CN106728837A - A kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma and preparation method thereof - Google Patents
A kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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Abstract
The present invention relates to a kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma, it is prepared from by the Chinese medicine material medicine of following weight proportion：The 350g of the root of kudzu vine 50, the 250g of rattletop 50, the 150g of fritillaria thunbergii 50, the 150g of aster 50, the 150g of balloonflower root 50, the 150g of the tuber of dwarf lilyturf 50, the 150g of lily 50, the 100g of buckeye 10, the 100g of radish seed 10, the 100g of Radix Glycyrrhizae 10, the 100g of garlic 10.
Description
Technical field:
The present invention is a kind of Chinese medicine composition, the present invention relates to a kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma
Technical background：
In the centralization-breeding factory in many areas of China, livestock and poultry stress environment (such as cold stress, heat stress) in certain
Under stimulation, the pathogenic microorganism, a series of syndromes shown in livestock and poultry respiratory system such as infection virus, bacterium, parasite
Group.During anti-system disease, chemicals can play certain therapeutic action, but the problems such as easily cause drug resistance；Weak poison
Seedling protective rate is high, but operating technology difficulty is big, should not promote；Inactivated vaccine is easy to operate, but its protective rate is far away from Attenuate vaccine.
Medicine of the present invention is based on China's traditional Chinese medicine to the pathogenetic understanding of cough and asthma and principle of reatment, with reference to existing
For pharmacological research achievement, Chinese medicine preparation is made by Chinese veterinarian's theory prescription.This medicine enhances the integrally-regulated work(of animal body
Can, can effectively alleviate the symptoms such as cough, asthma, the potential safety hazard that chemical drug is likely to result in is reduced, increased the security of medication.
The present invention provides a kind of Chinese medicine composition of wind-heat cough and asthma.Specifically with the root of kudzu vine, rattletop, fritillaria thunbergii, aster,
Balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae, garlic are raw material preparation.With functions such as gas under clearing heat and detoxicating, dissolving phlegm.
The invention further relates to the preparation method of the medicine.
The content of the invention：
Present invention solves the technical problem that be to disclose a kind of Chinese medicine composition, its by following weight proportion Chinese medicine material medicine
It is prepared from：
Root of kudzu vine 50-350g, rattletop 50-250g, fritillaria thunbergii 50-150g, aster 50-150g, balloonflower root 50-150g, tuber of dwarf lilyturf 50-
150g, lily 50-150g, buckeye 10-100g, radish seed 10-100g, Radix Glycyrrhizae 10-100g, garlic 10-100g.
Preferably, Chinese medicine composition of the invention, is prepared from by the Chinese medicine material medicine of following weight proportion：
Root of kudzu vine 100-300g, rattletop 100-200g, fritillaria thunbergii 60-140g, aster 60-140g, balloonflower root 60-140g, the tuber of dwarf lilyturf
60-140g, lily 60-140g, buckeye 20-90g, radish seed 20-90g, Radix Glycyrrhizae 20-90g, garlic 20-90g.
Most preferably, Chinese medicine composition of the invention, is prepared from by the Chinese medicine material medicine of following weight proportion：
Root of kudzu vine 150-250g, rattletop 120-180g, fritillaria thunbergii 80-120g, aster 80-120g, balloonflower root 80-120g, the tuber of dwarf lilyturf
80-120g, lily 80-120g, buckeye 30-80g, radish seed 30-80g, Radix Glycyrrhizae 30-80g, garlic 30-80g.
Chinese medicine composition of the invention, the root of kudzu vine is monarch drug in a prescription, and rattletop, fritillaria thunbergii are ministerial drug.Effect of each component is as follows：
The root of kudzu vine：It is the dry root of legume pueraria lobata, practises and claim elegant jessamine.Autumn, the excavation of season in winter two, take advantage of fresh-cut into sheet or small
Block；Dry.It is sweet, pungent, it is cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in table card heating, rigid neck and back
Bitterly, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is to the root of kudzu vine
Systematic research is carried out, it is believed that stem, leaf, flower, fruit, the root of the root of kudzu vine can be used as medicine.He《Compendium of Materia Medica》In so record：
" Pueraria lobota, property is sweet, pungent, flat, nontoxic, cures mainly：Quench one's thirst, high fever of the body, vomiting, all disadvantages, play cloudy gas, solve all poison ".《Do not record》：" cure the wound cold
Middle wind headache, expelling pathogenic factors from muscles and skin is delivered, and is perspired, loosing the interspaces of skin and muscles.Metal-inflicted wound is treated, analgesic coerces wind bitterly." " is taken root juice, and treatment is quenched one's thirst, typhoid fever high fever."
