CN106726704A - A kind of sterilization shampoo and preparation method thereof - Google Patents
A kind of sterilization shampoo and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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Abstract
The invention belongs to daily chemical product field, and in particular to a kind of sterilization shampoo and preparation method thereof.The sterilization shampoo that the present invention is provided includes following components and its percentage by weight:Tea Saponin 1 3%, APG 2 8%, cocoyl isethionate 1 4%, dodecanamide propyl amine oxide 1 5%, polyquaternium 53 0.1 0.5%, sucrose fatty ester 1 10%, rutin 1 5%, patchouli alcohol 1 3%, the methyl dioleates 0.2 1% of PEG 120, glycerine 1 5%, spices 0.1 0.3%, citric acid 0.1 0.5% and deionized water 54.7 90.5%.The sterilization shampoo that the present invention is provided has appropriateness cleaning washability, and moisturizing effect is good, gentleer to skin, nontoxic non-stimulated.The sterilization shampoo that the present invention is provided simultaneously also has functions that good bactericidal, anti-inflammatory anti-itch.
Description
Technical field
The invention belongs to daily chemical product field, and in particular to a kind of sterilization shampoo and preparation method thereof.
Background technology
In the environment that the sex pheromones such as hospital assemble more, sex pheromone can also be gathered on hair, hair
On dust and dirt be microbial growth good environment, especially root of hair temperature and humidity compares the life of suitable micro-organisms
Long, sex pheromone is once attached on hair and is possible to obtain substantial amounts of breeding.Sterilization shampoo can go hair removal
Dirt, while a certain amount of microorganism can be removed, but our common sterilization shampoos do not possess sterilizing function, so cannot
Thoroughly clear and killing sex pheromone.Therefore our health care belt may be threatened.Sterilization shampoo in the market
Seldom with sterilizing function, and generally addition preservative prevents the putrid and deteriorated of sterilization shampoo, and these preservatives are to people
The health of class has certain danger, while certain stimulation may be had to skin.
Chinese patent application CN104758233A discloses a kind of sterilization shampoo, mainly has:Surfactant, foam enhancing
Agent, tackifier, conditioner, pigment and essence.The bactericide of invention addition is by pure natural fermentation raw material by modern biotechnology skill
Art is processed, and with corrosion-resistant function, highly effective and safe, but the invention shampoo bactericidal anti-inflammatory effect is undesirable.
Chinese patent CN102293727B discloses a kind of formula of disinfecting shampoo and prepares method, its formula
Percentage by weight be:Lauroyl musculamine acid sodium 12%, gelatin 0.5%, stearic acid diethylene glycol dilaurate 1%, ethylenediamine tetra-acetic acid
Disodium 0.2%, eucalyptus oil 0.2%, Cocoamidopropyl betaine 4%, silicone emulsion 0.5%, shitosan 0.5%, olive oil
1.5%th, tea extract 5% and deionized water 74.6%, the sterilization shampoo is except clear with sterilizing and itch-relieving, anti-inflammatory analgesic, pro-skin
Outside refreshing the effects such as, also with healthcare function, such as anti-oxidant, removing free radical, preventing decayed tooth, anticancer, smelly eliminating, suppression Atherosclerosis
The healthcare function such as change, reducing blood lipid, hypotensive, treatment of vascular hardening, prevention yctalopia and cataract, while increased the clear of tealeaves
Perfume (or spice), makes hair remain vigor, but its anti-inflammation and sterilization effect has much room for improvement.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of sterilization shampoo and its system
Preparation Method.The sterilization shampoo that the present invention is provided has appropriateness cleaning washability, and moisturizing effect is good, nothing gentleer to skin
Poison is non-stimulated.The sterilization shampoo that the present invention is provided simultaneously also has functions that good bactericidal, anti-inflammatory anti-itch.
