin-, in mortar, grind and became pastel in 3 hours, 40 ℃ of dryings are got Radix Salviae Miltiorrhizae, add 7 times of amount 95% alcohol reflux 3 times, each 1 hour, merge extractive liquid, is evaporated to dry extract, and it is standby to be ground into fine powder; Fructus Tribuli, Scorpio and propose oil back medicinal residues and alcohol extraction after medicinal residues with putting in the extraction pot, adding 8 times of water gagings soaked 1 hour, decoct 3 times, each 2 hours, collecting decoction and carry oil back medicinal residues, relative density is 1 10-1 15 when being concentrated into 25 ℃, adds ethanol under stirring and reaches 75% to containing the alcohol amount, and placement is spent the night, filter, decompression recycling ethanol is concentrated into dry extract, is ground into fine powder, with above-mentioned fine powder, Benexate Hydrochloride mixing, dry below 60 ℃, encapsulated 1000, every capsules contains the material that is extracted by the 4g raw material.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101708315B (en) * | 2009-12-04 | 2012-01-04 | 卢速江 | Chinese medicinal preparation for treating headache and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181592B (en) * | 2007-11-27 | 2010-07-14 | 田锦林 | Chinese medicine for curing intractable headache and sick headache |
| CN103585602A (en) * | 2013-11-11 | 2014-02-19 | 范俐元 | Medicine for treating migraine and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163140A (en) * | 1997-01-20 | 1997-10-29 | 张志华 | Anning capsule and its preparing method |
| CN1288738A (en) * | 2000-05-26 | 2001-03-28 | 程耀庭 | Toutongning medicine for headache |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163140A (en) * | 1997-01-20 | 1997-10-29 | 张志华 | Anning capsule and its preparing method |
| CN1288738A (en) * | 2000-05-26 | 2001-03-28 | 程耀庭 | Toutongning medicine for headache |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708315B (en) * | 2009-12-04 | 2012-01-04 | 卢速江 | Chinese medicinal preparation for treating headache and preparation method thereof |
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