《This is through meeting original》：" root of kudzu vine is frivolous, and life is promoted the production of body fluid with then rising Yang, ripe with then inspiring stomach Qi, therefore controls that stomach is empty to make thirsty, the scattered use of the seven taste bighead atractylodes rhizomes
It.And qingshu yiqi decoction and golden cypress user, bright with heat impairment of yang, volume cranium must be swollen, and non-this can not be developed."
Rattletop：Alias:Longan root, week fiber crops, hole root of the tooth, are Ranunculaceae, rattletop platymiscium C.heracleifolia, Cimicifuga Dahurica
Or the rhizome of rattletop.Pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.Function delivers promoting eruption, clearing heat and detoxicating, rises and lifts yang-energy.With
In headache due to pathogenic wind-heat, dentalgia, aphtha, abscess of throat, measles without adequate eruption, sun poison hair spot；Prolapse of the anus, the prolapse of uterus.《Do not record》：Abdomen is disliked in master
Bitterly, gas poison pestilence when, fever and chills of having a headache, wind swells all poison, laryngalgia, aphtha.《Haigoushen》：Control children's wind, frightened epilepsy, when the hot disease of gas.Can control
The swollen pains of ability to speak wind NI, root of the tooth floats rotten stench, heat toxin purulence blood.Except cardiopulmonary wind toxin heat is obstructed and constipated, aphtha is unhappy.Treat carbuncle swells, pea
Sore；Decocting silk floss is stained with and is wiped in sore.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：Table children's acne rash, solves sore, throat (swollen)；Sound of breathing with cough is mute, lung heat, only dentalgia,
Acute tonsillitis, mumps.
Fritillaria thunbergii：The big hardship of taste, it is cold in nature.Clearing heat and eliminating phlegm, powder detoxifcation.Cough due to wind-heat evil is controlled, lung carbuncle larynx numbness, scrofula, sore swells
Poison.《Book on Chinese herbal medicine is just》：Control lung carbuncle lung greatly to wither, cough and asthma, spit blood, mental disorder most drops in bleeding from five sense organs or subcutaneous tissue, be apt to relieving stagnation, relieve the pain pain, dissipate-swelling is full, clears liver
Fire, bright knowledge, except when gas dysphoria with smothery sensation, jaundice drench close, excessive blood of having blood in stool；Relieving heat toxin, kills parasites and treats larynx numbness, scrofula, acute mastitis carbuncle on the back, one
Cut large carbuncle pyogenic infections, damp and hot evil sore, anal fistula, metal-inflicted wound bleeding, fiery sore pain, than bulbus fritillariae cirrhosae, the work(of clear drop, not less than several times.《Detailed outline
Pick up any lost article from the road》：The sharp phlegm of removing toxic substances, opens facilitaing lung gas, all lung man folder wind fire have phlegm person preferably this.《Shandong Chinese herbal medicine handbook》：Clearing lung and eliminating phlegm, system
Acid, removing toxic substances.
Aster：Pungent, sweet, hardship, temperature.Return lung is passed through.Root containing shionon (shionone), Quercetin, freidelin, epi-friedelin and
Volatile oil, still containing astersaponin (astersaponin), hydrolyzes to obtain hederagenin (hederagenin).Under function moistening lung
Gas；Preventing phlegm from forming and stopping coughing.Main cough；Deficiency syndrome of the lung labor is coughed；Consumptive lung disease lung carbuncle；Cough vomiting of pus and blood；Difficult urination.Breathed with cough for abundant expectoration, new chronic cough is coughed,
Labor is coughed hemoptysis.