The invention provides a kind of sterilization shampoo, including following components and its percentage by weight:
Tea Saponin 1-3%, APG 2-8%, cocoyl isethionate 1-4%, dodecanamide propyl amine oxide
1-5%, polyquaternium -530.1-0.5%, sucrose fatty ester 1-10%, rutin 1-5%, patchouli alcohol 1-3%, PEG-120
Methyl dioleate 0.2-1%, glycerine 1-5%, spices 0.1-0.3%, citric acid 0.1-0.5% and deionized water
54.7-90.5%.Tea Saponin is purchased from Hunan Lang Lin biological products Co., Ltd, and APG is purchased from the strong wound biotechnology in Guangzhou to be had
Limit company, cocoyl isethionate CAS NO61789-32-0, dodecanamide propyl amine oxide is purchased from the letter of Dongguan City ten thousand
Chemical Co., Ltd., the CAS of polyquaternium -53 NO:84647-38-1, sucrose fatty ester is purchased from that Wuhan is remote to be had into creating science and technology
Limit company, PEG-120 methyl dioleate CAS NO:86893-19-8.
Compatibility of the present invention is reasonable, science, and each component interacts, and has cooperateed with effect of bactericidal, anti-inflammatory anti-itch, while
The sterilization shampoo cleaning washability appropriateness that the present invention is provided, moisturizing effect is good, gentleer to skin, nontoxic non-stimulated.
Further, described sterilization shampoo is made up of following components and its percentage by weight:
Tea Saponin 2%, APG 5%, cocoyl isethionate 2.5%, dodecanamide propyl amine oxide 3%,
Polyquaternium -530.3%, sucrose fatty ester 5.5%, rutin 3%, patchouli alcohol 2%, the oleic acid of PEG-120 methyls two
Ester 0.6%, glycerine 3%, spices 0.2%, citric acid 0.2% and deionized water 72.7%.
Meanwhile, present invention also offers a kind of preparation method of sterilization shampoo, comprise the following steps:
Be placed in deionized water in batch can by S1, is heated to 60 DEG C, and polyquaternium -53, glycerine and sucrose are added while stirring
Fatty acid ester, continues to be heated to 75-90 DEG C, and stirring and dissolving obtains solution A;
At 75-90 DEG C of S2 constant temperature, to addition Tea Saponin, dodecanamide propyl amine oxide and alkane in step S1 resulting solutions A
Base glucosides is evenly stirred until dissolving, adds cocoyl isethionate, stirs, and obtains solution B;
Step S2 resulting solutions B is cooled to 30-40 DEG C by S3, and rutin, patchouli alcohol and essence, stirring are added while stirring
Uniformly, solution C is obtained to 5.5-6.5 with lemon acid for adjusting pH;
S4 at room temperature, to added in step S3 resulting solutions 3 PEG-120 methyls dioleates adjust viscosity to
2500-3000, is well mixed, and discharging is obtained final product.
Further, pH value is 6.1 in the step S3.
Further, viscosity is 2800 in the step S4.
Tea Saponin has good emulsification, dispersion, foaming, moistening and anti-inflammatory, town in the sterilization shampoo that the present invention is provided
Bitterly, the pharmacological action such as impermeabilisation;Rutin (C27H30O16, CAS NO:153-18-4) there is anti-inflammatory, antiviral effect;Hundred autumn Lee
Alcohol (C15H26O, CAS NO:5986-55-0) there is antibacterial sterilization.Tea Saponin, APG, hundred autumn Lee in the present invention
Alcohol and rutin play good cooperative effect, maximize and play hair washing bactericidal, effect of anti-inflammatory anti-itch, no longer add any
Preservative.The sterilization shampoo each component compatibility for providing of the invention is reasonable, science, mutually collaboration, restraining and sterilizing bacteria, anti-inflammatory anti-itch
Effect, while having appropriateness cleaning washability, moisturizing effect is good, gentleer to skin, nontoxic non-stimulated.
Compared with prior art, the sterilization shampoo that the present invention is provided can effectively restraining and sterilizing bacteria, anti-inflammatory anti-itch, while
Cleaning washability appropriateness, moisturizing effect is good, gentleer to skin, nontoxic non-stimulated.
Specific embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
A kind of sterilization shampoo of embodiment 1
The sterilization shampoo is made up of following components and its percentage by weight:
It is Tea Saponin 1%, APG 2%, cocoyl isethionate 1%, dodecanamide propyl amine oxide 1%, poly-
Quaternary ammonium salt -530.1%, sucrose fatty ester 1%, rutin 1%, patchouli alcohol 1%, PEG-120 methyl dioleates
0.2%th, glycerine 1%, spices 0.1%, citric acid 0.1% and deionized water 90.5%.
