CN106726669A - A kind of anti-aging cosmetics matrix containing sea cucumber polypeptide and preparation method thereof - Google Patents
A kind of anti-aging cosmetics matrix containing sea cucumber polypeptide and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of anti-aging cosmetics matrix containing sea cucumber polypeptide and preparation method thereof.The sea cucumber polypeptide is obtained through the hydrolysis such as clostridiopetidase A, papain, alkali protease.Its mean molecule quantity is less than 5000Da.The skin matrix includes 40% 50% sea cucumber polypeptide hydrolyzate, 5% 15% GL-B, 5% 15% ginseng root extract and 20% 50% water.Skin matrix of the invention can effectively improve the proliferation activity of Skin Cell, mitigate the symptom of skin senescence.
Description
Technical field
The present invention relates to a kind of feature skin care item, belong to cosmetic technical field, and in particular to one kind is more containing sea cucumber
Anti-aging cosmetics matrix of peptide and preparation method thereof.
Background technology
With advancing age and environmental pollution and the increasing of life stress, the skin senescence of people is more and more obvious,
Become to dry, lack flexibility, produce wrinkle and color is obscure.Anti-aging beauty-care skin care is also increasingly valued by people.
It is to adding various aging ingredients in cosmetics to suppress one of skin aging most effective way using cosmetics.
Recently, various active peptide components are applied in cosmetic product.
The content of the invention
Natural material is used it is an object of the invention to provide one kind, is prepared with biotechnology, anti-aging effects are significant
Skin matrix.
It is a further object of the present invention to provide a kind of hydrolysis preparation method of sea cucumber polypeptide, the applied environment temperature of the method
With hydrolysis efficiency is high, and hydrolysate molecular weight is small, and antioxidation is notable；The sea cucumber polypeptide is through clostridiopetidase A, Papain
What the hydrolysis such as enzyme, alkali protease was obtained.
Another object of the present invention is to provide the preparation method of above-mentioned skin matrix.
The object of the invention to solve the technical problems is realized using following technical scheme.Proposed according to the present invention
A kind of anti-aging cosmetics matrix, consist of the following components in percentage by weight：
The sea cucumber polypeptide hydrolyzate of 40-50%；
The GL-B of 5-15%；
The ginseng root extract of 5-15%；
The deionized water of 20-50%；Sea cucumber polypeptide hydrolyzate in the matrix, GL-B, ginseng root extract and
The weight sum of water each component is 100%.
Anti-aging cosmetics matrix of the invention, the sea cucumber polypeptide is obtained by following operation：
Sea cucumber raw material is cleaned and crush, is hydrolyzed with the compound enzyme system of clostridiopetidase A and multiple protein enzyme and is prepared sea cucumber active peptide；
Again with the method for UF membrane, small peptide of its middle-molecular-weihydroxyethyl in below 5kDa is enriched with；The small molecule sea cucumber polypeptide Transdermal absorption for obtaining
Good, collagen content is high, can provide nutrition for skin.
The method that multienzyme compounding hydrolysis prepares sea cucumber polypeptide, can be expressed as follows：
1) first new fresh sea cucumber is cleaned with running water, removes silt in sea cucumber body, sea cucumber mud is twisted into meat grinder；
2) ultra-pure water of the weight such as addition and sea cucumber mud raw material, is heated up to 40-60 DEG C；
3) the complex enzyme body being made up of neutral proteinase, papain and clostridiopetidase A of 700U/g-2500U/g is added
System, the enzymolysis processing 1-5h at 40-60 DEG C；
4) 5min-30min is incubated at being warming up to 110 DEG C -125 DEG C, the enzyme that goes out sterilizing；
5) centrifugation of 5000-12000rpm, removes residue；
6) to the centrifugation supernatant Ultra filtration membrane of 5000Da, the product of below molecular weight 5000Da is retained.
The composition of compound enzyme system：Neutral proteinase, papain and clostridiopetidase A, in its enzyme activity ratio 0.4：0.6：1
It is combined into compound enzyme system.Through being combined the sea cucumber hydrolyzate that enzyme system hydrolysis is obtained, its percent hydrolysis is up to more than 78%.
GL-B except can as NMF for skin provide lubrication and protection in addition to, due also to it is to macrophage
Immunological enhancement, with certain anti-inflammatory antiallergic effect.