Balloonflower root：Balloonflower root is China's tradition parts of generic medicinal plants, and effect has the functions such as facilitaing lung, eliminating the phlegm, relieving sore-throat, apocenosis, cures mainly
The symptoms such as coughing with a lot of sputum, abscess of throat.《This warp》：Main chest and hypochondrium such as lancination, abdomen is full, and borborygmus are faint, gas of throbbing with fear in terror.《Do not record》：
Relieving the five internal organs stomach, replenishing blood and vital energy, except fever and chills, wandering arthritis, middle benefit gas disappear paddy, treat laryngopharynx bitterly.《Haigoushen》：Diarrhea is controlled, pneumatosis is removed in blood-breaking,
Disperse accumulations is gathered, and sputum, main lung heat shortness of breath coughs inverse, except crymodynia in abdomen, is disliked and pediatric epilepsy scared in master.《Pearl sac》：Treat sore-throat, sharp lung
Gas, controls nasal obstruction.
The tuber of dwarf lilyturf：It is the Liliaceae Ophiopogon plant tuber of dwarf lilyturf (Ophitopogin japonicum (L.f) Ker.-Gawl.) root
Relatively thick, middle or proximal end often expands ovalisation or fusiform small root tuber, nature,taste and action：Sweet, slight bitter, cool, Yin-nourishing and body fluid promoting,
Moisten the lung and relieve the cough, relieving restlessness that clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry throat lung heat, cough, pulmonary tuberculosis.《Sheng Nong's herbal classic》：It is main
Stagnation of vital energy in the chest and abdomen, wound slanders full, and stomach channels is absolutely, thin thin to lose heart.《Haigoushen》：Heat toxin is controlled, only polydipsia, main flood appearance podomere is floated
It is swollen, lower water.Consumptive lung disease pyemesis is controlled, master lets out essence.《Mingyi Bielu》：Body weight mesh Huang is treated, rami cardiaci inferiores is full, consumptive disease visitor's heat, dry polydipsia, only
Vomiting, more impotence falls, strong the moon strengthening the essence, and disappear Gu Tiaozhong, protects god, determines lung qi, and five viscera settling makes us fertile strong.《Medication heart method》：Bushing gas is not
Foot and control the absurd row of blood.
Lily：The product are liliaceous plant tiger lily Lilium lancifolium Thunb., lily Lilium brownii
The dry meat of F.E.Brown var.viridulum Baker or morningstar lily lily (Lilium tenuifolium) Lilium pumilum DC.
Scale leaf.It is sweet, cold nature.The thoughts of returning home, lung channel.Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.For yin chronic cough, blood-stained sputum, dysphoria palpitates with fear,
Insomnia and dreamful sleep, it is absent-minded.With Yin nourishing and lung moistening cough-relieving effect, for the cough caused by dryness-heat of Lung-Yin deficiency, such as blood-stained sputum, all sorts of flowers
Cream.Control chronic cough of deficiency lung, labor is coughed spitting of blood, such as baihe gujin decoction.Unclear for pyreticosis waste heat with clearing away the heart fire and tranquillizing effect, dysphoria is shied
Throb with fear, insomnia and dreamful sleep etc..
Buckeye：It is Hippocastanaceae plant horse chestnut Aesulus chinensis Bge., Zhejiang Buckeye Aesculus
The drying of chinensis Bge.var.chekingensis (Hu et Fang) Fang Aesculus Wilsonii Rehd.
Mature seed.It is sweet, temperature.Return liver, stomach.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Swollen vexed, the gastral cavity pain for chest and abdomen.《Beneficial portion's square object is omited
Note》:Wind contraction is eaten long.《It is logical refined》:Gas can be descended.《Detailed outline is picked up any lost article from the road》：The inherited from one's ancestors side of Pueraria lobota, controls heart stomach cold bitterly, and worm is bitterly.Wide lower gas, controls
Gastral cavilty liver diaphragm expands, infantile malnutrition due to digestive disturbances or intestinalparasites malaria dysentery, haematemesis internal lesion caused by overexertion, flat stomach dredging collateral.