Preparation method:
Be placed in deionized water in batch can by S1, is heated to 60 DEG C, and polyquaternium -53, glycerine and sucrose are added while stirring
Fatty acid ester, continues to be heated to 83 DEG C, and stirring and dissolving obtains solution A;
At 83 DEG C of S2 constant temperature, to being added in step S1 resulting solutions A, Tea Saponin, dodecanamide propyl amine oxide and alkyl are sugared
Glycosides is evenly stirred until dissolving, adds cocoyl isethionate, stirs, and obtains solution B;
Step S2 resulting solutions B is cooled to 35 DEG C by S3, and rutin, patchouli alcohol and essence are added while stirring, and stirring is equal
It is even, it is 6.1 with lemon acid for adjusting pH, obtain solution C;
S4 adjusts viscosity at room temperature, to addition PEG-120 methyls dioleate in step S3 resulting solutions 3
2800, it is well mixed, discharging is obtained final product.
A kind of sterilization shampoo of embodiment 2
The sterilization shampoo is made up of following components and its percentage by weight:
Tea Saponin 2%, APG 5%, cocoyl isethionate 2.5%, dodecanamide propyl amine oxide 3%,
Polyquaternium -530.3%, sucrose fatty ester 5.5%, rutin 3%, patchouli alcohol 2%, the oleic acid of PEG-120 methyls two
Ester 0.6%, glycerine 3%, spices 0.2%, citric acid 0.2% and deionized water 72.7%.
Preparation method is similar to Example 1.
A kind of sterilization shampoo of embodiment 3
The sterilization shampoo is made up of following components and its percentage by weight:
It is Tea Saponin 3%, APG 8%, cocoyl isethionate 4%, dodecanamide propyl amine oxide 5%, poly-
Quaternary ammonium salt -530.5%, sucrose fatty ester 10%, rutin 5%, patchouli alcohol 3%, PEG-120 methyl dioleates
1%th, glycerine 5%, spices 0.3%, citric acid 0.5% and deionized water 54.7%.
Preparation method is similar to Example 1.
A kind of sterilization shampoo of comparative example 1
The sterilization shampoo is made up of following components and its percentage by weight:
Tea Saponin 2%, APG 5%, cocoyl isethionate 2.5%, dodecanamide propyl amine oxide 3%,
Polyquaternium -530.3%, sucrose fatty ester 5.5%, rutin 5%, PEG-120 methyls dioleate 0.6%, glycerine
3%th, spices 0.2%, citric acid 0.2% and deionized water 72.7%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is to be not added with patchouli alcohol, increased the consumption of rutin.
A kind of sterilization shampoo of comparative example 2
The sterilization shampoo is made up of following components and its percentage by weight:
Tea Saponin 2%, APG 5%, cocoyl isethionate 2.5%, dodecanamide propyl amine oxide 3%,
Polyquaternium -530.3%, sucrose fatty ester 5.5%, bisabolol 3%, patchouli alcohol 2%, PEG-120 methyls two
Oleate 0.6%, glycerine 3%, spices 0.2%, citric acid 0.2% and deionized water 72.7%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is that rutin is replaced with into bisabolol.
Test example one, initial foam high measure
1. test material:Sterilization shampoo prepared by embodiment 1-3 and comparative example 1-2.
2. content of the test:
Determined according to GB13173-2008, each sterilization shampoo 2.5g is taken respectively, dissolved with 150mg/kg hard water, be transferred to
In 1000mL volumetric flasks, and scale is diluted to, shaken up, then solution is placed in (40 ± 0.5) DEG C water bath with thermostatic control be aged, from adding water
Molten sample starts total time 30min, then determines foam height with Roche foam meter, and record initial foam is highly.
3. result of the test:Sterilization shampoo initial foam height, is shown in Table 1.
The sterilization shampoo initial foam height of table 1
Known by table 1, the initial foam height of sterilization shampoo prepared by the present invention is preferable.And comparative example 1-2 prepare kill
The foaming characteristic of bacterium shampoo is poorer than the effect of sterilization shampoo prepared by embodiment of the present invention 1-3, illustrate compatibility of the present invention rationally,
Science.
Test example two, irritation test
1. test material:Sterilization shampoo prepared by embodiment 1-3.
2. subjects:Cavy 150, body weight 250-300g, male.