The ginseng extract solution tool of 5%-15% promotes the activity of dermal fibroblasts, can increase the life of elastin laminin
Cheng Liang, so as to increase cytoactive, reduces the aging of skin.
The preparation method of the antisenility skin care matrix containing sea cucumber polypeptide, comprises the following steps：
1) stirring is opened, at ambient temperature, the GL-B of 5%-15% is slowly added in the water of 20%-50%,
It is stirred at room temperature；
The ginseng extract solution of the sea cucumber polypeptide hydrolyzate of 40%-50% and 5%-15% is added into step 1) resulting solution
In, stirring, low speed homogeneous, discharging obtains the cosmetic base with anti-aging effects.
Step 1) described in mixing speed be 800-1000rpm；The time of the constant temperature stirring is 30-60min.
Step 2) described in mixing speed be 800-1000rpm；The homogeneous speed of the low speed homogeneous is 1000-
1500rpm。
The cosmetic base containing sea cucumber polypeptide is applied to prepare the cosmetics comprising matrix.
The cosmetics comprising matrix contain the antisenility skin care matrix of above-mentioned sea cucumber polypeptide, wherein the skin matrix
Percentage by weight in the cosmetics is 5%-20%.
The cosmetics are skin-care cosmetics, including emulsion, eye essence, toner and Essence.
The cosmetics be functional cosmetics, including crease-resistant skin care item, Moisturizer, Skin whitening care cosmeticses, anti-acne shield
Skin product and anti-sweat skin care item.
The present invention by experiment sieving three kinds of moisturizings, aging ingredient as main functional component, by between each composition
Interaction is synergistic function, and effect is played to greatest extent.The mechanism initial guess for producing this synergistic effect is this
Covalent bond, hydrogen bond and the coefficient result of hydrophobic effect between a little materials.
Further, since active component of the invention can be degraded Transdermal absorption by skin, nutrition, tool can be supplied for skin
Have and long-acting go effect of wrinkling.
Brief description of the drawings
Fig. 1 is the SDS-PAGE of sea cucumber polypeptide hydrolysis；In figure 1 for participate in reaction soluble sea cucumber protein substrate, 2 be through
Cross the small peptide prod of sea cucumber of degraded.
Fig. 2 is the molecular weight distribution that sea cucumber hydrolyzes small peptide.
Fig. 3 is the inoxidizability contrast column statistical chart before and after sea cucumber proteolysis.
Specific embodiment
Sea cucumber is a kind of traditional marine products treasure, is of high nutritive value, and physiologically active enriches.Have now found that in sea cucumber containing various
Physiological activator can be used to develop both effectiveness skin care item, health products and medicine, such as sea cucumber polypeptide, sea cucumber polysaccharide, sea cucumber soap
Glycosides, aliphatic acid etc..
Ganoderma lucidum belongs to Mycophyta Basidiomycetes Aphyllophorales Polyporaceae plant, and Han dynasty was documented in before more than 2,000 years
《Sheng Nong's herbal classic》.Ganoderma lucidum can be used to treat various diseases, such as hypertension, bronchitis, arthritis, neurasthenia, Chronic Liver
Inflammation, ephritis, gastric ulcer, immunologic derangement, cancer etc..GL-B has the function of regulation human immune system and treating cancer,
And with specific immunity humidification, can be with the cell phagocytic activity of activated macrophage, the immunological regulation work(of raising body
Energy.
Panaxan and ginsenoside are rich in ginseng extract solution, tool promotes the activity of dermal fibroblasts, can be with
Increase the growing amount of elastin laminin, so as to increase cytoactive, reduce the aging of skin.
With the development of cosmetics industry, the product of natural origin due to using safety, effect is obvious the advantages of and
Welcome.Prepare sea cucumber active peptide using biotechnology hydrolysis, compounding ganoderma lucidum, the natural extract such as ginseng, can reach compared with
Good anti-aging effects, and it is relatively mild, it is few to stimulate.
A kind of anti-aging cosmetics matrix of the invention, the sea cucumber polypeptide hydrolyzate comprising 40-50%；The ganoderma lucidum of 5-15%
Polysaccharide；The ginseng root extract of 5-15%；The deionized water of 20-50%；Sea cucumber polypeptide hydrolyzate, ganoderma lucidum are more in the matrix
The percentage by weight sum of sugar, ginseng root extract and water each component is 100%.
