CN106687114B - 嘧啶化合物及其使用方法 - Google Patents

嘧啶化合物及其使用方法 Download PDF

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Publication number
CN106687114B
CN106687114B CN201580043036.0A CN201580043036A CN106687114B CN 106687114 B CN106687114 B CN 106687114B CN 201580043036 A CN201580043036 A CN 201580043036A CN 106687114 B CN106687114 B CN 106687114B
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CN106687114A (zh
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G.D.库尼
M.A.格利斯曼
K.J.霍格茨
S.L.马蒂厄
Y.Y.佩雷拉
V.达门西
H.卢西奇
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Yuma Therapeutics Inc
Brigham and Womens Hospital Inc
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Yuma Therapeutics Inc
Brigham and Womens Hospital Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
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    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/04—Ortho-condensed systems
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  • Pulmonology (AREA)
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  • Rheumatology (AREA)
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  • Pain & Pain Management (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
CN201580043036.0A 2014-06-13 2015-06-15 嘧啶化合物及其使用方法 Active CN106687114B (zh)

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Application Number Priority Date Filing Date Title
US201462012152P 2014-06-13 2014-06-13
US62/012152 2014-06-13
PCT/US2015/035735 WO2015192119A1 (en) 2014-06-13 2015-06-15 Pyrimidine compounds and methods using the same

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CN106687114A CN106687114A (zh) 2017-05-17
CN106687114B true CN106687114B (zh) 2021-08-31

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US (3) US10336768B2 (enExample)
EP (1) EP3154547B1 (enExample)
JP (1) JP6779867B2 (enExample)
CN (1) CN106687114B (enExample)
AU (1) AU2015274285C1 (enExample)
CA (1) CA2952230C (enExample)
ES (1) ES2954453T3 (enExample)
WO (1) WO2015192119A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106687114B (zh) * 2014-06-13 2021-08-31 尤马治疗公司 嘧啶化合物及其使用方法
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
JP7156154B2 (ja) * 2019-04-18 2022-10-19 株式会社島津製作所 培地処理システム及び培地処理方法
KR102112336B1 (ko) * 2019-08-12 2020-05-18 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
WO2022082108A1 (en) * 2020-10-16 2022-04-21 The Brigham And Women's Hospital, Inc. Compositions for inducing tumor immunity and reducing drug tolerance

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US2691655A (en) * 1952-05-24 1954-10-12 Burroughs Wellcome Co 2-amino-4-substituted amino-6-aryl pyrimidines and process of preparing same
US5863924A (en) * 1996-05-23 1999-01-26 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives
WO2006123165A2 (en) * 2005-05-19 2006-11-23 Astex Therapeutics Limited Pyrimidine derivatives as hsp90 inhibitors
WO2008059368A2 (en) * 2006-11-17 2008-05-22 Pfizer Products Inc. Fused 2-amino pyrimidine compounds and their use for the treatment of cancer

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DE19735800A1 (de) * 1997-08-18 1999-02-25 Boehringer Ingelheim Pharma Triazine mit adenosinantagonistischer Wirkung
EP1675861B1 (en) 2003-08-29 2015-12-23 Vernalis (R&D) Ltd. Pyrimidothiophene compounds
GB0416168D0 (en) 2004-07-20 2004-08-18 Vernalis Cambridge Ltd Pyrmidothiophene compounds
WO2006090094A1 (en) 2005-02-28 2006-08-31 Vernalis R & D Ltd Pyrimidothiophene compounds for use as hsp90 inhibitors
DE102005022977A1 (de) * 2005-05-19 2006-12-07 Merck Patent Gmbh Phenylchinazolinderivate
DE102006008880A1 (de) 2006-02-27 2007-09-06 Merck Patent Gmbh Aminopyrimidinderivate
EA200801968A1 (ru) 2006-03-11 2009-02-27 Вернэлис (Р&Д) Лтд. Пирролопиримидиновые производные, используемые в качестве ингибиторов hsp90
AR061185A1 (es) 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
CU20090141A7 (es) * 2007-02-06 2011-04-26 Pfizer Compuestos 2-amino pirimidina
JP2009067729A (ja) 2007-09-14 2009-04-02 Kyowa Hakko Kirin Co Ltd Ｈｓｐ９０ファミリー蛋白質阻害剤
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WO2013157021A1 (en) * 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
KR20150010793A (ko) 2012-05-25 2015-01-28 버그 엘엘씨 열 충격 단백질 (hsp) 90-베타의 조절에 의한 대사 증후군의 치료 방법들
BR112015011497B1 (pt) * 2012-11-27 2023-01-10 Thomas Helledays Stiftelse För Medicinsk Forskning Composto, e, formulação farmacêutica
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CN106687114B (zh) * 2014-06-13 2021-08-31 尤马治疗公司 嘧啶化合物及其使用方法
ES2768694T3 (es) * 2014-09-19 2020-06-23 Forma Therapeutics Inc Composiciones de quinolinona pirimidinas como inhibidores de isocitrato dehidrogenasa mutante

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US2691655A (en) * 1952-05-24 1954-10-12 Burroughs Wellcome Co 2-amino-4-substituted amino-6-aryl pyrimidines and process of preparing same
US5863924A (en) * 1996-05-23 1999-01-26 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives
WO2006123165A2 (en) * 2005-05-19 2006-11-23 Astex Therapeutics Limited Pyrimidine derivatives as hsp90 inhibitors
WO2008059368A2 (en) * 2006-11-17 2008-05-22 Pfizer Products Inc. Fused 2-amino pyrimidine compounds and their use for the treatment of cancer

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EP3154547A1 (en) 2017-04-19
JP2017521489A (ja) 2017-08-03
CN106687114A (zh) 2017-05-17
EP3154547B1 (en) 2023-06-07
CA2952230A1 (en) 2015-12-17
WO2015192119A1 (en) 2015-12-17
JP6779867B2 (ja) 2020-11-04
US20170107228A1 (en) 2017-04-20
EP3154547A4 (en) 2018-01-24
CA2952230C (en) 2023-03-21
AU2015274285C1 (en) 2021-07-01
US10961254B2 (en) 2021-03-30
US10336768B2 (en) 2019-07-02
ES2954453T3 (es) 2023-11-22
US20190389878A1 (en) 2019-12-26
AU2015274285A1 (en) 2017-02-02
US20210363154A1 (en) 2021-11-25
AU2015274285B2 (en) 2020-12-10

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