Radish seed：It is the mature seed of crucifer radish Raphanus sativusL..Fatty oil, volatile oil
Have in volatile oil erucic acid containing volume (Erucic acid) in the fat oils such as methyl mercaptan (Methyl mercaptan), linoleic acid,
Leukotrienes, glycerol sinapate (Glycerol sinapate) still containing raphanin (Raphanin) separate cupreol (β-
Sitosterol).It is mild-natured, it is taste is pungent, sweet.Return lung, spleen, stomach.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.It is swollen for retention of food and drink, gastral cavity abdomen
Bitterly, constipation, stagnant rush down dysentery, phlegm are stopped up and are breathed with cough.Enter spleen, stomach, lung channel, can help digestion de-swelling, effect significantly, have " rushing wall wall " it
Claim.Clinic is commonly used in real (food, the wet, stagnant) card for the treatment of.However, the product are only not the de-swelling that helps digestion, it is used to asthenic symptoms, obtain effect
Also it is good, because its property peace, its smell again not high, the disadvantage of unbiased victory, saying for " rushing wall wall " can not be limited to, have relieving stagnant Qi suspicion (reality
It is then having a surplus for flat gas), and give it up.
Radix Glycyrrhizae：It is sweet sweet, it is mild-natured and, enter the heart, spleen, lung, the warp of stomach four.It is raw with cooler, can purging intense heat and detonicating, relieving spasm to stop pain；Process
With partial temperature, exterior cold, tonifying middle-Jiao and Qi can be dissipated.Additionally, Radix Glycyrrhizae is also good at mediation property of medicine, the poison of hundred medicines is solved.Effect and effect：QI invigorating is mended
In；Relieving spasm to stop pain；Moisten the lung and relieve the cough；Purging intense heat and detonicating；Coordinating the drug actions of a prescription.Main burnout deficiency of food；The thin face of flesh is yellow；Palpitation；Stomachache loose stool；
Four limbs contraction；Hysteria；Cough and asthma；Abscess of throat；Ulcerative carbuncle swells and ache；Infant fetal toxin；And medicine, food poisoning.For spleen
Stomach is weak, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviates drug toxicity, strong
Property.
Garlic：Garlic Allium sativum L. (Garlic) belongs to Liliaceae allium, is used as medicine with bulb.Garlic is warm in nature, taste
Xin Ping；Enter spleen, stomach, lung channel.Removing toxic substances desinsection, swelling and pain relieving, antidiarrheal stop dysentery controls lung, expelling parasite, in addition with warm spleen warm stomach.Control carbuncle
Subcutaneous ulcer pyogenic infections, white bald tinea sore, dysentery diarrhea, tuberculosis pertussis, roundworm pinworm, eating accumulation, coldness and pain in the epigastrium, oedema turgor.《Name doctor is other
Record》：" dissipating carbuncle swells black mole sore, exorcising, gas of killing virus ".《Tang materia medica》：" lower gas, disappear paddy, changes meat ".《Bencao Shiyi》：" just eat not
Sharp mesh, eats bright more.Long food makes us serum, makes the hair white ".《Diet is occupied with breath to compose》：" survivor is hot, the ripe sweet temperature of person, except cold
It is wet, cloudy heresy is warded off, in lower hot air heating, grain-meat digesting breaks extravesated blood, attacks cold product.Control and rush down stomachache cruelly, dirty removing toxic substances is warded off in clearance lattice constipation, and disappear ruffian
Desinsection.Outer moxibustion ulcer, water-filling stops nosebleed ".
Composition described above of the invention is, by weight as proportioning, can to increase or reduce according to corresponding proportion in production,
Such as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also be in units of milligram, and weight can
To increase or reduce, but the respectively constant rate of the raw medicinal herbs weight proportion between composition.
The ratio of above weight proportion is obtained by science screening, fat for special circumstances, such as severe or mild
Or slight of stature, the proportioning of the amount of composition can be accordingly adjusted, increase or decrease no more than 100%, drug effect is constant.
Single medicinal material in composition described above, especially ministerial drug and adjutant, it is also possible to by appropriate with the identical property of medicine
Medicine is replaced, and Chinese medicine preparation its medicine effect after replacement is constant.