Anti-aging cosmetics matrix of the invention is added in cosmetics, its weight content in cosmetics is 5%-
20%.
Below by specific preferred embodiment combination accompanying drawing, the present invention is described in further detail, but reality of the invention
Apply mode not limited to this.
Embodiment 1
A kind of hydrolysis preparation method of sea cucumber polypeptide, concretely comprises the following steps：
1) first new fresh sea cucumber is cleaned with running water, removes silt in sea cucumber body, sea cucumber mud is twisted into meat grinder；
2) ultra-pure water of the weight such as addition and sea cucumber mud raw material, is heated up to 50 DEG C；
3) the compound enzyme system of 1000U/g is added, the compound enzyme system is by neutral proteinase, papain and clostridiopetidase A with enzyme
Work compares 0.4：0.6：1 composition.The enzymolysis processing 2h at 50 DEG C；
4) 20min is incubated at being warming up to 121 DEG C, the enzyme that goes out sterilizing；
5) centrifugation of 5000-12000rpm, removes residue；
6) the molecular weight contrast of solubility sea cucumber polypeptide before and after hydrolysis is analyzed with SDS-PAGE, as shown in accompanying drawing 1.
The result of Fig. 1 shows that sea cucumber polypeptide can quickly be degraded by compound protease in 2h, and its catabolite
Molecular weight it is smaller, in continuously distributed state.
7) with the method for liquid phase-mass spectrometry, the molecular weight distribution of sea cucumber range of hydrolysed peptides is further studied, as shown in accompanying drawing 2.
It has been investigated that, the product component after sea cucumber polypeptide hydrolysis is more complicated, and major absorbance peak is concentrated in together.Again through mass spectral analysis
After find, the molecular weight of sea cucumber range of hydrolysed peptides is mainly distributed between 300-1000Da, and this meets the molecular weight of bioactive micro peptide
Feature, is more beneficial for the absorption of body.
8) to the centrifugation supernatant Ultra filtration membrane of 5000Da, the product of below molecular weight 5000Da is retained.
9) determine the inoxidizability ability of sea cucumber small peptide using ORAC methods, and using undegradable soluble sea cucumber albumen as
Control.As shown in accompanying drawing 3.
After enzymolysis, its inoxidizability is significantly improved, and the application of this stronger support hydrolysis sea cucumber polypeptide is preceding
Scape, it was demonstrated that it is in the effect to aspects such as anti-agings.
Embodiment 2
A kind of preparation method of the anti-aging cosmetics matrix containing sea cucumber polypeptide, concretely comprises the following steps：
1) stirring (rotating speed is 800rpm) is opened, it is under greenhouse experiment, 10% GL-B (commercially available prod) is slow
Add in 30% deionized water, constant temperature stirring 20min obtains the GL-B aqueous solution；
2) 50% sea cucumber polypeptide hydrolyzate, 10% ginseng root extract time are added into the GL-B aqueous solution, stirring
After 10min, then low speed homogeneous (homogeneous speed is 1500rpm) 3min, discharge, obtain the skin matrix with anti-aging effects.
Embodiment 3
A kind of eye essence comprising skin matrix, by mass percentage, is made up of following component：
Component A：Lecithin (emulsifying agent) 1.0%, Queensland nut seed oil 1.5%, wheat-germ oil 0.5%, 16/18 alcohol
0.5%；
B component：AVC (acrylate copolymer) 0.5%, methyl hydroxybenzoate 0.1%, dipropylene glycol 5%, deionized water
77.6%；
Component C：Apple seed extract 2.0%, mushroom glucan 1.0%, Phenoxyethanol 0.3%；
D components：The skin matrix 10% of above-described embodiment 2.