3. content of the test:
Cavy is randomly divided into 3 groups, every group 50, embodiment 1-3 groups is denoted as.24h before experiment, cuts off guinea pig back backbone
The hair of both sides, it is respectively 3cm × 3cm not damage epidermis, unhairing scope or so, and is marked.(i.e. prepared by embodiment 1-3 to take tested material
Sterilization shampoo) each 0.5g is added on 4 layers of gauze of 2.5cm × 2.5cm, is affixed on mark skin, covered with one layer of oilpaper
Afterwards, with immobilization with adhesive tape, opposite side is blank.Tested material is removed after closing 4h, and residual tested material is washed away with clear water, in going
After except tested material 1,24,48h observation recipient site local skin reactions, press《Cosmetics health specification》(version in 2007) skin
Excitant/corrosion test carries out dermoreaction scoring, and the average value integrated with animal subject carries out overall merit, and observation is removed
Other side effects effect beyond excitant.
4. result of the test:
Each observing time point top average < 0.5 in experiment, belongs to nonirritant.That is, skin irritation test result
For:It is nonirritant.It is nontoxic non-stimulated therefore the sterilization shampoo of present invention offer is gentleer to skin.
Test example three, bacteriostatic test
1. test material:Sterilization shampoo prepared by embodiment 1-3 and comparative example 1-2.
2. subjects:Escherichia coli ATCC25922, staphylococcus aureus ATCC6538.
3. content of the test:
According to professional standard QB/T2850-2007 antibacterial bacteriostatic type detergent, fungistatic effect test, embodiment 1-3 are carried out
And the activity of the sterilization shampoo of comparative example 1-2 preparations is 1wt%, action time is 20 minutes, records bacteriostasis rate.
4. result of the test:Specific detection data, refers to table 2.
Each sterilization shampoo fungistatic effect test table of table 2
Note:* with comparative example 1 group compare p < 0.05;* compares p < 0.01 for 1 group with comparative example;▲2 groups are compared p with comparative example
< 0.05;▲▲2 groups are compared p < 0.01 with comparative example.
Known by table 2, sterilization shampoo fungistatic effect prepared by the present invention is preferable.And sterilized hair washing prepared by comparative example 1-2
The fungistatic effect of water is poorer than the effect of sterilization shampoo prepared by embodiment of the present invention 1-3, illustrate compatibility of the present invention rationally, section
Learn, each component act synergistically anti-inflammation, and the interaction of Tea Saponin, APG, patchouli alcohol and rutin, with other groups
Divide collaboration, maximize the effect for playing sterilization shampoo bactericidal.
Test example four, anti-inflammatory is tested
1. test material:Sterilization shampoo prepared by embodiment 1-3 and comparative example 1-2.
2. subjects:Mouse 60, body weight 25-30g, male.
3. content of the test:
1) mouse is randomly divided into 6 groups, every group 10, is denoted as blank control group, embodiment 1-3 groups and comparative example 1-2 groups;
2) dimethylbenzene 0.04ml drops are caused into inflammation in mouse right ear, left ear is used as control;
3) blank control group auris dextra is left intact after causing inflammation, and embodiment 1-3 groups and comparative example 1-2 groups are causing inflammation respectively
30min smears 0.5g sterilization shampoos afterwards, is smeared respectively second after 0.5 hour, mouse dislocates after 2 hours puts to death, along ear
Wide baseline cuts two ears, and round auricle is laid at the same position of left and right ear respectively with the card punch of diameter 7mm, weighs, and asks left and right
The difference of auricle weight, as the ear method of double differences, i.e. swelling, the significance of difference between comparative group.Using swelling as weigh antiphlogistic activity
Index, the smaller antiphlogistic activity for showing medicine of swelling is better.
4. result of the test:Each group sterilization shampoo anti-inflammatory the results are shown in Table 3.