Chinese medicine composition of the invention, be by by the pharmaceutically active substance of above-mentioned formula according to galenic pharmacy routine techniques system
It is standby into pharmaceutical dosage forms.When pharmaceutical preparation is prepared into, pharmaceutically acceptable carrier can be added if necessary, according to galenic pharmacy
It is prepared by routine techniques.Pharmaceutical dosage forms of the invention, exist in a unit, and the unit dosage form refers to preparation
Unit, such as every of tablet, every capsule of capsule, every bag of granule etc..
Chinese medicine preparation of the invention can be any pharmaceutically useful formulation, and these formulations include：Tablet, capsule, particle
Agent, pill, powder, paste, sublimed preparation, pulvis, solution, injection, suppository, spray, drops, patch.Preparation of the invention,
Preferably peroral dosage form, such as：Capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, paste etc..
Chinese medicine preparation of the invention, the preparation that it is administered orally can contain conventional excipient, such as adhesive, filling
Agent, diluent, tablet agent, lubricant, disintegrant, colouring agent, flavor enhancement and wetting agent.Applicable filler includes starch, sugarcane
Sugar, cellulose, mannitol, the lactose filler similar with other.Suitable disintegrant includes starch, polyvinylpyrrolidone
And starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as magnesium stearate.Can be filled out by mixing
Fill, the conventional method such as compressing tablet prepares solid oral composition.Being mixed repeatedly can be distributed in active material entirely to use
In those compositions of a large amount of fillers；Conventional adjunct ingredient includes：Mannitol, sorbierite, sodium pyrosulfite, bisulfite
Sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, monoacidic base gold
The carbonate of category, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride,
Sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon spread out
Biology, cellulose and its derivates, alginates, gelatin, polyvinylpyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate, carbonic acid
Hydrogen calcium, surfactant, polyethylene glycol, cyclodextrin, beta-schardinger dextrin, phospholipid material, kaolin, talcum powder, calcium stearate,
Magnesium stearate etc..
Preparation of the invention is determining usage and dosage according to condition when using, and can take 1-2 times daily, presses per kilogram body every time
Weight 0.5-3g dosage.
The present invention further provides the preparation method of Chinese medicine composition of the invention, the preparation method is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, that is, Chinese medicine composition is obtained.
Confirm that this preparation process stabilization is adapted to big production by study of pharmacy.
Beneficial effects of the present invention are illustrated below by way of experimental data：
Pharmacodynamics are tested
This Chinese medicine compound prescription causes to cough the influence of mouse to concentrated ammonia liquor
Experimental animal：Mouse, body weight 18-22g, male and female dual-purpose
Chinese medicine is prepared by the preparation method of embodiment 5
50 mouse are taken, male and female half and half are randomly divided into 5 groups, respectively every group 10, the isometric physiology salt of blank control group
Water, Chinese medicine control group GUILONG KECHUANNING JIAONANG (0.59g/Kg), Chinese medicine group, scarce ministerial drug group, scarce monarch drug in a prescription group are administered 2g/Kg respectively,
Gastric infusion, is administered once daily, continuous 5 days, and each group mouse fasting 16h, 30min after last dose, mouse is put into before experiment
In lured to cough to draw and breathes heavily instrument added with concentrated ammonia liquor, 15s is atomized, the cough latent period of observed and recorded mouse (goes out since spraying to animal
The time now coughed) and the interior cough number of times of 2min.
The antitussive effect of table 1
Remarks：Different lowercase letter indication differences significantly (P<0.05), different capitalizations represent difference extremely significantly (P<
0.01), same letter represents difference not significantly (P>0.05)
This product Chinese medicine group, lack ministerial drug group, lack the extension concentrated ammonia liquor that monarch drug in a prescription group can be different degrees of and cause mouse cough incubation period,
Reduce cough number of times in 2min, Chinese medicine group, the incubation period for lacking ministerial drug group and cough number of times inequality heteropole compared with blank control group
Significantly (P<0.01), the not notable (P of the incubation period of scarce monarch drug in a prescription group difference compared with blank control group>0.05), but cough number of times with
Blank control group is compared to inequality heteropole significantly (P<0.01).Show that the medical instrument has good antitussive action.