Embodiment 4
A kind of preparation method of the eye essence comprising skin matrix：
1) component A in embodiment 3 is added into oil phase pot, opens stirring, rotating speed is 1000rpm, and be warming up to 80 DEG C, guarantor
Warm 10min, obtains oil phase mixed liquor；
2) B component in embodiment 3 is added into water phase pot, opens stirring, rotating speed is 600rpm, and be warming up to 85 DEG C, guarantor
Warm 15min, obtains water and mixes liquid；
3) after water being mixed into liquid suction emulsification pot, emulsification pot stirring is opened, speed of agitator is 60rpm, true by control
Empty valve is slow by oil phase mixed liquor suction emulsification pot, then keeps vacuum (vacuum is -0.05Mpa) and mixing speed is not
Become, open homogeneous, the time of homogeneous is 5min, and the rotating speed of homogeneous is 3000rpm；
4) after the completion of homogeneous, open temperature lowering water and be cooled to 40 DEG C, add the component C stirring 5min in embodiment 3, stirring turns
Fast 60rpm, opens homogeneous, and the time of homogeneous is 1min, and the rotating speed of homogeneous is 1500rpm；D components are subsequently adding, are stirred
15min, rotating speed is 40rpm, discharging, obtains the eye essence comprising skin matrix.
Comparative example 1
The skin matrix of comparative example 1, is made up of the following component counted by weight：10% GL-B, 80% goes
Ionized water, 10% ginseng root extract；Its preparation method with skin matrix in embodiment 2 preparation method；
A kind of eye essence (i.e. the cosmetics comprising skin matrix) comprising skin matrix, by following by quality percentage
Component than counting is constituted：Each component and content are with the eye essence comprising matrix in embodiment 3；Its preparation method is with implementation
The preparation method of eye essence in example 4.
A kind of eye essence trial effect experiment comprising skin matrix：
Tested crowd：70 adult female volunteers, the age is between 45-55 one full year of life；
Test method：Made using embodiment 4 in area near the eyes (including palpebra inferior black eye collar region and canthus fishtail line region)
Eye essence prepared by standby eye essence and comparative example 1 (consumption is about 1/4 soya bean size)；After 15min and hold
Continue using after 4 weeks, with FOITS methods (skin fast optical imaging method), measurement skin pattern change, to assess canthus fishtail line
The depth and length of area's wrinkle and microgroove reduce degree, and its test result is as shown in table 1 below.
The trial effect experiment of eye essence of the table 1 containing sea cucumber polypeptide anti-aging matrix
From experimental result as can be seen that a kind of anti-aging eye essence (experimental example 4) containing sea cucumber polypeptide, flat reducing
Equal chill mark and average wrinkle volume aspect, the data display of 15min, embodiment 4 and comparative example 1 have certain immediately crease-resistant
Effect, both effect gaps are not obvious (especially chill mark decrement).And after 4 weeks, the long-acting anti-wrinkle effect of embodiment 4
Manifest, whether chill mark or wrinkle volume, have substantially reduction compared to comparative example 1.
In terms of composition, the 5% sea cucumber polypeptide hydrolyzates only many compared to comparative example 1 of embodiment 4, remaining composition is identical.
This explanation, sea cucumber polypeptide hydrolyzate has certain anti-aging effects, such as uses for a long time, and anti-wrinkle effect is notable.
The above, is only presently preferred embodiments of the present invention, and any formal limitation is not made to the present invention, therefore
It is every without departing from technical solution of the present invention content, any simply repaiied according to what technical spirit of the invention was made to above example
Change, equivalent variations and modification, still fall within the range of technical solution of the present invention.
Claims (10)
1. a kind of anti-aging cosmetics matrix, it is characterised in that consist of the following components in percentage by weight：
The sea cucumber polypeptide hydrolyzate of 40-50%；
The GL-B of 5-15%；
The ginseng root extract of 5-15%；
The deionized water of 20-50%；Sea cucumber polypeptide hydrolyzate, GL-B, ginseng root extract and water are each in the matrix
The weight sum of component is 100%.
2. anti-aging cosmetics matrix according to claim 1, it is characterised in that the sea cucumber polypeptide is by following operation
Obtain：
Sea cucumber raw material is cleaned and crush, is hydrolyzed with the compound enzyme system of clostridiopetidase A and multiple protein enzyme and is prepared sea cucumber active peptide；
Again with the method for UF membrane, small peptide of its middle-molecular-weihydroxyethyl in below 5kDa is enriched with；
The small molecule sea cucumber polypeptide Transdermal absorption for obtaining is good, and collagen content is high, can provide nutrition for skin.