The sterilization shampoo anti-inflammatory result of table 3
Group | Left ear weight/mg | Auris dextra weight/mg | The ear method of double differences (swelling)/mg |
Blank control group | 12.5±1.2 | 27.0±1.8 | 14.7±1.9 |
1 group of embodiment | 12.4±1.5 | 22.7±2.3 | 10.5±1.1*●▲ |
2 groups of embodiment | 12.4±1.4 | 21.6±1.7 | 9.6±0.9**●●▲▲ |
3 groups of embodiment | 12.6±1.3 | 22.3±1.8 | 10.1±1.2**●▲ |
1 group of comparative example | 12.5±1.1 | 24.3±2.1 | 11.7±1.0* |
2 groups of comparative example | 12.6±1.0 | 26.2±2.2 | 12.2±1.5* |
Note:* compared with blank control group, P<0.05;* compared with blank control group, P<0.01;●With 1 group of phase of comparative example
Than P<0.05;▲Compared with 2 groups of comparative example, P<0.05;▲▲Compared with 2 groups of comparative example, P<0.01.
Known by table 3, compared with blank control group, embodiment 1-3 groups and comparative example 1-2 groups are respectively provided with significant difference, i.e.,
The anti-inflammatory effects of sterilization shampoo prepared by the present invention are preferable.Meanwhile, the anti-inflammatory effects of sterilization shampoo prepared by comparative example 1-2
Effect than embodiment of the present invention 1-3 is poor, illustrate compatibility of the present invention rationally, science, each component interact, cooperateed with anti-inflammatory
Effect, and the anti-inflammatory effects of the sterilization shampoo of the preparation of embodiment 2 are optimal.
Claims (5)
1. a kind of sterilization shampoo, it is characterised in that including following components and its percentage by weight:
Tea Saponin 1-3%, APG 2-8%, cocoyl isethionate 1-4%, dodecanamide propyl amine oxide 1-
5%th, polyquaternium -530.1-0.5%, sucrose fatty ester 1-10%, rutin 1-5%, patchouli alcohol 1-3%, PEG-120 first
Base glucose dioleate 0.2-1%, glycerine 1-5%, spices 0.1-0.3%, citric acid 0.1-0.5% and deionized water 54.7-
90.5%.
2. sterilization shampoo according to claim 1, it is characterised in that be made up of following components and its percentage by weight:
Tea Saponin 2%, APG 5%, cocoyl isethionate 2.5%, dodecanamide propyl amine oxide 3%, poly- season
Ammonium salt -530.3%, sucrose fatty ester 5.5%, rutin 3%, patchouli alcohol 2%, PEG-120 methyl dioleates
0.6%th, glycerine 3%, spices 0.2%, citric acid 0.2% and deionized water 72.7%.
3. the preparation method of sterilization shampoo according to claim 1 and 2, it is characterised in that comprise the following steps:
Be placed in deionized water in batch can by S1, is heated to 60 DEG C, and polyquaternium -53, glycerine and sucrose fat are added while stirring
Acid esters, continues to be heated to 75-90 DEG C, and stirring and dissolving obtains solution A;
At 75-90 DEG C of S2 constant temperature, to being added in step S1 resulting solutions A, Tea Saponin, dodecanamide propyl amine oxide and alkyl are sugared
Glycosides is evenly stirred until dissolving, adds cocoyl isethionate, stirs, and obtains solution B;
Step S2 resulting solutions B is cooled to 30-40 DEG C by S3, and rutin, patchouli alcohol and essence are added while stirring, and stirring is equal
It is even, with lemon acid for adjusting pH to 5.5-6.5, obtain solution C;
S4 at room temperature, viscosity to 2500- is adjusted to PEG-120 methyls dioleate is added in step S3 resulting solutions C
3000, it is well mixed, discharging is obtained final product.
4. the preparation method of sterilization shampoo according to claim 3, it is characterised in that pH value is in the step S3
6.1。
5. the preparation method of sterilization shampoo according to claim 3, it is characterised in that viscosity is in the step S4
2800。
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103251541A (en) * | 2013-05-30 | 2013-08-21 | 云南七丹药业股份有限公司 | Liquid shampoo containing notoginsenoside and preparation method thereof |
CN106176270A (en) * | 2016-08-31 | 2016-12-07 | 威莱(广州)日用品有限公司 | A kind of amino acid shampoo of gentleness and preparation method thereof |
-
2016
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103251541A (en) * | 2013-05-30 | 2013-08-21 | 云南七丹药业股份有限公司 | Liquid shampoo containing notoginsenoside and preparation method thereof |
CN106176270A (en) * | 2016-08-31 | 2016-12-07 | 威莱(广州)日用品有限公司 | A kind of amino acid shampoo of gentleness and preparation method thereof |
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