This Chinese medicine compound prescription draws the influence for breathing heavily cavy to 2% acecoline and 0.1% histamine phosphate's mixture
Experimental animal：Baby guinea pig, 150-200g, male and female dual-purpose
Chinese medicine is prepared by the preparation method of embodiment 5
Take Baby guinea pig to be grouped at random, every group 10, be divided into 5 groups, respectively blank control group, positive controls, Chinese medicine
Group, scarce ministerial drug group, scarce monarch drug in a prescription group.Gastric infusion, 1h after administration, cavy is put into sprayer unit, with 2% acecoline
Constant-pressure atomization 30s quantitative with 0.1% histamine phosphate's mixture, records the asthmatic latent period of cavy, observes the work of relievining asthma of this medicine
With.
The antiasthmatic effect of table 1
This product Chinese medicine group, scarce ministerial drug group can be obviously prolonged 2% acecoline and 0.1% histamine phosphate's mixture
Draw the incubation period for breathing heavily cavy, the inequality heteropole significantly (P compared with blank control group<0.01) monarch drug in a prescription group and blank control group phase, are lacked
(P more not notable than difference>0.05), illustrate that this product has obvious antiasthmatic effect.
The present invention is found surprisingly that the collocation of each component of the present invention has synergistic function,
Specific embodiment：
The present invention is further illustrated by the following examples, but not as limitation of the present invention.Embodiment 1
Root of kudzu vine 250g, rattletop 100g, fritillaria thunbergii 80g, aster 80g, balloonflower root 80g, tuber of dwarf lilyturf 80g, lily 80g, buckeye
80g, radish seed 80g, Radix Glycyrrhizae 80g, garlic 80g
The preparation method of granule is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, system
Into 1000g, mix, granulation packing is obtained final product.
Embodiment 2
Root of kudzu vine 250g, rattletop 150g, fritillaria thunbergii 90g, aster 90g, balloonflower root 90g, tuber of dwarf lilyturf 90g, lily 90g, buckeye
70g, radish seed 70g, Radix Glycyrrhizae 70g, garlic 70g
The preparation method of tablet is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
Even, compressing tablet is obtained final product.
Embodiment 3
Root of kudzu vine 300g, rattletop 200g, fritillaria thunbergii 120g, aster 120g, balloonflower root 120g, tuber of dwarf lilyturf 120g, lily 120g, Suo sieve
Sub- 70g, radish seed 70g, Radix Glycyrrhizae 50g, garlic 50g
The preparation method of capsule is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, mixed
It is even, it is encapsulated to obtain final product.
Embodiment 4
Root of kudzu vine 300g, rattletop 200g, fritillaria thunbergii 120g, aster 120g, balloonflower root 120g, tuber of dwarf lilyturf 120g, lily 120g, Suo sieve
Sub- 90g, radish seed 90g, Radix Glycyrrhizae 50g, garlic 50g
The preparation method of oral liquid is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Collection volatile oil is standby, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.15-1.20g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate that step 2 is obtained plus ethanol take supernatant recovery to determining alcohol 60-80%, alcohol precipitation 48h
Ethanol is to without alcohol taste.
Step 4, volatile oil is added Tween 80 (1:3) mix, be added in extract solution, mix, add the sorbic acids of 1-3 ‰
Potassium, is mixed, and adds water and is made 1000ml, sterilizes, and packing is obtained final product.Embodiment 5
Root of kudzu vine 200g, rattletop 150g, fritillaria thunbergii 100g, aster 100g, balloonflower root 100g, tuber of dwarf lilyturf 100g, lily 100g, Suo sieve
Sub- 50g, radish seed 50g, Radix Glycyrrhizae 50g, garlic 50g
The preparation method of granule is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, system
Into 1000g, mix, granulation packing is obtained final product.
Embodiment 6
Root of kudzu vine 250g, rattletop 100g, fritillaria thunbergii 100g, aster 100g, balloonflower root 100g, tuber of dwarf lilyturf 90g, lily 90g, buckeye
50g, radish seed 50g, Radix Glycyrrhizae 50g, garlic 50g
The preparation method of granule is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, system
Into 1000g, mix, granulation packing is obtained final product.