3. anti-aging cosmetics matrix according to claim 2, it is characterised in that：Multienzyme compounding hydrolysis prepares sea cucumber polypeptide
Method：
1) first new fresh sea cucumber is cleaned with running water, removes silt in sea cucumber body, sea cucumber mud is twisted into meat grinder；
2) ultra-pure water of the weight such as addition and sea cucumber mud raw material, is heated up to 40-60 DEG C；
3) the compound enzyme system being made up of neutral proteinase, papain and clostridiopetidase A of 700U/g-2500U/g is added,
Enzymolysis processing 1-5h at 40-60 DEG C；
4) 5min-30min is incubated at being warming up to 110 DEG C -125 DEG C, the enzyme that goes out sterilizing；
5) centrifugation of 5000-12000rpm, removes residue；
6) to the centrifugation supernatant Ultra filtration membrane of 5000Da, the product of below molecular weight 5000Da is retained.
4. anti-aging cosmetics matrix according to claim 1, it is characterised in that：The composition of the compound enzyme system：In
Property protease, papain and clostridiopetidase A, in its enzyme activity ratio 0.4：0.6：1 is combined into compound enzyme system；Through compound enzyme system water
The sea cucumber hydrolyzate that solution is obtained, its percent hydrolysis is up to more than 78%.
5. anti-aging cosmetics matrix according to claim 1, it is characterised in that：The GL-B is from medicine-food two-purpose
Deep glossy ganoderma fermenting liquid, mycelium or Extraction and enrichment is obtained in fructification.
6. the preparation method of the anti-aging cosmetics matrix any one of claim 1-5, it is characterised in that：Including following
Step：
1) stirring is opened, at ambient temperature, the GL-B of 5%-15% is slowly added in the water of 20%-50%, room temperature
Stirring；
2) the ginseng extract solution of the sea cucumber polypeptide hydrolyzate of 40%-50% and 5%-15% is added into step 1) resulting solution
In, stirring, low speed homogeneous, discharging obtains the cosmetic base with anti-aging effects.
7. preparation method according to claim 6, it is characterised in that：
Step 1) described in mixing speed be 800-1000rpm；The time being stirred at room temperature is 30-60min；Step 2) in institute
The homogeneous speed of low speed homogeneous is stated for 1000-1500rpm, the time of low speed homogeneous is 3-6min；The mixing speed is 800-
1000rpm, the mixing time is 5-10min.
8. a kind of cosmetics of the anti-aging cosmetics matrix comprising any one of claim 1-5, it is characterised in that：Institute
Weight content of the skin matrix with senile-resistant efficacy in cosmetics is stated for 5%-20%：The cosmetics are skin type
Cosmetic or functional cosmetics；The skin-care cosmetics include emulsion, eye essence, toner and Essence；It is described
Functional cosmetics include crease-resistant skin care item, Moisturizer, Skin whitening care cosmeticses, anti-acne skin care item and anti-sweat skin care item.
9. cosmetics according to claim 8, it is characterised in that：By mass percentage, the eye essence by with
Under component composition：
Component A：Lecithin (emulsifying agent) 1.0%, Queensland nut seed oil 1.5%, wheat-germ oil 0.5%, 16/18 alcohol 0.5%；
B component：AVC (acrylate copolymer) 0.5%, methyl hydroxybenzoate 0.1%, dipropylene glycol 5%, deionized water 77.6%；
Component C：Apple seed extract 2.0%, mushroom glucan 1.0%, Phenoxyethanol 0.3%；
D components：Above-mentioned skin matrix 10%.