Embodiment 7
Root of kudzu vine 300g, rattletop 180g, fritillaria thunbergii 120g, aster 120g, balloonflower root 120g, tuber of dwarf lilyturf 100g, lily 100g, Suo sieve
Sub- 80g, radish seed 80g, Radix Glycyrrhizae 60g, garlic 60g
The preparation method of granule is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extraction volatile oil 6-10 hours,
Volatile oil is collected, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta-cyclodextrin bag
Compound, the liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing
8-12 times of material gross weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained,
Stand overnight, leaching supernatant is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, system
Into 1000g, mix, granulation packing is obtained final product.
Claims (6)
1. a kind of Chinese medicine composition for livestock and poultry wind-heat cough and asthma, is prepared from by the Chinese medicine material medicine of following weight proportion：
Root of kudzu vine 50-350g, rattletop 50-250g, fritillaria thunbergii 50-150g, aster 50-150g, balloonflower root 50-150g, tuber of dwarf lilyturf 50-
150g, lily 50-150g, buckeye 10-100g, radish seed 10-100g, Radix Glycyrrhizae 10-100g, garlic 10-100g.
2. composition according to claim 1, is prepared from by the Chinese medicine material medicine of following weight proportion：Root of kudzu vine 100-
300g, rattletop 100-200g, fritillaria thunbergii 60-140g, aster 60-140g, balloonflower root 60-140g, tuber of dwarf lilyturf 60-140g, lily 60-
140g, buckeye 20-90g, radish seed 20-90g, Radix Glycyrrhizae 20-90g, garlic 20-90g.
3. composition according to claim 1, is prepared from by the Chinese medicine material medicine of following weight proportion：
Root of kudzu vine 250g, rattletop 100g, fritillaria thunbergii 80g, aster 80g, balloonflower root 80g, tuber of dwarf lilyturf 80g, lily 80g, buckeye 80g, Lay
Fu 80g, Radix Glycyrrhizae 80g, garlic 80g.
4. composition according to claim 1, is any pharmaceutically useful formulation.
5. composition according to claim 4, the formulation is selected from：Tablet, capsule, granule, pill, powder, cream
Agent, sublimed preparation, pulvis, solution, injection, suppository, spray, drops, patch.
6. the preparation method of the composition described in claim 1, step is as follows：
Step one, take 6-10 times of garlic dosing material weight and measure water and soak 0.5-3 hour, extract volatile oil 6-10 hours, collection
Volatile oil, volatile oil is with beta-schardinger dextrin by weight 1:10 inclusions, 35-50 DEG C is dried to obtain volatile oil beta cyclodextrin inclusion complex,
Liquid storage after extraction；The dregs of a decoction are discarded.
Step 2, to take the root of kudzu vine, rattletop, fritillaria thunbergii, aster, balloonflower root, the tuber of dwarf lilyturf, lily, buckeye, radish seed, Radix Glycyrrhizae dosing material total
8-12 times of weight is measured decocting and is boiled 3 times, 2 hours every time, merges decoction liquor, and filtering merges with the liquid that step one is obtained, stands
Overnight, leaching supernatant, is concentrated under reduced pressure into relative density 1.21-1.27g/cm3 under the conditions of 50 DEG C, obtain concentrate；
Step 3, the concentrate for obtaining step 2 drying, are obtained dry cream；
Step 4, dry cream and volatile oil beta cyclodextrin inclusion complex are ground into fine powder, cross 100 mesh sieves, plus appropriate dextrin, be made
1000g, mixes, that is, Chinese medicine composition is obtained.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288293A (en) * | 2014-10-09 | 2015-01-21 | 卜兴强 | Traditional Chinese medicine for fever-type cough |
| CN105497879A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Anti-stress traditional Chinese medicine compound capable of improving product flavor |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288293A (en) * | 2014-10-09 | 2015-01-21 | 卜兴强 | Traditional Chinese medicine for fever-type cough |
| CN105497879A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Anti-stress traditional Chinese medicine compound capable of improving product flavor |
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Application publication date: 20170531 |