10. cosmetics according to claim 9, it is characterised in that：The eye essence is according to following processing step
Prepare：
1) component A is added into oil phase pot, opens stirring, and be warming up to 80 DEG C, be incubated 10min, obtain oil phase mixed liquor；By B groups
Point water phase pot is added, open stirring, and be warming up to 85 DEG C, be incubated 15min, obtained water and mix liquid；
2) after water being mixed into liquid suction emulsification pot, emulsification pot stirring is opened, is slowly mixed oil phase by controlling vacuum valve
Liquid suction emulsification pot, then keeps vacuum and mixing speed constant, opens homogeneous；
3) after the completion of homogeneous, open temperature lowering water and be cooled to 40 DEG C, add component C stirring 5min, speed of agitator 60rpm, open equal
Matter, the time of homogeneous is 1min, and the rotating speed of homogeneous is 1500rpm；D components are subsequently adding, 15min is stirred, rotating speed are 40rpm,
Discharging, obtains the eye essence comprising skin matrix.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375009A (en) * | 2017-07-27 | 2017-11-24 | 名臣健康用品股份有限公司 | A kind of antisenility skin care matrix containing sea cucumber polysaccharide and preparation method thereof |
| CN107397707A (en) * | 2017-07-25 | 2017-11-28 | 山东圣洲海洋生物科技股份有限公司 | A kind of skin care topical composition and preparation method thereof |
| CN107670097A (en) * | 2017-10-19 | 2018-02-09 | 北京九鼎君健医药科技项城有限公司 | A kind of oligopeptide Wound dressing for promoting diabetes wound healing and preparation method thereof |
| CN107737078A (en) * | 2017-09-13 | 2018-02-27 | 山东圣洲海洋生物科技股份有限公司 | A kind of sea cucumber Essence |
| CN110559251A (en) * | 2019-10-15 | 2019-12-13 | 严志晶 | Natural anti-wrinkle cosmetic material and preparation method thereof |
| CN112370369A (en) * | 2020-10-28 | 2021-02-19 | 梁志勇 | Marine protein skin moisturizer for resisting skin aging |
| CN113456561A (en) * | 2021-07-09 | 2021-10-01 | 广西和桂集团有限公司 | Preparation method and application of essence containing polypeptide and plant extract |
| CN116035216A (en) * | 2022-09-07 | 2023-05-02 | 浙江诺衍生物科技有限公司 | Anti-aging composition and preparation method and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101191139A (en) * | 2007-04-28 | 2008-06-04 | 付学军 | Integrated extraction technique for sea cucumber polypeptide and polysaccharide |
| CN101143155B (en) * | 2006-09-15 | 2010-05-12 | 中国科学院大连化学物理研究所 | Double ginseng composition and its application |
| CN101966141A (en) * | 2010-10-14 | 2011-02-09 | 珈侬生化科技(中国)有限公司 | Composite containing ginseng extracts and ganoderma extracts and application thereof |
| CN102743300A (en) * | 2012-07-18 | 2012-10-24 | 大连湘蓝生物科技有限公司 | Sea cucumber glycopeptide, preparation method and application in preparation of cosmetics |
| CN102907558A (en) * | 2012-11-16 | 2013-02-06 | 山东省海洋水产研究所 | Processing method of sea cucumber polypeptide |
| CN103421867A (en) * | 2012-05-14 | 2013-12-04 | 宁波餐之皇食品有限公司 | Preparation method of sea cucumber collagens |
| CN103468775A (en) * | 2013-06-05 | 2013-12-25 | 青岛耐特生物技术有限公司 | Method for extracting high-purity sea cucumber polypeptides |
| CN104523478A (en) * | 2014-12-05 | 2015-04-22 | 广东丸美生物技术股份有限公司 | Skin-care matrix with instant skin-tightening effects and its preparation method and use |
-
2016
- 2016-11-18 CN CN201611025160.7A patent/CN106726669A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143155B (en) * | 2006-09-15 | 2010-05-12 | 中国科学院大连化学物理研究所 | Double ginseng composition and its application |
| CN101191139A (en) * | 2007-04-28 | 2008-06-04 | 付学军 | Integrated extraction technique for sea cucumber polypeptide and polysaccharide |
| CN101966141A (en) * | 2010-10-14 | 2011-02-09 | 珈侬生化科技(中国)有限公司 | Composite containing ginseng extracts and ganoderma extracts and application thereof |
| CN103421867A (en) * | 2012-05-14 | 2013-12-04 | 宁波餐之皇食品有限公司 | Preparation method of sea cucumber collagens |
| CN102743300A (en) * | 2012-07-18 | 2012-10-24 | 大连湘蓝生物科技有限公司 | Sea cucumber glycopeptide, preparation method and application in preparation of cosmetics |
| CN102907558A (en) * | 2012-11-16 | 2013-02-06 | 山东省海洋水产研究所 | Processing method of sea cucumber polypeptide |
| CN103468775A (en) * | 2013-06-05 | 2013-12-25 | 青岛耐特生物技术有限公司 | Method for extracting high-purity sea cucumber polypeptides |
| CN104523478A (en) * | 2014-12-05 | 2015-04-22 | 广东丸美生物技术股份有限公司 | Skin-care matrix with instant skin-tightening effects and its preparation method and use |
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